The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Ventral Tegmental Area Neurons in Learned Appetitive Behavior and Positive Reinforcement
Abstract
Ventral tegmental area (VTA) neuron firing precedes behaviors elicited by reward-predictive sensory cues and scales with the magnitude and unpredictability of received rewards. These patterns are consistent with roles in the performance of learned appetitive behaviors and in positive reinforcement, respectively. The VTA includes subpopulations of neurons with different afferent connections, neurotransmitter content, and projection targets. Because the VTA and substantia nigra pars compacta are the sole sources of striatal and limbic forebrain dopamine, measurements of dopamine release and manipulations of dopamine function have provided critical evidence supporting a VTA contribution to these functions. However, the VTA also sends GABAergic and glutamatergic projections to the nucleus accumbens and prefrontal cortex. Furthermore, VTA-mediated but dopamine-independent positive reinforcement has been demonstrated. Consequently, identifying the neurotransmitter content and projection target of VTA neurons recorded in vivo will be critical for determining their contribution to learned appetitive behaviors.
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Citations
Cites
Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
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Dopamine, learning and motivation.
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“Microinjection of MOP receptor agonists directly into the VTA also elicits robust CPP (Hand et al. 1989, Shippenberg & Herz 1987), and rodents will learn to self-administer both MOP and δ opioid receptor agonists directly into the VTA (reviewed in McBride et al. 1999, Wise 2004).”
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“…function was largely ignored until the discovery that it includes dopaminergic neurons (the A10 group; Dahlstroem & Fuxe 1964) and that these neurons project widely to limbic areas implicated in motivation and positive reinforcement (Fallon & Moore 1978, Swanson 1982, Ungerstedt 1971a) (Figure 1).”
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“This increase in firing scales with the magnitude of reward received (e.g., vol- ume of juice; Tobler et al. 2005).”
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Cited by
Neuronal circuits for fear and anxiety
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The mysterious motivational functions of mesolimbic dopamine
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Dopamine neurons modulate neural encoding and expression of depression-related behaviour
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Circuit architecture of VTA dopamine neurons revealed by systematic input-output mapping
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Metadata
- Authors
- Fields, H. L., Hjelmstad, G. O., Margolis, E. B., & Nicola, S. M.
- Venue
- Annual Review of Neuroscience
- Publisher
- Annual Reviews
- Published
- 2007-07-01
- Volume
- 30
- Issue
- 1
- Pages
- 289-316
- ISSN
- 0147-006X (ISSN-L)
- 1545-4126
- OpenAlex
- W2107525024
- Cited by
- 621
- References
- 30
- FWCI
- 1.24
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fields, H. L., Hjelmstad, G. O., Margolis, E. B., & Nicola, S. M. (2007). Ventral Tegmental Area Neurons in Learned Appetitive Behavior and Positive Reinforcement. Annual Review of Neuroscience. https://doi.org/10.1146/annurev.neuro.30.051606.094341
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