The mysterious motivational functions of mesolimbic dopamine

Salamone, John D.; Correa, Mercè

doi:10.1016/j.neuron.2012.10.021

Cited by 1,418Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesNeuroscience and Neuropharmacology Research

The mysterious motivational functions of mesolimbic dopamine

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Salamone, John D., Correa, Mercè·2012·Neuron

DOI 10.1016/j.neuron.2012.10.021PMC PMC4450094

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Abstract

Nucleus accumbens dopamine is known to play a role in motivational processes, and dysfunctions of mesolimbic dopamine may contribute to motivational symptoms of depression and other disorders, as well as features of substance abuse. Although it has become traditional to label dopamine neurons as "reward" neurons, this is an overgeneralization, and it is important to distinguish between aspects of motivation that are differentially affected by dopaminergic manipulations. For example, accumbens dopamine does not mediate primary food motivation or appetite, but is involved in appetitive and aversive motivational processes including behavioral activation, exertion of effort, approach behavior, sustained task engagement, Pavlovian processes, and instrumental learning. In this review, we discuss the complex roles of dopamine in behavioral functions related to motivation.

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VTA-DA neurons play a central role in governing processes related to learning and the formation of memories associated with hedonic and motivational rewards.
“VTA-DA neurons play a central role in governing processes related to learning and the formation of memories associated with hedonic and motivational rewards (Rossato et al., 2009; Salamone and Correa, 2012; Wise, 2004).”
From Convergence of oxytocin and dopamine signalling in neuronal circuits: Insights into the neurobiology of social interactions across species (2024) · cites this paper as Salamone and Correa, 2012
The Summary and Conclusions (page unavailable) supports a role for mesolimbic dopamine in specific motivational and learning processes, and the Appetitive Instrumental Learning section reports that VTA dopamine-neuron stimulation can promote acquisition of food-reinforced responding. But the paper does not establish a central role in forming reward-related memories; it also cautions against equating dopamine with hedonia and says accumbens dopamine does not directly mediate hedonic reactions. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Incentive motivation for rewards depends on dopaminergic neurotransmission in the nucleus accumbens.
“It is well-known that incentive motivation for rewards depends on dopaminergic neurotransmission in the nucleus accumbens (Salamone et al. 2012).”
From Neurexin1α knockout in rats causes aberrant social behaviour: relevance for autism and schizophrenia (2025) · cites this paper as Salamone et al. 2012
The Summary and Conclusions (page not provided) says nucleus accumbens dopamine is important for aspects of appetitive motivation, including effort and cue-instigated approach. But the paper stresses that dopamine is critical for some motivational functions and not others; it does not support the unqualified claim that incentive motivation for rewards depends on it. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Amygdala and ACC inactivations caused changes to behaviour during a cognitive effort task that were different from those in physical effort tasks.
“Specifically, amygdala and ACC inactivations caused changes to behaviour during a cognitive effort task [27] that were different to those in physical effort tasks [2, 25, 26].”
From Neurocomputational mechanisms underlying subjective valuation of effort costs (2017) · cites this paper as [2]

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Phasic D1 and tonic D2 dopamine receptor signaling double dissociate the motivational effects of acute nicotine and chronic nicotine withdrawal
Grieder, T. E., George, O., Tan, H., George, S. R., Foll, B. L., Laviolette, S. R., & van der Kooy, D. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114422109 · Cited by 79 · see citing works
Effect of the Dopamine D1/5 Antagonist SCH 23390 on the Acquisition of Conditioned Fear
Inoue, T., Izumi, T., Maki, Y., Muraki, I., & Koyama, T. (2000) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(00)00254-9 · Cited by 77 · see citing works
Separate measures of ethanol seeking and drinking in the rat
Czachowski, C. L., Santini, L. A., Legg, B. H., & Samson, H. H. (2002) · Alcohol · doi:10.1016/s0741-8329(02)00236-7 · Cited by 74 · see citing works
Acute phenylalanine/tyrosine depletion reduces motivation to smoke cigarettes across stages of addiction
Venugopalan, V. V., Casey, K. F., O'Hara, C., O'Loughlin, J., Benkelfat, C., Fellows, L. K., & Leyton, M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.135 · Cited by 70 · see citing works
The role of nucleus accumbens dopamine in outcome encoding in instrumental and Pavlovian conditioning
Lex, B., & Hauber, W. (2010) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2009.11.002 · Cited by 61 · see citing works
Rapid Dopamine Signaling Differentially Modulates Distinct Microcircuits within the Nucleus Accumbens during Sucrose-Directed Behavior
Cacciapaglia, F., Wightman, R. M., & Carelli, R. M. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1340-11.2011 · Cited by 61 · see citing works
The dopamine augmenter L-DOPA does not affect positive mood in healthy human volunteers.
Liggins, J., Pihl, R. O., Benkelfat, C., & Leyton, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0028370 · Cited by 58 · see citing works
Involvement of dopamine and opioids in the motivation to eat: influence of palatability, homeostatic state, and behavioral paradigms
Barbano, M. F., Saux, M. L., & Cador, M. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1390-6 · Cited by 56 · see citing works
Dopamine Release in the Prefrontal Cortex and Striatum: Temporal and Behavioural Aspects
Hauber, W. (2010) · Pharmacopsychiatry · doi:10.1055/s-0030-1248300 · Cited by 56 · see citing works
At What Stage of Neural Processing Does Cocaine Act to Boost Pursuit of Rewards?
Hernández, G., Breton, Y.-A., Conover, K. L., & Shizgal, P. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015081 · Cited by 55 · see citing works
Regulatory impairments following selective 6-OHDA lesions of the neostriatum
Dunnett, S. B., & Iversen, S. D. (1982) · Behavioural Brain Research · doi:10.1016/0166-4328(82)90072-9 · Cited by 52 · see citing works
Pharmacological and Physiological Characterization of the Tremulous Jaw Movement Model of Parkinsonian Tremor: Potential Insights into the Pathophysiology of Tremor
Collins‐Praino, L. E., Paul, N. E., Rychalsky, K. L., Hinman, J. R., Chrobak, J. J., Senatus, P. B., & Salamone, J. D. (2011) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2011.00049 · Cited by 45 · see citing works
Self-citation
Slow phasic changes in nucleus accumbens dopamine release during fixed ratio acquisition: a microdialysis study
Segovia, K. N., Correa, M., & Salamone, J. D. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.07.078 · Cited by 44 · see citing works
Self-citation
Alterations in brain activation in posttraumatic stress disorder patients with severe hyperarousal symptoms and impulsive aggressiveness
Pavić, L. (2003) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-003-0411-z · Cited by 42 · see citing works
Changes in nucleus accumbens and neostriatal c‐Fos and DARPP‐32 immunoreactivity during different stages of food‐reinforced instrumental training
Segovia, K. N., Correa, M., Lennington, J. B., Conover, J. C., & Salamone, J. D. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08036.x · Cited by 40 · see citing works
Self-citation
A behavioral genetics approach to understanding D1 receptor involvement in phasic dopamine signaling
Wall, V., Parker, J. G., Fadok, J. P., Darvas, M., Zweifel, L. S., & Palmiter, R. D. (2010) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2010.09.011 · Cited by 39 · see citing works
Role of Nigrostriatal Dopamine System in Learning to Perform Sequential Motor Tasks in a Predictive Manner
松本, 直. (2000) · doi:10.11501/3172774 · Cited by 38 · see citing works
Commentary: WILL THE LAST PERSON WHO USES THE TERM ‘REWARD’ PLEASE TURN OUT THE LIGHTS? COMMENTS ON PROCESSES RELATED TO REINFORCEMENT, LEARNING, MOTIVATION AND EFFORT
Salamone, J. D. (2006) · Addiction Biology · doi:10.1111/j.1369-1600.2006.00011.x · Cited by 35 · see citing works
Self-citation
Intact discrimination reversal learning but slowed responding to reward-predictive cues after dopamine D1 and D2 receptor blockade in the nucleus accumbens of rats
Calaminus, C., & Hauber, W. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0532-y · Cited by 34 · see citing works
Effects of amphetamine, dexfenfluramine, diazepam, and other pharmacological and dietary manipulations on food "seeking" and "taking" behavior in non-human primates
Foltin, R. W. (2001) · Psychopharmacology · doi:10.1007/s002130100865 · Cited by 32 · see citing works

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An opportunity cost model of subjective effort and task performance
Kurzban, R., Duckworth, A., Kable, J. W., & Myers, J. (2013) · Behavioral and Brain Sciences · doi:10.1017/s0140525x12003196 · Cited by 1,381 · see citing works
The theory of constructed emotion: an active inference account of interoception and categorization
Barrett, L. F. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw154 · Cited by 1,426 · see citing works
“…with engaging in vigorous action and learning that is necessary to achieve the rewards that maintain efficient allostasis (or restore it in the event of disruption), rather than playing a necessary or sufficient role in rewards themselves (Salamone and Correa, 2012; Guitart-Masip et al. , 2014).”
Liking, wanting, and the incentive-sensitization theory of addiction
Berridge, K. C., & Robinson, T. E. (2016) · American Psychologist · doi:10.1037/amp0000059 · Cited by 1,440 · see citing works
Ventral tegmental area: cellular heterogeneity, connectivity and behaviour
Morales, M., & Margolis, E. B. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.165 · Cited by 1,108 · see citing works
Dopamine: Functions, Signaling, and Association with Neurological Diseases
Klein, M. O., Battagello, D. S., Cardoso, A. R., Hauser, D. N., Bittencourt, J. C., & Correa, R. G. (2019) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-018-0632-3 · Cited by 1,073 · see citing works
The Nucleus Accumbens: An Interface Between Cognition, Emotion, and Action
Floresco, S. B. (2015) · Annual Review of Psychology · doi:10.1146/annurev-psych-010213-115159 · Cited by 938 · see citing works
The theory of constructed emotion: an active inference account of interoception and categorization
Barrett, L. F. (2017) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsx060 · Cited by 950 · see citing works
“…with engaging in vigorous action and learning that is necessary to achieve the rewards that maintain efficient allostasis (or restore it in the event of disruption), rather than playing a necessary or sufficient role in rewards themselves (Salamone and Correa, 2012; Guitart-Masip et al., 2014).”
What does dopamine mean?
Berke, J. D. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0152-y · Cited by 904 · see citing works
Coming to terms with fear
LeDoux, J. E. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1400335111 · Cited by 891 · see citing works
The Neuroscience of Drug Reward and Addiction
Volkow, N. D., Michaelides, M., & Baler, R. (2019) · Physiological Reviews · doi:10.1152/physrev.00014.2018 · Cited by 863 · see citing works
Reward and aversion in a heterogeneous midbrain dopamine system
Lammel, S., Lim, B. K., & Malenka, R. C. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.03.019 · Cited by 804 · see citing works
Active Inference, homeostatic regulation and adaptive behavioural control
Pezzulo, G., Rigoli, F., & Friston, K. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.09.001 · Cited by 650 · see citing works
“context, dopaminergic responses appear to transfer from the US when it is encountere (as in the ‘‘liking’’ system) but instrumental to goal pursuit (Salamone and Correa, 2012).”
Influential
VTA dopaminergic neurons regulate ethologically relevant sleep-wake behaviors
Eban-Rothschild, A., Rothschild, G., Giardino, W. J., Jones, J. R., & de Lecea, L. (2016) · Nature Neuroscience · doi:10.1038/nn.4377 · Cited by 583 · see citing works
An active inference theory of allostasis and interoception in depression
Barrett, L. F., Quigley, K. S., & Hamilton, P. (2016) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2016.0011 · Cited by 554 · see citing works
Prolonged dopamine signalling in striatum signals proximity and value of distant rewards
Howe, M. W., Tierney, P. L., Sandberg, S. G., Phillips, P. E. M., & Graybiel, A. M. (2013) · Nature · doi:10.1038/nature12475 · Cited by 565 · see citing works
Understanding opioid reward
Fields, H. L., & Margolis, E. B. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.01.002 · Cited by 432 · see citing works
Inhibitory Input from the Lateral Hypothalamus to the Ventral Tegmental Area Disinhibits Dopamine Neurons and Promotes Behavioral Activation
Nieh, E. H., Vander Weele, C. M., Matthews, G. A., Presbrey, K. N., Wichmann, R., Leppla, C. A., Izadmehr, E. M., & Tye, K. M. (2016) · Neuron · doi:10.1016/j.neuron.2016.04.035 · Cited by 387 · see citing works
Neurocomputational mechanisms underlying subjective valuation of effort costs
Chong, T. T.-J., Apps, M., Giehl, K., Sillence, A., Grima, L. L., & Husain, M. (2017) · PLOS Biology · doi:10.1371/journal.pbio.1002598 · Cited by 415 · see citing works
Overlapping Brain Circuits for Homeostatic and Hedonic Feeding
Rossi, M. A., & Stuber, G. D. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2017.09.021 · Cited by 415 · see citing works
Nucleus Accumbens Subnuclei Regulate Motivated Behavior via Direct Inhibition and Disinhibition of VTA Dopamine Subpopulations
Yang, H., de Jong, J. W., Tak, Y., Peck, J., Bateup, H. S., & Lammel, S. (2018) · Neuron · doi:10.1016/j.neuron.2017.12.022 · Cited by 407 · see citing works
Treatment for Anhedonia: A Neuroscience Driven Approach: 2015 ADAA Scientific Research Symposium: Treatment for Anhedonia
Craske, M. G., Meuret, A. E., Ritz, T., Treanor, M., & Dour, H. J. (2016) · Depression and Anxiety · doi:10.1002/da.22490 · Cited by 387 · see citing works
Oxytocin, motivation and the role of dopamine
Love, T. M. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.06.011 · Cited by 369 · see citing works
Activational and effort-related aspects of motivation: neural mechanisms and implications for psychopathology
Salamone, J. D., Yohn, S. E., López-Cruz, L., San Miguel, N., & Correa, M. (2016) · Brain · doi:10.1093/brain/aww050 · Cited by 350 · see citing works
Self-citation
The Brain’s Response to Reward Anticipation and Depression in Adolescence: Dimensionality, Specificity, and Longitudinal Predictions in a Community-Based Sample
Stringaris, A., Vidal-Ribas Belil, P., Artiges, E., Lemaitre, H., Gollier-Briant, F., Wolke, S., Vulser, H., Miranda, R., Penttilä, J., Struve, M., et al. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.14101298 · Cited by 322 · see citing works
The neurobiology of social play and its rewarding value in rats
Vanderschuren, L. J. M. J., Achterberg, E. J. M., & Trezza, V. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.07.025 · Cited by 329 · see citing works
A Corticostriatal Path Targeting Striosomes Controls Decision-Making under Conflict
Friedman, A., Homma, D., Gibb, L. G., Amemori, K.-I., Rubin, S. J., Hood, A. S., Riad, M. H., & Graybiel, A. M. (2015) · Cell · doi:10.1016/j.cell.2015.04.049 · Cited by 309 · see citing works
An excitatory synapse hypothesis of depression
Thompson, S. M., Kallarackal, A. J., Kvarta, M. D., Van Dyke, A. M., LeGates, T. A., & Cai, X. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.03.003 · Cited by 265 · see citing works
Decreased motivation during chronic pain requires long-term depression in the nucleus accumbens
Schwartz, N., Temkin, P., Jurado, S., Lim, B. K., Heifets, B. D., Polepalli, J. S., & Malenka, R. C. (2014) · Science · doi:10.1126/science.1253994 · Cited by 278 · see citing works
Action versus valence in decision making
Guitart-Masip, M., Duzel, E., Dolan, R., & Dayan, P. (2014) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2014.01.003 · Cited by 270 · see citing works
Ventral tegmental area dopamine revisited: effects of acute and repeated stress
Holly, E. N., & Miczek, K. A. (2016) · Psychopharmacology · doi:10.1007/s00213-015-4151-3 · Cited by 265 · see citing works
Anti-anhedonic effect of ketamine and its neural correlates in treatment-resistant bipolar depression
Lally, N., Nugent, A. C., Luckenbaugh, D. A., Ameli, R., Roiser, J. P., & Zarate, C. A. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.105 · Cited by 271 · see citing works
The impact of sugar consumption on stress driven, emotional and addictive behaviors
Jacques, A., Chaaya, N., Beecher, K., Ali, S. A., Belmer, A., & Bartlett, S. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.05.021 · Cited by 271 · see citing works
The dopaminergic midbrain encodes the expected certainty about desired outcomes
Schwartenbeck, P., FitzGerald, T. H. B., Mathys, C., Dolan, R., & Friston, K. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhu159 · Cited by 219 · see citing works
Amygdala-Ventral Pallidum Pathway Decreases Dopamine Activity After Chronic Mild Stress in Rats
Chang, C.-H., & Grace, A. A. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.09.020 · Cited by 239 · see citing works
Mechanisms Underlying Motivational Deficits in Psychopathology: Similarities and Differences in Depression and Schizophrenia
Barch, D. M., Pagliaccio, D., & Luking, K. (2015) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2015_376 · Cited by 218 · see citing works
Overlapping neural systems represent cognitive effort and reward anticipation
Vassena, E., Silvetti, M., Boehler, C. N., Achten, E., Fias, W., & Verguts, T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091008 · Cited by 200 · see citing works
Increasing dopamine D2 receptor expression in the adult nucleus accumbens enhances motivation
Trifilieff, P., Feng, B., Urizar, E., Winiger, V, Ward, R. D., Taylor, K. M., Martinez, D., Moore, H., Balsam, P. D., Simpson, E. H., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.57 · Cited by 206 · see citing works
Mesolimbic Dopamine and the Regulation of Motivated Behavior
Salamone, J. D., Pardo, M., Yohn, S. E., López-Cruz, L., SanMiguel, N., & Correa, M. (2015) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2015_383 · Cited by 204 · see citing works
Self-citation
Reversal learning and dopamine: a Bayesian perspective
Costa, V. D., Tran, V. L., Turchi, J., & Averbeck, B. B. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.1989-14.2015 · Cited by 170 · see citing works
Is internet pornography causing sexual dysfunctions? A review with clinical reports
Park, B., Wilson, G., Berger, J., Christman, M., Reina, B., Bishop, F., Klam, W., & Doan, A. (2016) · Behavioral Sciences · doi:10.3390/bs6030017 · Cited by 187 · see citing works
New insights into the specificity and plasticity of reward and aversion encoding in the mesolimbic system
Volman, S. F., Lammel, S., Margolis, E. B., Kim, Y., Richard, J. M., Roitman, M. F., & Lobo, M. K. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3250-13.2013 · Cited by 168 · see citing works
Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity
Trifilieff, P., & Martinez, D. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.06.031 · Cited by 171 · see citing works
Social Play Behavior in Adolescent Rats is Mediated by Functional Activity in Medial Prefrontal Cortex and Striatum
van Kerkhof, L. W., Damsteegt, R., Trezza, V., Voorn, P., & Vanderschuren, L. J. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.83 · Cited by 161 · see citing works
Mapping anhedonia-specific dysfunction in a transdiagnostic approach: an ALE meta-analysis
Zhang, B., Lin, P., Shi, H., Öngür, D., Auerbach, R. P., Wang, X., Yao, S., & Wang, X. (2016) · Brain Imaging and Behavior · doi:10.1007/s11682-015-9457-6 · Cited by 152 · see citing works
Dopamine, effort-based choice, and behavioral economics: basic and translational research.
Salamone, J. D., Correa, M., Yang, J.-H., Rotolo, R., & Presby, R. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00052 · Cited by 142 · see citing works
Learning from Action: Reconsidering Movement Signaling in Midbrain Dopamine Neuron Activity
Coddington, L. T., & Dudman, J. T. (2019) · Neuron · doi:10.1016/j.neuron.2019.08.036 · Cited by 150 · see citing works
Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse
Korpi, E. R., den Hollander, B., Farooq, U., Vashchinkina, E., Rajkumar, R., Nutt, D. J., Hyytiä, P., & Dawe, G. S. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.010967 · Cited by 148 · see citing works
Adaptive effort investment in cognitive and physical tasks: A neurocomputational model
Verguts, T., Vassena, E., & Silvetti, M. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00057 · Cited by 118 · see citing works
A neural pathway controlling motivation to exert effort
Proulx, C. D., Aronson, S., Milivojevic, D., Molina, C., Loi, A., Monk, B., Shabel, S. J., & Malinow, R. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1801837115 · Cited by 119 · see citing works
Complementary neural circuits for divergent effects of oxytocin: social approach versus social anxiety
Steinman, M. Q., Duque-Wilckens, N., & Trainor, B. C. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.10.008 · Cited by 105 · see citing works
Anhedonia in depression symptomatology: appetite dysregulation and defective brain reward processing
Coccurello, R. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112041 · Cited by 106 · see citing works
Male-specific deficits in natural reward learning in a mouse model of neurodevelopmental disorders
Grissom, N. M., McKee, S. E., Schoch, H., Bowman, N., Havekes, R., O'Brien, W. T., Mahrt, E., Siegel, S., Commons, K., Portfors, C., et al. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.184 · Cited by 92 · see citing works
Sources of input to the rostromedial tegmental nucleus, ventral tegmental area, and lateral habenula compared: A study in rat
Yetnikoff, L., Cheng, A. Y., Lavezzi, H. N., Parsley, K. P., & Zahm, D. S. (2015) · Journal of Comparative Neurology · doi:10.1002/cne.23797 · Cited by 101 · see citing works
Mesolimbic Dopamine Function Is Related to Salience Network Connectivity: An Integrative Positron Emission Tomography and Magnetic Resonance Study
McCutcheon, R. A., Nour, M. M., Dahoun, T., Jauhar, S., Pepper, F., Expert, P., Veronese, M., Adams, R. A., Turkheimer, F., Mehta, M. A., et al. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.09.010 · Cited by 104 · see citing works
Assessment of reward responsiveness in the response bias probabilistic reward task in rats: implications for cross-species translational research
Der-Avakian, A., D'Souza, M. S., Pizzagalli, D. A., & Markou, A. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.74 · Cited by 100 · see citing works
Progress in understanding mood disorders: optogenetic dissection of neural circuits
Lammel, S., Tye, K. M., & Warden, M. R. (2014) · Genes, Brain and Behavior · doi:10.1111/gbb.12049 · Cited by 98 · see citing works
Involvement of Infralimbic Prefrontal Cortex but not Lateral Habenula in Dopamine Attenuation After Chronic Mild Stress
Moreines, J. L., Owrutsky, Z. L., & Grace, A. A. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.249 · Cited by 93 · see citing works
Influences of dopaminergic system dysfunction on late-life depression
Taylor, W. D., Zald, D. H., Felger, J. C., Christman, S., Claassen, D. O., Horga, G., Miller, J. M., Gifford, K., Rogers, B., Szymkowicz, S. M., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01265-0 · Cited by 89 · see citing works
Derationalizing delusions
Bell, V., Raihani, N., & Wilkinson, S. (2021) · Clinical Psychological Science · doi:10.1177/2167702620951553 · Cited by 78 · see citing works
From movement to motivation: a proposed framework to understand the antidepressant effect of exercise
Hird, E. J., Slanina-Davies, A., Lewis, G., Hamer, M., & Roiser, J. P. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02922-y · Cited by 79 · see citing works
Balancing reward and work: anticipatory brain activation in NAcc and VTA predict effort differentially
Kroemer, N. B., Guevara, A., Ciocanea Teodorescu, I., Wuttig, F., Kobiella, A., & Smolka, M. N. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.07.060 · Cited by 64 · see citing works
The neurobiology of social play behaviour: Past, present and future
Achterberg, E. J. M., & Vanderschuren, L. J. M. J. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105319 · Cited by 56 · see citing works
The hormonal signature of energy deficit: Increasing the value of food reward
Lockie, S. H., & Andrews, Z. B. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.08.003 · Cited by 50 · see citing works
Convergence of oxytocin and dopamine signalling in neuronal circuits: Insights into the neurobiology of social interactions across species
Rappeneau, V., & Castillo Díaz, F. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105675 · Cited by 51 · see citing works
“VTA-DA neurons play a central role in governing processes related to learning and the formation of memories associated with hedonic and motivational rewards (Rossato et al., 2009; Salamone and Correa, 2012; Wise, 2004).”
Background
The link between aberrant hypothalamic–pituitary–adrenal axis activity during development and the emergence of aggression—Animal studies
Walker, S. E., Papilloud, A., Huzard, D., & Sandi, C. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.10.008 · Cited by 49 · see citing works
Adolescent Alcohol Exposure Amplifies the Incentive Value of Reward-Predictive Cues Through Potentiation of Phasic Dopamine Signaling
Spoelder, M., Tsutsui, K. T., Lesscher, H. M. B., Vanderschuren, L. J. M. J., & Clark, J. J. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.139 · Cited by 48 · see citing works
Ventral tegmental area cholinergic mechanisms mediate behavioral responses in the forced swim test
Addy, N. A., Nunes, E. J., & Wickham, R. J. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.04.002 · Cited by 42 · see citing works
Amygdala Dopamine Receptors Are Required for the Destabilization of a Reconsolidating Appetitive Memory
Merlo, E., Ratano, P., Ilioi, E. C., Robbins, M. A. L. S., Everitt, B. J., & Milton, A. L. (2015) · eneuro · doi:10.1523/eneuro.0024-14.2015 · Cited by 38 · see citing works
Calcium-activated SK channels control firing regularity by modulating sodium channel availability in midbrain dopamine neurons
Iyer, R., Ungless, M. A., & Faisal, A. A. (2017) · Scientific Reports · doi:10.1038/s41598-017-05578-5 · Cited by 41 · see citing works
Is there a role for ghrelin in central dopaminergic systems? Focus on nigrostriatal and mesocorticolimbic pathways
Stievenard, A., Méquinion, M., Andrews, Z. B., Destée, A., Chartier-Harlin, M.-C., Viltart, O., & Vanbesien-Mailliot, C. C. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.11.021 · Cited by 39 · see citing works
Psychedelic-Assisted Therapy for Substance Use Disorders and Potential Mechanisms of Action
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Authors: Salamone, J. D., & Correa, M.
Affiliations: University of Connecticut (US)
Universitat Jaume I (ES)
Corresponding author: Salamone, John D.
ORCID: Salamone, John D.
Correa, Mercè
Venue: Neuron
Publisher: Elsevier BV
Published: 2012-11
Volume: 76
Issue: 3
Pages: 470-485
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2012.10.021
PMC: PMC4450094
OpenAlex: W2114520249
Cited by: 1,418
References: 207
Citations by year: 2026: 99 · 2025: 85 · 2024: 95 · 2023: 93 · 2022: 93 · 2021: 100 · 2020: 125 · 2019: 105 · 2018: 131 · 2017: 91 · 2016: 112 · 2015: 117 · 2014: 109 · 2013: 63
FWCI: 9.74
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 372 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Repositori UJI (Universitat Jaume I) (submittedVersion, public-domain)
Funders: National Institute of Mental Health (R03MH094966, R01MH078023)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: mesolimbic dopamine system, nucleus accumbens, motivation, reward, depression, substance abuse, effort, classical conditioning, operant conditioning, behavioral activation, approach behavior, aversive motivation, food motivation
MeSH terms: Animals, Appetitive Behavior, Dopamine, Humans, Limbic System, Motivation, Nucleus Accumbens

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The mysterious motivational functions of mesolimbic dopamine

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