The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.
REGULATION OF GLUCOSE PRODUCTION BY THE LIVER
Abstract
▪ Abstract Glucose is an essential nutrient for the human body. It is the major energy source for many cells, which depend on the bloodstream for a steady supply. Blood glucose levels, therefore, are carefully maintained. The liver plays a central role in this process by balancing the uptake and storage of glucose via glycogenesis and the release of glucose via glycogenolysis and gluconeogenesis. The several substrate cycles in the major metabolic pathways of the liver play key roles in the regulation of glucose production. In this review, we focus on the short- and long-term regulation glucose-6-phosphatase and its substrate cycle counterpart, glucokinase. The substrate cycle enzyme glucose-6-phosphatase catalyzes the terminal step in both the gluconeogenic and glycogenolytic pathways and is opposed by the glycolytic enzyme glucokinase. In addition, we include the regulation of GLUT 2, which facilitates the final step in the transport of glucose out of the liver and into the bloodstream.
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Cites
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Structure, Function, and Regulation of the Mammalian Facilitative Glucose Transporter Gene Family
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Cited by
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
Yoon, J. C., Puigserver, P., Chen, G., Donovan, J., Wu, Z., Rhee, J., Adelmant, G., Stafford, J., Kahn, C. R., Granner, D. K., et al. (2001) · Nature · doi:10.1038/35093050 · Cited by 1,821
Defects in Adaptive Energy Metabolism with CNS-Linked Hyperactivity in PGC-1α Null Mice
Lin, J., Wu, P.-H., Tarr, P. T., Lindenberg, K. S., St-Pierre, J., Zhang, C.-Y., Mootha, V. K., Jäger, S., Vianna, C. R., Reznick, R. M., et al. (2004) · Cell · doi:10.1016/j.cell.2004.09.013 · Cited by 1,162
Adiponectin, a Therapeutic Target for Obesity, Diabetes, and Endothelial Dysfunction
Achari, A., & Jain, S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061321 · Cited by 1,158
Nutrient-sensing mechanisms and pathways
Efeyan, A., Comb, W. C., & Sabatini, D. M. (2015) · Nature · doi:10.1038/nature14190 · Cited by 1,110
Regulation of glucose metabolism from a liver-centric perspective
Han, H.-S., Kang, G., Kim, J. S., Choi, B. H., & Koo, S.-H. (2016) · Experimental & Molecular Medicine · doi:10.1038/emm.2015.122 · Cited by 835
Metadata
- Authors
- Nordlie, R. C., Foster, J. D., & Lange, A. J.
- Venue
- Annual Review of Nutrition
- Publisher
- Annual Reviews
- Published
- 1999-07
- Volume
- 19
- Issue
- 1
- Pages
- 379-406
- ISSN
- 0199-9885 (ISSN-L)
- 1545-4312
- OpenAlex
- W2149300333
- Cited by
- 585
- References
- 85
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nordlie, R. C., Foster, J. D., & Lange, A. J. (1999). REGULATION OF GLUCOSE PRODUCTION BY THE LIVER. Annual Review of Nutrition. https://doi.org/10.1146/annurev.nutr.19.1.379
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
