The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Biosynthesis of Vitamin B2 (Riboflavin)
Abstract
The biosynthesis of one riboflavin molecule requires one molecule of GTP and two molecules of ribulose 5-phosphate as substrates. The imidazole ring of GTP is hydrolytically opened, yielding a 4,5-diaminopyrimidine which is converted to 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione by a sequence of deamination, side chain reduction and dephosphorylation. Condensation of 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione with 3,4-dihydroxy-2-butanone 4-phosphate obtained from ribulose 5-phosphate affords 6,7-dimethyl-8-ribityllumazine. Dismutation of the lumazine derivative yields riboflavin and 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione, which is recycled in the biosynthetic pathway. The structure of the biosynthetic enzyme, 6,7-dimethyl-8-ribityllumazine synthase, has been studied in considerable detail.
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Cites
Die Erhaltung der Orbitalsymmetrie
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Physiology and metabolic fluxes of wild-type and riboflavin-producing Bacillus subtilis
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Hümbelin, M., Griesser, V., Keller, T., Schurter, W., Haiker, M., Hohmann, H.-P., Ritz, H., Richter, G., Bacher, A., & van Loon, A. P. G. M. (1999) · Journal of Industrial Microbiology & Biotechnology · doi:10.1038/sj.jim.2900590 · Cited by 123
Self-citationRichter, G., Fischer, M. J., Krieger, C., Eberhardt, S., Lüttgen, H., Schaaff‐Gerstenschläger, I., & Bacher, A. (1997) · Journal of Bacteriology · doi:10.1128/jb.179.6.2022-2028.1997 · Cited by 112
Self-citationBiosynthesis of riboflavin. The structure of the four-carbon precursor
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Self-citationBiosynthesis of Water-Soluble Vitamins
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LeBlanc, J. G., Milani, C., de Giori, G. S., Sesma, F., van Sinderen, D., & Ventura, M. (2013) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2012.08.005 · Cited by 1,613
LeBlanc, J. G., Laiño, J. E., del Valle, M. J., Vannini, V., van Sinderen, D., Taranto, M. P., de Valdez, G. F., de Giori, G. S., & Sesma, F. (2011) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2011.05157.x · Cited by 529
Gut Microbiota Profiling: Metabolomics Based Approach to Unravel Compounds Affecting Human Health
Vernocchi, P., Del Chierico, F., & Putignani, L. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01144 · Cited by 426
One Hundred Years of Vitamins—A Success Story of the Natural Sciences
Eggersdorfer, M., Laudert, D., Létinois, U., McClymont, T., Medlock, J., Netscher, T., & Bonrath, W. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201205886 · Cited by 344
Effects of metabolites derived from gut microbiota and hosts on pathogens
Li, Z., Quan, G., Jiang, X., Yang, Y., Ding, X., Zhang, D., Wang, X., Hardwidge, P. R., Ren, W., & Zhu, G. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00314 · Cited by 157
Metadata
- Authors
- Bacher, A., Eberhardt, S., Fischer, M., Kis, K., & Richter, G.
- Venue
- Annual Review of Nutrition
- Publisher
- Annual Reviews
- Published
- 2000-07
- Volume
- 20
- Issue
- 1
- Pages
- 153-167
- ISSN
- 0199-9885 (ISSN-L)
- 1545-4312
- OpenAlex
- W2166756758
- Cited by
- 313
- References
- 23
- FWCI
- 0.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bacher, A., Eberhardt, S., Fischer, M., Kis, K., & Richter, G. (2000). Biosynthesis of Vitamin B2 (Riboflavin). Annual Review of Nutrition. https://doi.org/10.1146/annurev.nutr.20.1.153
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