Cited by 860Folate and B Vitamins ResearchPorphyrin Metabolism and DisordersAlcoholism and Thiamine Deficiency

Vitamin B12, folic acid, and the nervous system

Reynolds, Edward·2006·The Lancet Neurology

Abstract

There are many reasons for reviewing the neurology of vitamin-B12 and folic-acid deficiencies together, including the intimate relation between the metabolism of the two vitamins, their morphologically indistinguishable megaloblastic anaemias, and their overlapping neuropsychiatric syndromes and neuropathology, including their related inborn errors of metabolism. Folates and vitamin B12 have fundamental roles in CNS function at all ages, especially the methionine-synthase mediated conversion of homocysteine to methionine, which is essential for nucleotide synthesis and genomic and non-genomic methylation. Folic acid and vitamin B12 may have roles in the prevention of disorders of CNS development, mood disorders, and dementias, including Alzheimer's disease and vascular dementia in elderly people.

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Crossref · 10.1016/s1474-4422(06)70598-1

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  • Deficiency or lack of homeostasis of important micronutrients is another form of malnutrition that has major impacts on everyday performance, intellectual and emotional condition, as well as physical health.

    “Deficiency or lack of homeostasis of important micronutrients is another form of malnutrition that has major impacts on everyday performance, intellectual and emotional condition, as well as physical health (11, 12).”

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Authors
Reynolds, E.
Affiliations
King's College London (GB)
Corresponding author
Reynolds, Edward
Venue
The Lancet Neurology
Publisher
Elsevier BV
Published
2006-11
Volume
5
Issue
11
Pages
949-960
ISSN
1474-4422 (ISSN-L)
OpenAlex
W2167574472
Cited by
860
References
153
Citations by year
2026: 42 · 2025: 43 · 2024: 70 · 2023: 50 · 2022: 49 · 2021: 52 · 2020: 46 · 2019: 52 · 2018: 43 · 2017: 48 · 2016: 55 · 2015: 47 · 2014: 30 · 2013: 43 · 2012: 49
FWCI
3.93
Type
journal article
Language
en
Open access
closed
Locations
  • The Lancet Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Porphyrin Metabolism and Disorders
  • Health Sciences › Medicine › Neurology › Alcoholism and Thiamine Deficiency
Keywords
vitamin B12, folic acid, folate deficiency, megaloblastic anemia, neuropsychiatric syndromes, inborn errors of metabolism, methionine synthase, homocysteine, DNA methylation, nucleotide synthesis, central nervous system development, mood disorders, dementia, Alzheimer's disease, vascular dementia
MeSH terms
Animals, Folic Acid, Humans, Metabolic Diseases, Models, Biological, Multiple Sclerosis, Nervous System, Vitamin B 12, Vitamin B 12 Deficiency

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