AMP-activated protein kinase and its downstream transcriptional pathways
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The AMP-activated protein kinase (AMPK) is a key regulator of catabolic versus anabolic processes. Its properties as an energy sensor allow it to couple the energy status of the cell to the metabolic environment. These adaptations not only take place through the acute modulation of key metabolic enzymes via direct phosphorylation, but also through a slower transcriptional adaptative response. The question of how AMPK regulates the expression of a number of gene sets, such as those related to mitochondrial biogenesis, energy production and oxidative protection, is only beginning to be elucidated, and still many questions remain to be answered. In this review we will try to integrate our current knowledge on how AMPK regulates transcription in muscle and liver, which will serve as examples to illustrate the major advances in the field and the key challenges ahead.
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AMPK activation increases mitochondrial chemical energy generation by increasing the AMP-to-ATP ratio.
“Activation of AMPK increases mitochondrial chemical energy generation by increasing the AMP to ATP ratio236.”
From Mitochondrial and metabolic dysfunction in ageing and age-related diseases (2022) · cites this paper as [236]
The two-step activation of PGC-1α might be a conserved mechanism for AMPK to confer specificity among the various targets of SIRT1.
“This two-step activation of PGC-1α might be a conserved mechanism for AMPK to confer specificity among the various targets of SIRT1 (Canto & Auwerx, 2010).”
From Mitochondrial response to nutrient availability and its role in metabolic disease (2014) · cites this paper as Canto & Auwerx, 2010
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- Authors
- Cantó, C., & Auwerx, J.
- Affiliations
- École Polytechnique Fédérale de Lausanne (CH)
- Corresponding author
- Auwerx, Johan
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2010-07-17
- Volume
- 67
- Issue
- 20
- Pages
- 3407-3423
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC3622821
- OpenAlex
- W2067872036
- Cited by
- 421
- References
- 183
- Citations by year
- 2026: 17 · 2025: 28 · 2024: 19 · 2023: 23 · 2022: 20 · 2021: 24 · 2020: 25 · 2019: 23 · 2018: 28 · 2017: 32 · 2016: 20 · 2015: 27 · 2014: 25 · 2013: 30 · 2012: 33
- FWCI
- 3.08
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- reroDoc Digital Library (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-59820, P01DK059820)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- AMPK, transcriptional regulation, energy sensing, mitochondrial biogenesis, muscle, liver, metabolic adaptation, gene expression regulation
- MeSH terms
- Animals, Humans, Models, Biological, Transcription, Genetic, Signal Transduction, AMP-Activated Protein Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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