The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Vitamin E Regulatory Mechanisms
Abstract
Dietary and supplemental vitamin E is absorbed and delivered to the liver, but of the various antioxidants with vitamin E activity, only α-tocopherol is preferentially recognized by the α-tocopherol transfer protein (α-TTP) and is transferred to plasma, while the other vitamin E forms (e.g., γ-tocopherol or tocotrienols) are removed from the circulation. Hepatic α-TTP is required to maintain plasma and tissue α-tocopherol concentrations. The liver is the master regulator of the body's vitamin E levels in that it not only controls α-tocopherol concentrations, but also appears to be the major site of vitamin E metabolism and excretion. Vitamin Es are metabolized similarly to xenobiotics; they are initially ω-oxidized by cytochrome P450s, undergo several rounds of β-oxidation, and then are conjugated and excreted. As a result of these various mechanisms, liver α-tocopherol and other vitamin E concentrations are closely regulated; thus, any potential adverse vitamin E effects are limited.
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Cites
The Pecking Order of Free Radicals and Antioxidants: Lipid Peroxidation, α-Tocopherol, and Ascorbate
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Cited by
Vitamins C and E: Beneficial effects from a mechanistic perspective
Traber, M. G., & Stevens, J. F. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.017 · Cited by 1,076
Self-citationThe Role of Vitamin E in Immunity
Lee, G. Y., & Han, S. N. (2018) · Nutrients · doi:10.3390/nu10111614 · Cited by 582
Could Vitamins Help in the Fight Against COVID-19?
Jovic, T. H., Ali, S. R., Ibrahim, N., Jessop, Z. M., Tarassoli, S. P., Dobbs, T. D., Holford, P., Thornton, C. A., & Whitaker, I. S. (2020) · Nutrients · doi:10.3390/nu12092550 · Cited by 234
Implications of plasma thiol redox in disease
Oliveira, P. V. S., & Laurindo, F. R. M. (2018) · Clinical Science · doi:10.1042/cs20180157 · Cited by 127
Huang, J., Weinstein, S. J., Yu, K., Männistö, S., & Albanes, D. (2019) · Circulation Research · doi:10.1161/circresaha.119.314944 · Cited by 79
Metadata
- Authors
- Traber, M. G.
- Venue
- Annual Review of Nutrition
- Publisher
- Annual Reviews
- Published
- 2007-08-01
- Volume
- 27
- Issue
- 1
- Pages
- 347-362
- ISSN
- 0199-9885 (ISSN-L)
- 1545-4312
- OpenAlex
- W2136305436
- Cited by
- 411
- References
- 5
- FWCI
- 3.01
- Type
- journal article
- Language
- en
- Open access
- closed
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