Cited by 717Pancreatic and Hepatic Oncology ResearchCancer Genomics and DiagnosticsPancreatitis Pathology and Treatment

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Pancreatic Cancer

Open access

Maitra, Anirban, Hruban, Ralph H.·2008·Annual Review of Pathology: Mechanisms of Disease

DOI 10.1146/annurev.pathmechdis.3.121806.154305PMC PMC2666336

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Abstract

The past two decades have witnessed an explosion in our understanding of pancreatic cancer, and it is now clear that pancreatic cancer is a disease of inherited (germ-line) and somatic gene mutations. The genes mutated in pancreatic cancer include KRAS2, p16/CDKN2A, TP53, and SMAD4/DPC4, and these are accompanied by a substantial compendium of genomic and transcriptomic alterations that facilitate cell cycle deregulation, cell survival, invasion, and metastases. Pancreatic cancers do not arise de novo, and three distinct precursor lesions have been identified. Experimental models of pancreatic cancer have been developed in genetically engineered mice, which recapitulate the multistep progression of the cognate human disease. Although the putative cell of origin for pancreatic cancer remains elusive, minor populations of cells with stem-like properties have been identified that appear responsible for tumor initiation, metastases, and resistance of pancreatic cancer to conventional therapies.

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Crossref · 10.1146/annurev.pathmechdis.3.121806.154305

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Additional file 26 of Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma
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Additional file 24 of Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma
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Additional file 29 of Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma
Tong, Y., Sun, M., Chen, L., Wang, Y., Li, Y., Li, L., Zhang, X., Cai, Y., Qie, J., Pang, Y., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21628900
Additional file 27 of Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma
Tong, Y., Sun, M., Chen, L., Wang, Y., Li, Y., Li, L., Zhang, X., Cai, Y., Qie, J., Pang, Y., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21628894
Additional file 23 of Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma
Tong, Y., Sun, M., Chen, L., Wang, Y., Li, Y., Li, L., Zhang, X., Cai, Y., Qie, J., Pang, Y., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21628882
Additional file 28 of Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma
Tong, Y., Sun, M., Chen, L., Wang, Y., Li, Y., Li, L., Zhang, X., Cai, Y., Qie, J., Pang, Y., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21628897
Additional file 30 of Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma
Tong, Y., Sun, M., Chen, L., Wang, Y., Li, Y., Li, L., Zhang, X., Cai, Y., Qie, J., Pang, Y., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21628906
Additional file 25 of Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma
Tong, Y., Sun, M., Chen, L., Wang, Y., Li, Y., Li, L., Zhang, X., Cai, Y., Qie, J., Pang, Y., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21628888
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Additional file 7 of Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma
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Additional file 22 of Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma
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Additional file 3 of Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma
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Additional file 1 of Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma
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Additional file 9 of Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma
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Additional file 8 of Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma
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Additional file 21 of Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma
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Additional file 17 of Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma
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Additional file 5 of Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma
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Additional file 3 of Inhibition of P21-activated kinases 1 and 4 synergistically suppresses the growth of pancreatic cancer by stimulating anti-tumour immunity
Ma, Y., Dumesny, C., Dong, L., Ang, C.-S., Asadi, K., Zhan, Y., Nikfarjam, M., & He, H. (2024) · Figshare · doi:10.6084/m9.figshare.26725793
Additional file 4 of Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma
Tong, Y., Sun, M., Chen, L., Wang, Y., Li, Y., Li, L., Zhang, X., Cai, Y., Qie, J., Pang, Y., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21628912
Additional file 3 of NEMO/NF-κB signaling functions as a double-edged sword in PanIN formation versus progression to pancreatic cancer
Tsesmelis, M., Büttner, U. F. G., Gerstenlauer, M., Manfras, U., Tsesmelis, K., Du, Z., Sperb, N., Weissinger, S. E., Möller, P., Barth, T. F. E., et al. (2024) · Figshare · doi:10.6084/m9.figshare.27000798
Additional file 15 of Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma
Tong, Y., Sun, M., Chen, L., Wang, Y., Li, Y., Li, L., Zhang, X., Cai, Y., Qie, J., Pang, Y., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21628849
Additional file 19 of Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma
Tong, Y., Sun, M., Chen, L., Wang, Y., Li, Y., Li, L., Zhang, X., Cai, Y., Qie, J., Pang, Y., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21628867
Additional file 1 of Inhibition of P21-activated kinases 1 and 4 synergistically suppresses the growth of pancreatic cancer by stimulating anti-tumour immunity
Ma, Y., Dumesny, C., Dong, L., Ang, C.-S., Asadi, K., Zhan, Y., Nikfarjam, M., & He, H. Z. (2024) · Figshare · doi:10.6084/m9.figshare.26725787
Additional file 14 of Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma
Tong, Y., Sun, M., Chen, L., Wang, Y., Li, Y., Li, L., Zhang, X., Cai, Y., Qie, J., Pang, Y., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21628846
Additional file 1 of NEMO/NF-κB signaling functions as a double-edged sword in PanIN formation versus progression to pancreatic cancer
Tsesmelis, M., Büttner, U. F. G., Gerstenlauer, M., Manfras, U., Tsesmelis, K., Du, Z., Sperb, N., Weissinger, S. E., Möller, P., Barth, T. F. E., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25844465
Additional file 18 of Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma
Tong, Y., Sun, M., Chen, L., Wang, Y., Li, Y., Li, L., Zhang, X., Cai, Y., Qie, J., Pang, Y., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21628858
Additional file 2 of Inhibition of P21-activated kinases 1 and 4 synergistically suppresses the growth of pancreatic cancer by stimulating anti-tumour immunity
Ma, Y., Dumesny, C., Dong, L., Ang, C.-S., Asadi, K., Zhan, Y., Nikfarjam, M., & He, H. Z. (2024) · Figshare · doi:10.6084/m9.figshare.26725790
Additional file 6 of Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma
Tong, Y., Sun, M., Chen, L., Wang, Y., Li, Y., Li, L., Zhang, X., Cai, Y., Qie, J., Pang, Y., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21628918
Additional file 13 of Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma
Tong, Y., Sun, M., Chen, L., Wang, Y., Li, Y., Li, L., Zhang, X., Cai, Y., Qie, J., Pang, Y., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21628843
Additional file 10 of Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma
Tong, Y., Sun, M., Chen, L., Wang, Y., Li, Y., Li, L., Zhang, X., Cai, Y., Qie, J., Pang, Y., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21628834
Additional file 11 of Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma
Tong, Y., Sun, M., Chen, L., Wang, Y., Li, Y., Li, L., Zhang, X., Cai, Y., Qie, J., Pang, Y., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21628837
Additional file 16 of Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma
Tong, Y., Sun, M., Chen, L., Wang, Y., Li, Y., Li, L., Zhang, X., Cai, Y., Qie, J., Pang, Y., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21628852
Additional file 2 of Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma
Tong, Y., Sun, M., Chen, L., Wang, Y., Li, Y., Li, L., Zhang, X., Cai, Y., Qie, J., Pang, Y., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21628903
Additional file 20 of Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma
Tong, Y., Sun, M., Chen, L., Wang, Y., Li, Y., Li, L., Zhang, X., Cai, Y., Qie, J., Pang, Y., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21628873
Additional file 12 of Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma
Tong, Y., Sun, M., Chen, L., Wang, Y., Li, Y., Li, L., Zhang, X., Cai, Y., Qie, J., Pang, Y., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21628840
Recent Advancements in Diagnosis and Targeted Therapy of Pancreatic Cancer
Patil, J., & Kanugo, A. (2026) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/0118715206429348260126061757
MUC16 indicates poor prognosis in coexistent pancreatic ductal adenocarcinoma and serous cystadenoma: A case report and review of literature
Li, Y.-T., Zhang, Y.-P., Fang, Q.-D., Wu, H.-W., Xiao, Y., Wu, W.-M., Xue, H., Jin, Z.-Y., & Wang, Z.-W. (2026) · World Journal of Gastrointestinal Surgery · doi:10.4240/wjgs.v18.i3.115320
Signalisation et ciblage thérapeutique du récepteur tyrosine kinase AXL dans les cancers
Leconet, W. (2014) · theses.fr (ABES) · doi:10.70675/e91475a6z3b26z42ecza153zdc13a97fb5ec
Utilisation d’agents d’imagerie et de chimiothérapie conjugués à des peptides ciblant le récepteur aux LDL à des fins diagnostiques et thérapeutiques de l’adénocarcinome canalaire pancréatique
Acier, A. (2020) · theses.fr (ABES) · doi:10.70675/c986499cze490z42c8z802bzc8e87aa3134c

Authors: Maitra, A., & Hruban, R. H.
Affiliations: Johns Hopkins University (US)
ORCID: Maitra, Anirban
Hruban, Ralph H.
Venue: Annual Review of Pathology: Mechanisms of Disease
Publisher: Annual Reviews
Published: 2008-02-01
Volume: 3
Issue: 1
Pages: 157-188
ISSN: 1553-4006 (ISSN-L)
1553-4014
DOI: 10.1146/annurev.pathmechdis.3.121806.154305
PMC: PMC2666336
OpenAlex: W4211122150
Cited by: 707
References: 185
Citations by year: 2026: 16 · 2025: 10 · 2024: 31 · 2023: 29 · 2022: 55 · 2021: 46 · 2020: 46 · 2019: 39 · 2018: 43 · 2017: 42 · 2016: 41 · 2015: 53 · 2014: 59 · 2013: 48 · 2012: 32
FWCI: 3.60
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Annual Review of Pathology Mechanisms of Disease (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (R01CA113669, P50CA062924)
Topics: Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
Keywords: pancreatic cancer, germline mutations, somatic mutations, KRAS2, CDKN2A, TP53, genetic alterations, transcriptomic alterations, cell cycle dysregulation, metastasis, precursor lesions, genetically engineered mouse models, tumor progression, cancer stem cells, treatment resistance
MeSH terms: Animals, Disease Models, Animal, Humans, Pancreatic Neoplasms, Mice

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