Cited by 717Pancreatic and Hepatic Oncology ResearchCancer Genomics and DiagnosticsPancreatitis Pathology and Treatment

The DOI matches its Crossref record; 185 of the 185 references it cites were found in a registry or an index.

Pancreatic Cancer

Open access

Maitra, Anirban, Hruban, Ralph H.·2008·Annual Review of Pathology: Mechanisms of Disease

DOI 10.1146/annurev.pathmechdis.3.121806.154305PMC PMC2666336

Open this paper in CoChat — free account

Abstract

The past two decades have witnessed an explosion in our understanding of pancreatic cancer, and it is now clear that pancreatic cancer is a disease of inherited (germ-line) and somatic gene mutations. The genes mutated in pancreatic cancer include KRAS2, p16/CDKN2A, TP53, and SMAD4/DPC4, and these are accompanied by a substantial compendium of genomic and transcriptomic alterations that facilitate cell cycle deregulation, cell survival, invasion, and metastases. Pancreatic cancers do not arise de novo, and three distinct precursor lesions have been identified. Experimental models of pancreatic cancer have been developed in genetically engineered mice, which recapitulate the multistep progression of the cognate human disease. Although the putative cell of origin for pancreatic cancer remains elusive, minor populations of cells with stem-like properties have been identified that appear responsible for tumor initiation, metastases, and resistance of pancreatic cancer to conventional therapies.

Integrity signals

Registry

Crossref · 10.1146/annurev.pathmechdis.3.121806.154305

Cites

185 of 185 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

Retracted: Notch‐1 down‐regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells
Wang, Z., Zhang, Y., Banerjee, S., Li, Y., & Sarkar, F. H. (2006) · Cancer · doi:10.1002/cncr.21904 · Cited by 263
Retracted
Prospective identification of tumorigenic breast cancer cells
Al‐Hajj, M., Wicha, M. S., Benito‐Hernández, A., Morrison, S. J., & Clarke, M. F. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0530291100 · Cited by 10,579
Stem cells, cancer, and cancer stem cells
Reya, T., Morrison, S. J., Clarke, M. F., & Weissman, I. L. (2001) · Nature · doi:10.1038/35102167 · Cited by 9,738
MicroRNA expression profiles classify human cancers
Lü, J., Getz, G. A., Miska, E. A., Alvarez-Saavedra, E., Lamb, J., Peck, D., Sweet-Cordero, A., Ebert, B. L., Mak, R. H., Ferrando, A. A., et al. (2005) · Nature · doi:10.1038/nature03702 · Cited by 9,637
1969 Cancer Facts and Figures
(1968) · American Association of Industrial Nurses Journal · doi:10.1177/216507996801601208 · Cited by 8,811
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
Bonnet, D. A., & Dick, J. E. (1997) · Nature Medicine · doi:10.1038/nm0797-730 · Cited by 7,197
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
Bao, S., Wu, Q., McLendon, R. E., Hao, Y., Shi, Q., Hjelmeland, A. B., Dewhirst, M. W., Bigner, D. D., & Rich, J. N. (2006) · Nature · doi:10.1038/nature05236 · Cited by 6,517
Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial.
Burris, H. A., Moore, M. J., Andersen, J., Green, M. R., Rothenberg, M. L., Modiano, M., Cripps, M. C., Portenoy, R. K., Storniolo, A. M., Tarassoff, P. G., et al. (1997) · Journal of Clinical Oncology · doi:10.1200/jco.1997.15.6.2403 · Cited by 5,895
A microRNA expression signature of human solid tumors defines cancer gene targets
Volinia, S., Calin, G. A., Liu, C.-G., Ambs, S., Cimmino, A., Petrocca, F., Visone, R., Iorio, M., Roldo, C., Ferracin, M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510565103 · Cited by 5,697
A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
Lapidot, T., Sirard, C., Vormoor, J., Murdoch, B., Hoang, T., Caceres-Cortes, J., Minden, M., Paterson, B., Caligiuri, M. A., & Dick, J. E. (1994) · Nature · doi:10.1038/367645a0 · Cited by 4,783

Show all 185 references

Research works printed but not linked: 24

10.1001/jama.1995.03520440059037 · DOI
Goggins M, 1996, Cancer Res., 56, 5360
de vos tot Nederveen Cappel WH, 2003, Clin. Cancer Res., 9, 3598
Goggins M, 1998, Am. J. Pathol., 152, 1501
Hruban RH, 2006, Tumors of the Pancreas
Iacobuzio-Donahue CA, 2003, Cancer Res., 63, 8614
Argani P, 2001, Cancer Res., 61, 4320
Argani P, 2001, Clin. Cancer Res., 7, 3862
Moskaluk CA, 1997, Cancer Res., 57, 2140
Altomare DA, 2003, J. Cell Biochem., 88, 470
Schutte M, 1997, Cancer Res., 57, 3126
Redston MS, 1994, Cancer Res., 54, 3025
Wilentz RE, 2000, Cancer Res., 60, 2002
Schutte M, 1996, Cancer Res., 56, 2527
Goggins M, 1998, Cancer Res., 58, 5329
Sato N, 2003, Cancer Res., 63, 4158
Ryu B, 2002, Cancer Res., 62, 819
Deramaudt T, 2005, Biochim. Biophys. Acta, 1756, 97
Brembeck FH, 2003, Cancer Res., 63, 2005
Ryu B, 2002, Cancer Res., 62, 819
Zhou W, 1998, Cancer Epidemiol. Biomark. Prev., 7, 109
Yamada T, 1998, Clin. Cancer Res., 4, 1527
Yamamoto H, 2001, Cancer Res., 61, 3139
van der Heijden MS, 2003, Cancer Res., 63, 2585

Sorted by citations

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses
Jones, S., Zhang, X., Parsons, D. W., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Kamiyama, H., Jimeno, A., et al. (2008) · Science · doi:10.1126/science.1164368 · Cited by 3,969
Self-citation
Pancreatic cancer
Hidalgo, M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0901557 · Cited by 2,570
Distant metastasis occurs late during the genetic evolution of pancreatic cancer
Yachida, S., Jones, S., Bozic, I., Antal, T., Leary, R., Fu, B., Kamiyama, M., Hruban, R. H., Eshleman, J. R., Nowak, M. A., et al. (2010) · Nature · doi:10.1038/nature09515 · Cited by 2,502
Self-citation
HMGB1 in health and disease
Kang, R., Chen, R., Zhang, Q., Hou, W., Wu, S., Cao, L., Huang, J., Yu, Y., Fan, X.-G., Yan, Z., et al. (2014) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2014.05.001 · Cited by 956
Early Detection of Pancreatic Cancer: Opportunities and Challenges
Singhi, A. D., Koay, E. J., Chari, S. T., & Maitra, A. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.01.259 · Cited by 841
Self-citation
TGF-β signaling in health and disease
Massagué, J., & Sheppard, D. (2023) · Cell · doi:10.1016/j.cell.2023.07.036 · Cited by 890
Exomic Sequencing Identifies PALB2 as a Pancreatic Cancer Susceptibility Gene
Jones, S., Hruban, R. H., Kamiyama, M., Borges, M., Zhang, X., Parsons, D. W., Lin, J. C.-H., Palmisano, E., Brune, K., Jaffee, E. M., et al. (2009) · Science · doi:10.1126/science.1171202 · Cited by 826
Self-citation
Advanced pancreatic carcinoma: current treatment and future challenges
Stathis, A., & Moore, M. J. (2010) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2009.236 · Cited by 791
Epidemiology of pancreatic cancer: an overview
Raimondi, S., Maisonneuve, P., & Lowenfels, A. B. (2009) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2009.177 · Cited by 752
Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia
Pylayeva-Gupta, Y., Lee, K. E., Hajdu, C. H., Miller, G., & Bar-Sagi, D. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.04.024 · Cited by 721
Pancreatic Ductal Adenocarcinoma: Current and Evolving Therapies
Adamska, A., Domenichini, A., & Falasca, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071338 · Cited by 632
MicroRNAs in Plasma of Pancreatic Ductal Adenocarcinoma Patients as Novel Blood-Based Biomarkers of Disease
Wang, J., Chen, J., Chang, P., Leblanc, A. B., Li, D., Abbruzzesse, J. L., Frazier, M. L., Killary, A. M., & Sen, S. (2009) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-09-0094 · Cited by 566
Genetics and biology of pancreatic ductal adenocarcinoma
Ying, H., Dey, P., Yao, W., Kimmelman, A. C., Draetta, G. F., Maitra, A., & DePinho, R. A. (2016) · Genes & Development · doi:10.1101/gad.275776.115 · Cited by 527
Fabrication of gold nanoparticles for targeted therapy in pancreatic cancer
Patra, C. R., Bhattacharya, R., Mukhopadhyay, D., & Mukherjee, P. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.11.007 · Cited by 464
The causes and consequences of polyploidy in normal development and cancer
Davoli, T., & de Lange, T. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154234 · Cited by 424
EGF Receptor Signaling Is Essential for K-Ras Oncogene-Driven Pancreatic Ductal Adenocarcinoma
Navas, C., Hernández-Porras, I., Schuhmacher, A. J., Sibilia, M., Guerra, C., & Barbacid, M. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.08.001 · Cited by 391
Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma
Mazur, P. K., Herner, A., Mello, S. S., Wirth, M., Hausmann, S., Rivera, F. J. S., Lofgren, S., Kuschma, T., Hahn, S. A., Vangala, D., et al. (2015) · Nature Medicine · doi:10.1038/nm.3952 · Cited by 413
Tumor-stromal crosstalk in pancreatic cancer and tissue fibrosis
Thomas, D., & Radhakrishnan, P. (2019) · Molecular Cancer · doi:10.1186/s12943-018-0927-5 · Cited by 409
Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia
Jean–Paul De La, O., Emerson, L. L., Goodman, J. L., Froebe, S. C., Illum, B. E., Curtis, A. B., & Murtaugh, L. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810111105 · Cited by 396
Notch as a tumour suppressor
Nowell, C. S., & Radtke, F. (2017) · Nature reviews. Cancer · doi:10.1038/nrc.2016.145 · Cited by 379
Inflammation, Autophagy, and Obesity: Common Features in the Pathogenesis of Pancreatitis and Pancreatic Cancer
Gukovsky, I., Li, N., Todoric, J., Gukovskaya, A. S., & Karin, M. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.02.007 · Cited by 347
Pancreatic cancer: why is it so hard to treat?
Oberstein, P. E., & Olive, K. P. (2013) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x13478680 · Cited by 334
Hyaluronan, fluid pressure, and stromal resistance in pancreas cancer
Provenzano, P. P., & Hingorani, S. R. (2013) · British Journal of Cancer · doi:10.1038/bjc.2012.569 · Cited by 337
Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward pathwayPreprint
Kent, O. A., Chivukula, R. R., Mullendore, M. E., Wentzel, E. A., Feldmann, G., Lee, K. H., Liu, S., Leach, S. D., Maitra, A., & Mendell, J. T. (2010) · Genes & Development · doi:10.1101/gad.1950610 · Cited by 311
Self-citation
Mutant KRAS is a druggable target for pancreatic cancer
Zorde Khvalevsky, E., Gabai, R., Rachmut, I. H., Horwitz, E., Brunschwig, Z., Orbach, A., Shemi, A., Golan, T., Domb, A. J., Yavin, E., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1314307110 · Cited by 295
A Critical Analysis of the Clinical Use of Incretin-Based Therapies
Butler, P. C., Elashoff, M., Elashoff, R., & Gale, E. A. M. (2013) · Diabetes Care · doi:10.2337/dc12-2713 · Cited by 296
Restitution of Tumor Suppressor MicroRNAs Using a Systemic Nanovector Inhibits Pancreatic Cancer Growth in Mice
Pramanik, D., Campbell, N. R., Karikari, C. A., Chivukula, R. R., Kent, O. A., Mendell, J. T., & Maitra, A. (2011) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-11-0152 · Cited by 295
Self-citation
Detection of early pancreatic ductal adenocarcinoma with thrombospondin-2 and CA19-9 blood markers
Kim, J., Bamlet, W. R., Oberg, A. L., Chaffee, K. G., Donahue, G., Cao, X.-J., Chari, S., Garcia, B. A., Petersen, G. M., & Zaret, K. S. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aah5583 · Cited by 269
The Pathology and Genetics of Metastatic Pancreatic Cancer
Yachida, S., & Iacobuzio–Donahue, C. A. (2009) · Archives of Pathology & Laboratory Medicine · doi:10.5858/133.3.413 · Cited by 269
Circulating tumor DNA as an early cancer detection tool
Campos-Carrillo, A., Weitzel, J. N., Sahoo, P., Rockne, R. C., Mokhnatkin, J. V., Murtaza, M., Gray, S. W., Goetz, L. H., Goel, A., Schork, N. J., et al. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.107458 · Cited by 252
Mesenchymal lineage heterogeneity underlies nonredundant functions of pancreatic cancer-associated fibroblasts
Helms, E. J., Berry, M. W., Chaw, R. C., DuFort, C. C., Sun, D., Onate, M. K., Oon, C., Bhattacharyya, S., Sanford-Crane, H., Horton, W., et al. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0601 · Cited by 238
Molecular Pathogenesis of Pancreatic Cancer
Grant, T. J., Hua, K., & Singh, A. (2016) · Progress in Molecular Biology and Translational Science · doi:10.1016/bs.pmbts.2016.09.008 · Cited by 237
Immunohistochemically Detected Expression of 3 Major Genes (CDKN2A/p16, TP53, and SMAD4/DPC4) Strongly Predicts Survival in Patients With Resectable Pancreatic Cancer
Oshima, M., Okano, K., Muraki, S., Haba, R., Maeba, T., Suzuki, Y., & Yachida, S. (2013) · Annals of Surgery · doi:10.1097/sla.0b013e3182827a65 · Cited by 236
Resveratrol, a multitargeted agent, can enhance antitumor activity of gemcitabine in vitro and in orthotopic mouse model of human pancreatic cancer
Harikumar, K. B., Kunnumakkara, A. B., Sethi, G., Diagaradjane, P., Anand, P., Pandey, M. K., Gelovani, J. G., Krishnan, S., Guha, S., & Aggarwal, B. B. (2010) · International Journal of Cancer · doi:10.1002/ijc.25041 · Cited by 233
Pancreatic Cancer Metabolism: Breaking It Down to Build It Back Up
Perera, R. M., & Bardeesy, N. M. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0671 · Cited by 218
Systemic Administration of Polymeric Nanoparticle-Encapsulated Curcumin (NanoCurc) Blocks Tumor Growth and Metastases in Preclinical Models of Pancreatic Cancer
Bisht, S., Mizuma, M., Feldmann, G., Ottenhof, N. A., Hong, S., Pramanik, D., Chenna, V., Karikari, C. A., Sharma, R. B., Goggins, M., et al. (2010) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-10-0172 · Cited by 216
Self-citation
Cellular Histone Modification Patterns Predict Prognosis and Treatment Response in Resectable Pancreatic Adenocarcinoma: Results From RTOG 9704
Manuyakorn, A., Paulus, R., Farrell, J. J., Dawson, N. A., Tze, S., Cheung-Lau, G. C., Hines, O. J., Reber, H. A., Seligson, D. B., Horvath, S., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.24.5639 · Cited by 216
Advances in diagnosis, treatment and palliation of pancreatic carcinoma: 1990-2010
Sharma, C. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i7.867 · Cited by 216
Genetics of Biliary Tract Cancers and Emerging Targeted Therapies
Hezel, A. F., Deshpande, V., & Zhu, A. X. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.27.4787 · Cited by 212
MicroRNA Molecular Profiles Associated with Diagnosis, Clinicopathologic Criteria, and Overall Survival in Patients with Resectable Pancreatic Ductal Adenocarcinoma
Jamieson, N. B., Morran, D. C., Morton, J. P., Ali, A., Dickson, E. J., Carter, C. R., Sansom, O. J., Evans, T. R. J., McKay, C. J., & Oien, K. A. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-0679 · Cited by 209
The Axl receptor tyrosine kinase confers an adverse prognostic influence in pancreatic cancer and represents a new therapeutic target
Koorstra, J.-B. M., Karikari, C. A., Feldmann, G., Bisht, S., Rojas, P. L., Offerhaus, G. J. A., Alvarez, H., & Maitra, A. (2009) · Cancer Biology & Therapy · doi:10.4161/cbt.8.7.7923 · Cited by 208
Self-citation
Metabolic reprogramming of pancreatic cancer mediated by CDK4/6 inhibition elicits unique vulnerabilities
Franco, J., Balaji, U., Freinkman, E., Witkiewicz, A. K., & Knudsen, E. S. (2016) · Cell Reports · doi:10.1016/j.celrep.2015.12.094 · Cited by 199
Biochemical role of the collagen-rich tumour microenvironment in pancreatic cancer progression
Shields, M. A., Dangi-Garimella, S. Y., Redig, A. J., & Munshi, H. G. (2011) · Biochemical Journal · doi:10.1042/bj20111240 · Cited by 203
Beyond just a tight fortress: contribution of stroma to epithelial-mesenchymal transition in pancreatic cancer
Bulle, A. S., & Lim, K. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00341-1 · Cited by 208
Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics
Tang, S., Fu, J., Nall, D., Rodova, M., Shankar, S., & Srivastava, R. K. (2011) · International Journal of Cancer · doi:10.1002/ijc.26323 · Cited by 203
Inflammatory networks and immune surveillance of pancreatic carcinoma
Vonderheide, R. H., & Bayne, L. J. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.01.006 · Cited by 204
Pancreatic cancer cell/fibroblast co-culture induces M2 like macrophages that influence therapeutic response in a 3D model
Kuen, J., Darowski, D., Kluge, T., & Majety, M. (2017) · PLOS ONE · doi:10.1371/journal.pone.0182039 · Cited by 192
An iPSC Line from Human Pancreatic Ductal Adenocarcinoma Undergoes Early to Invasive Stages of Pancreatic Cancer Progression
Kim, J., Hoffman, J. P., Alpaugh, R. K., Rhim, A. D., Reichert, M., Stanger, B. Z., Furth, E. E., Sepulveda, A. R., Yuan, C., Won, K., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.05.036 · Cited by 198
Nontoxic radioactive Listeria at is a highly effective therapy against metastatic pancreatic cancer
Quispe‐Tintaya, W., Chandra, D., Jahangir, A., Harris, M., Casadevall, A., Dadachova, E., & Gravekamp, C. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1211287110 · Cited by 188
Ligand-dependent Notch Signaling Is Involved in Tumor Initiation and Tumor Maintenance in Pancreatic Cancer
Mullendore, M. E., Koorstra, J.-B. M., Li, Y., Offerhaus, G. J. A., Fan, X., Henderson, C. M., Matsui, W. H., Eberhart, C. G., Maitra, A., & Feldmann, G. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-2004 · Cited by 188
Self-citation
Evolution and dynamics of pancreatic cancer progression
Yachida, S., & Iacobuzio–Donahue, C. A. (2013) · Oncogene · doi:10.1038/onc.2013.29 · Cited by 185
MYC Instructs and Maintains Pancreatic Adenocarcinoma Phenotype
Sodir, N. M., Kortlever, R. M., Barthet, V. J. A., Campos, T., Pellegrinet, L., Kupczak, S., Anastasiou, P., Swigart, L. B., Soucek, L., Arends, M. J., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0435 · Cited by 188
Update on the management of pancreatic cancer: Surgery is not enough
Ansari, D., Gustafsson, A., & Andersson, R. E. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i11.3157 · Cited by 188
Arginase 1 is a key driver of immune suppression in pancreatic cancer
Menjivar, R. E., Nwosu, Z. C., Du, W., Donahue, K. L., Hong, H. S., Espinoza, C. E., Brown, K. L., Velez-Delgado, A., Yan, W., Lima, F., et al. (2023) · eLife · doi:10.7554/elife.80721 · Cited by 189
KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs
Tzatsos, A., Paskaleva, P., Ferrari, F., Deshpande, V., Stoykova, S., Contino, G., Wong, K., Lan, F., Trojer, P., Park, P. J., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64535 · Cited by 178
Zebrafish Models for Cancer
Liu, S., & Leach, S. D. (2011) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-011110-130330 · Cited by 180
Loss of the acinar-restricted transcription factor Mist1 accelerates Kras-induced pancreatic intraepithelial neoplasia
Shi, G., Zhu, L., Sun, Y., Bettencourt, R., Damsz, B., Hruban, R. H., & Konieczny, S. F. (2009) · Gastroenterology · doi:10.1053/j.gastro.2008.12.066 · Cited by 168
Self-citation
Downregulated miR-506 expression facilitates pancreatic cancer progression and chemoresistance via SPHK1/Akt/NF-κB signaling
Li, J., Wu, H., Li, W., Yin, L., Guo, S., Xu, X. M., Ouyang, Y., Zhao, Z., Liu, S., Tian, Y., et al. (2016) · Oncogene · doi:10.1038/onc.2016.90 · Cited by 167
Germline Brca2 Heterozygosity Promotes Kras -Driven Carcinogenesis in a Murine Model of Familial Pancreatic Cancer
Skoulidis, F., Cassidy, L. D., Pisupati, V., Jonasson, J. G., Bjarnason, H., Eyfjord, J. E., Karreth, F. A., Lim, M., Barber, L. M., Clatworthy, S. A., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.10.015 · Cited by 169
Inhibiting the Cyclin-Dependent Kinase CDK5 Blocks Pancreatic Cancer Formation and Progression through the Suppression of Ras-Ral Signaling
Feldmann, G., Mishra, A., Hong, S., Bisht, S., Strock, C. J., Ball, D. W., Goggins, M., Maitra, A., & Nelkin, B. D. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-1107 · Cited by 170
Self-citation
Pathology and Molecular Genetics of Pancreatic Neoplasms
Wood, L. D., & Hruban, R. H. (2012) · The Cancer Journal · doi:10.1097/ppo.0b013e31827459b6 · Cited by 168
Self-citation
Association of Pancreatic Fatty Infiltration With Pancreatic Ductal Adenocarcinoma
Hori, M., Takahashi, M., Hiraoka, N., Yamaji, T., Mutoh, M., Ishigamori, R., Furuta, K., Okusaka, T., Shimada, K., Kosuge, T., et al. (2014) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2014.5 · Cited by 161
MiT/TFE Family of Transcription Factors, Lysosomes, and Cancer
Perera, R. M., Malta, C. D., & Ballabio, A. (2018) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030518-055835 · Cited by 162
NFκB in Pancreatic Stellate Cells Reduces Infiltration of Tumors by Cytotoxic T Cells and Killing of Cancer Cells, via Up-regulation of CXCL12
Garg, B., Giri, B., Modi, S., Sethi, V., Castro, I., Umland, O., Ban, Y. J., Lavania, S., Dawra, R. K., Banerjee, S., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.05.051 · Cited by 152
The Silencing of MicroRNA 148a Production by DNA Hypermethylation Is an Early Event in Pancreatic Carcinogenesis
Hanoun, N., Delpu, Y., Suriawinata, A. A., Bournet, B., Bureau, C., Sèlves, J., Tsongalis, G. J., Dufresne, M., Buscail, L., Cordelier, P., et al. (2010) · Clinical Chemistry · doi:10.1373/clinchem.2010.144709 · Cited by 149
Mutations in key driver genes of pancreatic cancer: molecularly targeted therapies and other clinical implications
Hu, H.-F., Ye, Z., Qin, Y., Xu, X.-W., Yu, X.-J., Zhuo, Q.-F., & Ji, S.-R. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-00584-2 · Cited by 149
Molecular Signatures of Pancreatic Cancer
Hong, S., Park, J. Y., Hruban, R. H., & Goggins, M. (2011) · Archives of Pathology & Laboratory Medicine · doi:10.5858/2010-0566-ra.1 · Cited by 152
Self-citation
Interleukin-6 in inflammatory and malignant diseases of the pancreas
Lesina, M., Wörmann, S. M., Neuhöfer, P., Song, L., & Algül, H. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.01.002 · Cited by 149
Notch signaling in pancreatic cancer: oncogene or tumor suppressor?
Avila, J. L., & Kissil, J. L. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2013.03.003 · Cited by 141
Notch signaling pathway targeted therapy suppresses tumor progression and metastatic spread in pancreatic cancer
Yabuuchi, S., Pai, S. G., Campbell, N. R., de Wilde, R. F., Oliveira, E. D., Korangath, P. C., Streppel, M. M., Rasheed, Z. A., Hidalgo, M. M., Maitra, A., et al. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.01.054 · Cited by 140
Self-citation
Chronic pancreatitis: A path to pancreatic cancer
Pinho, A. V., Chantrill, L. A., & Rooman, I. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.08.015 · Cited by 138
Apoptotic pathways in pancreatic ductal adenocarcinoma
Hamacher, R., Schmid, R. M., Saur, D., & Schneider, G. (2008) · Molecular Cancer · doi:10.1186/1476-4598-7-64 · Cited by 134
Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: a comparative study in transgenic mice and human tissues
Aichler, M., Seiler, C., Tost, M., Siveke, J. T., Mazur, P. K., da Silva‐Buttkus, P., Bartsch, D. K., Langer, P., Chiblak, S., Dürr, A., et al. (2011) · The Journal of Pathology · doi:10.1002/path.3017 · Cited by 131
Therapeutic options for the management of pancreatic cancer
Rossi, M. L. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i32.11142 · Cited by 130
A resource for analysis of microRNA expression and function in pancreatic ductal adenocarcinoma cells
Kent, O. A., Mullendore, M. E., Wentzel, E. A., López‐Romero, P., Tan, A. C., Hector, A., West, K. M., Ochs, M. F., Hidalgo, M. M., Arking, D. E., et al. (2009) · Cancer Biology & Therapy · doi:10.4161/cbt.8.21.9685 · Cited by 124
Self-citation
Inactivation of TIF1γ Cooperates with KrasG12D to Induce Cystic Tumors of the Pancreas
Vincent, D. F., Yan, K.-P., Treilleux, I., Gay, F., Arfi, V., Kaniewski, B., Marie, J. C., Lépinasse, F., Martel, S., Goddard‐Léon, S., et al. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000575 · Cited by 122
WNT7B mediates autocrine Wnt/β-catenin signaling and anchorage-independent growth in pancreatic adenocarcinoma
Arensman, M., Kovochich, A., Kulikauskas, R. M., Lay, A. R., Yang, P.-T., Li, X., Donahue, T. R., Major, M. B., Moon, R. T., Chien, A. J., et al. (2013) · Oncogene · doi:10.1038/onc.2013.23 · Cited by 122
Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by MLH1 haploinsufficiency and complete deficiencyPreprint
Wang, L., Tsutsumi, S., Kawaguchi, T., Nagasaki, K., Tatsuno, K., Yamamoto, S., Sang, F., Sonoda, K., Sugawara, M., Saiura, A., et al. (2011) · Genome Research · doi:10.1101/gr.123109.111 · Cited by 120
Inflammation-Induced NFATc1–STAT3 Transcription Complex Promotes Pancreatic Cancer Initiation by Kras G12D
Baumgart, S., Chen, N., Siveke, J. T., König, A. O., Zhang, J., Singh, S. K., Wolf, E., Bartkuhn, M., Esposito, I., Heßmann, E., et al. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0593 · Cited by 122
XMD8-92 inhibits pancreatic tumor xenograft growth via a DCLK1-dependent mechanism
Sureban, S. M., May, R. J., Weygant, N., Qu, D., Chandrakesan, P., Bannerman-Menson, E., Ali, N., Pantazis, P., Westphalen, C. B., Wang, T. C., et al. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.05.011 · Cited by 120
Stromal reengineering to treat pancreas cancer
Stromnes, I. M., DelGiorno, K. E., Greenberg, P. D., & Hingorani, S. R. (2014) · Carcinogenesis · doi:10.1093/carcin/bgu115 · Cited by 119
Pancreatic Cancer: Pathobiology, Treatment Options, and Drug Delivery
Li, J., Wientjes, M. G., & Au, J. L. ‐. (2010) · The AAPS Journal · doi:10.1208/s12248-010-9181-5 · Cited by 120
The molecular and cellular heterogeneity of pancreatic ductal adenocarcinoma
Samuel, N., & Hudson, T. J. (2011) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2011.215 · Cited by 117
Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids
Huang, L., Desai, R., Conrad, D. N., Leite, N. C., Akshinthala, D., Lim, C. M., González, R. S., Muthuswamy, L. B., Gartner, Z. J., & Muthuswamy, S. K. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.03.022 · Cited by 119
Cyclin-dependent kinase inhibitor Dinaciclib (SCH727965) inhibits pancreatic cancer growth and progression in murine xenograft models
Feldmann, G., Mishra, A., Bisht, S., Karikari, C. A., Garrido‐Laguna, I., Rasheed, Z. A., Ottenhof, N. A., Dadon, T., Alvarez, H., Fendrich, V., et al. (2011) · Cancer Biology & Therapy · doi:10.4161/cbt.12.7.16475 · Cited by 118
Self-citation
Complete regression of advanced pancreatic ductal adenocarcinomas upon combined inhibition of EGFR and C-RAF
Blasco, M. T., Navas, C., Martín-Serrano, G., Graña-Castro, O., Lechuga, C. G., Martín-Díaz, L., Djurec, M., Li, J., Morales-Cacho, L., Esteban-Burgos, L., et al. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.03.002 · Cited by 115
Integrated Proteomic Profiling of Cell Line Conditioned Media and Pancreatic Juice for the Identification of Pancreatic Cancer Biomarkers
Makawita, S., Smith, C. R., Batruch, I., Zheng, Y., Rückert, F., Grützmann, R., Pilarsky, C. P., Gallinger, S., & Diamandis, E. P. (2011) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.008599 · Cited by 113
Targeting of surface alpha-enolase inhibits the invasiveness of pancreatic cancer cells
Principe, M., Ceruti, P., Shih, N., Chattaragada, M. S., Rolla, S., Conti, L., Bestagno, M., Zentilin, L., Yang, S., Migliorini, P., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.3572 · Cited by 110
Lycopene Inhibits Reactive Oxygen Species-Mediated NF-κB Signaling and Induces Apoptosis in Pancreatic Cancer Cells
Jeong, Y., Lim, J. W., & Kim, H. (2019) · Nutrients · doi:10.3390/nu11040762 · Cited by 110
Elevated microRNA miR-21 Levels in Pancreatic Cyst Fluid Are Predictive of Mucinous Precursor Lesions of Ductal Adenocarcinoma
Ryu, J. K., Matthaei, H., Molin, M. D., Hong, S., Canto, M. I., Schulick, R. D., Wolfgang, C. L., Goggins, M., Hruban, R. H., Cope, L., et al. (2011) · Pancreatology · doi:10.1159/000329183 · Cited by 109
Self-citation
KRAS2 Mutations in Human Pancreatic Acinar-Ductal Metaplastic Lesions Are Limited to Those with PanIN: Implications for the Human Pancreatic Cancer Cell of Origin
Shi, C., Hong, S., Lim, P., Kamiyama, H., Khan, M. A., Anders, R. A., Goggins, M., Hruban, R. H., & Eshleman, J. R. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-08-0206 · Cited by 109
Self-citation
Genetic Diversity of Pancreatic Ductal Adenocarcinoma and Opportunities for Precision Medicine
Knudsen, E. S., O'Reilly, E. M., Brody, J. R., & Witkiewicz, A. K. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.08.056 · Cited by 115
Interleukin-6: a villain in the drama of pancreatic cancer development and progression
Holmer, R., Goumas, F. A., Waetzig, G. H., Rose‐John, S., & Kalthoff, H. (2014) · Hepatobiliary & pancreatic diseases international · doi:10.1016/s1499-3872(14)60259-9 · Cited by 112
Significance of TP53, CDKN2A, SMAD4 and KRAS in Pancreatic Cancer
Stefanoudakis, D., Frountzas, M., Schizas, D., Michalopoulos, N. V., Drakaki, A., & Toutouzas, K. G. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46040177 · Cited by 110
Tumor-associated macrophages in pancreatic ductal adenocarcinoma: therapeutic opportunities and clinical challenges
Poh, A. R., & Ernst, M. (2021) · Cancers · doi:10.3390/cancers13122860 · Cited by 106
Resistance to Gemcitabine in Pancreatic Ductal Adenocarcinoma: A Physiopathologic and Pharmacologic Review
Koltai, T., Reshkin, S. J., Carvalho, T. M. A., Molfetta, D. D., Greco, M. R., Alfarouk, K. O., & Cardone, R. A. (2022) · Cancers · doi:10.3390/cancers14102486 · Cited by 119
Pancreas 3D Organoids: Current and Future Aspects as a Research Platform for Personalized Medicine in Pancreatic Cancer
Moreira, L., Bakir, B. S., Chatterji, P., Dantes, Z., Reichert, M., & Rustgi, A. K. (2017) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2017.12.004 · Cited by 112
ATP-binding cassette transporters in progression and clinical outcome of pancreatic cancer: What is the way forward?
Adamska, A., & Falasca, M. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i29.3222 · Cited by 107
Binding of pro-prion to filamin A disrupts cytoskeleton and correlates with poor prognosis in pancreatic cancer
Li, C., Yu, S., Nakamura, F., Yin, S., Xu, J., Petrolla, A. A., Singh, N., Tartakoff, A. M., Abbott, D. W., Xin, W., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39542 · Cited by 103
NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar–Ductal Transdifferentiation in the Pancreas
Chen, N., Singh, G., König, A. O., Liou, G., Störz, P., Zhang, J., Regul, L., Nagarajan, S., Kühnemuth, B., Johnsen, S. A., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.01.033 · Cited by 102

Authors: Maitra, A., & Hruban, R. H.
Affiliations: Johns Hopkins University (US)
ORCID: Maitra, Anirban
Hruban, Ralph H.
Venue: Annual Review of Pathology: Mechanisms of Disease
Publisher: Annual Reviews
Published: 2008-02-01
Volume: 3
Issue: 1
Pages: 157-188
ISSN: 1553-4006 (ISSN-L)
1553-4014
DOI: 10.1146/annurev.pathmechdis.3.121806.154305
PMC: PMC2666336
OpenAlex: W4211122150
Cited by: 707
References: 185
Citations by year: 2026: 16 · 2025: 10 · 2024: 31 · 2023: 29 · 2022: 55 · 2021: 46 · 2020: 46 · 2019: 39 · 2018: 43 · 2017: 42 · 2016: 41 · 2015: 53 · 2014: 59 · 2013: 48 · 2012: 32
FWCI: 3.60
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Annual Review of Pathology Mechanisms of Disease (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (R01CA113669, P50CA062924)
Topics: Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
Keywords: pancreatic cancer, germline mutations, somatic mutations, KRAS2, CDKN2A, TP53, genetic alterations, transcriptomic alterations, cell cycle dysregulation, metastasis, precursor lesions, genetically engineered mouse models, tumor progression, cancer stem cells, treatment resistance
MeSH terms: Animals, Disease Models, Animal, Humans, Pancreatic Neoplasms, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Pancreatic Cancer

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks