Cited by 717Pancreatic and Hepatic Oncology ResearchCancer Genomics and DiagnosticsPancreatitis Pathology and Treatment

The DOI matches its Crossref record; 185 of the 185 references it cites were found in a registry or an index.

Pancreatic Cancer

Open access

Maitra, Anirban, Hruban, Ralph H.·2008·Annual Review of Pathology: Mechanisms of Disease

DOI 10.1146/annurev.pathmechdis.3.121806.154305PMC PMC2666336

Open this paper in CoChat — free account

Abstract

The past two decades have witnessed an explosion in our understanding of pancreatic cancer, and it is now clear that pancreatic cancer is a disease of inherited (germ-line) and somatic gene mutations. The genes mutated in pancreatic cancer include KRAS2, p16/CDKN2A, TP53, and SMAD4/DPC4, and these are accompanied by a substantial compendium of genomic and transcriptomic alterations that facilitate cell cycle deregulation, cell survival, invasion, and metastases. Pancreatic cancers do not arise de novo, and three distinct precursor lesions have been identified. Experimental models of pancreatic cancer have been developed in genetically engineered mice, which recapitulate the multistep progression of the cognate human disease. Although the putative cell of origin for pancreatic cancer remains elusive, minor populations of cells with stem-like properties have been identified that appear responsible for tumor initiation, metastases, and resistance of pancreatic cancer to conventional therapies.

Integrity signals

Registry

Crossref · 10.1146/annurev.pathmechdis.3.121806.154305

Cites

185 of 185 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

Retracted: Notch‐1 down‐regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells
Wang, Z., Zhang, Y., Banerjee, S., Li, Y., & Sarkar, F. H. (2006) · Cancer · doi:10.1002/cncr.21904 · Cited by 263
Retracted
Prospective identification of tumorigenic breast cancer cells
Al‐Hajj, M., Wicha, M. S., Benito‐Hernández, A., Morrison, S. J., & Clarke, M. F. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0530291100 · Cited by 10,579
Stem cells, cancer, and cancer stem cells
Reya, T., Morrison, S. J., Clarke, M. F., & Weissman, I. L. (2001) · Nature · doi:10.1038/35102167 · Cited by 9,738
MicroRNA expression profiles classify human cancers
Lü, J., Getz, G. A., Miska, E. A., Alvarez-Saavedra, E., Lamb, J., Peck, D., Sweet-Cordero, A., Ebert, B. L., Mak, R. H., Ferrando, A. A., et al. (2005) · Nature · doi:10.1038/nature03702 · Cited by 9,637
1969 Cancer Facts and Figures
(1968) · American Association of Industrial Nurses Journal · doi:10.1177/216507996801601208 · Cited by 8,811
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
Bonnet, D. A., & Dick, J. E. (1997) · Nature Medicine · doi:10.1038/nm0797-730 · Cited by 7,197
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
Bao, S., Wu, Q., McLendon, R. E., Hao, Y., Shi, Q., Hjelmeland, A. B., Dewhirst, M. W., Bigner, D. D., & Rich, J. N. (2006) · Nature · doi:10.1038/nature05236 · Cited by 6,517
Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial.
Burris, H. A., Moore, M. J., Andersen, J., Green, M. R., Rothenberg, M. L., Modiano, M., Cripps, M. C., Portenoy, R. K., Storniolo, A. M., Tarassoff, P. G., et al. (1997) · Journal of Clinical Oncology · doi:10.1200/jco.1997.15.6.2403 · Cited by 5,895
A microRNA expression signature of human solid tumors defines cancer gene targets
Volinia, S., Calin, G. A., Liu, C.-G., Ambs, S., Cimmino, A., Petrocca, F., Visone, R., Iorio, M., Roldo, C., Ferracin, M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510565103 · Cited by 5,697
A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
Lapidot, T., Sirard, C., Vormoor, J., Murdoch, B., Hoang, T., Caceres-Cortes, J., Minden, M., Paterson, B., Caligiuri, M. A., & Dick, J. E. (1994) · Nature · doi:10.1038/367645a0 · Cited by 4,783

Show all 185 references

Research works printed but not linked: 24

10.1001/jama.1995.03520440059037 · DOI
Goggins M, 1996, Cancer Res., 56, 5360
de vos tot Nederveen Cappel WH, 2003, Clin. Cancer Res., 9, 3598
Goggins M, 1998, Am. J. Pathol., 152, 1501
Hruban RH, 2006, Tumors of the Pancreas
Iacobuzio-Donahue CA, 2003, Cancer Res., 63, 8614
Argani P, 2001, Cancer Res., 61, 4320
Argani P, 2001, Clin. Cancer Res., 7, 3862
Moskaluk CA, 1997, Cancer Res., 57, 2140
Altomare DA, 2003, J. Cell Biochem., 88, 470
Schutte M, 1997, Cancer Res., 57, 3126
Redston MS, 1994, Cancer Res., 54, 3025
Wilentz RE, 2000, Cancer Res., 60, 2002
Schutte M, 1996, Cancer Res., 56, 2527
Goggins M, 1998, Cancer Res., 58, 5329
Sato N, 2003, Cancer Res., 63, 4158
Ryu B, 2002, Cancer Res., 62, 819
Deramaudt T, 2005, Biochim. Biophys. Acta, 1756, 97
Brembeck FH, 2003, Cancer Res., 63, 2005
Ryu B, 2002, Cancer Res., 62, 819
Zhou W, 1998, Cancer Epidemiol. Biomark. Prev., 7, 109
Yamada T, 1998, Clin. Cancer Res., 4, 1527
Yamamoto H, 2001, Cancer Res., 61, 3139
van der Heijden MS, 2003, Cancer Res., 63, 2585

Sorted by citations

Items 201–300 of 717

Human profilin 1 is a negative regulator of CTL mediated cell‐killing and migration
Schoppmeyer, R., Zhao, R., Cheng, H., Hamed, M., Liu, C., Zhou, X., Schwarz, E. C., Zhou, Y., Knörck, A., Schwär, G., et al. (2017) · European Journal of Immunology · doi:10.1002/eji.201747124 · Cited by 50
Curing pancreatic cancer
Traub, B., Link, K. H., & Kornmann, M. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.05.030 · Cited by 51
Downregulation of ASPP2 in pancreatic cancer cells contributes to increased resistance to gemcitabine through autophagy activation
Song, B., Bian, Q., Zhang, Y., Shao, C., Li, G., Liu, A., Jing, W., Liu, R., Zhou, Y., Jin, G., et al. (2015) · Molecular Cancer · doi:10.1186/s12943-015-0447-5 · Cited by 50
A concise review on the current understanding of pancreatic cancer stem cells
Vaz, A. P., Ponnusamy, M. P., Seshacharyulu, P., & Batra, S. K. (2014) · Journal of Cancer Stem Cell Research · doi:10.14343/jcscr.2014.2e1004 · Cited by 50
Optimizing the multimodal approach to pancreatic cyst fluid diagnosis
Chai, S. M., Herba, K., Kumarasinghe, P. M., de Boer, W. B., Amanuel, B., Grieu‐Iacopetta, F., Lim, E. M., Segarajasingam, D. S., Yusoff, I. F., Choo, C., et al. (2012) · Cancer Cytopathology · doi:10.1002/cncy.21226 · Cited by 50
Targeting Fibrosis: The Bridge That Connects Pancreatitis and Pancreatic Cancer
Huang, C., Iovanna, J., & Santofimia‐Castaño, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094970 · Cited by 54
Obesity, autophagy and the pathogenesis of liver and pancreatic cancers
Aghajan, M., Li, N., & Karin, M. (2012) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2011.07008.x · Cited by 48
Pancreatic cancer stem cells: new understanding of tumorigenesis, clinical implications
Ischenko, I., Seeliger, H., Kleespies, A., Angele, M. K., Eichhorn, M., Jauch, K., & Bruns, C. J. (2009) · Langenbeck s Archives of Surgery · doi:10.1007/s00423-009-0502-z · Cited by 49
Epithelial-Stromal Interactions in Pancreatic Cancer
Zhang, Y., Crawford, H. C., & di Magliano, M. P. (2018) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020518-114515 · Cited by 52
Synergistic action of Smad4 and Pten in suppressing pancreatic ductal adenocarcinoma formation in mice
Xu, X., Ehdaie, B., Ohara, N., Yoshino, T., & Deng, C. (2009) · Oncogene · doi:10.1038/onc.2009.375 · Cited by 49
The association of circulating adiponectin levels with pancreatic cancer risk: A study within the prospective EPIC cohort
Grote, V. A., Rohrmann, S., Dossus, L., Nieters, A., Halkjær, J., Tjønneland, A. M., Overvad, K., Stegger, J. G., Chabbert‐Buffet, N., Boutron‐Ruault, M., et al. (2011) · International Journal of Cancer · doi:10.1002/ijc.26244 · Cited by 50
An Updated Review on Cancer Risk Associated with Incretin Mimetics and Enhancers
Tseng, C.-H., Lee, K.-Y., & Tseng, F.-H. (2015) · Journal of Environmental Science and Health, Part C · doi:10.1080/10590501.2015.1003496 · Cited by 49
Pancreatic Fibroblast Heterogeneity: From Development to Cancer
Garcia, P. E., Scales, M. K., Allen, B. L., & di Magliano, M. P. (2020) · Cells · doi:10.3390/cells9112464 · Cited by 48
Pancreatic Ductal Adenocarcinoma: Molecular Pathology and Predictive Biomarkers
Taherian, M., Wang, H., & Wang, H. (2022) · Cells · doi:10.3390/cells11193068 · Cited by 52
Cholecystokinin Receptor Antagonist Halts Progression of Pancreatic Cancer Precursor Lesions and Fibrosis in Mice
Smith, J. P., Cooper, T. K., McGovern, C. O., Gilius, E. L., Zhong, Q., Liao, J., Molinolo, A., Gutkind, J. S., & Matters, G. L. (2014) · Pancreas · doi:10.1097/mpa.0000000000000194 · Cited by 48
miR-139 and miR-200c regulate pancreatic cancer endothelial cell migration and angiogenesis
Li, L., Li, B., Chen, D., Liu, L., Huang, C., Lu, Z., LUN, L., & Wan, X. (2015) · Oncology Reports · doi:10.3892/or.2015.3945 · Cited by 46
Plasma Fatty Acid Composition in Patients with Pancreatic Cancer: Correlations to Clinical Parameters
Macášek, J., Vecka, M., Žák, A., Urbánek, M., Krechler, T., Petruzelka, L. B., Staňková, B., & Zeman, M. (2012) · Nutrition and Cancer · doi:10.1080/01635581.2012.716138 · Cited by 46
Genetic and molecular alterations in pancreatic cancer: Implications for personalized medicine
Chen, C. (2013) · Medical Science Monitor · doi:10.12659/msm.889636 · Cited by 48
Triptolide Induces Apoptosis and Inhibits the Growth and Angiogenesis of Human Pancreatic Cancer Cells by Downregulating COX-2 and VEGF
Ma, J., Sun, Y., Wang, Y., Wu, H., Jin, J., & Yu, X. (2013) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.3727/096504013x13657689382932 · Cited by 47
Molecular Biomarkers of Pancreatic Intraepithelial Neoplasia and Their Implications in Early Diagnosis and Therapeutic Intervention of Pancreatic Cancer
Guo, J., Xie, K., & Zheng, S. (2016) · International Journal of Biological Sciences · doi:10.7150/ijbs.14995 · Cited by 47
Genetic Alterations of Periampullary and Pancreatic Ductal Adenocarcinoma: An Overview
Sikdar, N., Saha, G., Dutta, A., Ghosh, S., Shrikhande, S. V., & Banerjee, S. (2018) · Current Genomics · doi:10.2174/1389202919666180221160753 · Cited by 51
AACR White Paper: Shaping the Future of Cancer Prevention – A Roadmap for Advancing Science and Public Health
Lippman, S. M., Abate-Shen, C. T., Maresso, K. C., Colditz, G. A., Dannenberg, A. J., Davidson, N. E., Disis, M. L., DuBois, R. N., Szabo, E. M., Giuliano, A. R., et al. (2018) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-18-0421 · Cited by 48
Self-citation
Reciprocal regulation of pancreatic ductal adenocarcinoma growth and molecular subtype by HNF4α and SIX1/4
Camolotto, S. A., Belova, V. K., Torre-Healy, L. A., Vahrenkamp, J. M., Berrett, K. C., Conway, H., Shea, J., Stubben, C., Moffitt, R. A., Gertz, J., et al. (2020) · Gut · doi:10.1136/gutjnl-2020-321316 · Cited by 46
Targeted Drug Delivery Systems for Pancreatic Cancer
Khare, V. R., Alam, N., Saneja, A., Dubey, R. D., & Gupta, P. N. (2014) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2014.2036 · Cited by 46
Inhibiting signal transducer and activator of transcription-3 increases response to gemcitabine and delays progression of pancreatic cancer
Venkatasubbarao, K., Peterson, L. L., Zhao, S., Hill, P., Cao, L., Zhou, Q., Nawrocki, S. T., & Freeman, J. W. (2013) · Molecular Cancer · doi:10.1186/1476-4598-12-104 · Cited by 46
Novel approaches in the management of pancreatic ductal adenocarcinoma: potential promises for the future
Goel, G., & Sun, W. (2015) · Journal of Hematology & Oncology · doi:10.1186/s13045-015-0141-5 · Cited by 46
LncRNA SNHG16 Induces the SREBP2 to Promote Lipogenesis and Enhance the Progression of Pancreatic Cancer
Yu, Y., Dong, J.-T., He, B., Zou, Y., Li, X., Xi, C.-H., & Yu, Y. (2019) · Future Oncology · doi:10.2217/fon-2019-0321 · Cited by 46
Dual Inhibition of Hedgehog and c-Met Pathways for Pancreatic Cancer Treatment
Rucki, A. A., Xiao, Q., Muth, S. T., Chen, J., Che, X., Kleponis, J., Sharma, R. B., Anders, R. A., Jaffee, E. M., & Zheng, L. (2017) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-16-0452 · Cited by 45
The Q705K and F359L Single-Nucleotide Polymorphisms of NOD-Like Receptor Signaling Pathway: Association with Chronic Pancreatitis, Pancreatic Cancer, and Periodontitis
Miśkiewicz, A., Szparecki, G., Durlik, M., Rydzewska, G. M., Ziobrowski, I., & Górska, R. (2015) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-015-0355-9 · Cited by 45
Enhancement of Carcinogenesis and Fatty Infiltration in the Pancreas in N-Nitrosobis(2-Oxopropyl)Amine-Treated Hamsters by High-Fat Diet
Hori, M., Kitahashi, T., Imai, T., Ishigamori, R., Takasu, S., Mutoh, M., Sügimura, T., Wakabayashi, K., & Takahashi, M. (2011) · Pancreas · doi:10.1097/mpa.0b013e318220e742 · Cited by 45
SIRT1 inhibits proliferation of pancreatic cancer cells expressing pancreatic adenocarcinoma up-regulated factor (PAUF), a novel oncogene, by suppression of β-catenin
Cho, I.-R., Koh, S. S., Malilas, W., Srisuttee, R., Moon, J., Choi, Y. W., Horio, Y., Oh, S., & Chung, Y.-H. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.05.107 · Cited by 47
Combining clinicopathological predictors and molecular biomarkers in the oncogenic K-RAS/Ki67/HIF-1α pathway to predict survival in resectable pancreatic cancer
Qin, R., Smyrk, T. C., Reed, N. R., Schmidt, R. L., Schnelldorfer, T., Chari, S. T., Petersen, G. M., & Tang, A. (2015) · British Journal of Cancer · doi:10.1038/bjc.2014.659 · Cited by 45
Molecular Pathology of Pancreatic Cancer: From Bench-to-Bedside Translation
Corbo, V., Tortora, G., & Scarpa, A. (2012) · Current Drug Targets · doi:10.2174/138945012800564103 · Cited by 44
Co-targeting of CXCR4 and hedgehog pathways disrupts tumor-stromal crosstalk and improves chemotherapeutic efficacy in pancreatic cancer
Khan, M. A., Srivastava, S. K., Zubair, H., Patel, G. K., Arora, S., Khushman, M. M., Carter, J. E., Gorman, G. S., Singh, S., & Singh, A. P. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.011748 · Cited by 44
Mechanisms of drug resistance of pancreatic ductal adenocarcinoma at different levels
Du, J., Gu, J., & Li, J. (2020) · Bioscience Reports · doi:10.1042/bsr20200401 · Cited by 44
Integrated transcriptome meta-analysis of pancreatic ductal adenocarcinoma and matched adjacent pancreatic tissues
Atay, S. (2020) · PeerJ · doi:10.7717/peerj.10141 · Cited by 44
NFATc4 Regulates Sox9 Gene Expression in Acinar Cell Plasticity and Pancreatic Cancer Initiation
Heßmann, E., Zhang, J., Chen, N., Hasselluhn, M. C., Liou, G., Störz, P., Ellenrieder, V., Billadeau, D. D., & König, A. O. (2015) · Stem Cells International · doi:10.1155/2016/5272498 · Cited by 43
Immune Therapy in GI Malignancies: A Review
Wang, J., Reiss, K. A., Khatri, R. G., Jaffee, E. M., & Laheru, D. A. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2015.60.7879 · Cited by 43
KRAS Mutations in Codon 12 or 13 Are Associated With Worse Prognosis in Pancreatic Ductal Adenocarcinoma
Sinn, B. V., Striefler, J. K., Rudl, M., Lehmann, A., Bahra, M., Denkert, C., Sinn, M., Stieler, J., Klauschen, F., Budczies, J., et al. (2014) · Pancreas · doi:10.1097/mpa.0000000000000077 · Cited by 43
Outlier Kinase Expression by RNA Sequencing as Targets for Precision Therapy
Kothari, V., Wei, I. H., Shankar, S., Sundaram, S. K., Wang, L., Ma, L. W., Vats, P., Grasso, C. S., Robinson, D. R., Wu, Y.-M., et al. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0336 · Cited by 43
Cellular and molecular aspects of pancreatic cancer
Gharibi, A., Adamian, Y., & Kelber, J. A. (2016) · Acta Histochemica · doi:10.1016/j.acthis.2016.01.009 · Cited by 43
Molecular Characterization of Pancreatic Neoplasms
Shi, C., Daniels, J. A., & Hruban, R. H. (2008) · Advances in Anatomic Pathology · doi:10.1097/pap.0b013e31817bf57d · Cited by 44
Self-citation
Deficiencies in Natural Killer Cell Numbers, Expansion, and Function at the Pre-Neoplastic Stage of Pancreatic Cancer by KRAS Mutation in the Pancreas of Obese Mice
Kaur, K., Chang, H.-H., Topchyan, P., Cook, J., Barkhordarian, A., Eibl, G., & Jewett, A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01229 · Cited by 43
Neurotensin receptor 1 signaling promotes pancreatic cancer progression
Takahashi, K., Ehata, S., Miyauchi, K., Morishita, Y., Miyazawa, K., & Miyazono, K. (2020) · Molecular Oncology · doi:10.1002/1878-0261.12815 · Cited by 40
Xenopus pancreas development
Pearl, E. J., Bilogan, C. K., Mukhi, S., Brown, D. D., & Horb, M. E. (2009) · Developmental Dynamics · doi:10.1002/dvdy.21935 · Cited by 43
Difficult Diagnostic Problems in Pancreatobiliary Neoplasia
Bledsoe, J. R., Shinagare, S. A., & Deshpande, V. (2015) · Archives of Pathology & Laboratory Medicine · doi:10.5858/arpa.2014-0205-ra · Cited by 41
Fibulin-5 blocks microenvironmental ROS in pancreatic cancer
Wang, M., Topalovski, M., Toombs, J. E., Wright, C. M., Moore, Z. R., Boothman, D., Yanagisawa, H., Wang, H.-M., Witkiewicz, A., Castrillon, D., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-15-0744 · Cited by 41
Omega-3 Fatty Acids Prevent Early Pancreatic Carcinogenesis via Repression of the AKT Pathway
Ding, Y., Mullapudi, B., Torres, C., Mascariñas, E., Mancinelli, G. E., Diaz, A. M., McKinney, R. D., Barron, M. R., Schultz, M., Heiferman, M. J., et al. (2018) · Nutrients · doi:10.3390/nu10091289 · Cited by 41
Molecular markers in pancreatic cancer diagnosis
Herreros‐Villanueva, M., Gironella, M., Castells, A., & Bujanda, L. (2013) · Clinica Chimica Acta · doi:10.1016/j.cca.2012.12.025 · Cited by 41
Quantitative molecular profiling of biomarkers for pancreatic cancer with functionalized quantum dots
Lee, K. H., Galloway, J. F., Park, J., Dvoracek, C. M., Dallas, M. R., Konstantopoulos, K., Maitra, A., & Searson, P. C. (2012) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2012.01.005 · Cited by 41
Self-citation
Triptolide suppresses proliferation, hypoxia-inducible factor-1α and c-Myc expression in pancreatic cancer cells
Ding, X., Zhou, X., Jiang, B., Zhao, Q., & Zhou, G. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3960 · Cited by 40
Widespread activation of the DNA damage response in human pancreatic intraepithelial neoplasia
Koorstra, J.-B. M., Hong, S., Shi, C., Meeker, A. K., Ryu, J. K., Offerhaus, G. J. A., Goggins, M., Hruban, R. H., & Maitra, A. (2009) · Modern Pathology · doi:10.1038/modpathol.2009.114 · Cited by 39
Self-citation
Ectopic Overexpression of Sonic Hedgehog (Shh) Induces Stromal Expansion and Metaplasia in the Adult Murine Pancreas
Fendrich, V., Oh, E. C. T., Bang, S., Karikari, C. A., Ottenhof, N. A., Bisht, S., Lauth, M., Brossart, P., Katsanis, N., Maitra, A., et al. (2011) · Neoplasia · doi:10.1593/neo.11088 · Cited by 43
Self-citation
Pancreatic cancer stem cells: Fact or fiction?
Bhagwandin, V. J., & Shay, J. W. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.02.007 · Cited by 40
Common Telomere Changes during In Vivo Reprogramming and Early Stages of Tumorigenesis
Marión, R. M., López de Silanes, I., Mosteiro, L., Gamache, B., Abad, M., Guerra, C., Megías, D., Serrano, M., & Blasco, M. A. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.01.001 · Cited by 39
Pancreatic Cancer Molecular Classifications: From Bulk Genomics to Single Cell Analysis
Pompella, L., Tirino, G., Pappalardo, A., Caterino, M., Ventriglia, A., Nacca, V., Orditura, M., Ciardiello, F., & Vita, F. D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21082814 · Cited by 40
Telomeres are shortened in acinar-to-ductal metaplasia lesions associated with pancreatic intraepithelial neoplasia but not in isolated acinar-to-ductal metaplasias
Hong, S., Heaphy, C. M., Shi, C., Eo, S., Cho, H., Meeker, A. K., Eshleman, J. R., Hruban, R. H., & Goggins, M. (2010) · Modern Pathology · doi:10.1038/modpathol.2010.181 · Cited by 41
Self-citation
Metabolic reprogramming by driver mutation-tumor microenvironment interplay in pancreatic cancer: new therapeutic targets
Andersen, H. B., Ialchina, R., Pedersen, S. F., & Czaplińska, D. (2021) · Cancer and Metastasis Reviews · doi:10.1007/s10555-021-10004-4 · Cited by 40
HIPK2 deficiency causes chromosomal instability by cytokinesis failure and increases tumorigenicity
Valente, D., Bossi, G., Moncada, A., Tornincasa, M., Indelicato, S., Piscuoglio, S., Karamitopoulou, E., Bartolazzi, A., Pierantoni, G. M., Fusco, A., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.3583 · Cited by 38
miR-208-Induced Epithelial to Mesenchymal Transition of Pancreatic Cancer Cells Promotes Cell Metastasis and Invasion
Liu, A., Shao, C., Jin, G., Liu, R., Hao, J., Song, B., Ouyang, L., & Hu, X. (2014) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-013-9805-3 · Cited by 39
Intra-tumoral heterogeneity of gemcitabine delivery and mass transport in human pancreatic cancer
Koay, E. J., Baio, F. E., Ondari, A., Truty, M. J., Vittorio Cristini, C., Thomas, R. M., Chen, R., Chatterjee, D., Kang, Y., Zhang, J., et al. (2014) · Physical Biology · doi:10.1088/1478-3975/11/6/065002 · Cited by 38
Self-citation
Anti-tumor efficacy of a therapeutic peptide based on thermo-responsive elastin-like polypeptide in combination with gemcitabine
Ryu, J. S., & Raucher, D. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.03.021 · Cited by 38
Increased Expression of the Glucose Transporter Type 1 Gene Is Associated With Worse Overall Survival in Resected Pancreatic Adenocarcinoma
Davis-Yadley, A. H., Abbott, A. M., Pimiento, J. M., Chen, D., & Malafa, M. P. (2015) · Pancreas · doi:10.1097/mpa.0000000000000580 · Cited by 38
Clinicopathological Characteristics of Young Patients With Pancreatic Cancer
Eguchi, H., Yamaue, H., Unno, M., Mizuma, M., Hamada, S., Igarashi, H., Kuroki, T., Satoi, S., Shimizu, Y., Tani, M., et al. (2016) · Pancreas · doi:10.1097/mpa.0000000000000636 · Cited by 38
Pancreatic Cancer Development and Progression: Remodeling the Model
Real, F. X., Cibrián–Uhalte, E., & Martinelli, P. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.07.033 · Cited by 41
Therapeutic Strategies to Overcome Fibrotic Barriers to Nanomedicine in the Pancreatic Tumor Microenvironment
Tanaka, H. Y., Nakazawa, T., Enomoto, A., Masamune, A., & Kano, M. R. (2023) · Cancers · doi:10.3390/cancers15030724 · Cited by 42
Elastin-like polypeptide for improved drug delivery for anticancer therapy: preclinical studies and future applications
Ryu, J. S., & Raucher, D. (2014) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2015.974546 · Cited by 37
Genetic variations associated with gemcitabine treatment outcome in pancreatic cancer
Li, L., Zhang, J., Jenkins, G. D., Xie, F. X., Carlson, E. E., Fridley, B. L., Bamlet, W. R., Petersen, G. M., McWilliams, R. R., & Wang, L. (2016) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0000000000000241 · Cited by 37
Deciphering the link between PI3K and PAK: An opportunity to target key pathways in pancreatic cancer?
Thillai, K., Lam, H., Sarker, D., & Wells, C. M. (2016) · Oncotarget · doi:10.18632/oncotarget.13309 · Cited by 37
Differential methylation landscape of pancreatic ductal adenocarcinoma and its precancerous lesions
Bararia, A., Dey, S., Gulati, S., Ghatak, S., Ghosh, S., Banerjee, S., & Sikdar, N. (2020) · Hepatobiliary & pancreatic diseases international · doi:10.1016/j.hbpd.2020.03.010 · Cited by 37
Early detection of pancreatic cancer
Garg, S. K., & Chari, S. T. (2020) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000663 · Cited by 39
Emerging molecular biology of pancreatic cancer.
Hruban, R. H., Maitra, A., Schulick, R. D., Laheru, D. A., Herman, J., Kern, S. E., & Goggins, M. (2008) · PubMed Central · Cited by 37
Self-citation
Genetically Engineered Mouse Models of K-Ras-Driven Lung and Pancreatic Tumors: Validation of Therapeutic TargetsPreprint
Drosten, M., Guerra, C. E., & Barbacid, M. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a031542 · Cited by 43
Diagnosis of Carcinogenic Pathologies through Breath Biomarkers: Present and Future Trends
Vassilenko, V., Moura, P. C., & Raposo, M. (2023) · Biomedicines · doi:10.3390/biomedicines11113029 · Cited by 36
Copy Number Variations in Pancreatic Cancer: From Biological Significance to Clinical Utility
Oketch, D. J. A., Giulietti, M., & Piva, F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010391 · Cited by 36
Pancreatic adenocarcinoma up-regulated factor (PAUF) enhances the expression of β-catenin, leading to a rapid proliferation of pancreatic cells
Cho, I.-R., Koh, S. S., Min, H.-J., Kim, S. J., Lee, Y., Park, E.-H., Srisuttee, R., Jhun, B. H., Oh, S., Johnston, R. N., et al. (2011) · Experimental & Molecular Medicine · doi:10.3858/emm.2011.43.2.010 · Cited by 36
Tumor suppressor Fbxw7 antagonizes WNT signaling by targeting β-catenin for degradation in pancreatic cancer
Jiang, J., Sun, C., Tian, S., Yu, C., Chen, M., & Zhang, H. (2016) · Tumor Biology · doi:10.1007/s13277-016-5217-5 · Cited by 36
Inhibition of the MEK/ERK pathway augments nab-paclitaxel-based chemotherapy effects in preclinical models of pancreatic cancer
Awasthi, N., Monahan, S., Stefaniak, A., Schwarz, M. A., & Schwarz, R. E. (2017) · Oncotarget · doi:10.18632/oncotarget.23684 · Cited by 35
Inflammation and pancreatic cancer: molecular and functional interactions between S100A8, S100A9, NT-S100A8 and TGFβ1
Basso, D., Bozzato, D., Padoan, A., Moz, S., Zambon, C., Fogar, P., Greco, E., Scorzeto, M., Simonato, F., Navaglia, F., et al. (2014) · Cell Communication and Signaling · doi:10.1186/1478-811x-12-20 · Cited by 36
CTHRC1 promotes angiogenesis by recruiting Tie2-expressing monocytes to pancreatic tumors
Lee, J., Song, J., Kwon, E., Jo, S., Kang, M. K., Kim, Y., Hwang, Y., Bae, H., Kang, T. H., Chang, S., et al. (2016) · Experimental & Molecular Medicine · doi:10.1038/emm.2016.87 · Cited by 36
Pathogenesis of Pancreatic Cancer
Murtaugh, L. C. (2013) · Toxicologic Pathology · doi:10.1177/0192623313508250 · Cited by 40
K RAS mutation and epithelial–macrophage interplay in pancreatic neoplastic transformation
Bishehsari, F., Zhang, L., Barlass, U., Preite, N. Z., Turturro, S. B., Najor, M. S., Shetuni, B., Zayas, J. P., Mahdavinia, M., Abukhdeir, A. M., et al. (2018) · International Journal of Cancer · doi:10.1002/ijc.31592 · Cited by 35
Non-coding RNAs in pancreatic ductal adenocarcinoma: New approaches for better diagnosis and therapy
Mortoglou, M., Tabin, Z. K., Arısan, E. D., Kocher, H. M., & Onganer, P. U. (2021) · Translational Oncology · doi:10.1016/j.tranon.2021.101090 · Cited by 36
Emergence of zebrafish models in oncology for validating novel anticancer drug targets and nanomaterials
Mimeault, M., & Batra, S. K. (2012) · Drug Discovery Today · doi:10.1016/j.drudis.2012.08.002 · Cited by 35
Loss of SMAD4 Is Associated With Poor Tumor Immunogenicity and Reduced PD-L1 Expression in Pancreatic Cancer
Principe, D. R., Underwood, P. W., Kumar, S., Timbers, K. E., Koch, R. M., Trevino, J. G., Munshi, H. G., & Rana, A. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.806963 · Cited by 35
Proteome alterations in pancreatic ductal adenocarcinoma
Pan, S., Brentnall, T. A., & Chen, R. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.11.020 · Cited by 34
Role of Peroxisome Proliferator-Activated Receptor β/δ and B-Cell Lymphoma-6 in Regulation of Genes Involved in Metastasis and Migration in Pancreatic Cancer Cells
Coleman, J. D., Thompson, J. T., Smith, R. W., Prokopczyk, B., & Heuvel, J. P. V. (2013) · PPAR Research · doi:10.1155/2013/121956 · Cited by 34
Nutrients and the Pancreas: An Epigenetic Perspective
Weisbeck, A., & Jansen, R. J. (2017) · Nutrients · doi:10.3390/nu9030283 · Cited by 34
Insights Into SMAD4 Loss in Pancreatic Cancer From Inducible Restoration of TGF-β Signaling
Fullerton, P. T., Creighton, C. J., & Matzuk, M. M. (2015) · Molecular Endocrinology · doi:10.1210/me.2015-1102 · Cited by 33
Epigenetic Landscape in Pancreatic Ductal Adenocarcinoma: On the Way to Overcoming Drug Resistance?
Čierniková, S., Earl, J., García‐Bermejo, L., Števurková, V., Carrato, A., & Smolková, B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21114091 · Cited by 36
Co-expression analysis of pancreatic cancer proteome reveals biology and prognostic biomarkers
Mantini, G., Vallés‐Martí, A., Large, T. Y. S. L., Capula, M., Funel, N., Pham, T. V., Piersma, S. R., Geert Kazemier, M., Bijlsma, M. F., Giovannetti, E., et al. (2020) · Cellular Oncology · doi:10.1007/s13402-020-00548-y · Cited by 34
Recent development of gene therapy for pancreatic cancer using non-viral nanovectors
Liu, Y., Wu, W., Wang, Y., Han, S., Yuan, Y., Huang, J., Shuai, X., & Peng, Z. M. (2021) · Biomaterials Science · doi:10.1039/d1bm00748c · Cited by 35
Process of hepatic metastasis from pancreatic cancer: biology with clinical significance
Shi, H., Li, J., & Fu, D. (2015) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-015-2024-0 · Cited by 33
Loss of runt‐related transcription factor 3 induces gemcitabine resistance in pancreatic cancer
Horiguchi, S., Shiraha, H., Nagahara, T., Kataoka, J., Iwamuro, M., Matsubara, M., Nishina, S., Kato, H., Takaki, A., Nouso, K., et al. (2013) · Molecular Oncology · doi:10.1016/j.molonc.2013.04.004 · Cited by 33
Mutation analysis of the PALB2 gene in unselected pancreatic cancer patients in the Czech Republic
Borecká, M., Zemánková, P., Vočka, M., Souček, P., Soukupová, J., Kleiblová, P., Sevcik, J., Kleibl, Z., & Janatová, M. (2016) · Cancer Genetics · doi:10.1016/j.cancergen.2016.03.003 · Cited by 33
BAG3 regulates stability of IL-8 mRNA via interplay between HuR and miR-4312 in PDACs
Li, C., Jiang, J., Wang, J.-M., Sun, J. T., An, M., Li, S., Yan, J. Y., & Wang, H. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0874-5 · Cited by 33
Inhibiting the Growth of Pancreatic Adenocarcinoma In Vitro and In Vivo through Targeted Treatment with Designer Gold Nanotherapeutics
Kudgus, R. A., Szabolcs, A., Khan, J. A., Walden, C. A., Reid, J. M., Robertson, J. D., Bhattacharya, R., & Mukherjee, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057522 · Cited by 32
Gene-expression profiling in pancreatic cancer
Lopez-Casas, P. P., & López-Fernández, L. A. (2010) · Expert Review of Molecular Diagnostics · doi:10.1586/erm.10.43 · Cited by 32
Young adulthood and adulthood adiposity in relation to incidence of pancreatic cancer: a prospective study of 0.5 million Chinese adults and a meta-analysis
Pang, Y., Holmes, M. V., Kartsonaki, C., Yu, C., Yang, L., Bian, Z., Chen, Y., Bragg, F., Iona, A., Millwood, I. Y., et al. (2017) · Journal of Epidemiology & Community Health · doi:10.1136/jech-2017-208895 · Cited by 33
Adenosquamous Carcinoma of the Pancreas: A Distinct Clinicopathologic Entity
Trikudanathan, G., & Dasanu, C. A. (2010) · Southern Medical Journal · doi:10.1097/smj.0b013e3181ebadbd · Cited by 32

Authors: Maitra, A., & Hruban, R. H.
Affiliations: Johns Hopkins University (US)
ORCID: Maitra, Anirban
Hruban, Ralph H.
Venue: Annual Review of Pathology: Mechanisms of Disease
Publisher: Annual Reviews
Published: 2008-02-01
Volume: 3
Issue: 1
Pages: 157-188
ISSN: 1553-4006 (ISSN-L)
1553-4014
DOI: 10.1146/annurev.pathmechdis.3.121806.154305
PMC: PMC2666336
OpenAlex: W4211122150
Cited by: 707
References: 185
Citations by year: 2026: 16 · 2025: 10 · 2024: 31 · 2023: 29 · 2022: 55 · 2021: 46 · 2020: 46 · 2019: 39 · 2018: 43 · 2017: 42 · 2016: 41 · 2015: 53 · 2014: 59 · 2013: 48 · 2012: 32
FWCI: 3.60
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Annual Review of Pathology Mechanisms of Disease (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (R01CA113669, P50CA062924)
Topics: Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
Keywords: pancreatic cancer, germline mutations, somatic mutations, KRAS2, CDKN2A, TP53, genetic alterations, transcriptomic alterations, cell cycle dysregulation, metastasis, precursor lesions, genetically engineered mouse models, tumor progression, cancer stem cells, treatment resistance
MeSH terms: Animals, Disease Models, Animal, Humans, Pancreatic Neoplasms, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Pancreatic Cancer

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks