Cited by 1,241Heme Oxygenase-1 and Carbon MonoxideHemoglobin structure and functionPorphyrin Metabolism and Disorders

The DOI matches its Crossref record; 240 of the 240 references it cites were found in a registry or an index.

Mechanisms of Cell Protection by Heme Oxygenase-1

Gozzelino, Raffaella, Jeney, Viktoria, Soares, Miguel P.·2010·Annual Review of Pharmacology and Toxicology

Abstract

Heme oxygenases (HO) catabolize free heme, that is, iron (Fe) protoporphyrin (IX), into equimolar amounts of Fe 2+ , carbon monoxide (CO), and biliverdin. The stress-responsive HO-1 isoenzyme affords protection against programmed cell death. The mechanism underlying this cytoprotective effect relies on the ability of HO-1 to catabolize free heme and prevent it from sensitizing cells to undergo programmed cell death. This cytoprotective effect inhibits the pathogenesis of a variety of immune-mediated inflammatory diseases.

Overview

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Registry

Crossref · 10.1146/annurev.pharmtox.010909.105600

Cites

240 of 240 references verified0 citation errors · 0 not checkable

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Citations

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1 retracted

Show all 237 references

Research works printed but not linked: 5

  1. Otterbein LE, 1999, Am. J. Physiol. Renal Physiol., 276, L688
  2. Wang H, 2005, Endocrinology, 147, 262
  3. Loegering DJ, 1981, J. Traumatol., 21, 130
  4. Carrell RW, 1980, Tex. Rep. Biol. Med., 40, 431
  5. Ellis JT, 1998, J. Heart Valve Dis., 7, 376

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Items 501–600 of 1,001

Metadata

Authors
Gozzelino, R., Jeney, V., & Soares, M. P.
Affiliations
  • Instituto Gulbenkian de Ciência (PT)
  • Instituto Gulbenkian de Ciência, Oeiras, Portugal;
Venue
Annual Review of Pharmacology and Toxicology
Published
2010-02-01
Volume
50
Issue
1
Pages
323-354
ISSN
  • 0362-1642 (ISSN-L)
  • 1545-4304
OpenAlex
W2162853795
Cited by
1,241
References
237
Citations by year
2026: 66 · 2025: 61 · 2024: 55 · 2023: 72 · 2022: 92 · 2021: 114 · 2020: 101 · 2019: 60 · 2018: 87 · 2017: 75 · 2016: 65 · 2015: 99 · 2014: 77 · 2013: 69 · 2012: 74
FWCI
6.01
Type
journal article
Language
en
Open access
closed
Locations
  • The Annual Review of Pharmacology and Toxicology (publishedVersion)
  • PubMed (publishedVersion)
  • University of Debrecen Electronic Archive (University of Debrecen) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heme Oxygenase-1 and Carbon Monoxide
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Porphyrin Metabolism and Disorders
Keywords
heme oxygenase-1, heme degradation, carbon monoxide, biliverdin, bilirubin, programmed cell death, cytoprotection, immune-mediated inflammatory diseases, stress response
MeSH terms
Animals, Biliverdine, Carbon Monoxide, Heme, Humans, Inflammation, Tumor Necrosis Factor-alpha, Gene Expression Regulation, Enzymologic, Apoptosis, Cytoprotection, Heme Oxygenase-1

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