Gene Therapy with Viral Vectors

In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector

Naldini, L., Blömer, U., Gallay, P., Ory, D., Mulligan, R., Gage, F. H., Verma, I. M., & Trono, D. (1996) · Science · doi:10.1126/science.272.5259.263 · Cited by 4,903 · see citing works

Characteristics of a human cell line transformed by DNA from human adenovirus type 5

Graham, F. L., Russell, W. C., Smiley, J., & Nairn, R. (1977) · Journal of General Virology · doi:10.1099/0022-1317-36-1-59 · Cited by 4,793 · see citing works

A Third-Generation Lentivirus Vector with a Conditional Packaging System

Dull, T., Zufferey, R., Kelly, M., Mandel, R. J., Nguyen, M., Trono, D., & Naldini, L. (1998) · Journal of Virology · doi:10.1128/jvi.72.11.8463-8471.1998 · Cited by 3,341 · see citing works

Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5

Bergelson, J. M., Cunningham, J. A., Droguett, G., Kurt‐Jones, E. A., Krithivas, A., Hong, J. S., Horwitz, M. S., Crowell, R. L., & Finberg, R. W. (1997) · Science · doi:10.1126/science.275.5304.1320 · Cited by 3,102 · see citing works

Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease.

Cavazzana-Calvo, M., Hacein-Bey, S., Basile, G. D. S., Gross, F., Yvon, E., Nusbaum, P., Selz, F., Hue, C., Certain, S., Casanova, J., et al. (2000) · Science · doi:10.1126/science.288.5466.669 · Cited by 2,703 · see citing works

Integrins αvβ3 and αvβ5 promote adenovirus internalization but not virus attachment

Wickham, T. J., Mathias, P., Cheresh, D. A., & Nemerow, G. R. (1993) · Cell · doi:10.1016/0092-8674(93)90231-e · Cited by 2,199 · see citing works

Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo

Zufferey, R., Nagy, D., Mandel, R. J., Naldini, L., & Trono, D. (1997) · Nature Biotechnology · doi:10.1038/nbt0997-871 · Cited by 1,977 · see citing works

Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus

Mann, R., Mulligan, R. C., & Baltimore, D. (1983) · Cell · doi:10.1016/0092-8674(83)90344-6 · Cited by 1,855 · see citing works

Self-Inactivating Lentivirus Vector for Safe and Efficient In Vivo Gene Delivery

Zufferey, R., Dull, T., Mandel, R. J., Bukovsky, A., Quiroz, D., Naldini, L., & Trono, D. (1998) · Journal of Virology · doi:10.1128/jvi.72.12.9873-9880.1998 · Cited by 1,815 · see citing works

T Lymphocyte-Directed Gene Therapy for ADA − SCID: Initial Trial Results After 4 Years

Blaese, R. M., Culver, K. W., Miller, A. D., Carter, C. S., Fleisher, T. A., Clerici, M., Shearer, G. M., Chang, L., Chiang, Y. L., Tolstoshev, P., et al. (1995) · Science · doi:10.1126/science.270.5235.475 · Cited by 1,546 · see citing works

Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector.

Naldini, L., Blömer, U., Gage, F. H., Trono, D., & Verma, I. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11382 · Cited by 1,499 · see citing works

Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection.

Miller, A. D., Adam, M., & Miller, A. D. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.8.4239 · Cited by 1,445 · see citing works

Membrane-Associated Heparan Sulfate Proteoglycan Is a Receptor for Adeno-Associated Virus Type 2 Virions

Summerford, C., & Samulski, R. J. (1998) · Journal of Virology · doi:10.1128/jvi.72.2.1438-1445.1998 · Cited by 1,409 · see citing works

Production of High-Titer Recombinant Adeno-Associated Virus Vectors in the Absence of Helper Adenovirus

Xiao, X., Li, J., & Samulski, R. J. (1998) · Journal of Virology · doi:10.1128/jvi.72.3.2224-2232.1998 · Cited by 1,381 · see citing works

Neurodegeneration Prevented by Lentiviral Vector Delivery of GDNF in Primate Models of Parkinson's Disease

Kordower, J. H., Emborg, M. E., Bloch, J., Ma, S. Y., Chu, Y., Leventhal, L., McBride, J. L., Chen, E., Palfi, S., Roitberg, B. Z., et al. (2000) · Science · doi:10.1126/science.290.5492.767 · Cited by 1,244 · see citing works

Development of a self-inactivating lentivirus vector

Miyoshi, H., Blömer, U., Takahashi, M., Gage, F. H., & Verma, I. M. (1998) · Journal of Virology · doi:10.1128/jvi.72.10.8150-8157.1998 · Cited by 1,196 · see citing works

Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector

Kay, M. A., Manno, C. S., Ragni, M. V., Larson, P. J., Couto, L. B., McClelland, A., Glader, B. E., Chew, A. K., Tai, S. J., Herzog, R. W., et al. (2000) · Nature Genetics · doi:10.1038/73464 · Cited by 1,019 · see citing works

Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences

Follenzi, A., Ailles, L., Bakovic, S., Geuna, M., & Naldini, L. (2000) · Nature Genetics · doi:10.1038/76095 · Cited by 926 · see citing works

Integration of murine leukemia virus DNA depends on mitosis.

Roe, T., Reynolds, T. C., Yu, G., & Brown, P. O. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05858.x · Cited by 921 · see citing works

Gene Therapy Death Prompts Review of Adenovirus Vector

Marshall, E. (1999) · Science · doi:10.1126/science.286.5448.2244 · Cited by 918 · see citing works

Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges.

Danos, O., & Mulligan, R. C. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.17.6460 · Cited by 898 · see citing works

HIV-1 genome nuclear import is mediated by a central DNA flap.

Zennou, V., Petit, C., Guétard, D., Nerhbass, U., Montagnier, L., & Charneau, P. (2000) · Cell · doi:10.1016/s0092-8674(00)80828-4 · Cited by 893 · see citing works

Gene Therapy in Peripheral Blood Lymphocytes and Bone Marrow for ADA − Immunodeficient Patients

Bordignon, C., Notarangelo, L. D., Nobili, N., Ferrari, G., Casorati, G., Panina‐Bordignon, P., Mazzolari, E., Maggioni, D., Rossi, C., Servida, P., et al. (1995) · Science · doi:10.1126/science.270.5235.470 · Cited by 830 · see citing works

A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells

Bukrinsky, M., Haggerty, S., Dempsey, M. P., Sharova, N., Adzhubei, A. A., Spitz, L., Lewis, P. F., Goldfarb, D. S., Emerman, M., & Stevenson, M. (1993) · Nature · doi:10.1038/365666a0 · Cited by 801 · see citing works

An Adenovirus Vector with Genetically Modified Fibers Demonstrates Expanded Tropism via Utilization of a Coxsackievirus and Adenovirus Receptor-Independent Cell Entry Mechanism

Dmitriev, I. P., Krasnykh, V. N., Miller, C. R., Wang, M., Kashentseva, E. A., Mikheeva, G., Belousova, N., & Curiel, D. T. (1998) · Journal of Virology · doi:10.1128/jvi.72.12.9706-9713.1998 · Cited by 768 · see citing works

Cross-Packaging of a Single Adeno-Associated Virus (AAV) Type 2 Vector Genome into Multiple AAV Serotypes Enables Transduction with Broad Specificity

Rabinowitz, J. E., Rolling, F., Li, C., Conrath, H., Xiao, W., Xiao, X., & Samulski, R. J. (2002) · Journal of Virology · doi:10.1128/jvi.76.2.791-801.2002 · Cited by 762 · see citing works

Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors

Ferrari, F. K., Samulski, T., Shenk, T., & Samulski, R. J. (1996) · Journal of Virology · doi:10.1128/jvi.70.5.3227-3234.1996 · Cited by 761 · see citing works

Helper-free stocks of recombinant adeno-associated viruses: normal integration does not require viral gene expression

Samulski, R. J., Chang, L., & Shenk, T. E. (1989) · Journal of Virology · doi:10.1128/jvi.63.9.3822-3828.1989 · Cited by 742 · see citing works

A Helper-Dependent Adenovirus Vector System: Removal of Helper Virus by Cre-Mediated Excision of the Viral Packaging Signal

Parks, R. J., Chen, L., Anton, M., Sankar, U., Rudnicki, M. A., & Graham, F. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13565 · Cited by 725 · see citing works

Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector

Blömer, U., Naldini, L., Kafri, T., Trono, D., Verma, I. M., & Gage, F. H. (1997) · Journal of Virology · doi:10.1128/jvi.71.9.6641-6649.1997 · Cited by 725 · see citing works

αVβ5 integrin: a co-receptor for adeno-associated virus type 2 infection

Summerford, C., Bartlett, J. S., & Samulski, R. J. (1999) · Nature Medicine · doi:10.1038/4768 · Cited by 711 · see citing works

Immune responses to adenovirus and adeno-associated virus in humans

Chirmule, N., Propert, K. J., Magosin, S. A., Qian, Y., Qian, R., & Wilson, J. M. (1999) · Gene Therapy · doi:10.1038/sj.gt.3300994 · Cited by 684 · see citing works

From the Cover: Recombinant adeno-associated virus type 2, 4, and 5 vectors: Transduction of variant cell types and regions in the mammalian central nervous system

Davidson, B. L., Stein, C. S., Heth, J., Martins, I., Kotin, R. M., Derksen, T. A., Zabner, J., Ghodsi, A., & Chiorini, J. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.050581197 · Cited by 679 · see citing works

Transduction of human CD34+ cells that mediate long-term engraftment of NOD/SCID mice by HIV vectors.

Miyoshi, H., Smith, K. A., Mosier, D., Verma, I., & Torbett, B. (1999) · Science · doi:10.1126/science.283.5402.682 · Cited by 668 · see citing works

The trans-activator gene of HTLV-III is essential for virus replication

Fisher, A. G., Feinberg, M. B., Josephs, S. F., Harper, M., Marselle, L. M., Reyes, G. R., Gonda, M. A., Aldovini, A., Debouk, C., Gallo, R. C., et al. (1986) · Nature · doi:10.1038/320367a0 · Cited by 628 · see citing works

Active nuclear import of human immunodeficiency virus type 1 preintegration complexes.

Bukrinsky, M. I., Sharova, N., Dempsey, M. P., Stanwick, T. L., Bukrinskaya, A. G., Haggerty, S., & Stevenson, M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.14.6580 · Cited by 607 · see citing works

Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors

Kafri, T., Blömer, U., Peterson, D. A., Gage, F. H., & Verma, I. M. (1997) · Nature Genetics · doi:10.1038/ng1197-314 · Cited by 604 · see citing works

Engraftment of gene–modified umbilical cord blood cells in neonates with adenosine deaminase deficiency

Kohn, D. B., Weinberg, K. I., Nolta, J. A., Heiss, L. N., Lenarsky, C., Crooks, G. M., Hanley, M. E., Annett, G., Brooks, J. S., El-Khoureiy, A., et al. (1995) · Nature Medicine · doi:10.1038/nm1095-1017 · Cited by 592 · see citing works

Correction of sickle cell disease in transgenic mouse models by gene therapy

Pawliuk, R., Westerman, K. A., Fabry, M. E., Payen, E., Tighe, R., Bouhassira, E. E., Acharya, S. A., Ellis, J., London, I. M., Eaves, C. J., et al. (2001) · Science · doi:10.1126/science.1065806 · Cited by 579 · see citing works

Therapeutic haemoglobin synthesis in β-thalassaemic mice expressing lentivirus-encoded human β-globin

May, C., Rivella, S., Callegari, J., Heller, G., Gaensler, K. M. L., Luzzatto, L., & Sadelain, M. (2000) · Nature · doi:10.1038/35017565 · Cited by 567 · see citing works

Location of the Trans -Activating Region on the Genome of Human T-Cell Lymphotropic Virus Type III

Sodroski, J., Patarca, R., Rosen, C. A., Wong‐Staal, F., & Haseltine, W. A. (1985) · Science · doi:10.1126/science.2990041 · Cited by 556 · see citing works

Self-inactivating retroviral vectors designed for transfer of whole genes into mammalian cells.

Yu, S. F., von Rüden, T., Kantoff, P. W., Garber, C., Seiberg, M., Rüther, U., Anderson, W. F., Wagner, E. F., & Gilboa, E. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.10.3194 · Cited by 541 · see citing works

The herpes simplex virus amplicon: A new eucaryotic defective-virus cloning-amplifying vector

Spaete, R. R. (1982) · Cell · doi:10.1016/0092-8674(82)90035-6 · Cited by 511 · see citing works

Stable and efficient gene transfer into the retina using an HIV-based lentiviral vector

Miyoshi, H., Takahashi, M., Gage, F. H., & Verma, I. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.19.10319 · Cited by 494 · see citing works

HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway

Gallay, P. A., Hope, T. J., Chin, D. J., & Trono, D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.18.9825 · Cited by 484 · see citing works

Use of adeno-associated virus as a mammalian DNA cloning vector: transduction of neomycin resistance into mammalian tissue culture cells.

Hermonat, P. L., & Muzyczka, N. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.20.6466 · Cited by 480 · see citing works

Adenoviral Gene Therapy Leads to Rapid Induction of Multiple Chemokines and Acute Neutrophil-Dependent Hepatic Injury in Vivo

Muruve, D. A., Barnes, M. J., Stillman, I. E., & Libermann, T. A. (1999) · Human Gene Therapy · doi:10.1089/10430349950018364 · Cited by 447 · see citing works

Rabies virus glycoprotein pseudotyping of lentiviral vectors enables retrograde axonal transport and access to the nervous system after peripheral delivery

Mazarakis, N. D. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.19.2109 · Cited by 425 · see citing works

Efficient transduction of nondividing human cells by feline immunodeficiency virus lentiviral vectors

Poeschla, E. M., Wong-Staal, F., & Looney, D. J. (1998) · Nature Medicine · doi:10.1038/nm0398-354 · Cited by 416 · see citing works

A Defective HSV-1 Vector Expresses Escherichia coli β-Galactosidase in Cultured Peripheral Neurons

Geller, A. I., & Breakefield, X. O. (1988) · Science · doi:10.1126/science.2843986 · Cited by 412 · see citing works

The role of Kupffer cell activation and viral gene expression in early liver toxicity after infusion of recombinant adenovirus vectors

Lieber, A., He, C. Y., Meuse, L. A., Schowalter, D., Kirillova, I., Winther, B., & Kay, M. A. (1997) · Journal of Virology · doi:10.1128/jvi.71.11.8798-8807.1997 · Cited by 412 · see citing works

High-efficiency gene transfer into mammalian cells: generation of helper-free recombinant retrovirus with broad mammalian host range.

Cone, R. D., & Mulligan, R. C. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.20.6349 · Cited by 406 · see citing works

Incompletely reverse-transcribed human immunodeficiency virus type 1 genomes in quiescent cells can function as intermediates in the retroviral life cycle

Zack, J. A., Haislip, A. M., Krogstad, P. A., & Chen, I. S. (1992) · Journal of Virology · doi:10.1128/jvi.66.3.1717-1725.1992 · Cited by 400 · see citing works

Immunodeficiency virus rev trans-activator modulates the expression of the viral regulatory genes

Malim, M. H., Hauber, J., Fenrick, R., & Cullen, B. R. (1988) · Nature · doi:10.1038/335181a0 · Cited by 392 · see citing works

Mutational Analysis of the Adeno-Associated Virus Type 2 (AAV2) Capsid Gene and Construction of AAV2 Vectors with Altered Tropism

Wu, P., Xiao, W. S., Conlon, T. J., Hughes, J. A., Agbandje‐McKenna, M., Ferkol, T. W., Flotte, T. R., & Muzyczka, N. (2000) · Journal of Virology · doi:10.1128/jvi.74.18.8635-8647.2000 · Cited by 390 · see citing works

Persistence and Expression of the Herpes Simplex Virus Genome in the Absence of Immediate-Early Proteins

Samaniego, L. A., Neiderhiser, L., & DeLuca, N. A. (1998) · Journal of Virology · doi:10.1128/jvi.72.4.3307-3320.1998 · Cited by 373 · see citing works

Efficient Gene Transfer into Human CD34 + Cells by a Retargeted Adenovirus Vector

Shayakhmetov, D. M., Papayannopoulou, T., Stamatoyannopoulos, G., & Lieber, A. (2000) · Journal of Virology · doi:10.1128/jvi.74.6.2567-2583.2000 · Cited by 367 · see citing works

An adenoviral vector deleted for all viral coding sequences results in enhanced safety and extended expression of a leptin transgene

Morsy, M., Gu, M., Motzel, S. L., Zhao, J., Lin, J., Su, Q., Allen, H., Franlin, L. L., Parks, R. J., Graham, F. L., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.14.7866 · Cited by 365 · see citing works

Differential susceptibility of primary and established human glioma cells to adenovirus infection: targeting via the epidermal growth factor receptor achieves fiber receptor-independent gene transfer.

Miller, C. R., Buchsbaum, D. J., Reynolds, P. N., Douglas, J. T., Gillespie, G. Y., Mayo, M. S., Raben, D., & Curiel, D. T. (1998) · PubMed · Cited by 346 · see citing works

Cloning and Characterization of Adeno-Associated Virus Type 5

Chiorini, J. A., Kim, F., Yang, L. C., & Kotin, R. M. (1999) · Journal of Virology · doi:10.1128/jvi.73.2.1309-1319.1999 · Cited by 332 · see citing works

Generation of helper-free amphotropic retroviruses that transduce a dominant-acting, methotrexate-resistant dihydrofolate reductase gene.

Miller, A. D., Law, M.-F., & Verma, I. M. (1985) · Molecular and Cellular Biology · doi:10.1128/mcb.5.3.431 · Cited by 332 · see citing works

Adeno-Associated Virus Type 5 (AAV5) but Not AAV2 Binds to the Apical Surfaces of Airway Epithelia and Facilitates Gene Transfer

Zabner, J., Seiler, M. P., Walters, R. H., Kotin, R., Fulgeras, W., Davidson, B., & Chiorini, J. (2000) · Journal of Virology · doi:10.1128/jvi.74.8.3852-3858.2000 · Cited by 329 · see citing works

Adenovirus targeted to heparan-containing receptors increases its gene delivery efficiency to multiple cell types

Wickham, T. J., Roelvink, P. W., Brough, D. E., & Kovesdi, I. (1996) · Nature Biotechnology · doi:10.1038/nbt1196-1570 · Cited by 325 · see citing works

Efficient lentiviral transduction of liver requires cell cycling in vivo

Park, F., Ohashi, K., Chiu, W. S., Naldini, L., & Kay, M. A. (2000) · Nature Genetics · doi:10.1038/71673 · Cited by 323 · see citing works

T lymphocytes with a normal ADA gene accumulate after transplantation of transduced autologous umbilical cord blood CD34+ cells in ADA-deficient SCID neonates

Kohn, D. B., Hershfield, M. S., Carbonaro, D. A., Shigeoka, A. O., Brooks, J., Smogorzewska, E. M., Barsky, L. W., Chan, R., Burotto, F., Annett, G., et al. (1998) · Nature Medicine · doi:10.1038/nm0798-775 · Cited by 323 · see citing works

Characterization of an Adenovirus Vector Containing a Heterologous Peptide Epitope in the HI Loop of the Fiber Knob

Krasnykh, V. N., Dmitriev, I. P., Mikheeva, G., Miller, C. R., Belousova, N., & Curiel, D. T. (1998) · Journal of Virology · doi:10.1128/jvi.72.3.1844-1852.1998 · Cited by 314 · see citing works

Filovirus-pseudotyped lentiviral vector can efficiently and stably transduce airway epithelia in vivo

Kobinger, G. P., Weiner, D. J., Yu, Q., & Wilson, J. M. (2001) · Nature Biotechnology · doi:10.1038/85664 · Cited by 307 · see citing works

Progression to the G1b Phase of the Cell Cycle Is Required for Completion of Human Immunodeficiency Virus Type 1 Reverse Transcription in T Cells

Korin, Y. D., & Zack, J. A. (1998) · Journal of Virology · doi:10.1128/jvi.72.4.3161-3168.1998 · Cited by 301 · see citing works

Stable gene transfer to the nervous system using a non-primate lentiviral vector

Mitrophanous, K. A., Yoon, S., Rohll, J. B., Patil, D., Wilkes, F. J., Kim, V. N., Kingsman, S. M., Kingsman, A. J., & Mazarakis, N. D. (1999) · Gene Therapy · doi:10.1038/sj.gt.3301023 · Cited by 277 · see citing works

A Packaging Cell Line for Lentivirus Vectors

Kafri, T., van Praag, H., Ouyang, L., Gage, F. H., & Verma, I. (1999) · Journal of Virology · doi:10.1128/jvi.73.1.576-584.1999 · Cited by 276 · see citing works

Adeno-associated virus vectors preferentially transduce cells in S phase.

Russell, D. W., Miller, A. D., & Alexander, I. E. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.19.8915 · Cited by 275 · see citing works

Overcoming adeno-associated virus vector size limitation through viral DNA heterodimerization

Sun, L., Li, J., & Xiao, X. (2000) · Nature Medicine · doi:10.1038/75087 · Cited by 267 · see citing works

Human Foamy Virus Replication: A Pathway Distinct from That of Retroviruses and Hepadnaviruses

Yu, S. F., Baldwin, D. N., Gwynn, S. R., Yendapalli, S., & Linial, M. L. (1996) · Science · doi:10.1126/science.271.5255.1579 · Cited by 249 · see citing works

Cellular immune response to adenoviral vector infected cells does not require de novo viral gene expression: Implications for gene therapy

Kafri, T., Morgan, D., Krahl, T., Sarvetnick, N., Sherman, L. A., & Verma, I. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.19.11377 · Cited by 244 · see citing works

Cloning of adeno-associated virus type 4 (AAV4) and generation of recombinant AAV4 particles

Chiorini, J. A., Yang, L., Liu, Y., Safer, B., & Kotin, R. M. (1997) · Journal of Virology · doi:10.1128/jvi.71.9.6823-6833.1997 · Cited by 231 · see citing works

Targeted adeno-associated virus vector transduction of nonpermissive cells mediated by a bispecific F(ab'γ)2 antibody

Bartlett, J. S., Kleinschmidt, J. A., Boucher, R. C., & Samulski, R. J. (1999) · Nature Biotechnology · doi:10.1038/6185 · Cited by 229 · see citing works

A Rev-Independent Human Immunodeficiency Virus Type 1 (HIV-1)-Based Vector That Exploits a Codon-Optimized HIV-1 gag-pol Gene

Kotsopoulou, E., Kim, V. N., Kingsman, A. J., Kingsman, S. M., & Mitrophanous, K. A. (2000) · Journal of Virology · doi:10.1128/jvi.74.10.4839-4852.2000 · Cited by 228 · see citing works

Host Control of HIV-1 Parasitism in T Cells by the Nuclear Factor of Activated T Cells

Kinoshita, S. M., Chen, B. K., Kaneshima, H., & Nolan, G. P. (1998) · Cell · doi:10.1016/s0092-8674(00)81630-x · Cited by 228 · see citing works

Adeno-associated virus 2 co-receptors?-first reply

Qing, K., Hansen, J. J., & Srivastava, A. (1999) · Nature Medicine · doi:10.1038/8526 · Cited by 227 · see citing works

Role for highly regulated rep gene expression in adeno-associated virus vector production

Li, J., Samulski, R. J., & Xiao, X. (1997) · Journal of Virology · doi:10.1128/jvi.71.7.5236-5243.1997 · Cited by 227 · see citing works

DNA-damaging agents greatly increase the transduction of nondividing cells by adeno-associated virus vectors

Alexander, I. E., Russell, D. W., & Miller, A. D. (1994) · Journal of Virology · doi:10.1128/jvi.68.12.8282-8287.1994 · Cited by 224 · see citing works

Lack of high affinity fiber receptor activity explains the resistance of ciliated airway epithelia to adenovirus infection.

Zabner, J., Freimuth, P., Puga, A., Fabrega, A. J., & Welsh, M. J. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119625 · Cited by 222 · see citing works

kat: a high-efficiency retroviral transduction system for primary human T lymphocytes

Finer, M., Dull, T., Qin, L., Farson, D. A., & Roberts, M. (1994) · Blood · doi:10.1182/blood.v83.1.43.43 · Cited by 221 · see citing works

A Stable System for the High-Titer Production of Multiply Attenuated Lentiviral Vectors

Klages, N., Zufferey, R., & Trono, D. (2000) · Molecular Therapy · doi:10.1006/mthe.2000.0103 · Cited by 219 · see citing works

DNA synthesis and topoisomerase inhibitors increase transduction by adeno-associated virus vectors.

Russell, D. W., Alexander, I. E., & Miller, A. D. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5719 · Cited by 218 · see citing works

Immune reconstitution in ADA-SCID after PBL gene therapy and discontinuation of enzyme replacement

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Therapeutic Challenges to Retinitis Pigmentosa: From Neuroprotection to Gene Therapy

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The Power of Field-Flow Fractionation in Characterization of Nanoparticles in Drug Delivery

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Vaccines delivered by integration-deficient lentiviral vectors targeting dendritic cells induces strong antigen-specific immunity

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Adenovirus as vehicle for anticancer genetic immunotherapy

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Gene Transfer to Rabbit Retina with Electron Avalanche Transfection

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Liver-Directed Adenoviral Gene Transfer in Murine Succinate Semialdehyde Dehydrogenase Deficiency

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Gene therapy for proliferative ocular diseases

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Current status of gene delivery and gene therapy in lacrimal gland using viral vectors

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Advances in gene therapy for intervertebral disc degeneration

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Novel strategies for Alzheimer's disease treatment

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Cellular Vehicles for Cancer Gene Therapy

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