Cited by 267Virus-based gene therapy researchRNA Interference and Gene DeliveryViral Infectious Diseases and Gene Expression in Insects

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Gene Therapy with Viral Vectors

Kootstra, Neeltje A., Verma, Inder M.·2003·Annual Review of Pharmacology and Toxicology

DOI 10.1146/annurev.pharmtox.43.100901.140257

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Abstract

A key factor in the success of gene therapy is the development of gene delivery systems that are capable of efficient gene transfer in a broad variety of tissues, without causing any pathogenic effect. Currently, viral vectors based on many different viruses have been developed, and their performance and pathogenicity has been evaluated in animal models. The results of these studies form the basis for the first clinical trials for correcting genetic disorders using retroviral, adenoviral, and adeno-associated viral vectors. Even though the results of these trials are encouraging, vector development is still required to improve and refine future treatment of hereditary disorders.

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In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector
Naldini, L., Blömer, U., Gallay, P., Ory, D., Mulligan, R., Gage, F. H., Verma, I. M., & Trono, D. (1996) · Science · doi:10.1126/science.272.5259.263 · Cited by 4,903
Self-citation
Characteristics of a human cell line transformed by DNA from human adenovirus type 5
Graham, F. L., Russell, W. C., Smiley, J., & Nairn, R. (1977) · Journal of General Virology · doi:10.1099/0022-1317-36-1-59 · Cited by 4,793
A Third-Generation Lentivirus Vector with a Conditional Packaging System
Dull, T., Zufferey, R., Kelly, M., Mandel, R. J., Nguyen, M., Trono, D., & Naldini, L. (1998) · Journal of Virology · doi:10.1128/jvi.72.11.8463-8471.1998 · Cited by 3,341
Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5
Bergelson, J. M., Cunningham, J. A., Droguett, G., Kurt‐Jones, E. A., Krithivas, A., Hong, J. S., Horwitz, M. S., Crowell, R. L., & Finberg, R. W. (1997) · Science · doi:10.1126/science.275.5304.1320 · Cited by 3,102
Gene Therapy of Human Severe Combined Immunodeficiency (SCID)-X1 Disease
Cavazzana, M., Hacein‐Bey‐Abina, S., Basile, G. D. S., Gross, F., Yvon, E. S., Nusbaum, P., Selz, F., Hue, C., Dogniaux, S., Casanova, J., et al. (2000) · Science · doi:10.1126/science.288.5466.669 · Cited by 2,685
Integrins αvβ3 and αvβ5 promote adenovirus internalization but not virus attachment
Wickham, T. J., Mathias, P., Cheresh, D. A., & Nemerow, G. R. (1993) · Cell · doi:10.1016/0092-8674(93)90231-e · Cited by 2,199
Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo
Zufferey, R., Nagy, D., Mandel, R. J., Naldini, L., & Trono, D. (1997) · Nature Biotechnology · doi:10.1038/nbt0997-871 · Cited by 1,977
Self-Inactivating Lentivirus Vector for Safe and Efficient In Vivo Gene Delivery
Zufferey, R., Dull, T., Mandel, R. J., Bukovsky, A., Quiroz, D., Naldini, L., & Trono, D. (1998) · Journal of Virology · doi:10.1128/jvi.72.12.9873-9880.1998 · Cited by 1,815
Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus
Mann, R., Mulligan, R. C., & Baltimore, D. (1983) · Cell · doi:10.1016/0092-8674(83)90344-6 · Cited by 1,776
T Lymphocyte-Directed Gene Therapy for ADA − SCID: Initial Trial Results After 4 Years
Blaese, R. M., Culver, K. W., Miller, A. D., Carter, C. S., Fleisher, T. A., Clerici, M., Shearer, G. M., Chang, L., Chiang, Y. L., Tolstoshev, P., et al. (1995) · Science · doi:10.1126/science.270.5235.475 · Cited by 1,546

Show all 138 references

Research works printed but not linked: 7

10.1073/pnas.050581197 · DOI · Paper page
Kearns WG, 1996, Gene Ther., 3, 748
Shenk TE. 2001. Adenoviridae: the viruses and their replication. See Ref.140, pp. 2265–300
Miller CR, 1998, Cancer Res., 58, 5738
Roizman B, Knipe DM. 2001. Herpes simplex viruses and their replication. See Ref.140, pp. 2399–460
Hoogerbrugge PM, 1996, Gene Ther., 3, 179
Knipe DM, Howley PM, eds. 2001. Fields' Virology, Vol. 2. Philadelphia: Lippincott, Williams & Wilkins

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Authors: Kootstra, N. A., & Verma, I. M.
Affiliations: Salk Institute for Biological Studies (US)
ORCID: Kootstra, Neeltje A.
Verma, Inder M.
Venue: Annual Review of Pharmacology and Toxicology
Publisher: Annual Reviews
Published: 2003-04
Volume: 43
Issue: 1
Pages: 413-439
ISSN: 0362-1642 (ISSN-L)
1545-4304
DOI: 10.1146/annurev.pharmtox.43.100901.140257
OpenAlex: W2156754275
Cited by: 267
References: 138
Citations by year: 2026: 3 · 2025: 8 · 2024: 1 · 2023: 5 · 2022: 1 · 2021: 6 · 2020: 6 · 2019: 1 · 2018: 9 · 2017: 4 · 2016: 8 · 2015: 12 · 2014: 15 · 2013: 15 · 2012: 14
FWCI: 2.78
Type: journal article
Language: en
Open access: closed
Locations: The Annual Review of Pharmacology and Toxicology (publishedVersion)
PubMed (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Pure Amsterdam UMC (submittedVersion)
Funders: American Cancer Society
Wayne and Gladys Valley Foundation
Fordham University
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Viral Infectious Diseases and Gene Expression in Insects
Keywords: gene therapy, viral vectors, gene delivery systems, retroviral vectors, adenoviral vector, adeno-associated virus vectors, clinical trials, genetic disorders
MeSH terms: Genetic Vectors, Humans, Viruses, Genetic Therapy, Gene Transfer Techniques

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