Gene Therapy with Viral Vectors

In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector

Naldini, L., Blömer, U., Gallay, P., Ory, D., Mulligan, R., Gage, F. H., Verma, I. M., & Trono, D. (1996) · Science · doi:10.1126/science.272.5259.263 · Cited by 4,903

Characteristics of a human cell line transformed by DNA from human adenovirus type 5

Graham, F. L., Russell, W. C., Smiley, J., & Nairn, R. (1977) · Journal of General Virology · doi:10.1099/0022-1317-36-1-59 · Cited by 4,793

A Third-Generation Lentivirus Vector with a Conditional Packaging System

Dull, T., Zufferey, R., Kelly, M., Mandel, R. J., Nguyen, M., Trono, D., & Naldini, L. (1998) · Journal of Virology · doi:10.1128/jvi.72.11.8463-8471.1998 · Cited by 3,341

Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5

Bergelson, J. M., Cunningham, J. A., Droguett, G., Kurt‐Jones, E. A., Krithivas, A., Hong, J. S., Horwitz, M. S., Crowell, R. L., & Finberg, R. W. (1997) · Science · doi:10.1126/science.275.5304.1320 · Cited by 3,102

Gene Therapy of Human Severe Combined Immunodeficiency (SCID)-X1 Disease

Cavazzana, M., Hacein‐Bey‐Abina, S., Basile, G. D. S., Gross, F., Yvon, E. S., Nusbaum, P., Selz, F., Hue, C., Dogniaux, S., Casanova, J., et al. (2000) · Science · doi:10.1126/science.288.5466.669 · Cited by 2,685

Integrins αvβ3 and αvβ5 promote adenovirus internalization but not virus attachment

Wickham, T. J., Mathias, P., Cheresh, D. A., & Nemerow, G. R. (1993) · Cell · doi:10.1016/0092-8674(93)90231-e · Cited by 2,199

Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo

Zufferey, R., Nagy, D., Mandel, R. J., Naldini, L., & Trono, D. (1997) · Nature Biotechnology · doi:10.1038/nbt0997-871 · Cited by 1,977

Self-Inactivating Lentivirus Vector for Safe and Efficient In Vivo Gene Delivery

Zufferey, R., Dull, T., Mandel, R. J., Bukovsky, A., Quiroz, D., Naldini, L., & Trono, D. (1998) · Journal of Virology · doi:10.1128/jvi.72.12.9873-9880.1998 · Cited by 1,815

Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus

Mann, R., Mulligan, R. C., & Baltimore, D. (1983) · Cell · doi:10.1016/0092-8674(83)90344-6 · Cited by 1,776

T Lymphocyte-Directed Gene Therapy for ADA − SCID: Initial Trial Results After 4 Years

Blaese, R. M., Culver, K. W., Miller, A. D., Carter, C. S., Fleisher, T. A., Clerici, M., Shearer, G. M., Chang, L., Chiang, Y. L., Tolstoshev, P., et al. (1995) · Science · doi:10.1126/science.270.5235.475 · Cited by 1,546

Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector.

Naldini, L., Blömer, U., Gage, F. H., Trono, D., & Verma, I. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11382 · Cited by 1,499

Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection.

Miller, A. D., Adam, M., & Miller, A. D. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.8.4239 · Cited by 1,445

Membrane-Associated Heparan Sulfate Proteoglycan Is a Receptor for Adeno-Associated Virus Type 2 Virions

Summerford, C., & Samulski, R. J. (1998) · Journal of Virology · doi:10.1128/jvi.72.2.1438-1445.1998 · Cited by 1,409

Production of High-Titer Recombinant Adeno-Associated Virus Vectors in the Absence of Helper Adenovirus

Xiao, X., Li, J., & Samulski, R. J. (1998) · Journal of Virology · doi:10.1128/jvi.72.3.2224-2232.1998 · Cited by 1,381

Neurodegeneration Prevented by Lentiviral Vector Delivery of GDNF in Primate Models of Parkinson's Disease

Kordower, J. H., Emborg, M. E., Bloch, J., Ma, S. Y., Chu, Y., Leventhal, L., McBride, J. L., Chen, E., Palfi, S., Roitberg, B. Z., et al. (2000) · Science · doi:10.1126/science.290.5492.767 · Cited by 1,251

Development of a self-inactivating lentivirus vector

Miyoshi, H., Blömer, U., Takahashi, M., Gage, F. H., & Verma, I. M. (1998) · Journal of Virology · doi:10.1128/jvi.72.10.8150-8157.1998 · Cited by 1,196

Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector

Kay, M. A., Manno, C. S., Ragni, M. V., Larson, P. J., Couto, L. B., McClelland, A., Glader, B. E., Chew, A. K., Tai, S. J., Herzog, R. W., et al. (2000) · Nature Genetics · doi:10.1038/73464 · Cited by 1,019

Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences

Follenzi, A., Ailles, L., Bakovic, S., Geuna, M., & Naldini, L. (2000) · Nature Genetics · doi:10.1038/76095 · Cited by 926

Integration of murine leukemia virus DNA depends on mitosis.

Roe, T., Reynolds, T. C., Yu, G., & Brown, P. O. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05858.x · Cited by 921

Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges.

Danos, O., & Mulligan, R. C. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.17.6460 · Cited by 898

HIV-1 Genome Nuclear Import Is Mediated by a Central DNA Flap

Zennou, V., Petit, C., Guétard, D., Nerhbass, U., Montagnier, L., & Charneau, P. (2000) · Cell · doi:10.1016/s0092-8674(00)80828-4 · Cited by 864

Gene Therapy in Peripheral Blood Lymphocytes and Bone Marrow for ADA − Immunodeficient Patients

Bordignon, C., Notarangelo, L. D., Nobili, N., Ferrari, G., Casorati, G., Panina‐Bordignon, P., Mazzolari, E., Maggioni, D., Rossi, C., Servida, P., et al. (1995) · Science · doi:10.1126/science.270.5235.470 · Cited by 830

A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells

Bukrinsky, M., Haggerty, S., Dempsey, M. P., Sharova, N., Adzhubei, A. A., Spitz, L., Lewis, P. F., Goldfarb, D. S., Emerman, M., & Stevenson, M. (1993) · Nature · doi:10.1038/365666a0 · Cited by 801

An Adenovirus Vector with Genetically Modified Fibers Demonstrates Expanded Tropism via Utilization of a Coxsackievirus and Adenovirus Receptor-Independent Cell Entry Mechanism

Dmitriev, I. P., Krasnykh, V. N., Miller, C. R., Wang, M., Kashentseva, E. A., Mikheeva, G., Belousova, N., & Curiel, D. T. (1998) · Journal of Virology · doi:10.1128/jvi.72.12.9706-9713.1998 · Cited by 768

Cross-Packaging of a Single Adeno-Associated Virus (AAV) Type 2 Vector Genome into Multiple AAV Serotypes Enables Transduction with Broad Specificity

Rabinowitz, J. E., Rolling, F., Li, C., Conrath, H., Xiao, W., Xiao, X., & Samulski, R. J. (2002) · Journal of Virology · doi:10.1128/jvi.76.2.791-801.2002 · Cited by 762

Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors

Ferrari, F. K., Samulski, T., Shenk, T., & Samulski, R. J. (1996) · Journal of Virology · doi:10.1128/jvi.70.5.3227-3234.1996 · Cited by 761

Gene Therapy Death Prompts Review of Adenovirus Vector

Marshall, E. (1999) · Science · doi:10.1126/science.286.5448.2244 · Cited by 760

Helper-free stocks of recombinant adeno-associated viruses: normal integration does not require viral gene expression

Samulski, R. J., Chang, L., & Shenk, T. E. (1989) · Journal of Virology · doi:10.1128/jvi.63.9.3822-3828.1989 · Cited by 742

A Helper-Dependent Adenovirus Vector System: Removal of Helper Virus by Cre-Mediated Excision of the Viral Packaging Signal

Parks, R. J., Chen, L., Anton, M., Sankar, U., Rudnicki, M. A., & Graham, F. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13565 · Cited by 725

Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector

Blömer, U., Naldini, L., Kafri, T., Trono, D., Verma, I. M., & Gage, F. H. (1997) · Journal of Virology · doi:10.1128/jvi.71.9.6641-6649.1997 · Cited by 723

αVβ5 integrin: a co-receptor for adeno-associated virus type 2 infection

Summerford, C., Bartlett, J. S., & Samulski, R. J. (1999) · Nature Medicine · doi:10.1038/4768 · Cited by 711

Immune responses to adenovirus and adeno-associated virus in humans

Chirmule, N., Propert, K. J., Magosin, S. A., Qian, Y., Qian, R., & Wilson, J. M. (1999) · Gene Therapy · doi:10.1038/sj.gt.3300994 · Cited by 684

The trans-activator gene of HTLV-III is essential for virus replication

Fisher, A. G., Feinberg, M. B., Josephs, S. F., Harper, M., Marselle, L. M., Reyes, G. R., Gonda, M. A., Aldovini, A., Debouk, C., Gallo, R. C., et al. (1986) · Nature · doi:10.1038/320367a0 · Cited by 635

Transduction of Human CD34 + Cells That Mediate Long-Term Engraftment of NOD/SCID Mice by HIV Vectors

Miyoshi, H., Smith, K. A., Mosier, D. E., Verma, I. M., & Torbett, B. E. (1999) · Science · doi:10.1126/science.283.5402.682 · Cited by 620

Active nuclear import of human immunodeficiency virus type 1 preintegration complexes.

Bukrinsky, M. I., Sharova, N., Dempsey, M. P., Stanwick, T. L., Bukrinskaya, A. G., Haggerty, S., & Stevenson, M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.14.6580 · Cited by 607

Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors

Kafri, T., Blömer, U., Peterson, D. A., Gage, F. H., & Verma, I. M. (1997) · Nature Genetics · doi:10.1038/ng1197-314 · Cited by 604

Engraftment of gene–modified umbilical cord blood cells in neonates with adenosine deaminase deficiency

Kohn, D. B., Weinberg, K. I., Nolta, J. A., Heiss, L. N., Lenarsky, C., Crooks, G. M., Hanley, M. E., Annett, G., Brooks, J. S., El-Khoureiy, A., et al. (1995) · Nature Medicine · doi:10.1038/nm1095-1017 · Cited by 592

Correction of sickle cell disease in transgenic mouse models by gene therapy

Pawliuk, R., Westerman, K. A., Fabry, M. E., Payen, E., Tighe, R., Bouhassira, E. E., Acharya, S. A., Ellis, J., London, I. M., Eaves, C. J., et al. (2001) · Science · doi:10.1126/science.1065806 · Cited by 579

Therapeutic haemoglobin synthesis in β-thalassaemic mice expressing lentivirus-encoded human β-globin

May, C., Rivella, S., Callegari, J., Heller, G., Gaensler, K. M. L., Luzzatto, L., & Sadelain, M. (2000) · Nature · doi:10.1038/35017565 · Cited by 567

Location of the Trans -Activating Region on the Genome of Human T-Cell Lymphotropic Virus Type III

Sodroski, J., Patarca, R., Rosen, C. A., Wong‐Staal, F., & Haseltine, W. A. (1985) · Science · doi:10.1126/science.2990041 · Cited by 556

Self-inactivating retroviral vectors designed for transfer of whole genes into mammalian cells.

Yu, S. F., von Rüden, T., Kantoff, P. W., Garber, C., Seiberg, M., Rüther, U., Anderson, W. F., Wagner, E. F., & Gilboa, E. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.10.3194 · Cited by 540

Recombinant adeno-associated virus type 2, 4, and 5 vectors: Transduction of variant cell types and regions in the mammalian central nervous system

Davidson, B. L., Stein, C. S., Heth, J. A., Martins, I., Kotin, R. M., Derksen, T. A., Zabner, J., Ghodsi, A., & Chiorini, J. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3428 · Cited by 531

The herpes simplex virus amplicon: A new eucaryotic defective-virus cloning-amplifying vector

Spaete, R. R. (1982) · Cell · doi:10.1016/0092-8674(82)90035-6 · Cited by 511

Stable and efficient gene transfer into the retina using an HIV-based lentiviral vector

Miyoshi, H., Takahashi, M., Gage, F. H., & Verma, I. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.19.10319 · Cited by 497

HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway

Gallay, P. A., Hope, T. J., Chin, D. J., & Trono, D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.18.9825 · Cited by 484

Use of adeno-associated virus as a mammalian DNA cloning vector: transduction of neomycin resistance into mammalian tissue culture cells.

Hermonat, P. L., & Muzyczka, N. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.20.6466 · Cited by 480

Adenoviral Gene Therapy Leads to Rapid Induction of Multiple Chemokines and Acute Neutrophil-Dependent Hepatic Injury in Vivo

Muruve, D. A., Barnes, M. J., Stillman, I. E., & Libermann, T. A. (1999) · Human Gene Therapy · doi:10.1089/10430349950018364 · Cited by 447

Rabies virus glycoprotein pseudotyping of lentiviral vectors enables retrograde axonal transport and access to the nervous system after peripheral delivery

Mazarakis, N. D. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.19.2109 · Cited by 425

Efficient transduction of nondividing human cells by feline immunodeficiency virus lentiviral vectors

Poeschla, E. M., Wong-Staal, F., & Looney, D. J. (1998) · Nature Medicine · doi:10.1038/nm0398-354 · Cited by 416

A Defective HSV-1 Vector Expresses Escherichia coli β-Galactosidase in Cultured Peripheral Neurons

Geller, A. I., & Breakefield, X. O. (1988) · Science · doi:10.1126/science.2843986 · Cited by 412

The role of Kupffer cell activation and viral gene expression in early liver toxicity after infusion of recombinant adenovirus vectors

Lieber, A., He, C. Y., Meuse, L., Schowalter, D., Kirillova, I., Winther, B., & Kay, M. A. (1997) · Journal of Virology · doi:10.1128/jvi.71.11.8798-8807.1997 · Cited by 411

High-efficiency gene transfer into mammalian cells: generation of helper-free recombinant retrovirus with broad mammalian host range.

Cone, R. D., & Mulligan, R. C. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.20.6349 · Cited by 406

Incompletely reverse-transcribed human immunodeficiency virus type 1 genomes in quiescent cells can function as intermediates in the retroviral life cycle

Zack, J. A., Haislip, A. M., Krogstad, P. A., & Chen, I. S. (1992) · Journal of Virology · doi:10.1128/jvi.66.3.1717-1725.1992 · Cited by 400

Mutational Analysis of the Adeno-Associated Virus Type 2 (AAV2) Capsid Gene and Construction of AAV2 Vectors with Altered Tropism

Wu, P., Xiao, W. S., Conlon, T. J., Hughes, J. A., Agbandje‐McKenna, M., Ferkol, T. W., Flotte, T. R., & Muzyczka, N. (2000) · Journal of Virology · doi:10.1128/jvi.74.18.8635-8647.2000 · Cited by 396

Immunodeficiency virus rev trans-activator modulates the expression of the viral regulatory genes

Malim, M. H., Hauber, J., Fenrick, R., & Cullen, B. R. (1988) · Nature · doi:10.1038/335181a0 · Cited by 392

Persistence and Expression of the Herpes Simplex Virus Genome in the Absence of Immediate-Early Proteins

Samaniego, L. A., Neiderhiser, L., & DeLuca, N. A. (1998) · Journal of Virology · doi:10.1128/jvi.72.4.3307-3320.1998 · Cited by 373

Efficient Gene Transfer into Human CD34 + Cells by a Retargeted Adenovirus Vector

Shayakhmetov, D. M., Papayannopoulou, T., Stamatoyannopoulos, G., & Lieber, A. (2000) · Journal of Virology · doi:10.1128/jvi.74.6.2567-2583.2000 · Cited by 367

An adenoviral vector deleted for all viral coding sequences results in enhanced safety and extended expression of a leptin transgene

Morsy, M., Gu, M., Motzel, S. L., Zhao, J., Lin, J., Su, Q., Allen, H., Franlin, L. L., Parks, R. J., Graham, F. L., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.14.7866 · Cited by 365

Differential susceptibility of primary and established human glioma cells to adenovirus infection: targeting via the epidermal growth factor receptor achieves fiber receptor-independent gene transfer.

Miller, C. R., Buchsbaum, D. J., Reynolds, P. N., Douglas, J. T., Gillespie, G. Y., Mayo, M. S., Raben, D., & Curiel, D. T. (1998) · PubMed · Cited by 346

Cloning and Characterization of Adeno-Associated Virus Type 5

Chiorini, J. A., Kim, F., Yang, L. C., & Kotin, R. M. (1999) · Journal of Virology · doi:10.1128/jvi.73.2.1309-1319.1999 · Cited by 332

Generation of helper-free amphotropic retroviruses that transduce a dominant-acting, methotrexate-resistant dihydrofolate reductase gene.

Miller, A. D., Law, M.-F., & Verma, I. M. (1985) · Molecular and Cellular Biology · doi:10.1128/mcb.5.3.431 · Cited by 332

Adeno-Associated Virus Type 5 (AAV5) but Not AAV2 Binds to the Apical Surfaces of Airway Epithelia and Facilitates Gene Transfer

Zabner, J., Seiler, M. P., Walters, R. H., Kotin, R., Fulgeras, W., Davidson, B., & Chiorini, J. (2000) · Journal of Virology · doi:10.1128/jvi.74.8.3852-3858.2000 · Cited by 329

Adenovirus targeted to heparan-containing receptors increases its gene delivery efficiency to multiple cell types

Wickham, T. J., Roelvink, P. W., Brough, D. E., & Kovesdi, I. (1996) · Nature Biotechnology · doi:10.1038/nbt1196-1570 · Cited by 325

Efficient lentiviral transduction of liver requires cell cycling in vivo

Park, F., Ohashi, K., Chiu, W. S., Naldini, L., & Kay, M. A. (2000) · Nature Genetics · doi:10.1038/71673 · Cited by 323

T lymphocytes with a normal ADA gene accumulate after transplantation of transduced autologous umbilical cord blood CD34+ cells in ADA-deficient SCID neonates

Kohn, D. B., Hershfield, M. S., Carbonaro, D. A., Shigeoka, A. O., Brooks, J., Smogorzewska, E. M., Barsky, L. W., Chan, R., Burotto, F., Annett, G., et al. (1998) · Nature Medicine · doi:10.1038/nm0798-775 · Cited by 323

Characterization of an Adenovirus Vector Containing a Heterologous Peptide Epitope in the HI Loop of the Fiber Knob

Krasnykh, V. N., Dmitriev, I. P., Mikheeva, G., Miller, C. R., Belousova, N., & Curiel, D. T. (1998) · Journal of Virology · doi:10.1128/jvi.72.3.1844-1852.1998 · Cited by 314

Filovirus-pseudotyped lentiviral vector can efficiently and stably transduce airway epithelia in vivo

Kobinger, G., Weiner, D. J., Yu, Q., & Wilson, J. M. (2001) · Nature Biotechnology · doi:10.1038/85664 · Cited by 309

Progression to the G1b Phase of the Cell Cycle Is Required for Completion of Human Immunodeficiency Virus Type 1 Reverse Transcription in T Cells

Korin, Y. D., & Zack, J. A. (1998) · Journal of Virology · doi:10.1128/jvi.72.4.3161-3168.1998 · Cited by 301

Stable gene transfer to the nervous system using a non-primate lentiviral vector

Mitrophanous, K. A., Yoon, S., Rohll, J. B., Patil, D., Wilkes, F. J., Kim, V. N., Kingsman, S. M., Kingsman, A. J., & Mazarakis, N. D. (1999) · Gene Therapy · doi:10.1038/sj.gt.3301023 · Cited by 278

Adeno-associated virus vectors preferentially transduce cells in S phase.

Russell, D. W., Miller, A. D., & Alexander, I. E. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.19.8915 · Cited by 275

Overcoming adeno-associated virus vector size limitation through viral DNA heterodimerization

Sun, L., Li, J., & Xiao, X. (2000) · Nature Medicine · doi:10.1038/75087 · Cited by 267

A Packaging Cell Line for Lentivirus Vectors

Kafri, T., van Praag, H., Ouyang, L., Gage, F. H., & Verma, I. M. (1999) · Journal of Virology · doi:10.1128/jvi.73.1.576-584.1999 · Cited by 257

Human Foamy Virus Replication: A Pathway Distinct from That of Retroviruses and Hepadnaviruses

Yu, S. F., Baldwin, D. N., Gwynn, S. R., Yendapalli, S., & Linial, M. L. (1996) · Science · doi:10.1126/science.271.5255.1579 · Cited by 249

Cellular immune response to adenoviral vector infected cells does not require de novo viral gene expression: Implications for gene therapy

Kafri, T., Morgan, D., Krahl, T., Sarvetnick, N., Sherman, L. A., & Verma, I. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.19.11377 · Cited by 244

Cloning of adeno-associated virus type 4 (AAV4) and generation of recombinant AAV4 particles

Chiorini, J. A., Yang, L., Liu, Y., Safer, B., & Kotin, R. M. (1997) · Journal of Virology · doi:10.1128/jvi.71.9.6823-6833.1997 · Cited by 231

Targeted adeno-associated virus vector transduction of nonpermissive cells mediated by a bispecific F(ab'γ)2 antibody

Bartlett, J. S., Kleinschmidt, J. A., Boucher, R. C., & Samulski, R. J. (1999) · Nature Biotechnology · doi:10.1038/6185 · Cited by 229

A Rev-Independent Human Immunodeficiency Virus Type 1 (HIV-1)-Based Vector That Exploits a Codon-Optimized HIV-1 gag-pol Gene

Kotsopoulou, E., Kim, V. N., Kingsman, A. J., Kingsman, S. M., & Mitrophanous, K. A. (2000) · Journal of Virology · doi:10.1128/jvi.74.10.4839-4852.2000 · Cited by 228

Host Control of HIV-1 Parasitism in T Cells by the Nuclear Factor of Activated T Cells

Kinoshita, S. M., Chen, B. K., Kaneshima, H., & Nolan, G. P. (1998) · Cell · doi:10.1016/s0092-8674(00)81630-x · Cited by 228

Adeno-associated virus 2 co-receptors?-first reply

Qing, K., Hansen, J. J., & Srivastava, A. (1999) · Nature Medicine · doi:10.1038/8526 · Cited by 227

Role for highly regulated rep gene expression in adeno-associated virus vector production

Li, J., Samulski, R. J., & Xiao, X. (1997) · Journal of Virology · doi:10.1128/jvi.71.7.5236-5243.1997 · Cited by 227

DNA-damaging agents greatly increase the transduction of nondividing cells by adeno-associated virus vectors

Alexander, I. E., Russell, D. W., & Miller, A. D. (1994) · Journal of Virology · doi:10.1128/jvi.68.12.8282-8287.1994 · Cited by 224

Lack of high affinity fiber receptor activity explains the resistance of ciliated airway epithelia to adenovirus infection.

Zabner, J., Freimuth, P., Puga, A., Fabrega, A. J., & Welsh, M. J. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119625 · Cited by 222

kat: a high-efficiency retroviral transduction system for primary human T lymphocytes

Finer, M., Dull, T., Qin, L., Farson, D. A., & Roberts, M. (1994) · Blood · doi:10.1182/blood.v83.1.43.43 · Cited by 221

A Stable System for the High-Titer Production of Multiply Attenuated Lentiviral Vectors

Klages, N., Zufferey, R., & Trono, D. (2000) · Molecular Therapy · doi:10.1006/mthe.2000.0103 · Cited by 219

DNA synthesis and topoisomerase inhibitors increase transduction by adeno-associated virus vectors.

Russell, D. W., Alexander, I. E., & Miller, A. D. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5719 · Cited by 218

Immune reconstitution in ADA-SCID after PBL gene therapy and discontinuation of enzyme replacement

Aiuti, A., Vai, S., Mortellaro, A., Casorati, G., Ficara, F., Andolfi, G., Ferrari, G., Tabucchi, A., Carlucci, F., Ochs, H. D., et al. (2002) · Nature Medicine · doi:10.1038/nm0502-423 · Cited by 207

In vivo gene therapy of metachromatic leukodystrophy by lentiviral vectors: correction of neuropathology and protection against learning impairments in affected mice

Consiglio, A., Quattrini, A., Martino, S., Bensadoun, J. C., Dolcetta, D., Trojani, A., Benaglia, G., Marchesini, S., Cestari, V., Oliverio, A., et al. (2001) · Nature Medicine · doi:10.1038/85454 · Cited by 201

A Cosmid-Based System for Constructing Mutants of Herpes Simplex Virus Type 1

Cunningham, C., & Davison, A. J. (1993) · Virology · doi:10.1006/viro.1993.1572 · Cited by 201

HIV-1 Infection Requires a Functional Integrase NLS

Bouyac, M., Dvorin, J. D., Fouchier, R. A. M., Jenkins, Y., Meyer, B. E., Wu, L. I., Emerman, M., & Malim, M. H. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00240-4 · Cited by 201

A new dual-vector approach to enhance recombinant adeno-associated virus-mediated gene expression through intermolecular cis activation

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Herpes Simplex Virus Type 1 DNA Amplified as Bacterial Artificial Chromosome in Escherichia coli: Rescue of Replication-Competent Virus Progeny and Packaging of Amplicon Vectors

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