The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Sex Differences in Pharmacokinetics and Pharmacodynamics
Abstract
The importance of reviewing and studying sex-based differences in pharmacologic parameters is demonstrated by the increasing data on gender variation in drug efficacy and toxicity profiles. Sex-based differences in the four major factors that contribute to interindividual pharmacokinetic variability—bioavailability, distribution, metabolism, and elimination—are theorized to stem from variations between men and women in factors such as body weight, plasma volume, gastric emptying time, plasma protein levels, cytochrome P450 activity, drug transporter function, and excretion activity. Sex-determined variations in pharmacodynamics have traditionally been more difficult to study, but a number of recent studies have explored these differences. This review examines the biologic basis of differences in pharmacokinetics and pharmacodynamics between the sexes and summarizes studies that have addressed these differences. As an example, sex-based variation in the efficacy and toxicity of antiretroviral therapy in human immunodeficiency virus (HIV)-infected patients is explored more thoroughly to illustrate some of the factors underlying sex-based differences in drug therapy.
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Cites
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Gender variations in clinical pain experience
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Sex, gender, and pain: women and men really are different
Fillingim, R. B. (2000) · Current Review of Pain · doi:10.1007/s11916-000-0006-6 · Cited by 488
Gender Differences in Gut Transit Shown with a Newly Developed Radiological Procedure
Sadik, R., Abrahamsson, H., & Stotzer, P.-O. (2003) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520310000410 · Cited by 183
Prednisolone Pharmacokinetics and Pharmacodynamics in Relation to Sex and Race
Magee, M. H., Blum, R. A., Lates, C. D., & Jusko, W. J. (2001) · The Journal of Clinical Pharmacology · doi:10.1177/00912700122012733 · Cited by 125
Cited by
Zanger, U. M., & Schwab, M. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.12.007 · Cited by 4,169
Sex bias in neuroscience and biomedical research
Beery, A. K., & Zucker, I. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.07.002 · Cited by 1,763
Sex Differences in Pharmacokinetics and Pharmacodynamics
Soldin, O. P., & Mattison, D. R. (2009) · Clinical Pharmacokinetics · doi:10.2165/00003088-200948030-00001 · Cited by 1,163
Sex and gender differences in substance use disorders
McHugh, R. K., Votaw, V. R., Sugarman, D. E., & Greenfield, S. F. (2018) · Clinical Psychology Review · doi:10.1016/j.cpr.2017.10.012 · Cited by 1,076
Studying sex and gender differences in pain and analgesia: a consensus report
Greenspan, J. D., Craft, R. M., LeResche, L., Arendt-Nielsen, L., Berkley, K. J., Fillingim, R. B., Gold, M. S., Holdcroft, A., Lautenbacher, S., Mayer, E. A., et al. (2007) · Pain · doi:10.1016/j.pain.2007.10.014 · Cited by 1,033
Metadata
- Authors
- Gandhi, M., Aweeka, F., Greenblatt, R. M., & Blaschke, T. F.
- Venue
- Annual Review of Pharmacology and Toxicology
- Publisher
- Annual Reviews
- Published
- 2004-02-10
- Volume
- 44
- Issue
- 1
- Pages
- 499-523
- ISSN
- 0362-1642 (ISSN-L)
- 1545-4304
- OpenAlex
- W1892429132
- Cited by
- 542
- References
- 7
- FWCI
- 4.30
- Type
- journal article
- Language
- en
- Open access
- closed
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