Sex Differences in Pharmacokinetics and Pharmacodynamics

Soldin, Offie P.; Mattison, Donald R.

doi:10.2165/00003088-200948030-00001

Cited by 1,163Sex and Gender in HealthcarePharmacogenetics and Drug MetabolismPharmaceutical studies and practices

The DOI matches its Crossref record; 134 of the 134 references it cites were found in a registry or an index.

Sex Differences in Pharmacokinetics and Pharmacodynamics

Open access

Soldin, Offie P., Mattison, Donald R.·2009·Clinical Pharmacokinetics

DOI 10.2165/00003088-200948030-00001PMC PMC3644551

Open this paper in CoChat — free account

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.2165/00003088-200948030-00001

Cites

134 of 134 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Many drugs aiming to cure or mediate disease have been pulled from the market due to unforeseen issues arising in one sex or another.
“Many drugs aiming to cure or mediate disease have been pulled from the market due to unforeseen issues arising in one sex or another [50, 51].”
From Alzheimer’s disease-associated protective variant Plcg2-P522R modulates peripheral macrophage function in a sex-dimorphic manner (2024) · cites this paper as [50]
Results of TBI clinical trials are not always analyzed by sex.
“Moreover, results are not always analyzed by sex.”
From Sex Differences in Traumatic Brain Injury: What We Know and What We Should Know (2019) · cites this paper as [22]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Goodman & Gilman's The Pharmacological Basis of Therapeutics
Brunton, L. L. (1985) · Cited by 7,321
Goodman and Gilman's the Pharmacological Basis of Therapeutics
Stigelman, W. H., & Pharm, D. (1986) · Military Medicine · doi:10.1093/milmed/151.1.386 · Cited by 6,796
High Blood Alcohol Levels in Women: The Role of Decreased Gastric Alcohol Dehydrogenase Activity and First-Pass Metabolism
Frezza, M., di Padova, C., Pozzato, G., Terpin, M., Baraona, E., & Lieber, C. S. (1990) · New England Journal of Medicine · doi:10.1056/nejm199001113220205 · Cited by 1,328
Sex-Based Differences in the Effect of Digoxin for the Treatment of Heart Failure
Rathore, S. S., Wang, Y., & Krumholz, H. M. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021266 · Cited by 688
Exploring the Biological Contributions to Human Health
Institute of Medicine (2001) · National Academies Press eBooks · doi:10.17226/10028 · Cited by 658
Gender Differences in Pharmacokinetics of Alcohol
Baraona, E., Abittan, C. S., Dohmen, K., Moretti, M., Pozzato, G., Chayes, Z. W., Schaefer, C., & Lieber, C. S. (2001) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2001.tb02242.x · Cited by 583
Sex Differences in Pharmacokinetics and Pharmacodynamics
Gandhi, M., Aweeka, F. T., Greenblatt, R. M., & Blaschke, T. F. (2004) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.44.101802.121453 · Cited by 546
Olanzapine
Callaghan, J. T., Bergstrom, R. F., Ptak, L. R., & Beasley, C. M. (1999) · Clinical Pharmacokinetics · doi:10.2165/00003088-199937030-00001 · Cited by 544
Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption
Custodio, J. M., Wu, C., & Benet, L. Z. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.08.043 · Cited by 436
Effect of age and gender on the activity of human hepatic CYP3A
Hunt, C. M., Westerkam, W. R., & Stave, G. M. (1992) · Biochemical Pharmacology · doi:10.1016/0006-2952(92)90010-g · Cited by 426
Regional levels of drug transporters along the human intestinal tract: Co-expression of ABC and SLC transporters and comparison with Caco-2 cells
Englund, G., Rorsman, F., Rönnblom, A., Karlbom, U., Lazorova, L., Gråsjö, J., Kindmark, A., & Artursson, P. (2006) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2006.04.010 · Cited by 368
Reference values for resting blood flow to organs of man
Williams, L. R., & Leggett, R. W. (1989) · Clinical Physics and Physiological Measurement · doi:10.1088/0143-0815/10/3/001 · Cited by 358
Renal hemodynamics and tubular function in normal human pregnancy
Davison, J. M., & Dunlop, W. (1980) · Kidney International · doi:10.1038/ki.1980.124 · Cited by 339
Clinical physiology in obstetrics
Chamberlain, G. V. P., & Hytten, F. E. (1998) · Medical Entomology and Zoology · Cited by 326
Racial and gender differences in N-acetyltransferase, xanthine oxidase, and CYP1A2* activities
Relling, M. V., Lin, J., Ayers, G. D., & Evans, W. E. (1992) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1992.203 · Cited by 314
Pharmacokinetic Changes During Pregnancy and Their Clinical Relevance
Loebstein, R., Lalkin, A., & Koren, G. (1997) · Clinical Pharmacokinetics · doi:10.2165/00003088-199733050-00002 · Cited by 312
Human liver catechol-O-methyltransferase pharmacogenetics
Boudíková, B., Szumlanski, C. L., Maidak, B. L., & Weinshilboum, R. M. (1990) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1990.166 · Cited by 248
Effect of four different oral contraceptives on various sex hormones and serum-binding globulins
Wiegratz, I., Kutschera, E., Lee, J. H., Moore, C., Mellinger, U., Winkler, U. H., & Kuhl, H. (2003) · Contraception · doi:10.1016/s0010-7824(02)00436-5 · Cited by 239
Sex differences in the serotonin 1A receptor and serotonin transporter binding in the human brain measured by PET
Jovanovic, H., Lundberg, J., Karlsson, P., Cerin, Å., Saijo, T., Varrone, A., Halldin, C., & Nordström, A. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.10.016 · Cited by 232
Gender differences in drug effects: implications for anesthesiologists
Pleym, H., Spigset, O., Kharasch, E. D., & Dale, O. (2003) · Acta Anaesthesiologica Scandinavica · doi:10.1034/j.1399-6576.2003.00036.x · Cited by 230
Differences in decline in GFR with age between males and females. Reference data on clearances of inulin and PAH in potential kidney donors
Berg, U. (2006) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfl227 · Cited by 223
High‐dose ribavirin in combination with standard dose peginterferon for treatment of patients with chronic hepatitis C†
Lindahl, K., Ståhle, L., Bruchfeld, A. N., & Schvarcz, R. (2005) · Hepatology · doi:10.1002/hep.20563 · Cited by 215
The effect of age, sex, and rifampin administration on intestinal and hepatic cytochrome P450 3A activity
Gorski, J. C. (2003) · Clinical Pharmacology & Therapeutics · doi:10.1016/s0009-9236(03)00187-5 · Cited by 210
Clinical Pharmacokinetics of Phenytoin
Richens, A. (1979) · Clinical Pharmacokinetics · doi:10.2165/00003088-197904030-00001 · Cited by 201
The influence of environmental and genetic factors on CYP2D6, CYP1A2 and UDP-glucuronosyltransferases in man using sparteine, caffeine, and paracetamol as probes
Bock, K. W., Schrenk, D., Forster, A., Griese, E., rike, K. M., Brockmeier, D., & Eichelbaum, M. F. (1994) · Pharmacogenetics · doi:10.1097/00008571-199408000-00005 · Cited by 199
Human gastric alcohol dehydrogenase activity: effect of age, sex, and alcoholism.
Seitz, H. K., Egerer, G., Simanowski, U. A., Waldherr, R., Eckey, R., Agarwal, D. P., GOEDDE, H. W., & von Wartburg, J. P. (1993) · Gut · doi:10.1136/gut.34.10.1433 · Cited by 191
Sex, gender and women's occupational health: The importance of considering mechanism
Messing, K., & Stellman, J. M. (2005) · Environmental Research · doi:10.1016/j.envres.2005.03.015 · Cited by 185
Effects of Cimetidine on Gastric Alcohol Dehydrogenase Activity and Blood Ethanol Levels
Caballería, J., Baraona, E., Rodamilans, M., & Lieber, C. S. (1989) · Gastroenterology · doi:10.1016/0016-5085(89)91562-x · Cited by 174
Estrogen increases sensitivity of hepatic Kupffer cells to endotoxin
Ikejima, K., Enomoto, N., Iimuro, Y., Ikejima, A., Fang, D., Xu, J., Forman, D. T., Brenner, D. A., & Thurman, R. G. (1998) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1998.274.4.g669 · Cited by 172
Gender-based effects on methylprednisolone pharmacokinetics and pharmacodynamics
Lew, K. H., Ludwig, E. A., Milad, M. A., Donovan, K., Middleton, E., Ferry, J. J., & Jusko, W. J. (1993) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1993.167 · Cited by 169
Reproductive physiology and treatment-related loss of sex hormone production
Sklar, C. A. (1999) · Medical and Pediatric Oncology · doi:10.1002/(sici)1096-911x(199907)33:1 · Cited by 167
The Stomach and Duodenum
Eusterman, G. B., & Balfour, D. C. (1937) · The American Journal of the Medical Sciences · doi:10.1097/00000441-193701000-00018 · Cited by 165
Increased severity of alcoholic liver injury in female rats: role of oxidative stress, endotoxin, and chemokines
Nanji, A. A., Jokelainen, K., Fotouhinia, M., Rahemtulla, A., Thomas, P., Tipoe, G. L., Su, G. L., & Dannenberg, A. J. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.281.6.g1348 · Cited by 161
Effects of Gender and Age on Plasma Levels of Clozapine and Its Metabolites
Lane, H., Chang, Y.-C., Chang, W., Lin, S., Tseng, Y.-T., & Jann, M. W. (1999) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v60n0108 · Cited by 158
The Effect of Age, Sex and Level of Intake of Dietary Fibre from Wheat on Large-Bowel Function in Thirty Healthy Subjects
Stephen, A. M., Wiggins, H. S., Englyst, H. N., Cole, T. J., Wayman, B. J., & Cummings, J. H. (1986) · British Journal of Nutrition · doi:10.1079/bjn19860116 · Cited by 154
Clinical Pharmacokinetics of Anticonvulsants
HVIDBERG, E. F., & Dam, M. (1976) · Clinical Pharmacokinetics · doi:10.2165/00003088-197601030-00001 · Cited by 151
Cytochrome P450 2E1 genotype and chlorzoxazone metabolism in healthy and alcoholic Caucasian subjects
le Lucas, D., nez, C. M., Girre, C., Berthou, F. O., nez, P. B., Joannet, I., Hispard, É., Bardou, L., & nez, J.-F. O. M. (1995) · Pharmacogenetics · doi:10.1097/00008571-199510000-00005 · Cited by 150
Tissue distribution of S-adenosylmethionine and S-adenosylhomocysteine in the rat. Effect of age, sex and methionine administration on the metabolism of S-adenosylmethionine, S-adenosylhomocysteine and polyamines
Eloranta, T. O. (1977) · Biochemical Journal · doi:10.1042/bj1660521 · Cited by 147
EFFECT OF GENDER AND SEX HORMONES ON VASCULAR OXIDATIVE STRESS
Miller, A. A., Silva, T. M. D., Jackman, K. A., & Sobey, C. G. (2007) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2007.04732.x · Cited by 147
Serum protein binding of drugs during and after pregnancy in humans
Dean, M. E., Stock, B. H., Patterson, R. J., & Levy, G. (1980) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1980.158 · Cited by 139
Gender differences in human pharmacokinetics and pharmacodynamics
Fletcher, C. V., Acosta, E. P., & Strykowski, J. M. (1994) · Journal of Adolescent Health · doi:10.1016/s1054-139x(94)90628-9 · Cited by 129
Gender‐Specific Effects on Verapamil Pharmacokinetics and Pharmacodynamics in Humans
KRECICSHEPARD, M., Barnas, C., SLIMKO, J., Jones, M. P., & Schwartz, J. B. (2000) · The Journal of Clinical Pharmacology · doi:10.1177/00912700022008883 · Cited by 116
Diazepam Kinetics in Relation to Age and Sex
Ochs, H. R., Greenblatt, D. J., Divoll, M., Abernethy, D. R., Feyerabend, H., & Dengler, H. J. (2008) · Pharmacology · doi:10.1159/000137524 · Cited by 114
Role of intestinal sterol transporters Abcg5, Abcg8, and Npc1l1 in cholesterol absorption in mice: gender and age effects
Duan, L.-P., Wang, H. H., Ōhashi, A., & Wang, D. Q. ‐. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00172.2005 · Cited by 111
Disposition of chlordiazepoxide: Sex differences and effects of oral contraceptives
Roberts, R. K., Desmond, P. V., Wilkinson, G. R., & Schenker, S. (1979) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt1979256826 · Cited by 100
Effects of ranitidine on blood alcohol levels after ethanol ingestion. Comparison with other H2-receptor antagonists
DiPadova, C. (1992) · JAMA · doi:10.1001/jama.267.1.83 · Cited by 99
The effects of age and sex on the disposition of acetylsalicylic acid and its metabolites.
Ho, P. C., TRIGGS, E. J., Bourne, D. W. A., & Heazlewood, V. J. (1985) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1985.tb02695.x · Cited by 95
Dose-Response and Time Course of Effect of Rocuronium in Male and Female Anesthetized Patients
Xue, F., Tong, S. Y., Liao, X., Liu, J. H., An, G., & Luo, L. K. (1997) · Anesthesia & Analgesia · doi:10.1097/00000539-199709000-00033 · Cited by 94
Body composition and resting metabolic rate: the myth of feminine metabolism
Cunningham, J. (1982) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/36.4.721 · Cited by 83
Regulation of cardiac ion channels via non-genomic action of sex steroid hormones: Implication for the gender difference in cardiac arrhythmias
Furukawa, T., & Kurokawa, J. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.04.008 · Cited by 82
Sex‐related differences in the plasma protein binding of lignocaine and diazepam.
Routledge, P., Stargel, W. W., Kitchell, B. B., Barchowsky, A., & Shand, D. (1981) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1981.tb00528.x · Cited by 82
GASTRIC ALCOHOL DEHYDROGENASE ACTIVITY IN MAN: INFLUENCE OF GENDER, AGE, ALCOHOL CONSUMPTION AND SMOKING IN A CAUCASIAN POPULATION
Parlesak, A. (2002) · Alcohol and Alcoholism · doi:10.1093/alcalc/37.4.388 · Cited by 80
Mefloquine antimalarial prophylaxis in pregnancy: dose finding and pharmacokinetic study.
Nosten, F. H., Karbwang, J., White, N. J., Honeymoon, Bangchang, K. N., BUNNAG, D., & Harinasuta, T. (1990) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1990.tb03746.x · Cited by 79
Gender, age, smoking behaviour and plasma clozapine concentrations in 193 Chinese inpatients with schizophrenia
Tang, Y., Mao, P., Li, F., Li, W., Chen, Q., Jiang, F., Cai, Z., & Mitchell, P. B. (2007) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2007.02852.x · Cited by 78
Sex Differences in the Metabolism of Ethanol and Acetaldehyde in Normal Subjects
Arthur, M. J. P., Lee, A., & Wright, R. (1984) · Clinical Science · doi:10.1042/cs0670397 · Cited by 77
The influence of age and gender on the stereoselective metabolism and pharmacokinetics of mephobarbital in humans
Hooper, W. D., & Mi, Q. (1990) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1990.207 · Cited by 76
Faster clearance of sustained release verapamil in men versus women: Continuing observations on sex-specific differences after oral administration of verapamil
KRECICSHEPARD, M. (2000) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2000.109356 · Cited by 74
Effect of chronic infusion of olanzapine and clozapine on food intake and body weight gain in male and female rats
Choi, S., DiSilvio, B. E., Unangst, J. L., & Fernstrom, J. D. (2007) · Life Sciences · doi:10.1016/j.lfs.2007.08.009 · Cited by 73
Increased oral clearance of metoprolol in pregnancy
H�gstedt, S., LINDBERG, B. S., & Rane, A. (1983) · European Journal of Clinical Pharmacology · doi:10.1007/bf00613820 · Cited by 73
The Mechanisms of Action of Reproductive Toxicants
Mattison, D. R., & Thomford, P. J. (1989) · Toxicologic Pathology · doi:10.1177/019262338901700213 · Cited by 72
Self-citation
STIMULATION OF THE SEX ACCESSORIES OF HYPOPHYSECTOMIZED MALE RATS BY NON-GONADOTROPHIC HORMONES OF THE PITUITARY GLAND
Lostroh, A. J., & Li, C. H. (1957) · European Journal of Endocrinology · doi:10.1530/acta.0.0250001 · Cited by 69
Pharmacokinetics and Pharmacodynamics of Atenolol During Pregnancy and Postpartum
Hébert, M. F., Carr, D. B., Anderson, G. D., Blough, D. K., Green, G. E., Brateng, D. A., Kantor, E. D., Benedetti, T. J., & Easterling, T. R. (2004) · The Journal of Clinical Pharmacology · doi:10.1177/0091270004269704 · Cited by 67
Dose-Response and Time Course of Effect of Rocuronium in Male and Female Anesthetized Patients
Xue, F., Tong, S. Y., Liao, X., et al. (1997) · Anesthesia & Analgesia · doi:10.1213/00000539-199709000-00033 · Cited by 67
Gender and age as factors in the inhibition of renal clearance of amantadine by quinine and quinidine
Gaudry, S. E., SITAR, D. S., Smyth, D. D., McKenzie, J. K., & Aoki, F. Y. (1993) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1993.104 · Cited by 66
The effects of menopause and hormone replacement therapies on prednisolone and erythromycin pharmacokinetics*
Harris, R. Z., Tsunoda, S. M., Mroczkowski, P. J., Wong, H., & Benet, L. Z. (1996) · Clinical Pharmacology & Therapeutics · doi:10.1016/s0009-9236(96)90112-5 · Cited by 64
Pharmacokinetic Profile of Sulfisoxazole following Intravenous, Intramuscular, and Oral Administration to Man
Kaplan, S. A., Weinfeld, R. E., Abruzzo, C. W., & Lewis, M. (1972) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600610521 · Cited by 63
Alterations in prednisolone disposition as a result of time of administration, gender and dose.
Meffin, P. J., Brooks, P., & Sallustio, B. (1984) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1984.tb02363.x · Cited by 62
Nonlinear Intestinal Absorption of 5-Hydroxytryptamine Receptor Antagonist Caused by Absorptive and Secretory Transporters
Tamai, I., Saheki, A., Saitoh, R., Sai, Y., YAMADA, I., & Tsuji, A. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37004-1 · Cited by 62
Gaps in knowledge in treating pregnant women
Mattison, D. R., & Zajicek, A. (2006) · Gender Medicine · doi:10.1016/s1550-8579(06)80205-6 · Cited by 61
Self-citation
Human liver dehydroepiandrosterone sulfotransferase: Nature and extent of individual variation
Aksoy, I. A., Sochorová, V., & Weinshilboum, R. M. (1993) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1993.181 · Cited by 60
Placental transfer and maternal midazolam kinetics
Kanto, J., Sjövall, S., Erkkola, R., HIMBERG, J.-J., & Kangas, L. (1983) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1983.107 · Cited by 58
Relative Binding of Testosterone and Estradiol to Testosterone-Estradiol-Binding Globulin*
Vigersky, R. A., 河野, 伸., SAUER, M. A., Lipsett, M. B., & Loriaux, D. L. (1979) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-49-6-899 · Cited by 58
Age and sex differences of dehydroepiandrosterone sulfate (DHEAS) and cortisol (CRT) plasma levels in normal controls and Alzheimer's disease (AD)
Leblhuber, F., Neubauer, C. J., Peichl, M., Reisecker, F., Steinparz, F. X., Windhager, E., & Dienstl, E. (1993) · Psychopharmacology · doi:10.1007/bf02257402 · Cited by 58
Gender and oral contraceptive steroids as determinants of drug glucuronidation: effects on clofibric acid elimination.
Miners, J. O., Robson, R., & Birkett, D. (1984) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1984.tb02461.x · Cited by 56
Sex differences in drug metabolism: cytochrome P-450 and uridine diphosphate glucuronosyltransferase.
Anderson, G. D. (2002) · PubMed · Cited by 56
Influence of gender on the course of neuromuscular block following a single bolus dose of cisatracurium or rocuronium
Adamus, M., Gabrhelík, T., & Marek, O. (2008) · European Journal of Anaesthesiology · doi:10.1017/s026502150800402x · Cited by 55
Sex differences in pharmacokinetics and toxicity of antiretroviral therapy
Umeh, O. C., & Currier, J. S. (2006) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2.2.273 · Cited by 55
Route of Administration and Sex Differences in the Pharmacokinetics of Aspirin, Administered as Its Lysine Salt
Aarons, L. J., Hopkins, K., Rowland, M., Brossel, S., & Thiercelin, J. F. (1989) · Pharmaceutical Research · doi:10.1023/a:1015978104017 · Cited by 52
Physiological alterations during pregnancy: Impact on toxicokinetics
Mattison, D. R. (1991) · Fundamental and Applied Toxicology · doi:10.1016/0272-0590(91)90103-b · Cited by 51
Self-citation
Comparison of the Pharmacokinetics of Cephradine and Cefazolin in Pregnant and Non-Pregnant Women
Philipson, A., Stiernstedt, G., & Ehrnebo, M. (1987) · Clinical Pharmacokinetics · doi:10.2165/00003088-198712020-00004 · Cited by 49
Effects of sex on the pharmacokinetic and pharmacodynamic properties of quinidine
El‐Eraky, H., & Thomas, S. H. L. (2003) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.2003.01865.x · Cited by 48
Different effects of heparin in males and females.
Campbell, N. R. C., Hull, R., Brant, R., Hogan, D. B., Pineo, G. F., & Raskob, G. E. (1998) · PubMed · Cited by 47
Sex-specific differences in cortisol production rates in humans
Vierhapper, H., Nowotny, P., & Waldhäusl, W. K. (1998) · Metabolism · doi:10.1016/s0026-0495(98)90353-5 · Cited by 47
Menstrual Cycle Variability in Midazolam Pharmacokinetics
Kharasch, E. D., Mautz, D. S., Senn, T., Lentz, G. M., & Cox, K. (1999) · The Journal of Clinical Pharmacology · doi:10.1177/009127009903900311 · Cited by 45
Altered Drug Binding to Serum Proteins in Pregnant Women: Therapeutic Relevance
Peruccam, E., Ruprah, M., & Richens, A. (1981) · Journal of the Royal Society of Medicine · doi:10.1177/014107688107400606 · Cited by 45
Sex‐Related Liver Injury Due to Alcohol Involves Activation of Kupffer Cells by Endotoxin
Thurman, R. G. (1999) · Canadian Journal of Gastroenterology and Hepatology · doi:10.1155/2000/735262 · Cited by 45
Erythromycin and clindamycin absorption and elimination in pregnant women
Philipson, A., Sabath, L. D., & Charles, D. (1976) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt197619168 · Cited by 43
Studies on body composition. I. Body fluid compartments and exchangeable potassium in normal males and females.
Ljunggren, H., Ikkos, D., & Luft, R. (1957) · PubMed · Cited by 43
Nonlinear Pharmacokinetics of Fluvoxamine and Gender Differences
Härtter, S., Wetzel, H., Hammes, E., Torkzadeh, M., & Hiemke, C. (1998) · Therapeutic Drug Monitoring · doi:10.1097/00007691-199808000-00016 · Cited by 41
Sex differences in the intramuscular absorption and bioavailability of cephradine
Vukovich, R. A., BRANNICK, L. J., Sugerman, A., & NEISS, E. S. (1975) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt1975182215 · Cited by 40
Kinetics of intravenous chlordiazepoxide: Sex differences in drug distribution
Greenblatt, D. J., Shader, R. I., Franke, K., MacLaughlin, D. S., Ransil, B. J., & Koch‐Weser, J. (1977) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt1977226893 · Cited by 40
Liver, Alcohol and Gender
Müller, C. J. (2006) · Wiener Medizinische Wochenschrift · doi:10.1007/s10354-006-0348-8 · Cited by 39
Pharmacokinetics of digoxin in pregnancy
Luxford, A. M. E., & Kellaway, G. S. (1983) · European Journal of Clinical Pharmacology · doi:10.1007/bf00544027 · Cited by 38
Aging and drug interactions. III. Individual and combined effects of cimetidine and cimetidine and ciprofloxacin on theophylline metabolism in healthy male and female nonsmokers.
Loi, C., Parker, B. M., Cusack, B. J., & Vestal, R. E. (1997) · PubMed · Cited by 37
Sex Differences in the Subunits of Glutathione-S-Transferase Isoenzyme from Rat and Human Kidney
Butera, L., Feinfeld, D. A., & Bhargava, M. (2017) · Enzyme · doi:10.1159/000468728 · Cited by 36
Treatment of hypertension in pregnancy with beta‐adrenoceptor antagonists.
Dubois, D., Petitcolas, J., Temperville, B., Klepper, A., & Catherine, P. (1982) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1982.tb01944.x · Cited by 35
The effects of pregnancy on ethanol clearance
Badger, T. M., Hidestrand, M., Shankar, K., McGuinn, W. D., & Ronis, M. J. J. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.02.019 · Cited by 35
Frequency distribution of free warfarin and free phenytoin fraction values in serum of healthy human adults
Yacobi, A., Lampman, T., & Levy, G. (1977) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt1977213283 · Cited by 34
Population Pharmacokinetic Analysis of Mizolastine and Validation from Sparse Data on Patients Using the Nonparametric Maximum Likelihood Method
Mesnil, F., Mentré, F., Dubruc, C., Thénot, J., & Mallet, A. (1998) · Journal of Pharmacokinetics and Biopharmaceutics · doi:10.1023/a:1020505722924 · Cited by 33
Setting occupational health standards: toxicokinetic differences among and between men and women.
Silvaggio, T., & Mattison, D. R. (1994) · PubMed · Cited by 31
Self-citation
Neuere Antipsychotika
Aichhorn, W., Whitworth, A. B., Weiss, E. M., Hinterhuber, H., & Marksteiner, J. (2006) · Der Nervenarzt · doi:10.1007/s00115-006-2112-0 · Cited by 29
Microheterogeneity of α1-acid glycoprotein: variation during the menstrual cycle in healthy women, and profile in women receiving estrogen-progestogen treatment
Succari, M., Foglietti, M. J., & Percheron, F. (1990) · Clinica Chimica Acta · doi:10.1016/0009-8981(90)90108-5 · Cited by 29
Sex differences in the pharmacokinetics of salicylates
Trnavsk�, Z., & Trnavsk�, K. (1983) · European Journal of Clinical Pharmacology · doi:10.1007/bf00542358 · Cited by 28
Gender-Related Differences in Iron Absorption by Preadolescent Children
Woodhead, J. C., Drulis, J. M., Nelson, S. E., Janghorbani, M., & Fomon, S. J. (1991) · Pediatric Research · doi:10.1203/00006450-199105010-00005 · Cited by 28
Sex‐Related Differences in the Pharmacokinetics of Oral Ciprofloxacin
Overholser, B. R., Kays, M. B., Forrest, A., & Sowinski, K. M. (2004) · The Journal of Clinical Pharmacology · doi:10.1177/0091270004266843 · Cited by 28
Cimetidine Inhibition of Human Gastric and Liver Alcohol Dehydrogenase Isoenzymes: Identification of Inhibitor Complexes by Kinetics and Molecular Modeling
Stone, C. L., Hurley, T. D., Peggs, C. F., Kedishvili, N. Y., Davis, G. J., Thomasson, H. R., Li, T., & BOSRON, W. F. (1995) · Biochemistry · doi:10.1021/bi00012a019 · Cited by 27
Vecuronium: an anthropometric comparison
Houghton, I., Aun, C., & Oh, T. E. (1992) · Anaesthesia · doi:10.1111/j.1365-2044.1992.tb03250.x · Cited by 27
Gastrointestinal and Dermal Absorption: Interspecies Differences
Calabrese, E. J. (1984) · Drug Metabolism Reviews · doi:10.3109/03602538409033556 · Cited by 27
We've Come A Long Way, Maybe: Recruitment of Women and Analysis of Results by Sex in Clinical Research
Marrocco, A., & Stewart, D. E. (2001) · Journal of Women s Health & Gender-Based Medicine · doi:10.1089/152460901300039520 · Cited by 27
Effect of Gender on the Pharmacokinetics of Ofloxacin
Sowinski, K. M., Abel, S. R., Clark, W. R., & Mueller, B. A. (1999) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.19.6.442.31044 · Cited by 26
Chronic propranolol administration during pregnancy
Smith, M. T., Livingstone, I., Eadie, M. J., Hooper, W. D., & TRIGGS, E. J. (1983) · European Journal of Clinical Pharmacology · doi:10.1007/bf00542115 · Cited by 25
Human Corticotropin-Releasing Hormone (hCRH) Test: Sex and Age Differences in Plasma ACTH and Cortisol Responses and their Reproducibility in Healthy Adults.
TANAKA, K., Shimizu, N., Imura, H., Fukata, J., Hibi, I., Tanaka, T., Nakagawa, S., Fujieda, K., Takebe, K., YOSHINAGA, K., et al. (1993) · Endocrine Journal · doi:10.1507/endocrj.40.571 · Cited by 24
LITHIUM IN PREGNANCY
Schou, M., & Amdisen, A. (1970) · The Lancet · doi:10.1016/s0140-6736(70)91289-4 · Cited by 23
Women with asthma: a review of potential variables and preferred medical management
Ostrom, N. K. (2006) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)61062-9 · Cited by 23
Aging and Drug Interactions. III. Individual and Combined Effects of Cimetidine and Ciprofloxacin on Theophylline Metabolism in Healthy Male and Female Nonsmokers
Loi, C., Parker, B. M., Cusack, B. J., & Vestal, R. E. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36457-2 · Cited by 22
Variability in the Bioavailability of Phenytoin Capsules in Males and Females
Meyer, M. C., Straughn, A. B., Mhatre, R. M., Shah, V. P., Chen, M., Williams, R. L., & Lesko, L. J. (2001) · Pharmaceutical Research · doi:10.1023/a:1011075502215 · Cited by 19
Pharmacokinetics and Safety of Oral Eletriptan during Different Phases of the Menstrual Cycle in Healthy Volunteers
Shah, A. K., LaBoy‐Goral, L., Scott, N., Morse, M. T., & Apseloff, G. (2001) · The Journal of Clinical Pharmacology · doi:10.1177/00912700122012922 · Cited by 19
Pharmacokinetics of ofloxacin in elderly patients and in healthy young subjects
Molinaro, M., Villani, P., Regazzi, M. B., Rondanelli, R., & Doveri, G. (1992) · European Journal of Clinical Pharmacology · doi:10.1007/bf02280765 · Cited by 19
Sex Differences in Hepatic Gluconeogenic Capacity After Chronic Alcohol Consumption
Sumida, K. D., Hill, J. M., & Matveyenko, A. V. (2007) · Clinical Medicine & Research · doi:10.3121/cmr.2007.729 · Cited by 19
Molecular non-genetic biomarkers of effect related to acephate cocarcinogenesis: sex- and tissue-dependent induction or suppression of murine CYPs
Paolini, M., Pozzetti, L., Sapone, A., Mesirca, R., Perocco, P., Mazzullo, M., & Cantelli‐Forti, G. (1997) · Cancer Letters · doi:10.1016/s0304-3835(97)00177-8 · Cited by 18
Gender differences in the disposition of metronidazole
Carcas, A. J., Guerra, P., Frías, J., Soto, A., Fernandez-Aijón, A., Montuenga, C., & Govantes, C. (2001) · International Journal of Clinical Pharmacology and Therapeutics · doi:10.5414/cpp39213 · Cited by 18
Weight gain in pregnancy--30 year of research.
Fe, H. (1981) · PubMed · Cited by 18
Development and pharmacology of fluvastatin.
Jokubaitis, L. A. (1994) · PubMed · Cited by 17
Sex differences in the risk of multiple myeloma associated with agriculture.
Zahm, S. H., Blair, A., & Weisenburger, D. D. (1992) · Occupational and Environmental Medicine · doi:10.1136/oem.49.11.815-a · Cited by 16
Use of Skeletal Measurements: Estimating the Lean Body Mass of Young Women
Young, C. M., & TENSUAN, R. S. (1963) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(21)18788-7 · Cited by 16
Sex differences in iron absorption
Jacobs, A. J. (1976) · Proceedings of The Nutrition Society · doi:10.1079/pns19760028 · Cited by 15
Intersubject variation of warfarin binding to protein in serum of normal subjects.
Yacobi, A., Rg, S., Ar, D., & Levy, G. (1976) · PubMed · Cited by 12
Comparative bioavailability of two oral formulations of flurazepam in human subjects
Cooper, S. F., Drolet, D. W., & Dugal, R. (1984) · Biopharmaceutics & Drug Disposition · doi:10.1002/bdd.2510050206 · Cited by 11
Factors influencing elimination and distribution of fleroxacin: metaanalysis of individual data from 10 pharmacokinetic studies
Reigner, B. G., & Welker, H. A. (1996) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.40.3.575 · Cited by 10
Serum protein binding of diazepam in maternal and foetal serum during pregnancy.
Lee, J., Ss, C., Richens, A., Menabawey, M., & Chard, T. (1982) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1982.tb02027.x · Cited by 9
Estimating the lean body mass of young women. Use of skeletal measurements.
Cm, Y., & TENSUAN, R. S. (1963) · PubMed · Cited by 8
Influence of Sex on the Pharmacokinetics of Ciprofloxacin and Ofloxacin
Konieczna, L., Chmielewska, A., & Lamparczyk, H. (2006) · Chemotherapy · doi:10.1159/000092538 · Cited by 6
A micromethod for absorption of specific antibody using an enzyme-linked immunosorbent assay (ELISA)
Calabrese, V. P. (1984) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(84)90031-1 · Cited by 5
Pharmacokinetics and pharmacodynamics of vecuronium bromide
Nomura, T. (1992) · Journal of Anesthesia · doi:10.1007/s0054020060028 · Cited by 1

Flagged first, then by citations

Research works printed but not linked: 10

Zahm, 1992 Nov, Br J Ind Med, 49, 815
Ikejima, 1998 Apr, Am J Physiol, 274, G669
Yacobi, 1976 Aug, Res Commun Chem Pathol Pharmacol, 14, 743
Hytten, 1981 Jul 4, S Afr Med J, 60, 15
Campbell, 1998 Apr, Clin Invest Med, 21, 71
Jokubaitis, 1996 Jan, Br J Clin Pract Suppl, 77A, 11
Anderson, 2002 Jan-Feb, J Gend Specif Med, 5, 25
Ljunggren, 1957, Acta Endocrinol Suppl (Copenh), 25, 1
Silvaggio, 1994 Aug, J Occup Med, 36, 849
Cho, 1970, Chemotherapy (Tokyo), 18, 377

Sorted by citations

KDIGO 2024 clinical practice guideline for the evaluation and management of chronic kidney disease
Stevens, P. E., Ahmed, S. B., Carrero, J. J., Foster, B., Francis, A., Hall, R. K., Herrington, W. G., Hill, G., Inker, L. A., Kazancıoğlu, R., et al. (2024) · Kidney International · doi:10.1016/j.kint.2023.10.018 · Cited by 8,530
Sex bias in neuroscience and biomedical research
Beery, A. K., & Zucker, I. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.07.002 · Cited by 1,763
Consensus Guidelines for Therapeutic Drug Monitoring in Neuropsychopharmacology: Update 2017
Hiemke, C., Bergemann, N., Clement, H. ‐., Conca, A., Deckert, J., Domschke, K., Eckermann, G., Egberts, K. M., Gerlach, M., Greiner, C., et al. (2017) · Pharmacopsychiatry · doi:10.1055/s-0043-116492 · Cited by 1,494
Sex and gender differences in substance use disorders
McHugh, R. K., Votaw, V. R., Sugarman, D. E., & Greenfield, S. F. (2018) · Clinical Psychology Review · doi:10.1016/j.cpr.2017.10.012 · Cited by 1,076
AGNP Consensus Guidelines for Therapeutic Drug Monitoring in Psychiatry: Update 2011
Hiemke, C., Baumann, P., Bergemann, N., Conca, A., Dietmaier, O., Egberts, K. M., Fric, M., Gerlach, M., Greiner, C., Gründer, G., et al. (2011) · Pharmacopsychiatry · doi:10.1055/s-0031-1286287 · Cited by 871
Sex differences in heart failure
Lam, C. S. P., Arnott, C. G., Beale, A. L., Chandramouli, C., Hilfiker‐Kleiner, D., Kaye, D. M., Ky, B., Santema, B. T., Sliwa, K. S., & Voors, A. A. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz835 · Cited by 873
Sex differences in pharmacokinetics predict adverse drug reactions in women
Zucker, I., & Prendergast, B. J. (2020) · Biology of Sex Differences · doi:10.1186/s13293-020-00308-5 · Cited by 777
Sex Differences in Traumatic Brain Injury: What We Know and What We Should Know
Gupte, R. P., Brooks, W. M., Vukas, R. R., Pierce, J. D., & Harris, J. L. (2019) · Journal of Neurotrauma · doi:10.1089/neu.2018.6171 · Cited by 533
50 years of hurdles and hope in anxiolytic drug discovery
Griebel, G., & Holmes, A. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4075 · Cited by 430
Influence of Patient Sex and Gender on Medication Use, Adherence, and Prescribing Alignment with Guidelines
Manteuffel, M., Williams, S., Chen, W., Verbrugge, R. R., Pittman, D. G., & Steinkellner, A. R. (2013) · Journal of Women s Health · doi:10.1089/jwh.2012.3972 · Cited by 423
Ovarian hormones and obesity
Leeners, B., Geary, N., Tobler, P. N., & Asarian, L. (2017) · Human Reproduction Update · doi:10.1093/humupd/dmw045 · Cited by 407
Sexual dimorphism in cardiometabolic health: the role of adipose tissue, muscle and liver
Goossens, G. H., Jocken, J. W. E., & Blaak, E. E. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-00431-8 · Cited by 359
Effects and Mechanisms of Phthalates’ Action on Reproductive Processes and Reproductive Health: A Literature Review
Hlisníková, H., Petrovičová, I., Kolena, B., Šidlovská, M., & Sirotkin, A. V. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17186811 · Cited by 355
Sex Differences in Drug Disposition
Soldin, O. P., Chung, S. H., & Mattison, D. R. (2011) · BioMed Research International · doi:10.1155/2011/187103 · Cited by 353
Self-citation
Sex Differences in Risk of Severe Adverse Events in Patients Receiving Immunotherapy, Targeted Therapy, or Chemotherapy in Cancer Clinical Trials
Unger, J. M., Vaidya, R., Albain, K. S., LeBlanc, M., Minasian, L. M., Gotay, C. C., Henry, N. L., Fisch, M. J., Lee, S. M., Blanke, C. D., et al. (2022) · Journal of Clinical Oncology · doi:10.1200/jco.21.02377 · Cited by 337
Variations between women and men in risk factors, treatments, cardiovascular disease incidence, and death in 27 high-income, middle-income, and low-income countries (PURE): a prospective cohort study
Walli-Attaei, M., Joseph, P. G., Rosengren, A., Chow, C. K., Rangarajan, S., Lear, S. A., AlHabib, K. F., Davletov, K., Dans, A., Lanas, F. T., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30543-2 · Cited by 349
Impact of gastrointestinal physiology on drug absorption in special populations––An UNGAP review
Stillhart, C., Vučićević, K. M., Augustijns, P., Basit, A. W., Batchelor, H. K., Flanagan, T. R., Gesquiere, I., Greupink, R., Keszthelyi, D., Koskinen, M., et al. (2020) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2020.105280 · Cited by 343
Gender differences in the effects of cardiovascular drugs
Tamargo, J. L., Rosano, G. M. C., Walther, T., Duarte, J., Niessner, A., Kaski, J., Ceconi, C., Drexel, H., Kjeldsen, K. P., Savarese, G., et al. (2016) · European Heart Journal - Cardiovascular Pharmacotherapy · doi:10.1093/ehjcvp/pvw042 · Cited by 325
Reported adverse drug reactions in women and men: Aggregated evidence from globally collected individual case reports during half a century
Watson, S., Caster, O., Rochon, P. A., & den Ruijter, H. M. (2019) · EClinicalMedicine · doi:10.1016/j.eclinm.2019.10.001 · Cited by 313
Drug-microbiota interactions: an emerging priority for precision medicine
Zhao, Q. C., Chen, Y., Huang, W., Zhou, H., & Zhang, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01619-w · Cited by 309
Total cholesterol as a risk factor for coronary heart disease and stroke in women compared with men: A systematic review and meta-analysis
Peters, S. A. E., Singhateh, Y., MacKay, D., Huxley, R., & Woodward, M. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.03.016 · Cited by 290
Identifying optimal doses of heart failure medications in men compared with women: a prospective, observational, cohort study
Santema, B. T., Ouwerkerk, W., Tromp, J., Sama, I. E., Ravera, A., Regitz‐Zagrosek, V., Hillege, H. L., Samani, N. J., Zannad, F. M., Dickstein, K., et al. (2019) · The Lancet · doi:10.1016/s0140-6736(19)31792-1 · Cited by 259
Pharmacogenomics, pharmacokinetics and pharmacodynamics: interaction with biological differences between men and women
Franconi, F., & Campesi, I. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12362 · Cited by 256
Sex differences in addictive disorders
Fattore, L., Melis, M., Fadda, P., & Fratta, W. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.04.003 · Cited by 265
Untitled work
Gerdts (2022) · doi:10.1093/eurheartj/ehac470 · Cited by 241
Improvement in inner retinal function in glaucoma with nicotinamide (vitamin B3 ) supplementation: A crossover randomized clinical trial
Hui, F., Tang, J., Williams, P. A., McGuinness, M. B., Hadoux, X., Casson, R. J., Coote, M., Trounce, I. A., Martin, K. R., van Wijngaarden, P., et al. (2020) · Clinical & Experimental Ophthalmology · doi:10.1111/ceo.13818 · Cited by 226
An analysis of neuroscience and psychiatry papers published from 2009 and 2019 outlines opportunities for increasing discovery of sex differences
Rechlin, R. K., Splinter, T. F. L., Hodges, T. E., Albert, A. Y., & Galea, L. A. M. (2022) · Nature Communications · doi:10.1038/s41467-022-29903-3 · Cited by 218
Relevance of Stress and Female Sex Hormones for Emotion and Cognition
ter Horst, J. P., de Kloet, E. R., Schächinger, H., & Oitzl, M. S. (2011) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-011-9774-2 · Cited by 227
Evidence-based survey of the elimination rates of ethanol from blood with applications in forensic casework
Jones, A. W. (2010) · Forensic Science International · doi:10.1016/j.forsciint.2010.02.021 · Cited by 207
Polypharmacy, inappropriate prescribing, and deprescribing in older people: through a sex and gender lens
Rochon, P. A., Petrović, M., Cherubini, A., Onder, G., O’Mahony, D., Sternberg, S. A., Stall, N. M., & Gurwitz, J. H. (2021) · The Lancet Healthy Longevity · doi:10.1016/s2666-7568(21)00054-4 · Cited by 198
Occurrence and Partitioning of Bisphenol Analogues in Adults’ Blood from China
Jin, H., Zhu, J. H., Chen, Z., Hong, Y., & Cai, Z. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.7b03958 · Cited by 200
Sex- and Gender-Based Pharmacological Response to Drugs
Mauvais‐Jarvis, F., Berthold, H. K., Campesi, I., Carrero, J. J., Dhakal, S., Franconi, F., Gouni‐Berthold, I., Heiman, M. L., Kautzky‐Willer, A., Klein, S. L., et al. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000206 · Cited by 203
Advances in predictive in vitro models of drug-induced nephrotoxicity
Soo, J. Y.-C., Jansen, J., Masereeuw, R., & Little, M. H. (2018) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0003-9 · Cited by 191
Differences in the epidemiology, management and outcomes of kidney disease in men and women
Chesnaye, N. C., Carrero, J. J., Hecking, M., & Jager, K. J. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-023-00784-z · Cited by 185
Sex-Dependent Outcome of Hepatitis B and C Viruses Infections: Synergy of Sex Hormones and Immune Responses?
Ruggieri, A., Gagliardi, M. C., & Anticoli, S. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02302 · Cited by 181
Gender differences in the effect of cardiovascular drugs: a position document of the Working Group on Pharmacology and Drug Therapy of the ESC
Rosano, G. M. C., Lewis, B. S., Agewall, S., Waßmann, S., Vitale, C., Schmidt, H. H. H. W., Drexel, H., Patak, A., Torp-Pedersen, C. T., Kjeldsen, K. P., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv161 · Cited by 182
Fetal Sex‐Based Differences in Maternal Hormones, Angiogenic Factors, and Immune Mediators During Pregnancy and the Postpartum Period
Enninga, E. A. L., Nevala, W. K., Creedon, D. J., Markovic, S. N., & Holtan, S. G. (2014) · American Journal of Reproductive Immunology · doi:10.1111/aji.12303 · Cited by 171
Let’s talk about sex: Differences in drug therapy in males and females
Madla, C. M., Gavins, F. K. H., Merchant, H. A., Orlu, M., Murdan, S., & Basit, A. W. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.05.014 · Cited by 167
Systematic Analysis of Adverse Event Reports for Sex Differences in Adverse Drug Events
Yu, Y., Chen, J., Li, D., Wang, L., Wang, W., & Liu, H. (2016) · Scientific Reports · doi:10.1038/srep24955 · Cited by 162
Sex differences in adverse drug reactions reported to the National Pharmacovigilance Centre in the Netherlands: An explorative observational study
de Vries, S. T., Denig, P., Ekhart, C., Burgers, J. S., Kleefstra, N., Mol, P. G. M., & van Puijenbroek, E. (2019) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13923 · Cited by 152
Nutrition and human health from a sex–gender perspective
Marino, M., Masella, R., Bulzomi, P., Campesi, I., Malorni, W., & Franconi, F. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.02.001 · Cited by 159
Gender Differences in Chronic Kidney Disease: Underpinnings and Therapeutic Implications
Carrero, J. J. (2010) · Kidney & Blood Pressure Research · doi:10.1159/000320389 · Cited by 146
Sex Differences in Efficacy and Toxicity of Systemic Treatments: An Undervalued Issue in the Era of Precision Oncology
Özdemir, B. C., Csajka, C., Dotto, G. P., & Wagner, D. (2018) · Journal of Clinical Oncology · doi:10.1200/jco.2018.78.3290 · Cited by 142
Failure of target attainment of beta-lactam antibiotics in critically ill patients and associated risk factors: a two-center prospective study (EXPAT)
Abdulla, A., Dijkstra, A., Hunfeld, N., Endeman, H., Bahmany, S., Ewoldt, T. M. J., Muller, A. E., van Gelder, T., Gommers, D. A. M. P. J., & Koch, B. C. P. (2020) · Critical Care · doi:10.1186/s13054-020-03272-z · Cited by 140
Survival of cutaneous melanoma based on sex, age, and stage in the United States, 1992–2011
Enninga, E. A. L., Moser, J. C., Weaver, A. L., Markovic, S. N., Brewer, J. D., Leontovich, A. A., Hieken, T. J., Shuster, L. T., Kottschade, L. A., Olariu, A., et al. (2017) · Cancer Medicine · doi:10.1002/cam4.1152 · Cited by 136
Sex and gender influences on pharmacological response: an overview
Franconi, F., & Campesi, I. (2014) · Expert Review of Clinical Pharmacology · doi:10.1586/17512433.2014.922866 · Cited by 139
Individualized medicine: Sex, hormones, genetics, and adverse drug reactions
Moyer, A. M., Matey, E. T., & Miller, V. M. (2019) · Pharmacology Research & Perspectives · doi:10.1002/prp2.541 · Cited by 134
Sex-Related Differences in Pharmacokinetics and Pharmacodynamics of Frequently Prescribed Drugs: A Review of the Literature
Farkouh, A., Riedl, T., Gottardi, R., Czejka, M. J., & Kautzky‐Willer, A. (2019) · Advances in Therapy · doi:10.1007/s12325-019-01201-3 · Cited by 135
Sex differences matter: Males and females are equal but not the same
Szadvári, I., Ostatníková, D., & Durdiaková, J. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.114038 · Cited by 149
Urine Excretion, Organ Distribution, and Placental Transfer of 6PPD and 6PPD-Quinone in Mice and Potential Developmental Toxicity through Nuclear Receptor Pathways
Zhao, H. N., Thomas, S. P., Zylka, M. J., Dorrestein, P. C., & Hu, W. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.3c05026 · Cited by 132
Improving the enrollment of women and racially/ethnically diverse populations in cardiovascular clinical trials: An ASPC practice statement
Michos, E. D., Reddy, T. K., Gulati, M., Brewer, L. C., Bond, R. M., Velarde, G., Bailey, A. L., Echols, M. R., Nasser, S. A., Bays, H. E., et al. (2021) · American Journal of Preventive Cardiology · doi:10.1016/j.ajpc.2021.100250 · Cited by 128
Calcitonin gene-related peptide-targeting drugs for migraine: how pharmacology might inform treatment decisions
Al‐Hassany, L., Goadsby, P. J., Danser, A. H. J., & MaassenVanDenBrink, A. (2022) · The Lancet Neurology · doi:10.1016/s1474-4422(21)00409-9 · Cited by 126
Sex and gender differences in myocarditis and dilated cardiomyopathy: An update
Fairweather, D., Beetler, D. J., Musigk, N., Heidecker, B., Lyle, M. A., Cooper, L. T., & Bruno, K. A. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1129348 · Cited by 124
Updated Clinical Pharmacokinetics and Pharmacodynamics of Oxycodone
Kinnunen, M., Piirainen, P., Kokki, H. J., Lammi, P., & Kokki, M. (2019) · Clinical Pharmacokinetics · doi:10.1007/s40262-018-00731-3 · Cited by 123
Sex differences in heart failure
Eisenberg, E., Palo, K. E. D., & Piña, I. L. (2018) · Clinical Cardiology · doi:10.1002/clc.22917 · Cited by 122
Medication Regimen Complexity and Polypharmacy as Factors Associated With All-Cause Mortality in Older People
Wimmer, B. C., Bell, J. S., Fastbom, J., Wiese, M. D., & Johnell, K. (2015) · Annals of Pharmacotherapy · doi:10.1177/1060028015621071 · Cited by 120
Side effect burden of antipsychotic drugs in real life – Impact of gender and polypharmacy
Iversen, T., Steen, N. E., Dieset, I., Hope, S., Mørch, R. H., Gardsjord, E. S., Jørgensen, K. N., Melle, I. S., Andreassen, O. A., Molden, E., et al. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.11.004 · Cited by 125
Sex and the kidneys: current understanding and research opportunities
Merz, C. N. B., Dember, L. M., Ingelfinger, J. R., Vinson, A. J., Neugarten, J., Sandberg, K. L., Sullivan, J. C., Maric‐Bilkan, C., Rankin, T. L., Kimmel, P. L., et al. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0208-6 · Cited by 119
FGF21 attenuates neurodegeneration through modulating neuroinflammation and oxidant-stress
Kang, K., Xu, P., Wang, M., Chunyu, J., Sun, X., Ren, G., Xiao, W. L., & Li, D. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110439 · Cited by 122
The Lieber‐DeCarli Diet—A Flagship Model for Experimental Alcoholic Liver Disease
Guo, F., Zheng, K., Benedé‐Ubieto, R., Cubero, F. J., & Nevzorova, Y. A. (2018) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13840 · Cited by 120
Transgenerational hypocortisolism and behavioral disruption are induced by the antidepressant fluoxetine in male zebrafish Danio rerio
Vera-Chang, M. N., St‐Jacques, A. D., Gagné, R., Martyniuk, C. J., Yauk, C. L., Moon, T. W., & Trudeau, V. L. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1811695115 · Cited by 118
Adverse effects in women: implications for drug development and regulatory policies
Parekh, A., Fadiran, E. O., Uhl, K., & Throckmorton, D. C. (2011) · Expert Review of Clinical Pharmacology · doi:10.1586/ecp.11.29 · Cited by 114
Female gender as a susceptibility factor for drug-induced liver injury
Amacher, D. E. (2013) · Human & Experimental Toxicology · doi:10.1177/0960327113512860 · Cited by 114
Assessment of multiple exposure to chemical elements and health risks among residents near Huodehong lead-zinc mining area in Yunnan, Southwest China
Wang, Y., Wang, R., Fan, L., Chen, T., Bai, Y., Yu, Q., & Liu, Y. (2017) · Chemosphere · doi:10.1016/j.chemosphere.2017.01.055 · Cited by 112
Focus on Sex and Gender: What We Need to Know in the Management of Rheumatoid Arthritis
Maranini, B., Bortoluzzi, A., Silvagni, E., & Govoni, M. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12030499 · Cited by 111
Clinical pharmacokinetics and pharmacogenetics of tamoxifen and endoxifen
Sanchez‐Spitman, A., Swen, J. J., Dezentjé, V. O., Moes, D. J. A. R., Gelderblom, H. A. J., & Guchelaar, H. (2019) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2019.1610390 · Cited by 110
Considerations for Studying Sex as a Biological Variable in Spinal Cord Injury
Stewart, A. N., MacLean, S. M., Stromberg, A. J., Whelan, J. P., Bailey, W. M., Gensel, J. C., & Wilson, M. E. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00802 · Cited by 118
Gender matters in medical education
Bleakley, A. (2012) · Medical Education · doi:10.1111/j.1365-2923.2012.04351.x · Cited by 108
Antipsychotic medication for women with schizophrenia spectrum disorders
Brand, B. A., Haveman, Y. R. A., de Beer, F., de Boer, J. N., Dazzan, P., & Sommer, I. E. (2021) · Psychological Medicine · doi:10.1017/s0033291721004591 · Cited by 106
Conventional laboratory housing increases morbidity and mortality in research rodents: results of a meta-analysis
Cait, J., Cait, A., Scott, R. W., Winder, C. B., & Mason, G. J. (2022) · BMC Biology · doi:10.1186/s12915-021-01184-0 · Cited by 114
Circadian Regulation of Drug Responses: Toward Sex-Specific and Personalized Chronotherapy
Lévi, F., Okyar, A., Hadadi, É., Innominato, P. F., & Ballesta, A. (2023) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-051920-095416 · Cited by 104
Practical compendium of antiarrhythmic drugs: a clinical consensus statement of the European Heart Rhythm Association of the European Society of Cardiology
Merino, J. L., Tamargo, J. L., Blomström‐Lundqvist, C., Boriani, G., Crijns, H. J. G. M., Dobrev, D., Goette, A., Hohnloser, S. H., Naccarelli, G. V., Reiffel, J. A., et al. (2025) · EP Europace · doi:10.1093/europace/euaf076 · Cited by 112
Sex-biased gene expression across mammalian organ development and evolution
Rodríguez-Montes, L., Ovchinnikova, S., Yuan, X., Studer, T., Sarropoulos, I., Anders, S., Kaessmann, H., & Cardoso-Moreira, M. (2023) · Science · doi:10.1126/science.adf1046 · Cited by 103
Sex Differences in Dopamine Receptors and Relevance to Neuropsychiatric Disorders
Williams, O. O. F., Coppolino, M., George, S. R., & Perreault, M. L. (2021) · Brain Sciences · doi:10.3390/brainsci11091199 · Cited by 106
Sex‐related differences in hospital admissions attributed to adverse drug reactions in the Netherlands
Rodenburg, E. M., Stricker, B. H. C., & Visser, L. E. (2010) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2010.03811.x · Cited by 99
Gender in Endocrine Diseases: Role of Sex Gonadal Hormones
Lauretta, R., Sansone, M., Sansone, A., Romanelli, F., & Appetecchia, M. (2018) · International Journal of Endocrinology · doi:10.1155/2018/4847376 · Cited by 93
Sex-Gender Variable: Methodological Recommendations for Increasing Scientific Value of Clinical Studies
Franconi, F., Campesi, I., Colombo, D., & Antonini, P. (2019) · Cells · doi:10.3390/cells8050476 · Cited by 96
Sex Differences in Drug Effects: Interaction with Sex Hormones in Adult Life
Spoletini, I., Vitale, C., Malorni, W., & Rosano, G. M. C. (2012) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-30726-3_5 · Cited by 90
Gender differences in biologic treatment outcomes—a study of 1750 patients with psoriatic arthritis using Danish Health Care Registers
Højgaard, P., Ballegaard, C., Cordtz, R., Zobbe, K., Clausen, M. F., Glintborg, B., Kristensen, L. E., & Dreyer, L. (2018) · Rheumatology · doi:10.1093/rheumatology/key140 · Cited by 88
Gender, genetics, and analgesia: understanding the differences in response to pain relief
Packiasabapathy, S., & Sadhasivam, S. (2018) · Journal of Pain Research · doi:10.2147/jpr.s94650 · Cited by 88
Genes that escape X chromosome inactivation modulate sex differences in valve myofibroblasts
Aguado, B. A., Walker, C. J., Grim, J. C., Schroeder, M. E., Batan, D., Vogt, B. J., Rodriguez, A. G., Schwisow, J. A., Moulton, K. S., Weiss, R. M., et al. (2022) · Circulation · doi:10.1161/circulationaha.121.054108 · Cited by 87
Sex, hormones, and genotype interact to influence psychiatric disease, treatment, and behavioral research
Gobinath, A. R., Choleris, E., & Galea, L. A. M. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.23872 · Cited by 87
Sex Differences in the Pharmacokinetics of Antidepressants: Influence of Female Sex Hormones and Oral Contraceptives
Damoiseaux, V. A., Proost, J. H., Jiawan, V. C. R., & Melgert, B. N. (2014) · Clinical Pharmacokinetics · doi:10.1007/s40262-014-0145-2 · Cited by 86
Atrial fibrillation in women: treatment
Ko, D., Rahman, F., Martins, M. A. P., Hylek, E. M., Ellinor, P. T., Schnabel, R. B., Benjamin, E. J., & Christophersen, I. E. (2016) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.171 · Cited by 87
Sex and Adverse Events of Adjuvant Chemotherapy in Colon Cancer: An Analysis of 34 640 Patients in the ACCENT Database
Wagner, D., Grothey, A. F., André, T., Dixon, J. G., Wolmark, N., Haller, D. G., Allegra, C. J., de Gramont, A., Cutsem, E. V., Alberts, S. R., et al. (2020) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djaa124 · Cited by 86
Age and sex in drug development and testing for adults
Tannenbaum, C., & Day, D. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.04.027 · Cited by 87
Visceral Inflammation and Immune Activation Stress the Brain
Holzer, P., Farzi, A., Hassan, A. M., Zenz, G., Jačan, A., & Reichmann, F. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01613 · Cited by 84
Point Prevalence Survey of Antibiotic Use across 13 Hospitals in Uganda
Kiggundu, R., Wittenauer, R., Waswa, J. P., Nakambale, H. N., Kitutu, F. E., Murungi, M., Okuna, N., Seru, M., Lawry, L. L., Joshi, M. P., et al. (2022) · Antibiotics · doi:10.3390/antibiotics11020199 · Cited by 84
Acute citrulline malate supplementation improves upper- and lower-body submaximal weightlifting exercise performance in resistance-trained females
Glenn, J. M., Gray, M., Wethington, L. N., Stone, M. S., Stewart, R. W., & Moyen, N. E. (2017) · European Journal of Nutrition · doi:10.1007/s00394-015-1124-6 · Cited by 83
A Sex- and Gender-Based Analysis of Adverse Drug Reactions: A Scoping Review of Pharmacovigilance Databases
Brabete, A. C., Greaves, L., Maximos, M., Huber, E., Li, A., & Lê, M. (2022) · Pharmaceuticals · doi:10.3390/ph15030298 · Cited by 83
Adverse Drug Reactions to Guideline-Recommended Heart Failure Drugs in Women
Bots, S. H., Groepenhoff, F., Eikendal, A. L. M., Tannenbaum, C., Rochon, P. A., Regitz‐Zagrosek, V., Miller, V. M., Day, D., Asselbergs, F. W., & den Ruijter, H. M. (2019) · JACC Heart Failure · doi:10.1016/j.jchf.2019.01.009 · Cited by 82
European principles of care for women and girls with inherited bleeding disorders
van Galen, K. P. M., Lavin, M., Skouw‐Rasmussen, N., Fischer, K., Noone, D., Pollard, D., Mauser‐Bunschoten, E. P., Khair, K., Gomez, K., van Loon, E., et al. (2021) · Haemophilia · doi:10.1111/hae.14379 · Cited by 82
Gender Differences in Medication Adherence Among Adolescent and Young Adult Kidney Transplant Recipients
Boucquemont, J., Pai, A. L. H., Dharnidharka, V. R., Hébert, D., Furth, S. L., & Foster, B. J. (2018) · Transplantation · doi:10.1097/tp.0000000000002359 · Cited by 82
Clinical trial diversity: An opportunity for improved insight into the determinants of variability in drug response
Gross, A. S., Harry, A., Clifton, C. S., & Pasqua, O. E. D. (2022) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.15242 · Cited by 79
Sarcopenia is a prognostic outcome marker in children with high‐risk hepatoblastoma
Ritz, A., Kolorz, J., Hubertus, J., Ley‐Zaporozhan, J., von Schweinitz, D., Koletzko, S., Häberle, B., Schmid, I., Kappler, R., Berger, M., et al. (2021) · Pediatric Blood & Cancer · doi:10.1002/pbc.28862 · Cited by 78
Sex and Gender Differences in Anticancer Treatment Toxicity: A Call for Revisiting Drug Dosing in Oncology
Özdemir, B. C., Gerard, C. L., & da Silva, C. E. (2022) · Endocrinology · doi:10.1210/endocr/bqac058 · Cited by 83
Hormonal Regulation of Liver Cytochrome P450 Enzymes
Waxman, D. J., & Chang, T. K. H. (2015) · Springer eBooks · doi:10.1007/978-3-319-12108-6_11 · Cited by 78
Sex differences in frailty among older adults
Zeidan, R. S., McElroy, T., Rathor, L., Martenson, M. S., Lin, Y., & Mankowski, R. T. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112333 · Cited by 79
Potential Applications of Chitosan-Based Nanomaterials to Surpass the Gastrointestinal Physiological Obstacles and Enhance the Intestinal Drug Absorption
Pathomthongtaweechai, N., & Muanprasat, C. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13060887 · Cited by 79
Zebrafish as an animal model in epilepsy studies with multichannel EEG recordings
Cho, S., Byun, D., Nam, T., Choi, S., Lee, B., Kim, M.-K., & Kim, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-03482-6 · Cited by 78

Authors: Soldin, O. P., & Mattison, D. R.
Affiliations: National Institutes of Health (US)
Corresponding author: Soldin, Offie P.
ORCID: Soldin, Offie P.
Mattison, Donald R.
Venue: Clinical Pharmacokinetics
Publisher: Springer Science and Business Media LLC
Published: 2009
Volume: 48
Issue: 3
Pages: 143-157
ISSN: 0312-5963 (ISSN-L)
DOI: 10.2165/00003088-200948030-00001
PMC: PMC3644551
OpenAlex: W2017331060
Cited by: 1,163
References: 133
Citations by year: 2026: 111 · 2025: 136 · 2024: 133 · 2023: 127 · 2022: 119 · 2021: 109 · 2020: 95 · 2019: 67 · 2018: 57 · 2017: 53 · 2016: 31 · 2015: 23 · 2014: 24 · 2013: 27 · 2012: 16
FWCI: 2.08
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Clinical Pharmacokinetics (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Center for Research Resources (M01RR023942)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (5U10HD047890-S, U10HD047890)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
Keywords: sex differences, pharmacokinetics, pharmacodynamics, pregnancy, drug absorption, drug distribution, drug metabolism, drug elimination, dosing regimen, therapeutic monitoring, drug safety, drug prescribing
MeSH terms: Biological Availability, Body Weight, Clinical Trials as Topic, Pharmaceutical Preparations, Female, Humans, Male, Menstrual Cycle, Pharmacokinetics, Pharmacology, Pregnancy, Sex Factors, Tissue Distribution, United States, United States Food and Drug Administration, Body Fat Distribution

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Sex Differences in Pharmacokinetics and Pharmacodynamics

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks