The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Transporters and Renal Drug Elimination
Abstract
Carrier-mediated processes, often referred to as transporters, play key roles in the reabsorption and secretion of many endogenous and xenobiotic compounds by the kidney. The renal proximal tubule is the primary site of active transport for a wide variety of substrates, including organic anions/cations, peptides, and nucleosides. During the past decade, significant advances in molecular identification and characterization of transporter proteins have been made. Although it is generally noted that these transporters significantly contribute to renal drug handling and variability in drug disposition, the extent of our knowledge regarding the specific roles of such transporters in drug disposition and drug-drug interactions remains, for the most part, limited. In this review, we summarize recent progress in terms of molecular and functional characterization of renal transporters and their clinical relevance to drug therapy.
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Cites
Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line
Cole, S. P. C., Bhardwaj, G., Gerlach, J. H., Mackie, J. E., Grant, C. E., Almquist, K. C., Stewart, A. J., Kurz, E. U., Duncan, A. M. V., & Deeley, R. G. (1992) · Science · doi:10.1126/science.1360704 · Cited by 3,037
Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter
Gründemann, D., Schechinger, B., Rappold, G., & Schömig, E. (1998) · Nature Neuroscience · doi:10.1038/1557 · Cited by 374
Recent advances in the molecular biology of nucleoside transporters of mammalian cells
Cass, C. E., Young, J. D., & Baldwin, S. A. (1998) · Biochemistry and Cell Biology · doi:10.1139/o98-095 · Cited by 185
β-Lactam Antibiotics as Substrates for OCTN2, an Organic Cation/Carnitine Transporter
Ganapathy, M. E., Huang, W., Rajan, D. P., Carter, A. L., Sugawara, M., Iseki, K., Leibach, F. H., & Ganapathy, V. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.3.1699 · Cited by 175
Cited by
Pharmacokinetics and dosage adjustment in patients with renal dysfunction
Verbeeck, R. K., & Musuamba, F. T. (2009) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-009-0678-8 · Cited by 717
Importance of P-glycoprotein at blood–tissue barriers
Fromm, M. F. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.06.002 · Cited by 592
Mannermaa, E., Vellonen, K.-S., & Urtti, A. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.07.024 · Cited by 349
Huang, J., Xie, C., Zhang, X., Jiang, Y., Li, J., Fan, Q., & Pu, K. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201909560 · Cited by 258
Renal elimination of perfluorocarboxylates (PFCAs)
Han, X., Nabb, D. L., Russell, M. H., Kennedy, G. L., & Rickard, R. W. (2012) · Chemical Research in Toxicology · doi:10.1021/tx200363w · Cited by 250
Metadata
- Authors
- Lee, W., & Kim, R. B.
- Venue
- Annual Review of Pharmacology and Toxicology
- Publisher
- Annual Reviews
- Published
- 2004-02-10
- Volume
- 44
- Issue
- 1
- Pages
- 137-166
- ISSN
- 0362-1642 (ISSN-L)
- 1545-4304
- OpenAlex
- W1853241466
- Cited by
- 222
- References
- 4
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- closed
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