The DOI matches its Crossref record; 102 of the 102 references it cites were found in a registry or an index.
REGULATION OF PLATELET FUNCTIONS BY P2 RECEPTORS
Abstract
▪ Abstract The main role of blood platelets is to ensure primary hemostasis, which is the maintenance of vessel integrity and cessation of bleeding upon injury. While playing a major part in acute arterial thrombosis, platelets are also involved in inflammation, atherosclerosis, and angiogenesis. ADP and ATP play a crucial role in platelet activation, and their receptors are potential targets for antithrombotic drugs. The ATP-gated cation channel P2X 1 and the two G protein–coupled ADP receptors, P2Y 1 and P2Y 12, selectively contribute to platelet aggregation and formation of a thrombus. Owing to its central role in the growth and stabilization of a thrombus, the P2Y 12 receptor is an established target of antithrombotic drugs such as clopidogrel. Studies in P2Y 1 and P2X 1 knockout mice and selective P2Y 1 and P2X 1 antagonists have shown that these receptors are also attractive targets for new antithrombotic compounds. The potential role of platelet P 2 receptors in the involvement of platelets in inflammatory processes is also discussed.
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Cites
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Cited by
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Activation of Platelet Function Through G Protein–Coupled Receptors
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The phenotypic legacy of admixture between modern humans and Neandertals
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“In addition, the first step in ATP hydrolysis leads to the generation of ADP and ADP is a major agonist of platelet recruitment and aggregation (Gachet, 2006).”
Background
Metadata
- Authors
- Gachet, C.
- Venue
- Annual Review of Pharmacology and Toxicology
- Publisher
- Annual Reviews
- Published
- 2006-02-01
- Volume
- 46
- Issue
- 1
- Pages
- 277-300
- ISSN
- 0362-1642 (ISSN-L)
- 1545-4304
- OpenAlex
- W2128978853
- Cited by
- 295
- References
- 102
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gachet, C. (2006). REGULATION OF PLATELET FUNCTIONS BY P2 RECEPTORS. Annual Review of Pharmacology and Toxicology. https://doi.org/10.1146/annurev.pharmtox.46.120604.141207
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
