The DOI matches its Crossref record; 177 of the 177 references it cites were found in a registry or an index.
Transcriptional Control of Mitochondrial Biogenesis and Function
Abstract
Mitochondria play central roles in energy homeostasis, metabolism, signaling, and apoptosis. Accordingly, the abundance, morphology, and functional properties of mitochondria are finely tuned to meet cell-specific energetic, metabolic, and signaling demands. This tuning is largely achieved at the level of transcriptional regulation. A highly interconnected network of transcription factors regulates a broad set of nuclear genes encoding mitochondrial proteins, including those that control replication and transcription of the mitochondrial genome. The same transcriptional network senses cues relaying cellular energy status, nutrient availability, and the physiological state of the organism and enables short- and long-term adaptive responses, resulting in adjustments to mitochondrial function and mitochondrial biogenesis. Mitochondrial dysfunction is associated with many human diseases. Characterization of the transcriptional mechanisms that regulate mitochondrial biogenesis and function can offer insights into possible therapeutic interventions aimed at modulating mitochondrial function.
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1 retracted
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Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
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BackgroundLeptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
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BackgroundInfluential
Cited by
Bhatti, J. S., Bhatti, G. K., & Reddy, P. H. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.11.010 · Cited by 1,655
Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes
Zatterale, F., Longo, M., Naderi, J., Raciti, G. A., Desiderio, A., Miele, C., & Beguinot, F. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2019.01607 · Cited by 1,180
Redox regulation of mitochondrial function
Handy, D. E., & Loscalzo, J. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4123 · Cited by 588
Caielli, S., Athale, S., Domic, B., Murat, E., Chandra, M., Banchereau, R., Baisch, J., Phelps, K., Clayton, S., Gong, M., et al. (2016) · Journal of Experimental Medicine · doi:10.1084/jem.20151876 · Cited by 501
The Protein Import Machinery of Mitochondria—A Regulatory Hub in Metabolism, Stress, and Disease
Harbauer, A. B., Zahedi, R. P., Sickmann, A., Pfanner, N., & Meisinger, C. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.01.010 · Cited by 381
Metadata
- Authors
- Hock, M. B., & Kralli, A.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2009-03-01
- Volume
- 71
- Issue
- 1
- Pages
- 177-203
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2128557475
- Cited by
- 614
- References
- 177
- FWCI
- 2.24
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hock, M. B., & Kralli, A. (2009). Transcriptional Control of Mitochondrial Biogenesis and Function. Annual Review of Physiology. https://doi.org/10.1146/annurev.physiol.010908.163119
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
