The DOI matches its Crossref record; 102 of the 102 references it cites were found in a registry or an index.
SODIUM CHANNELS IN ALVEOLAR EPITHELIAL CELLS: Molecular Characterization, Biophysical Properties, and Physiological Significance
Abstract
▪ Abstract At birth, fetal distal lung epithelial (FDLE) cells switch from active chloride secretion to active sodium (Na+) reabsorption. Sodium ions Senter the FDLE and alveolar type II (ATII) cells mainly through apical nonselective cation and Na+-selective channels, with conductances of 4–26 pS (picoSiemens) in FDLE and 20–25 pS in ATII cells. All these channels are inhibited by amiloride with a 50% inhibitory concentration of <1 μM, and some are also inhibited by [N-ethyl-N-isopropyl]-2′-4′-amiloride (50% inhibitory concentration of <1 μM). Both FDLE and ATII cells contain the α-, β-, and γ-rENaC (rat epithelial Na+ channels) mRNAs; reconstitution of an ATII cell Na+-channel protein into lipid bilayers revealed the presence of 25-pS Na+ single channels, inhibited by amiloride and [N-ethyl-N-isopropyl]-2′-4′-amiloride. A variety of agents, including cAMP, oxygen, glucocorticoids, and in some cases Ca 2+, increased the activity and/or rENaC mRNA levels. The phenotypic properties of these channels differ from those observed in other Na+-absorbing epithelia. Pharmacological blockade of alveolar Na+ transport in vivo, as well as experiments with newborn α-rENaC knock-out mice, demonstrate the importance of active Na+ transport in the reabsorption of fluid from the fetal lung and in reabsorbing alveolar fluid in the injured adult lung. Indeed, in a number of inflammatory diseases, increased production of reactive oxygen-nitrogen intermediates, such as peroxynitrite (ONOO−), may damage ATII and FDLE Na+ channels, decrease Na+ reabsorption in vivo, and thus contribute to the formation of alveolar edema.
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Cites
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Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits
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Pathogenesis of Acute Respiratory Distress Syndrome
Huppert, L., Matthay, M., & Ware, L. (2019) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0039-1683996 · Cited by 459
Dada, L. A., Chandel, N. S., Ridge, K. M., Pedemonte, C., Bertorello, A. M., & Sznajder, J. I. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200316826 · Cited by 314
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Metadata
- Authors
- Matalon, S., & O'Brodovich, H.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 1999-03
- Volume
- 61
- Issue
- 1
- Pages
- 627-661
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2143766390
- Cited by
- 339
- References
- 102
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- closed
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- Matalon, S., & O'Brodovich, H. (1999). SODIUM CHANNELS IN ALVEOLAR EPITHELIAL CELLS: Molecular Characterization, Biophysical Properties, and Physiological Significance. Annual Review of Physiology. https://doi.org/10.1146/annurev.physiol.61.1.627
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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