Cited by 321Developmental Biology and Gene RegulationNeonatal Respiratory Health ResearchRenal and related cancers

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Epithelial-Mesenchymal Interactions in the Developing Lung

Shannon, John M., Hyatt, Brian A.·2004·Annual Review of Physiology

DOI 10.1146/annurev.physiol.66.032102.135749

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Abstract

Classical experiments in embryology have shown that normal growth, morphogenetic patterning, and cellular differentiation in the developing lung depend on interactive signaling between the endodermal epithelium and mesenchyme derived from splanchnic mesoderm. These interactions are mediated by a myriad of diffusible factors that are precisely regulated in their temporal and spatial expression. In this review we first describe factors regulating formation of the embryonic foregut. We then discuss the experiments demonstrating the importance of tissue interactions in lung patterning and differentiation. Finally, we detail the roles that a few key signaling systems-fibroblast growth factors and their receptors, sonic hedgehog and Gli genes, Wnt genes and beta-catenin, and BMP4-play as mediators of epithelial-mesenchymal interactions in the developing lung.

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Authors: Shannon, J. M., & Hyatt, B. A.
Affiliations: Cincinnati Children's Hospital Medical Center (US)
Venue: Annual Review of Physiology
Publisher: Annual Reviews
Published: 2004-03-01
Volume: 66
Issue: 1
Pages: 625-645
ISSN: 0066-4278 (ISSN-L)
1545-1585
DOI: 10.1146/annurev.physiol.66.032102.135749
OpenAlex: W2137075665
Semantic Scholar: 44ca64a235304c55d005355606216882e6b05a45
Cited by: 321
References: 118
Citations by year: 2026: 3 · 2025: 4 · 2024: 4 · 2023: 7 · 2022: 6 · 2021: 11 · 2020: 8 · 2019: 13 · 2018: 4 · 2017: 13 · 2016: 10 · 2015: 17 · 2014: 14 · 2013: 14 · 2012: 23
FWCI: 2.21
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Physiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL071898, P50-HL56387, P50HL056387)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
Health Sciences › Medicine › Oncology › Renal and related cancers
Keywords: epithelial-mesenchymal interactions, lung development, lung morphogenesis, lung differentiation, fibroblast growth factor, Sonic hedgehog, Wnt signaling, β-catenin, BMP4, splanchnic mesoderm, endodermal epithelium, signaling molecules
MeSH terms: Animals, Embryo, Mammalian, Endoderm, Epithelium, Embryonic and Fetal Development, Humans, Lung, Mesoderm

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Epithelial-Mesenchymal Interactions in the Developing Lung

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