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Epithelial-Mesenchymal Interactions in the Developing Lung
Abstract
Classical experiments in embryology have shown that normal growth, morphogenetic patterning, and cellular differentiation in the developing lung depend on interactive signaling between the endodermal epithelium and mesenchyme derived from splanchnic mesoderm. These interactions are mediated by a myriad of diffusible factors that are precisely regulated in their temporal and spatial expression. In this review we first describe factors regulating formation of the embryonic foregut. We then discuss the experiments demonstrating the importance of tissue interactions in lung patterning and differentiation. Finally, we detail the roles that a few key signaling systems-fibroblast growth factors and their receptors, sonic hedgehog and Gli genes, Wnt genes and beta-catenin, and BMP4-play as mediators of epithelial-mesenchymal interactions in the developing lung.
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“During the early developmental stages, epithelial-mesenchymal interactions (EMIs) trigger the development of various tissues and organs through specific signaling pathways and transcription factors.”
From Reprogramming of three-dimensional microenvironments for in vitro hair follicle induction (2022) · cites this paper as [3]
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“For example, EMIs drive stomach specification (1), duct patterning of the kidney (2) and lung (3), and bud formation of the lacrimal gland (4) and teeth (5).”
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Metadata
- Authors
- Shannon, J. M., & Hyatt, B. A.
- Affiliations
- Cincinnati Children's Hospital Medical Center (US)
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2004-03-01
- Volume
- 66
- Issue
- 1
- Pages
- 625-645
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2137075665
- Semantic Scholar
- 44ca64a235304c55d005355606216882e6b05a45
- Cited by
- 321
- References
- 118
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 7 · 2022: 6 · 2021: 11 · 2020: 8 · 2019: 13 · 2018: 4 · 2017: 13 · 2016: 10 · 2015: 17 · 2014: 14 · 2013: 14 · 2012: 23
- FWCI
- 2.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL071898, P50-HL56387, P50HL056387)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
- Health Sciences › Medicine › Oncology › Renal and related cancers
- Keywords
- epithelial-mesenchymal interactions, lung development, lung morphogenesis, lung differentiation, fibroblast growth factor, Sonic hedgehog, Wnt signaling, β-catenin, BMP4, splanchnic mesoderm, endodermal epithelium, signaling molecules
- MeSH terms
- Animals, Embryo, Mammalian, Endoderm, Epithelium, Embryonic and Fetal Development, Humans, Lung, Mesoderm
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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