Understanding circuit dynamics using the stomatogastric nervous system of lobsters and crabs.
Abstract
Studies of the stomatogastric nervous systems of lobsters and crabs have led to numerous insights into the cellular and circuit mechanisms that generate rhythmic motor patterns. The small number of easily identifiable neurons allowed the establishment of connectivity diagrams among the neurons of the stomatogastric ganglion. We now know that (a) neuromodulatory substances reconfigure circuit dynamics by altering synaptic strength and voltage-dependent conductances and (b) individual neurons can switch among different functional circuits. Computational and experimental studies of single-neuron and network homeostatic regulation have provided insight into compensatory mechanisms that can underlie stable network performance. Many of the observations first made using the stomatogastric nervous system can be generalized to other invertebrate and vertebrate circuits.
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Studies of the connectomes of C. elegans and the crustacean stomatogastric ganglion demonstrate that connectivity knowledge constrains, but does not dictate, a particular circuit mechanism.
“Moreover, studies of the connectomes of C. elegans and the crustacean stomatogastric ganglion demonstrate that connectivity knowledge constrains, but does not dictate, a particular circuit mechanism56–58.”
From A Drosophila computational brain model reveals sensorimotor processing (2024) · cites this paper as [56]
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- Authors
- Marder, E., & Bucher, D.
- Affiliations
- Brandeis University (US)
- University of Florida (US)
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2007-03-01
- Volume
- 69
- Issue
- 1
- Pages
- 291-316
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2159254892
- Cited by
- 681
- References
- 1
- Citations by year
- 2026: 22 · 2025: 20 · 2024: 38 · 2023: 23 · 2022: 35 · 2021: 31 · 2020: 26 · 2019: 30 · 2018: 37 · 2017: 38 · 2016: 22 · 2015: 37 · 2014: 50 · 2013: 41 · 2012: 43
- FWCI
- 2.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- stomatogastric ganglion, stomatogastric nervous system, lobster, crabs, rhythmic motor patterns, neuromodulation, synaptic efficacy, voltage-dependent conductance, network dynamics, computational neuroscience
- MeSH terms
- Animals, Brachyura, Homeostasis, Humans, Nephropidae, Nervous System Physiological Phenomena, Pylorus, Stomach, Ganglia, Invertebrate
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