Neuropeptide signaling near and far: how localized and timed is the action of neuropeptides in brain circuits?

Nässel, Dick R.

doi:10.1007/s10158-009-0090-1

Cited by 125Neurobiology and Insect Physiology ResearchNeuropeptides and Animal PhysiologyNeuroscience and Neuropharmacology Research

Neuropeptide signaling near and far: how localized and timed is the action of neuropeptides in brain circuits?

Nässel, Dick R.·2009·Invertebrate Neuroscience

DOI 10.1007/s10158-009-0090-1

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Abstract

Neuropeptide signaling is functionally very diverse and one and the same neuropeptide may act as a circulating neurohormone, as a locally released neuromodulator or even as a cotransmitter of classical fast-acting neurotransmitters. Thus, neuropeptides are produced by a huge variety of neuron types in different parts of the nervous system. Within the central nervous system (CNS) there are numerous types of peptidergic interneurons, some with strictly localized and patterned branching morphologies, others with widespread and diffuse arborizations. From morphology alone it is often difficult to predict the sphere of influence of a peptidergic interneuron, especially since it has been shown that neuropeptides can diffuse over tens of micrometers within neuropils, and that peptides probably are released exclusively in perisynaptic (or non-synaptic) regions. This review addresses some questions related to peptidergic signaling in the insect CNS. How diverse are the spatial relations between peptidergic neurons and their target neurons and what determines the sphere of functional influence? At one extreme there is volume transmission and at the other targeted cotransmission at synapses. Also temporal aspects of peptidergic signaling are of interest: how transient are peptidergic messages? Factors important for these spatial and temporal aspects of peptidergic signaling are proximity between release sites and cognate receptors, distribution of peptidase activity that can terminate peptide action and colocalization of other neuroactive compounds in the presynaptic peptidergic neuron (and corresponding receptors in target neurons). Other factors such as expression of different channel types, receptor inactivation mechanisms and second messenger systems probably also contribute to the diversity in temporal properties of peptide signaling.

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Secreted neuropeptides are thought to persist long enough (e.g., minutes) in brain interstitial spaces for diffusion to very-high-affinity NP-GPCRs hundreds of micrometers distant from release sites.
“secreted neuropeptides are thought to persist long enough (e.g., minutes) in brain interstitial spaces for diffusion to very-high-affinity NP-GPCRs hundreds of micrometers distant from release sites”
From Single-cell transcriptomic evidence for dense intracortical neuropeptide networks (2019) · cites this paper as Nässel, 2009

Atlas of an Insect Brain
Strausfeld, N. (1976) · Springer Berlin Heidelberg · doi:10.1007/978-3-642-66179-2 · Cited by 1,178 · see citing works
Ablation of Insulin-Producing Neurons in Flies: Growth and Diabetic Phenotypes
Rulifson, E. J., Kim, S. K., & Nusse, R. (2002) · Science · doi:10.1126/science.1070058 · Cited by 1,064 · see citing works
Tools for neuroanatomy and neurogenetics in Drosophila
Pfeiffer, B. D., Jenett, A., Hammonds, A. S., Ngo, T.-T. B., Misra, S., Murphy, C., Scully, A. L., Carlson, J. W., Wan, K. H., Laverty, T., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803697105 · Cited by 974 · see citing works
Atlas of an insect brain
Strausfeld, N. J. (1976) · Medical Entomology and Zoology · Cited by 967 · see citing works
Molecular, Anatomical, and Functional Organization of the Drosophila Olfactory System
Couto, A., Alenius, M., & Dickson, B. J. (2005) · Current Biology · doi:10.1016/j.cub.2005.07.034 · Cited by 967 · see citing works
Dendritic peptide release and peptide-dependent behaviours
Ludwig, M., & Leng, G. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1845 · Cited by 945 · see citing works
Molecular Architecture of Smell and Taste in Drosophila
Vosshall, L. B., & Stocker, R. F. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094306 · Cited by 860 · see citing works
Genetic Dissection of Neural Circuits
Luo, L., Callaway, E. M., & Svoboda, K. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.002 · Cited by 754 · see citing works
Understanding circuit dynamics using the stomatogastric nervous system of lobsters and crabs.
Marder, E., & Bucher, D. (2007) · Annual Review of Physiology · doi:10.1146/annurev.physiol.69.031905.161516 · Cited by 681 · see citing works
Hemolymph Sugar Homeostasis and Starvation-Induced Hyperactivity Affected by Genetic Manipulations of the Adipokinetic Hormone-Encoding Gene in Drosophila melanogaster
Lee, G., & Park, J. H. (2004) · Genetics · doi:10.1534/genetics.167.1.311 · Cited by 621 · see citing works
Genetic and Functional Subdivision of the Drosophila Antennal Lobe
Fishilevich, E., & Vosshall, L. B. (2005) · Current Biology · doi:10.1016/j.cub.2005.07.066 · Cited by 608 · see citing works
A receptor that mediates the post-mating switch in Drosophila reproductive behaviour
Yapici, N., Kim, Y., Ribeiro, C., & Dickson, B. J. (2007) · Nature · doi:10.1038/nature06483 · Cited by 590 · see citing works
Remote Control of Behavior through Genetically Targeted Photostimulation of Neurons
Lima, S. Q., & Miesenböck, G. (2005) · Cell · doi:10.1016/j.cell.2005.02.004 · Cited by 562 · see citing works
Neuropeptides and Neuropeptide Receptors in the Drosophila melanogaster GenomePreprint
Hewes, R. S., & Taghert, P. H. (2001) · Genome Research · doi:10.1101/gr.169901 · Cited by 541 · see citing works
Differential regulation of circadian pacemaker output by separate clock genes in Drosophila
Park, J. H., Helfrich‐Förster, C., Lee, G., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3608 · Cited by 533 · see citing works
Mismatches between neurotransmitter and receptor localizations in brain: observations and implications
Herkenham, M. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90268-5 · Cited by 520 · see citing works
Neuropeptides in the nervous system of Drosophila and other insects: multiple roles as neuromodulators and neurohormones
Nässel, D. R. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00057-6 · Cited by 482 · see citing works
Self-citation
Neuronal assemblies of the <i>Drosophila</i> mushroom body
Tanaka, N. K., Tanimoto, H., & Ito, K. (2008) · Journal of Comparative Neurology · doi:10.1002/cne.21692 · Cited by 470 · see citing works
Developmental Control of Foraging and Social Behavior by the Drosophila Neuropeptide Y-like System
Wu, Q., Wen, T., Lee, G., Park, J. H., Cai, H. N., & Shen, P. (2003) · Neuron · doi:10.1016/s0896-6273(03)00396-9 · Cited by 432 · see citing works
Peptidergic transmission in sympathetic ganglia of the frog.
Jan, L. Y., & Jan, Y. N. (1982) · The Journal of Physiology · doi:10.1113/jphysiol.1982.sp014228 · Cited by 390 · see citing works
Select Drosophila glomeruli mediate innate olfactory attraction and aversion
Semmelhack, J. L., & Wang, J. W. (2009) · Nature · doi:10.1038/nature07983 · Cited by 360 · see citing works
A Presynaptic Gain Control Mechanism Fine-Tunes Olfactory Behavior
Root, C. M., Masuyama, K., Green, D. S., Enell, L. E., Nässel, D. R., Lee, C., & Wang, J. W. (2008) · Neuron · doi:10.1016/j.neuron.2008.07.003 · Cited by 352 · see citing works
Self-citation
Neuronal architecture of the central complex in Drosophila melanogaster
Hanesch, U., Fischbach, K., & Heisenberg, M. (2004) · Cell and Tissue Research · doi:10.1007/bf00261838 · Cited by 349 · see citing works
The roles of co-transmission in neural network modulation
Nusbaum, M. P. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01723-9 · Cited by 343 · see citing works
The Organization of Extrinsic Neurons and Their Implications in the Functional Roles of the Mushroom Bodies inDrosophila melanogasterMeigenPreprint
Ito, K., Suzuki, K., Estes, P. S., Ramaswami, M., Yamamoto, D., & Strausfeld, N. J. (1998) · Learning & Memory · doi:10.1101/lm.5.1.52 · Cited by 337 · see citing works
PDF Receptor Signaling in Drosophila Contributes to Both Circadian and Geotactic Behaviors
Mertens, I., Vandingenen, A., Johnson, E. C., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.009 · Cited by 336 · see citing works
Coexistence of peptides with classical neurotransmitters
Hökfelt, T. G. M., Millhorn, D. E., Seroogy, K. B., Tsuruo, Y., Ceccatelli, S., Lindh, B., Meister, B., Melander, T., Schalling, M., Bartfai, T., et al. (1987) · Cellular and Molecular Life Sciences · doi:10.1007/bf01945354 · Cited by 332 · see citing works
Serotonin and neuropeptide F have opposite modulatory effects on fly aggression
Dierick, H. A., & Greenspan, R. J. (2007) · Nature Genetics · doi:10.1038/ng2029 · Cited by 332 · see citing works
Neuropeptides and their precursors in the fruitfly, Drosophila melanogaster☆
Broeck, J. V. (2001) · Peptides · doi:10.1016/s0196-9781(00)00376-4 · Cited by 321 · see citing works
Widespread Receptivity to Neuropeptide PDF throughout the Neuronal Circadian Clock Network of Drosophila Revealed by Real-Time Cyclic AMP Imaging
Shafer, O. T., Kim, D. J., Dunbar‐Yaffe, R., Nikolaev, V. O., Lohse, M. J., & Taghert, P. H. (2008) · Neuron · doi:10.1016/j.neuron.2008.02.018 · Cited by 319 · see citing works
A review of neurohormone GPCRs present in the fruitfly Drosophila melanogaster and the honey bee Apis mellifera
Hauser, F., Cazzamali, G., Williamson, M. P., Blenau, W., & Grimmelikhuijzen, C. J. P. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.07.005 · Cited by 302 · see citing works
Organization of the Drosophila Circadian Control Circuit
Nitabach, M. N., & Taghert, P. H. (2008) · Current Biology · doi:10.1016/j.cub.2007.11.061 · Cited by 285 · see citing works
Drosophila GPCR Han Is a Receptor for the Circadian Clock Neuropeptide PDF
Hyun, S., Lee, Y., Hong, S.-T., Bang, S., Paik, D., Kang, J., Shin, J., Lee, J., Jeon, K., Hwang, S., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.08.025 · Cited by 280 · see citing works
Regulation of aversion to noxious food by Drosophila neuropeptide Y– and insulin-like systems
Wu, Q., Zhao, Z., & Shen, P. (2005) · Nature Neuroscience · doi:10.1038/nn1540 · Cited by 279 · see citing works
Peptidomics of the Larval Drosophila melanogasterCentral Nervous System
Baggerman, G., Cerstiaens, A., LOOF, A. D., & Schoofs, L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206257200 · Cited by 265 · see citing works
A novel diuretic hormone receptor inDrosophila: evidence for conservation of CGRP signaling
Johnson, E. C., Shafer, O. T., Trigg, J. S., Park, J. H., Schooley, D. A., Dow, J. A. T., & Taghert, P. H. (2005) · Journal of Experimental Biology · doi:10.1242/jeb.01529 · Cited by 254 · see citing works
Serotonin and serotonin-immunoreactive neurons in the nervous system of insects
Nässel, D. R. (1988) · Progress in Neurobiology · doi:10.1016/0301-0082(88)90002-0 · Cited by 244 · see citing works
Self-citation
Living synaptic vesicle marker: Synaptotagmin‐GFP
Zhang, Y., Rodesch, C. K., & Broadie, K. S. (2002) · genesis · doi:10.1002/gene.10144 · Cited by 239 · see citing works
The Extraretinal Eyelet ofDrosophila: Development, Ultrastructure, and Putative Circadian Function
Helfrich‐Förster, C., Edwards, T. N., Yasuyama, K., Wisotzki, B., Schneuwly, S., Stanewsky, R., Meinertzhagen, I. A., & Hofbauer, A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-21-09255.2002 · Cited by 230 · see citing works
Development and morphology of the clock‐gene‐expressing lateral neurons of Drosophila melanogaster
Helfrich‐Förster, C., Shafer, O. T., Wülbeck, C., Grieshaber, E., Rieger, D., & Taghert, P. H. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.21146 · Cited by 229 · see citing works
A Command Chemical Triggers an Innate Behavior by Sequential Activation of Multiple Peptidergic Ensembles
Kim, Y., Žitňan, D., Galizia, C. G., Cho, K.-H., & Adams, M. E. (2006) · Current Biology · doi:10.1016/j.cub.2006.06.027 · Cited by 228 · see citing works
Peptide Cotransmitter at a Neuromuscular Junction
Adams, M. E., & O’Shea, M. (1983) · Science · doi:10.1126/science.6134339 · Cited by 224 · see citing works
Disruption of a Behavioral Sequence by Targeted Death of Peptidergic Neurons in Drosophila
McNabb, S. L., Baker, J. D., Agapite, J., et al. (1997) · Neuron · doi:10.1016/s0896-6273(00)80963-0 · Cited by 206 · see citing works
Pigment‐dispersing hormone‐immunoreactive neurons in the nervous system of wild‐type Drosophila melanogaster and of several mutants with altered circadian rhythmicity
Helfrich‐Förster, C., & Homberg, U. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903370202 · Cited by 206 · see citing works
Peptidergic clock neurons in Drosophila: Ion transport peptide and short neuropeptide F in subsets of dorsal and ventral lateral neurons
Johard, H. A. D., Yoishii, T., Dircksen, H., Cusumano, P., Rouyer, F., Helfrich‐Förster, C., & Nässel, D. R. (2009) · The Journal of Comparative Neurology · doi:10.1002/cne.22099 · Cited by 205 · see citing works
Self-citation
Mapping Peptidergic Cells in Drosophila: Where DIMM Fits In
Park, D., Veenstra, J. A., Park, J. H., & Taghert, P. H. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001896 · Cited by 204 · see citing works
Neuropeptides in interneurons of the insect brain
Nässel, D. R., & Homberg, U. (2006) · Cell and Tissue Research · doi:10.1007/s00441-006-0210-8 · Cited by 201 · see citing works
Self-citation
Drosophila neuropeptide F and its receptor, NPFR1, define a signaling pathway that acutely modulates alcohol sensitivity
Wen, T., Parrish, C. A., Xu, D., Wu, Q., & Shen, P. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406814102 · Cited by 197 · see citing works
The neuropeptide SIFamide modulates sexual behavior in Drosophila
Terhzaz, S., Rosay, P., Goodwin, S. F., & Veenstra, J. A. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.11.030 · Cited by 194 · see citing works
Reevaluation ofDrosophila melanogaster's neuronal circadian pacemakers reveals new neuronal classes
Shafer, O. T., Helfrich‐Förster, C., Renn, S. C. P., & Taghert, P. H. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.21021 · Cited by 194 · see citing works
Presynaptic peptidergic modulation of olfactory receptor neurons in Drosophila
Ignell, R., Root, C. M., Birse, R. T., Wang, J. W., Nässel, D. R., & Winther, Å. M. E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813004106 · Cited by 193 · see citing works
Self-citation
Neuropeptides as synaptic transmitters
Salio, C., Lossi, L., Ferrini, F., & Merighi, A. (2006) · Cell and Tissue Research · doi:10.1007/s00441-006-0268-3 · Cited by 181 · see citing works
A large population of diverse neurons in the Drosophilacentral nervous system expresses short neuropeptide F, suggesting multiple distributed peptide functions
Nässel, D. R., Enell, L. E., Santos, J. G., Wegener, C., & Johard, H. A. D. (2008) · BMC Neuroscience · doi:10.1186/1471-2202-9-90 · Cited by 179 · see citing works
Self-citation
Systematic G-protein-coupled Receptor Analysis inDrosophila melanogaster Identifies a Leucokinin Receptor with Novel Roles
Radford, J. C., Davies, S. A., & Dow, J. A. T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203694200 · Cited by 177 · see citing works
Neuropeptides in the insect brain: a review
N�ssel, D. R. (1993) · Cell and Tissue Research · doi:10.1007/bf00304608 · Cited by 175 · see citing works
Self-citation
Localization of an insulin-like peptide in brains of two flies
Cao, C., & Brown, M. R. (2001) · Cell and Tissue Research · doi:10.1007/s004410100367 · Cited by 172 · see citing works
Peptidomics of CNS‐associated neurohemal systems of adult Drosophila melanogaster: A mass spectrometric survey of peptides from individual flies
Predel, R., Wegener, C., Russell, W. K., Tichy, S. E., Russell, D. H., & Nachman, R. J. (2004) · The Journal of Comparative Neurology · doi:10.1002/cne.20145 · Cited by 171 · see citing works
Transmembrane/Juxtamembrane Domain-Dependent Dscam Distribution and Function during Mushroom Body Neuronal Morphogenesis
Wang, J., Ma, X., Yang, J. S., Zheng, X., Zugates, C. T., Lee, C.-H. J., & Lee, T. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.033 · Cited by 168 · see citing works
Peptidomic analysis of the larval Drosophila melanogaster central nervous system by two‐dimensional capillary liquid chromatography quadrupole time‐of‐flight mass spectrometry
Baggerman, G., Boonen, K., Verleyen, P., LOOF, A. D., & Schoofs, L. (2005) · Journal of Mass Spectrometry · doi:10.1002/jms.744 · Cited by 160 · see citing works
Costorage and coexistence of neuropeptides in the mammalian CNS
Merighi, A. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(01)00031-4 · Cited by 158 · see citing works
Neuroarchitecture of the central complex of the desert locust: Intrinsic and columnar neurons
Heinze, S., & Homberg, U. (2008) · The Journal of Comparative Neurology · doi:10.1002/cne.21842 · Cited by 158 · see citing works
The mushroom bodies of Drosophila melanogaster: An immunocytological and golgi study of Kenyon cell organization in the calyces and lobes
Strausfeld, N. J., Sinakevitch, I. G., & Vilinsky, I. (2003) · Microscopy Research and Technique · doi:10.1002/jemt.10368 · Cited by 155 · see citing works
Neurotransmitters and neuropeptides in the brain of the locust
Homberg, U. (2002) · Microscopy Research and Technique · doi:10.1002/jemt.10024 · Cited by 148 · see citing works
Cracking neural circuits in a tiny brain: new approaches for understanding the neural circuitry of Drosophila
Olsen, S. R., & Wilson, R. I. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.07.006 · Cited by 138 · see citing works
Peptidergic transmission: From morphological correlates to functional implications
Zupanc, G. K. H. (1996) · Micron · doi:10.1016/0968-4328(95)00028-3 · Cited by 135 · see citing works
Circadian rhythms in light-evoked responses of the fly's compound eye, and the effects of neuromodulators 5-HT and the peptide PDF
Chen, B., Shaw, S. R., & Meinertzhagen, I. A. (1999) · Journal of Comparative Physiology A · doi:10.1007/s003590050400 · Cited by 132 · see citing works
Neural Lineages of theDrosophilaBrain: A Three-Dimensional Digital Atlas of the Pattern of Lineage Location and Projection at the Late Larval Stage
Pereanu, W., & Hartenstein, V. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4708-05.2006 · Cited by 125 · see citing works
Tachykinin-related peptides modulate odor perception and locomotor activity in Drosophila
Winther, Å. M. E., Acebes, Á., & Ferrús, A. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.10.010 · Cited by 124 · see citing works
Synaptic Localization and Restricted Diffusion of aDrosophilaNeuronal Synaptobrevin - Green Fluorescent Protein Chimerain Vivo
Estes, P. S., Ho, G. L. Y., Narayanan, R., & Ramaswami, M. (2000) · Journal of Neurogenetics · doi:10.3109/01677060009084496 · Cited by 123 · see citing works
Pigment‐dispersing hormone‐like peptide in the nervous system of the flies Phormia and Drosophila: Immunocytochemistry and partial characterization
Nässel, D. R., Shiga, S., Mohrherr, C. J., et al. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903310204 · Cited by 123 · see citing works
Self-citation
Glutamate, GABA and Acetylcholine Signaling Components in the Lamina of the Drosophila Visual System
Kołodziejczyk, A. M., Sun, X., Meinertzhagen, I. A., & Nässel, D. R. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002110 · Cited by 121 · see citing works
Self-citation
Intrinsic neurons of <i>Drosophila</i> mushroom bodies express short neuropeptide F: Relations to extrinsic neurons expressing different neurotransmitters
Johard, H. A. D., Enell, L. E., Gustafsson, E., Trifilieff, P., Veenstra, J. A., & Nässel, D. R. (2008) · Journal of Comparative Neurology · doi:10.1002/cne.21636 · Cited by 120 · see citing works
Self-citation
γ‐Aminobutyric acid (GABA) signaling components in Drosophila: Immunocytochemical localization of GABAB receptors in relation to the GABAA receptor subunit RDL and a vesicular GABA transporter
Enell, L. E., Hamasaka, Y., Kołodziejczyk, A. M., & Nässel, D. R. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21472 · Cited by 112 · see citing works
Self-citation
Direct mass spectrometric peptide profiling and fragmentation of larval peptide hormone release sites in Drosophila melanogaster reveals tagma‐specific peptide expression and differential processing
Wegener, C., Reinl, T., Jänsch, L., & Predel, R. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03634.x · Cited by 109 · see citing works
Release of Peptide Cotransmitters inAplysia: Regulation and Functional Implications
Vilim, F. S., Cropper, E. C., Price, D. A., et al. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-24-08105.1996 · Cited by 105 · see citing works
The Neuropeptide PDF Acts Directly on Evening Pacemaker Neurons to Regulate Multiple Features of Circadian Behavior
Lear, B. C., Zhang, L., & Allada, R. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000154 · Cited by 105 · see citing works
Neuroarchitecture of Aminergic Systems in the Larval Ventral Ganglion of Drosophila melanogaster
Vömel, M., & Wegener, C. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001848 · Cited by 103 · see citing works
SIFamide is a highly conserved neuropeptide: a comparative study in different insect species
Verleyen, P., Huybrechts, J., Baggerman, G., Lommel, A. V., LOOF, A. D., & Schoofs, L. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.05.173 · Cited by 103 · see citing works
Functional characterization of a neuropeptide F‐like receptor from Drosophila melanogaster
Feng, G., Reale, V., Chatwin, H. M., Kennedy, K., Venard, R., Ericsson, C., Yu, K., Evans, P. D., & Hall, L. M. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02719.x · Cited by 101 · see citing works
Immunocytochemical localization of Diploptera punctata allatostatin‐like peptide in Drosophila melanogaster
Yoon, J. G., & Stay, B. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903630310 · Cited by 100 · see citing works
Widely distributedDrosophila G-protein-coupled receptor (CG7887) is activated by endogenous tachykinin-related peptides
Birse, R. T., Johnson, E. C., Taghert, P. H., & Nässel, D. R. (2005) · Journal of Neurobiology · doi:10.1002/neu.20189 · Cited by 100 · see citing works
Self-citation
Neurotransmitters regulate rhythmic size changes amongst cells in the fly's optic lobe
Pyza, E., & Meinertzhagen, I. A. (1996) · Journal of Comparative Physiology A · doi:10.1007/bf00189588 · Cited by 93 · see citing works
Analyzing the functional consequences of transmitter complexity
Březina, V. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01120-x · Cited by 93 · see citing works
Neurotransmitters and neuromodulators in the insect visual system
Nässel, D. R. (1991) · Progress in Neurobiology · doi:10.1016/0301-0082(91)90027-x · Cited by 90 · see citing works
Self-citation
Neuropeptide proctolin associated with an identified skeletal motoneuron
O’Shea, M., & BISHOP, C. A. (1982) · Journal of Neuroscience · doi:10.1523/jneurosci.02-09-01242.1982 · Cited by 89 · see citing works
Are dendrites in Drosophila homologous to vertebrate dendrites?
Sánchez‐Soriano, N., Bottenberg, W., Fiala, A., Haessler, U., Kerassoviti, A., Knust, E., Löhr, R., & Prokop, A. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.09.026 · Cited by 88 · see citing works
Differential Receptor Activation by Cockroach Adipokinetic Hormones Produces Differential Effects on Ion Currents, Neuronal Activity, and Locomotion
Wicher, D., Agricola, H., Söhler, S., et al. (2005) · Journal of Neurophysiology · doi:10.1152/jn.01007.2005 · Cited by 87 · see citing works
Costorage and Corelease of Modulatory Peptide Cotransmitters with Partially Antagonistic Actions on the Accessory Radula Closer Muscle ofAplysia californica
Vilim, F. S., Price, D. A., Lesser, W., et al. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-24-08092.1996 · Cited by 86 · see citing works
Isolation, characterization and expression of the eclosion hormone gene of Drosophila melanogaster
Horodyski, F. M., Ewer, J., Riddiford, L. M., et al. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb18026.x · Cited by 83 · see citing works
Neuronal expression of tachykinin‐related peptides and gene transcript during postembryonic development of Drosophila
Winther, Å. M. E., Siviter, R. J., Isaac, R. E., Predel, R., & Nässel, D. R. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10790 · Cited by 83 · see citing works
Self-citation
Characterization and distribution of NKD, a receptor for Drosophila tachykinin-related peptide 6
Poels, J., Birse, R. T., Nachman, R. J., Fichna, J., Janecka, A. E., Broeck, J. V., & Nässel, D. R. (2008) · Peptides · doi:10.1016/j.peptides.2008.10.012 · Cited by 83 · see citing works
Self-citation
Identification and characterization of a G protein-coupled receptor for the neuropeptide proctolin in Drosophila melanogaster
Johnson, E. C., Garczynski, S. F., Park, D., CRIM, J. W., Nässel, D. R., & Taghert, P. H. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1030108100 · Cited by 80 · see citing works
Self-citation
Coexistence of neuroactive substances in neurons
(1985) · General and Comparative Endocrinology · doi:10.1016/0016-6480(85)90435-6 · Cited by 77 · see citing works
Mapping of serotonin, dopamine, and histamine in relation to different clock neurons in the brain of Drosophila
Hamasaka, Y., & Nässel, D. R. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20807 · Cited by 77 · see citing works
Self-citation
Immunocytochemical mapping of a C-terminus anti-peptide antibody to the GABA receptor subunit, RDL in the nervous system of Drosophila melanogaster
Harrison, J. B., Chen, H. H., Sattelle, E., Barker, P. J., Huskisson, N. S., Rauh, J. J., Bai, D., & Sattelle, D. B. (1996) · Cell and Tissue Research · doi:10.1007/s004410050587 · Cited by 76 · see citing works
Molecular evolution of neuropeptides in the genus Drosophila
Wegener, C., & Gorbashov, A. (2008) · Genome biology · doi:10.1186/gb-2008-9-8-r131 · Cited by 76 · see citing works
Neurochemical fine tuning of a peripheral tissue: peptidergic and aminergic regulation of fluid secretion by Malpighian tubules in the tobacco hawkmothM. sexta
Skaer, N., Nässel, D. R., Maddrell, S. H. P., et al. (2002) · Journal of Experimental Biology · doi:10.1242/jeb.205.13.1869 · Cited by 75 · see citing works
Self-citation
Divergent co‐transmitter actions underlie motor pattern activation by a modulatory projection neuron
Stein, W., DeLong, N. D., Wood, D. E., & Nusbaum, M. P. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05744.x · Cited by 74 · see citing works
Taurine‐, aspartate‐ and glutamate‐like immunoreactivity identifies chemically distinct subdivisions of Kenyon cells in the cockroach mushroom body
Sinakevitch, I. G., Farris, S. M., & Strausfeld, N. J. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1355 · Cited by 73 · see citing works
Neuroarchitecture of Peptidergic Systems in the Larval Ventral Ganglion of Drosophila melanogaster
Santos, J. G., Vömel, M., Struck, R., Homberg, U., Nässel, D. R., & Wegener, C. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000695 · Cited by 72 · see citing works
Self-citation
Coexistence of Neuroactive Substances in Neurons
Fuxé, K. (1985) · Neurochemistry International · doi:10.1016/0197-0186(85)90132-9 · Cited by 68 · see citing works
Immunohistochemical localization of a ligand‐binding and a structural subunit of nicotinic acetylcholine receptors in the central nervous system of Drosophila melanogaster
Schuster, R., Phannavong, B., Schröder, C., & Gundelfinger, E. D. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903350202 · Cited by 64 · see citing works
Neuropeptidases and the metabolic inactivation of insect neuropeptides
Isaac, R. E., Bland, N. D., & Shirras, A. D. (2008) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2008.12.011 · Cited by 64 · see citing works
Targeting of Peptidergic Vesicles in Cotransmitting Terminals
Karhunen, T., Vilim, F. S., Alexeeva, V., Weiss, K. R., & Church, P. J. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-03-j0005.2001 · Cited by 60 · see citing works
A novel peptide-processing activity of insect peptidyl-dipeptidase A (angiotensin I-converting enzyme): the hydrolysis of lysyl-arginine and arginyl-arginine from the C-terminus of an insect prohormone peptide
Isaac, R. E., Schoofs, L., Williams, T. A., et al. (1998) · Biochemical Journal · doi:10.1042/bj3300061 · Cited by 58 · see citing works
Identification of a proctolin preprohormone gene ( Proct ) of Drosophila melanogaster : Expression and predicted prohormone processing
Taylor, C. A., Winther, Å. M. E., Siviter, R. J., Shirras, A. D., Isaac, R. E., & Nässel, D. R. (2004) · Journal of Neurobiology · doi:10.1002/neu.10301 · Cited by 58 · see citing works
Self-citation
Neuroactive Substances in the Antennal Lobe
Homberg, U., & Müller, U. (1999) · Springer eBooks · doi:10.1007/978-3-662-07911-9_8 · Cited by 56 · see citing works
Analysis of Neuropeptide Expression and Localization in Adult Drosophila melanogaster Central Nervous System by Affinity Cell-Capture Mass Spectrometry
Yew, J. Y., Wang, Y., Barteneva, N. S., Dikler, S., Kutz‐Naber, K. K., Li, L., & Kravitz, E. A. (2009) · Journal of Proteome Research · doi:10.1021/pr800601x · Cited by 55 · see citing works
Tachykinin-Related Peptide and GABA-Mediated Presynaptic Inhibition of Crayfish Photoreceptors
Glantz, R. M., Miller, C. S., & Nässel, D. R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-05-01780.2000 · Cited by 53 · see citing works
Self-citation
Invertebrate neuropeptides and hormones: basic knowledge and recent advances.
Satake, H. (2006) · Cited by 52 · see citing works
Immunocytochemical distribution of angiotensin I-converting enzyme-like immunoreactivity in the brain and testis of insects
Schoofs, L., Veelaert, D., LOOF, A. D., et al. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01398-x · Cited by 52 · see citing works
Coexistence and corelease of cholinergic and peptidergic transmitters in frog sympathetic ganglia.
Jan, Y. N., & Jan, L. Y. (1983) · PubMed · Cited by 44 · see citing works
Regulating Peptidergic Modulation of Rhythmically Active Neural Circuits
Nusbaum, M. P. (2002) · Brain Behavior and Evolution · doi:10.1159/000067791 · Cited by 43 · see citing works
Neurotransmitter regulation of circadian structural changes in the fly's visual system
Meinertzhagen, I. A., & Pyza, E. (1999) · Microscopy Research and Technique · doi:10.1002/(sici)1097-0029(19990415)45:2 · Cited by 42 · see citing works
Expression of the ligand‐binding nicotinic acetylcholine receptor subunit Dα2 in the Drosophila central nervous system
Jonas, P., Phannavong, B., Schuster, R., Schröder, C., & Gundelfinger, E. D. (1994) · Journal of Neurobiology · doi:10.1002/neu.480251203 · Cited by 38 · see citing works
Morphological characterization of single fan-shaped body neurons in Drosophila melanogaster
Li, W., Pan, Y., Wang, Z., Gong, H., Gong, Z., & Liu, L. (2009) · Cell and Tissue Research · doi:10.1007/s00441-009-0781-2 · Cited by 38 · see citing works
Conserved roles for peptidases in the processing of invertebrate neuropeptides
Isaac, R. E., Siviter, R. J., Stancombe, P., et al. (2000) · Biochemical Society Transactions · doi:10.1042/bst0280460 · Cited by 35 · see citing works
Extracellular Peptidase Activity Tunes Motor Pattern Modulation
Wood, D. E., & Nusbaum, M. P. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-10-04185.2002 · Cited by 35 · see citing works
Neuropeptide degradation produces functional inactivation in the crustacean nervous system
Coleman, M., Konstant, P., Rothman, B., et al. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-10-06205.1994 · Cited by 33 · see citing works
Development and steroid regulation of RFamide immunoreactivity in antennal-lobe neurons of the sphinx mothManduca sexta
Schachtner, J., Trosowski, B., D’Hanis, W., et al. (2004) · Journal of Experimental Biology · doi:10.1242/jeb.01036 · Cited by 33 · see citing works
Locomotor and geotactic behavior of Drosophila melanogaster over-expressing neprilysin 2
Bland, N. D., Robinson, P. J., Thomas, J. E., et al. (2008) · Peptides · doi:10.1016/j.peptides.2008.10.020 · Cited by 32 · see citing works
Functional division of intrinsic neurons in the mushroom bodies of male Spodoptera littoralis revealed by antibodies against aspartate, taurine, FMRF-amide, Mas-allatotropin and DC0
Sjöholm, M., Sinakevitch, I., Strausfeld, N. J., et al. (2006) · Arthropod Structure & Development · doi:10.1016/j.asd.2006.03.001 · Cited by 30 · see citing works
Parasynaptic signalling by fast neurotransmitters: the cerebellar cortex
Szapiro, G., & Barbour, B. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.03.077 · Cited by 29 · see citing works
Direct peptide profiling of lateral cell groups of the antennal lobes of Manduca sexta reveals specific composition and changes in neuropeptide expression during development
Utz, S., Huetteroth, W., Wegener, C., Kahnt, J., Predel, R., & Schachtner, J. (2007) · Developmental Neurobiology · doi:10.1002/dneu.20381 · Cited by 28 · see citing works
A putative tachykinin receptor in the cockroach brain: molecular cloning and analysis of expression by means of antisera to portions of the receptor protein
Johard, H. A. D., Muren, J. E., Nichols, R., Larhammar, D., & Nässel, D. R. (2001) · Brain Research · doi:10.1016/s0006-8993(01)03004-9 · Cited by 27 · see citing works
Self-citation
Presynaptic target of Ca2+ action on neuropeptide and acetylcholine release in Aplysia californica
Ohnuma, K., Whim, M. D., Fetter, R. D., et al. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.00647.x · Cited by 27 · see citing works
Glial investment of the adult and developing antennal lobe of Drosophila
Oland, L. A., Biebelhausen, J. P., & Tolbert, L. P. (2008) · The Journal of Comparative Neurology · doi:10.1002/cne.21762 · Cited by 25 · see citing works
Metabolic inactivation of the circadian transmitter, pigment dispersing factor (PDF), by neprilysin-like peptidases in Drosophila
Isaac, R. E., Johnson, E. C., Audsley, N., et al. (2007) · Journal of Experimental Biology · doi:10.1242/jeb.012088 · Cited by 24 · see citing works
Localization in the Nervous System of Drosophila Melanogaster of a C‐Terminus Anti‐Peptide Antibody to a Cloned Drosophila Muscarinic Acetylcholine Receptor
Harrison, J. B., Chen, H. H., Blake, A. D., et al. (1995) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1995.tb00768.x · Cited by 23 · see citing works
Identification and localization of a neprilysin‐like activity that degrades tachykinin‐related peptides in the brain of the cockroach, Leucophaea maderae, and locust, Locusta migratoria
Isaac, R. E., & Nässel, D. R. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10561 · Cited by 18 · see citing works
Self-citation
Precocious development of parvalbumin-like immunoreactive interneurons in the hippocampal formation and entorhinal cortex of the fetal cynomolgus monkey
Berger, B., Grissac, N. D., & Alvarez, C. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19990118)403:3 · Cited by 16 · see citing works
Post-genomic approaches to resolve neuropeptide signaling in Drosophila.
Johnson, E. C., & Satake, H. (2006) · Cited by 14 · see citing works
Global and local modulatory supply to the mushroom bodies of the moth Spodoptera littoralis
Sinakevitch, I., Sjöholm, M., Hansson, B. S., et al. (2008) · Arthropod Structure & Development · doi:10.1016/j.asd.2008.01.001 · Cited by 14 · see citing works
Immunocytochemical analysis of putative allatostatin receptor (DAR-2) distribution in the CNS of larval Drosophila melanogaster
Bowser, P. R. F., & Tobe, S. S. (2004) · Peptides · doi:10.1016/j.peptides.2004.08.026 · Cited by 12 · see citing works
Some Features of Peptidergic Transmission
Jan, Y. N., & Jan, L. Y. (1983) · Progress in brain research · doi:10.1016/s0079-6123(08)60006-0 · Cited by 7 · see citing works
Untitled work
(2000) · doi:10.1002/(sici)1096-9861(20000228)418:1

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Authors: Nässel, D. R.
Affiliations: Stockholm University (SE)
Corresponding author: Nässel, Dick R.
ORCID: Nässel, Dick R.
Venue: Invertebrate Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2009-09-16
Volume: 9
Issue: 2
Pages: 57-75
ISSN: 1354-2516 (ISSN-L)
1439-1104
DOI: 10.1007/s10158-009-0090-1
OpenAlex: W2053983287
Cited by: 125
References: 136
Citations by year: 2026: 5 · 2025: 18 · 2024: 14 · 2023: 4 · 2022: 7 · 2021: 9 · 2020: 9 · 2019: 6 · 2018: 4 · 2017: 7 · 2016: 7 · 2015: 3 · 2014: 4 · 2013: 8 · 2012: 6
FWCI: 0.57
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Invertebrate Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: Vetenskapsrådet
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: neuropeptide signaling, insect central nervous system, volume transmission, co-transmission, neuromodulation, neurohormones, peptide diffusion, proteolytic activity, receptor inactivation, second messenger signaling, neuronal morphology
MeSH terms: Animals, Brain, Drosophila, Insecta, Neural Pathways, Synaptic Transmission, Neurons, Neuropeptides, Time Factors, Signal Transduction, Insect Proteins, Drosophila Proteins

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Neuropeptide signaling near and far: how localized and timed is the action of neuropeptides in brain circuits?

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