Cited by 2,568Plant-Microbe Interactions and ImmunityInsect-Plant Interactions and ControlPlant Pathogenic Bacteria Studies

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Salicylic Acid, a Multifaceted Hormone to Combat Disease

Vlot, A. Corina, Dempsey, D'Maris Amick, Klessig, Daniel F.·2009·Annual Review of Phytopathology

DOI 10.1146/annurev.phyto.050908.135202

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Abstract

For more than 200 years, the plant hormone salicylic acid (SA) has been studied for its medicinal use in humans. However, its extensive signaling role in plants, particularly in defense against pathogens, has only become evident during the past 20 years. This review surveys how SA in plants regulates both local disease resistance mechanisms, including host cell death and defense gene expression, and systemic acquired resistance (SAR). Genetic studies reveal an increasingly complex network of proteins required for SA-mediated defense signaling, and this process is amplified by several regulatory feedback loops. The interaction between the SA signaling pathway and those regulated by other plant hormones and/or defense signals is also discussed.

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Characterization and Biological Function of the ISOCHORISMATE SYNTHASE2 Gene of Arabidopsis
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Hypersensitive Cell Death and Papilla Formation in Barley Attacked by the Powdery Mildew Fungus Are Associated with Hydrogen Peroxide but Not with Salicylic Acid Accumulation1
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Overexpression of a Rice NPR1 Homolog Leads to Constitutive Activation of Defense Response and Hypersensitivity to Light
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The tobacco salicylic acid-binding protein 3 (SABP3) is the chloroplast carbonic anhydrase, which exhibits antioxidant activity and plays a role in the hypersensitive defense response
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Arabidopsis MAP kinase 4 regulates salicylic acid‐ and jasmonic acid/ethylene‐dependent responses via EDS1 and PAD4
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Kinetics of Salicylate-Mediated Suppression of Jasmonate Signaling Reveal a Role for Redox Modulation
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Transcription factor AtMYB103 is required for anther development by regulating tapetum development, callose dissolution and exine formation in Arabidopsis
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Pseudomonas syringae type III effector AvrRpt2 alters Arabidopsis thaliana auxin physiology
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Controlled levels of salicylic acid are required for optimal photosynthesis and redox homeostasis
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The Gain-of-Function Arabidopsis acd6 Mutant Reveals Novel Regulation and Function of the Salicylic Acid Signaling Pathway in Controlling Cell Death, Defenses, and Cell Growth
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Functional analysis of regulatory sequences controlling PR‐1 gene expression in Arabidopsis
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A family of conserved bacterial effectors inhibits salicylic acid-mediated basal immunity and promotes disease necrosis in plants
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Genetically Engineered Resistance to Fusarium Head Blight in Wheat by Expression of Arabidopsis NPR1
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Evidence for a disease‐resistance pathway in rice similar to the NPR1‐mediated signaling pathway in Arabidopsis
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Salicylic acid dependent signaling promotes basal thermotolerance but is not essential for acquired thermotolerance in Arabidopsis thaliana
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LESION SIMULATING DISEASE 1 Is Required for Acclimation to Conditions That Promote Excess Excitation Energy
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Chloroplast Signaling andLESION SIMULATING DISEASE1Regulate Crosstalk between Light Acclimation and Immunity inArabidopsis
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A Haplotype-Specific Resistance Gene Regulated by BONZAI1 Mediates Temperature-Dependent Growth Control in Arabidopsis
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Arabidopsis CaM Binding Protein CBP60g Contributes to MAMP-Induced SA Accumulation and Is Involved in Disease Resistance against Pseudomonas syringae
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The Coactivator Function ofArabidopsisNPR1 Requires the Core of Its BTB/POZ Domain and the Oxidation of C-Terminal Cysteines
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A Gain-of-Function Mutation in an Arabidopsis Toll Interleukin1 Receptor–Nucleotide Binding Site–Leucine-Rich Repeat Type R Gene Triggers Defense Responses and Results in Enhanced Disease Resistance
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Endogenous Methyl Salicylate in Pathogen-Inoculated Tobacco Plants1
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Salicylic Acid Is an Uncoupler and Inhibitor of Mitochondrial Electron Transport
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Light Regulation and Daytime Dependency of Inducible Plant Defenses in Arabidopsis: Phytochrome Signaling Controls Systemic Acquired Resistance Rather Than Local Defense
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The Arabidopsis ssi1 Mutation Restores Pathogenesis-Related Gene Expression in npr1 Plants and Renders Defensin Gene Expression Salicylic Acid Dependent
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Activation of an EDS1-Mediated R -Gene Pathway in the snc1 Mutant Leads to Constitutive, NPR1-Independent Pathogen Resistance
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Arabidopsis Isochorismate Synthase Functional in Pathogen-induced Salicylate Biosynthesis Exhibits Properties Consistent with a Role in Diverse Stress Responses
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Identification and Cloning of a Negative Regulator of Systemic Acquired Resistance, SNI1, through a Screen for Suppressors of npr1-1
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S-Nitrosylation of AtSABP3 Antagonizes the Expression of Plant Immunity
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Histone H2A.Z and homologues of components of the SWR1 complex are required to control immunity in Arabidopsis
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Methyl Salicylate Production and Jasmonate Signaling Are Not Essential for Systemic Acquired Resistance in Arabidopsis
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The SUMO E3 ligase, AtSIZ1, regulates flowering by controlling a salicylic acid‐mediated floral promotion pathway and through affects on FLC chromatin structure
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Tobacco plants epigenetically suppressed in phenylalanine ammonia‐lyase expression do not develop systemic acquired resistance in response to infection by tobacco mosaic virus
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Plastidial Fatty Acid Signaling Modulates Salicylic Acid– and Jasmonic Acid–Mediated Defense Pathways in the Arabidopsis ssi2 Mutant
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Evidence of mitochondrial involvement in the transduction of signals required for the induction of genes associated with pathogen attack and senescence
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Salicylic acid production in response to biotic and abiotic stress depends on isochorismate in Nicotiana benthamiana
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Induced Resistance Responses in Maize
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The Phytotoxin Coronatine Contributes to Pathogen Fitness and Is Required for Suppression of Salicylic Acid Accumulation in Tomato Inoculated with Pseudomonas syringae pv. tomato DC3000
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Is Salicylic Acid a Translocated Signal of Systemic Acquired Resistance in Tobacco?
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A Putative Nucleoporin 96 Is Required for Both Basal Defense and Constitutive Resistance Responses Mediated by suppressor of npr1-1 , constitutive 1
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Identification of likely orthologs of tobacco salicylic acid‐binding protein 2 and their role in systemic acquired resistance in Arabidopsis thaliana
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Silencing of the Mitogen-Activated Protein Kinase MPK6 Compromises Disease Resistance in Arabidopsis
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The Chimeric Arabidopsis CYCLIC NUCLEOTIDE-GATED ION CHANNEL11/12 Activates Multiple Pathogen Resistance Responses
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The GH3 Acyl Adenylase Family Member PBS3 Regulates Salicylic Acid-Dependent Defense Responses in Arabidopsis
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A recessive mutation in the Arabidopsis SSI2 gene confers SA‐ and NPR1‐independent expression of PR genes and resistance against bacterial and oomycete pathogens
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A “Whirly” Transcription Factor Is Required for Salicylic Acid-Dependent Disease Resistance in Arabidopsis
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Suppression and Restoration of Lesion Formation in Arabidopsis lsd Mutants
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S-Nitrosoglutathione Reductase Affords Protection against Pathogens in Arabidopsis, Both Locally and Systemically
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A Humidity-Sensitive Arabidopsis Copine Mutant Exhibits Precocious Cell Death and Increased Disease Resistance
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Interaction of NIMIN1 with NPR1 Modulates PR Gene Expression in Arabidopsis
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A single amino acid insertion in the WRKY domain of the Arabidopsis TIR–NBS–LRR–WRKY‐type disease resistance protein SLH1 (sensitive to low humidity 1) causes activation of defense responses and hypersensitive cell death
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Effects of Endogenous Salicylic Acid on Nodulation in the Model Legumes Lotus japonicus and Medicago truncatula
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Overexpression of salicylic acid carboxyl methyltransferase reduces salicylic acid-mediated pathogen resistance in Arabidopsis thaliana
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Authors: Vlot, A. C., Dempsey, D. A., & Klessig, D. F.
Affiliations: Helmholtz Munich (DE)
Boyce Thompson Institute (US)
ORCID: Vlot, A. Corina
Klessig, Daniel F.
Venue: Annual Review of Phytopathology
Publisher: Annual Reviews
Published: 2009-09-01
Volume: 47
Issue: 1
Pages: 177-206
ISSN: 0066-4286 (ISSN-L)
1545-2107
DOI: 10.1146/annurev.phyto.050908.135202
OpenAlex: W2143014195
Cited by: 2,568
References: 245
Citations by year: 2026: 130 · 2025: 145 · 2024: 140 · 2023: 172 · 2022: 218 · 2021: 210 · 2020: 227 · 2019: 167 · 2018: 159 · 2017: 142 · 2016: 134 · 2015: 150 · 2014: 158 · 2013: 150 · 2012: 119
FWCI: 7.54
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Phytopathology (publishedVersion)
PubMed (publishedVersion)
Max Planck Institute for Plasma Physics (submittedVersion)
Max Planck Digital Library (submittedVersion)
Site cant be reached (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Funders: National Science Foundation
Institute of Materials Research and Engineering
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant-Microbe Interactions and Immunity
Life Sciences › Agricultural and Biological Sciences › Insect Science › Insect-Plant Interactions and Control
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Pathogenic Bacteria Studies
Keywords: salicylic acid, plant disease resistance, systemic acquired resistance, plant defense signaling, host cell death, defense gene expression, plant hormones, feedback loops, plant-pathogen interaction
MeSH terms: Plant Diseases, Plant Growth Regulators, Plant Proteins, Plants, Signal Transduction, Salicylic Acid

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Salicylic Acid, a Multifaceted Hormone to Combat Disease

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