CT and Conventional and Diffusion-weighted MR Imaging in Acute Stroke: Study in 691 Patients at Presentation to the Emergency Department

Abstract

PURPOSE: To compare the diagnostic accuracy of computed tomography (CT) and magnetic resonance (MR) imaging in a consecutive series of patients at presentation to the emergency department with symptoms of acute stroke. MATERIALS AND METHODS: Clinical data and images obtained in 691 consecutive patients with suspected acute stroke were examined. Results of first and second head CT and brain diffusion-weighted (DW) and conventional MR imaging were compared with each other and with the final neurologic discharge diagnosis. RESULTS: Five hundred seventy-three patients underwent CT at presentation, with 42% sensitivity (95% CI: 37%, 46%) and 91% specificity (95% CI: 82%, 96%). A total of 173 patients underwent a second CT examination, with 77% sensitivity (95% CI: 70%, 84%) and 79% specificity (95% CI: 49%, 95%). Of 498 MR images, 411 were DW, with 94% sensitivity (95% CI: 1%, 96%) and 97% specificity (95% CI: 88%, 100%), and 87 were conventional, with 70% sensitivity (95% CI: 58%, 81%) and 94% specificity (95% CI: 70%, 100%). By using DW MR imaging in the early period (<6 hours after presentation to emergency department), a 97% sensitivity (95% CI: 92%, 100%) and a 100% specificity (95% CI: 69%, 100%) were achieved, compared with 58% (29%-84%) and 100% (16%-100%), respectively, with conventional MR imaging, and 40% (35%-45%) and 92% (84%-97%), respectively, with CT. Negative predictive value was higher with DW MR imaging (73%) than with conventional (42%) MR imaging or CT (24%). In studies conducted within 12 hours, DW MR imaging achieved substantially superior accuracy than did CT. After 12 hours, accuracy was equivalent. CONCLUSION: In the diagnosis of stroke in the early period (<12 hours after presentation), DW MR imaging is superior to conventional MR imaging and CT.