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The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Diffusion-Tensor Imaging Implicates Prefrontal Axonal Injury in Executive Function Impairment Following Very Mild Traumatic Brain Injury

Lipton, Michael L., Gulko, Edwin, Zimmerman, Molly E., Friedman, Benjamin W., Kim, Mimi, Gellella, Erik, Gold, Tamar, Shifteh, Keivan, Ardekani, Babak A., Branch, Craig A.·2009·Radiology

Abstract

PURPOSE: To determine whether frontal white matter diffusion abnormalities can help predict acute executive function impairment after mild traumatic brain injury (mTBI). MATERIALS AND METHODS: This study had institutional review board approval, included written informed consent, and complied with HIPAA. Diffusion-tensor imaging and standardized neuropsychologic assessments were performed in 20 patients with mTBI within 2 weeks of injury and 20 matched control subjects. Fractional anisotropy (FA) and mean diffusivity (MD) images (imaging parameters: 3.0 T, 25 directions, b = 1000 sec/mm(2)) were compared by using whole-brain voxelwise analysis. Spearman correlation analyses were performed to evaluate associations between diffusion measures and executive function. RESULTS: Multiple clusters of lower frontal white matter FA, including the dorsolateral prefrontal cortex (DLPFC), were present in patients (P < .005), with several clusters also demonstrating higher MD (P < .005). Patients performed worse on tests of executive function. Lower DLPFC FA was significantly correlated with worse executive function performance in patients (P < .05). CONCLUSION: Impaired executive function following mTBI is associated with axonal injury involving the DLPFC.

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Crossref · 10.1148/radiol.2523081584

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Metadata

Authors
Lipton, M. L., Gulko, E., Zimmerman, M. E., Friedman, B. W., Kim, M., Gellella, E., Gold, T., Shifteh, K., Ardekani, B. A., & Branch, C. A.
Venue
Radiology
Published
2009-09
Volume
252
Issue
3
Pages
816-824
ISSN
  • 0033-8419 (ISSN-L)
  • 1527-1315
OpenAlex
W2108029018
Cited by
290
References
4
FWCI
15.83
Type
journal article
Language
en
Open access
closed

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