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Probable Alzheimer disease: diagnosis with proton MR spectroscopy.
Abstract
PURPOSE: To distinguish probable Alzheimer disease (AD) from other dementias (ODs) and normality in the elderly. MATERIALS AND METHODS: A double-blind trial of proton magnetic resonance (MR) spectroscopy was performed, principally in gray matter, in the occipital cortex of 114 patients with dementia (AD [n = 65], OD [n = 39], or frontal lobe dementia [FLD] [n = 10]), 98 patients without dementia, and 32 healthy control subjects. RESULTS: Reduced levels of N-acetylaspartate (NAA) (P < .0005) and increased levels of myo-inositol (MI) (P < .0005) characterize AD. Patients with OD had significantly reduced levels of NAA (P < .01) but normal levels of MI (P [vs AD] < .0005). When MI/NAA was used, AD was distinguished from normality with 83% sensitivity and 98% specificity. When MI/creatine was used, OD was distinguished from AD and FLD with a negative predictive rate of 80%, sensitivity of 82%, and specificity of 64%. CONCLUSION: Hydrogen-1 MR spectroscopy enables identification of mild to moderate AD with a specificity and sensitivity that suggest clinical utility.
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Cited by
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LANG, F., BUSCH, G. L., RITTER, M., VÖLKL, H., WALDEGGER, S., GULBINS, E., & HÄUSSINGER, D. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.1.247 · Cited by 1,891
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Cheng, L. L., Ma, M. J., Becerra, L., Ptak, T., Tracey, I., Lackner, A., & González, R. G. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.12.6408 · Cited by 339
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Metadata
- Authors
- Shonk, T. K., Moats, R. A., Gifford, P., Michaelis, T., Mandigo, J. C., Izumi, J., & Ross, B. D.
- Venue
- Radiology
- Published
- 1995-04
- Volume
- 195
- Issue
- 1
- Pages
- 65-72
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- OpenAlex
- W2143854933
- Cited by
- 299
- References
- 0
- FWCI
- 12.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- Shonk, T. K., Moats, R. A., Gifford, P., Michaelis, T., Mandigo, J. C., Izumi, J., & Ross, B. D. (1995). Probable Alzheimer disease: diagnosis with proton MR spectroscopy. Radiology. https://doi.org/10.1148/radiology.195.1.7892497
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