The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
T1 and T2 in the Brain of Healthy Subjects, Patients with Parkinson Disease, and Patients with Multiple System Atrophy: Relation to Iron Content
Abstract
PURPOSE: To investigate the potential of magnetic resonance imaging for identification and quantification of brain iron in healthy subjects, patients with Parkinson disease, and patients with multiple system atrophy. MATERIALS AND METHODS: Forty-nine subjects were studied at 1.5 T. Regional T1 and T2 values were compared among groups and also with histopathologic estimates of iron concentration. RESULTS: In healthy subjects, interregional T1 and T2 differences in the cortex and basal ganglia showed a good correlation with reported values for iron concentration, and intraregional variations were generally consistent with reported variability of iron concentration. Patients with multiple system atrophy had T1 and T2 shortening in the globus pallidus consistent with reported increases in ferritin-bound iron and changes in the putamen consistent with accumulation of hemosiderin (posterior portion) and neuromelanin (remainder). Both groups of patients had changes in the cortex that are consistent with decreased ferritin concentration and T2 changes in white matter consistent with demyelination. Patients with Parkinson disease also had a (nonsignificant) T2 shortening in the substantia nigra that was suggestive of iron accumulation. CONCLUSION: Most of the T1 and T2 findings appear to be related to changes in iron content and form and may possibly be used as indicators of such changes.
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DEXTER, D. T., CARAYON, A., JAVOY-AGID, F., AGID, Y., WELLS, F. R., DANIEL, S. E., LEES, A. J., JENNER, P., & MARSDEN, C. D. (1991) · Brain · doi:10.1093/brain/114.4.1953 · Cited by 1,043
The oxidant stress hypothesis in Parkinson's disease: Evidence supporting it
Fahn, S., & Cohen, G. (1992) · Annals of Neurology · doi:10.1002/ana.410320616 · Cited by 927
Brain iron and ferritin in Parkinson’s and Alzheimer’s diseases
Jellinger, K., Paulus, W., Grundke-Iqbal, I., Riederer, P., & Youdim, M. B. H. (1990) · Journal of Neural Transmission - Parkinson's Disease and Dementia Section · doi:10.1007/bf02252926 · Cited by 445
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Magnetic resonance fingerprinting
Ma, D., Gulani, V., Seiberlich, N., Liu, K., Sunshine, J. L., Duerk, J. L., & Griswold, M. A. (2013) · Nature · doi:10.1038/nature11971 · Cited by 1,577
Imaging iron stores in the brain using magnetic resonance imaging
Haacke, E. M., Cheng, N. Y. C., House, M. J., Liu, Q., Neelavalli, J., Ogg, R. J., Khan, A., Ayaz, M., Kirsch, W., & Obenaus, A. (2005) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2004.10.001 · Cited by 995
Sasaki, M., Shibata, E., Tohyama, K., Takahashi, J., Otsuka, K., Tsuchiya, K., Takahashi, S., Ehara, S., Terayama, Y., & Sakai, A. (2006) · Neuroreport · doi:10.1097/01.wnr.0000227984.84927.a7 · Cited by 496
Tracer kinetic modelling for DCE-MRI quantification of subtle blood–brain barrier permeability
Heye, A. K., Thrippleton, M. J., Armitage, P. A., Valdés Hernández, M. D. C., Makin, S. D., Glatz, A., Sakka, E., & Wardlaw, J. M. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2015.10.018 · Cited by 187
Andersen, H. H., Johnsen, K. B., & Moos, T. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1509-8 · Cited by 151
Metadata
- Authors
- Vymazal, J., Righini, A., Brooks, R. A., Canesi, M., Mariani, C., Leonardi, M., & Pezzoli, G.
- Venue
- Radiology
- Published
- 1999-05
- Volume
- 211
- Issue
- 2
- Pages
- 489-495
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- OpenAlex
- W2152732392
- Cited by
- 342
- References
- 4
- FWCI
- 3.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: T1 and T2 in the Brain of Healthy Subjects, Patients with Parkinson Disease, and Patients with Multiple System Atrophy: Relation to Iron Content. https://app.cochat.ai/papers/10.1148/radiology.211.2.r99ma53489
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- Vymazal, J., Righini, A., Brooks, R. A., Canesi, M., Mariani, C., Leonardi, M., & Pezzoli, G. (1999). T1 and T2 in the Brain of Healthy Subjects, Patients with Parkinson Disease, and Patients with Multiple System Atrophy: Relation to Iron Content. Radiology. https://doi.org/10.1148/radiology.211.2.r99ma53489
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
