The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Extrapulmonary Tuberculosis: Pathophysiology and Imaging Findings
Abstract
Extrapulmonary tuberculosis (TB) represents approximately 15% of all TB infections. It is difficult to diagnose on the basis of imaging characteristics and clinical symptoms, and biopsy is required in many cases. Radiologists must be aware of the imaging findings of extrapulmonary TB to identify the condition in high-risk patients, even in the absence of active pulmonary infection. In extrapulmonary TB, the lymphatic system is most frequently affected. The presence of necrotic lymph nodes and other organ-specific imaging features increases the diagnostic probability of extrapulmonary TB. Disseminated infection and central nervous system involvement are the most frequent manifestations in immunosuppressed patients. Renal disease can occur in immunocompetent patients with very long latency periods between the primary pulmonary infection and genitourinary involvement. In several cases, gastrointestinal, solid-organ, and peritoneal TB show nonspecific imaging findings. Tuberculous spondylitis is the most frequent musculoskeletal manifestation. It is usually diagnosed late and affects multiple vertebral segments with extensive paraspinal abscess. Articular disease is the second most frequent musculoskeletal manifestation, and synovitis is its predominant imaging finding. ©RSNA, 2019
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The results of a meta-analysis showed that EPTB represents almost 15% of TB cases, and approximately 10–35% of cases can be found in the head and neck region, most frequently in lymph nodes (87.9%), the other most common location being the larynx [23,26,27].”
From Head and Neck Tuberculosis: A Rare Diagnosis and the Role of Surgical Biopsy and Histopathological Evaluation in Extrapulmonary Disease (2025) · cites this paper as [26]
Citations
Cites
Global tuberculosis report (2014)
Gabbasova, L. A., & Who, E. R. E. (2014) · Cited by 12,702
Garg, R. K., & Somvanshi, D. S. (2011) · Journal of Spinal Cord Medicine · doi:10.1179/2045772311y.0000000023 · Cited by 818
Epidemiology of Extrapulmonary Tuberculosis in the United States, 1993–2006
Peto, H. M., Pratt, R. H., Harrington, T. A., LoBue, P. A., & Armstrong, L. R. (2009) · Clinical Infectious Diseases · doi:10.1086/605559 · Cited by 741
Tuberculosis: A Radiologic Review
Burrill, J., Williams, C. J., Bain, G., Conder, G., Hine, A. L., & Misra, R. R. (2007) · Radiographics · doi:10.1148/rg.275065176 · Cited by 605
Tuberculosis of the central nervous system: overview of neuroradiological findings
Bernaerts, A., Vanhoenacker, F. M. H. M., Parizel, P. M., Goethem, J. W. V., van Altena, R., Laridon, A. M., Roeck, J. D., Coeman, V., & de Schepper, A. M. (2002) · European Radiology · doi:10.1007/s00330-002-1608-7 · Cited by 421
Pulmonary Tuberculosis: Role of Radiology in Diagnosis and Management
Nachiappan, A. C., Rahbar, K., Xiao Hua, S. H. I., Guy, E., Barbosa, E. J. M., Shroff, G. S., Ocazionez, D., Schlesinger, A. E., Katz, S. I., & Hammer, M. M. (2017) · Radiographics · doi:10.1148/rg.2017160032 · Cited by 363
Spinal Tuberculosis: Current Concepts
Rajasekaran, S., Soundararajan, D. C. R., Shetty, A. P., & Kanna, R. M. (2018) · Global Spine Journal · doi:10.1177/2192568218769053 · Cited by 347
Imaging of Extrapulmonary Tuberculosis
Engin, G., Acunaş, B., Acunaş, G., & Tunacı, M. (2000) · Radiographics · doi:10.1148/radiographics.20.2.g00mc07471 · Cited by 306
Discrimination of Tuberculous Spondylitis from Pyogenic Spondylitis on MRI
Jung, N. Y., Jee, W.-H., Ha, K.-Y., Park, C.-K., & Byun, J.-Y. (2004) · American Journal of Roentgenology · doi:10.2214/ajr.182.6.1821405 · Cited by 261
Imaging Spectrum of CNS Vasculitis
Razek, A. A. K. A., Alvarez, H., Bagg, S., Refaat, S., & Castillo, M. (2014) · Radiographics · doi:10.1148/rg.344135028 · Cited by 237
Research works printed but not linked: 5
- World Health Organization, 2018, Global tuberculosis report
- Ahuja A, 2001, AJNR Am J Neuroradiol, 22, 735
- Whiteman M, 1995, AJNR Am J Neuroradiol, 16, 1319
- Lakmichi MA, 2011, Rev Urol, 13, 176
- Grace GA, 2017, Indian J Med Res, 145, 425
Cited by
Items 301–327 of 327
Atnafu, A., Wassie, L., Tilahun, M., Girma, S., Alemayehu, M., Dereje, A., Assefa, G., Desta, T., Agize, H., Fisseha, E., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26231242
Adult Appendicular Skeletal Infection
Khan, S. H. M., & Bloem, H. L. (2023) · Springer eBooks · doi:10.1007/978-3-030-57376-8_62-1
Challenges in the Diagnosis of Extrapulmonary Tuberculosis and Comparison of Diagnostic Methods
Güler, Ö., ALTUN, Z., Özel, S. H., Deniz, M. T., Sayan, M., & Akhan, S. (2026) · Kocaeli Üniversitesi Sağlık Bilimleri Dergisi · doi:10.30934/kusbed.1803934
santos, M. P., Silva, A. S. E., Laranjo, P., Dias, F., & Shigaev, A. (2026) · Cureus · doi:10.7759/cureus.102629
“The diagnosis of BCG-related osteoarticular infection is difficult and often delayed due to its subtle or nonspecific symptoms [8], frequently unremarkable early imaging findings, and the frequent negativity of standard microbiological cultures [5,8].”
Progress in the Diagnosis and Treatment of Tuberculous Meningitis
Căliman-Sturdza, O. A. (2026) · Infectious diseases · doi:10.5772/intechopen.1014269
杨, 璐. (2026) · Advances in Clinical Medicine · doi:10.12677/acm.2026.162693
Extrapulmonary Tuberculosis (TB) Mimicking Meigs’ Syndrome: A Case Report
Khan, N., Ahmed, A., Shiroley, E., Mirza, M., & Molefe, T. (2026) · Cureus · doi:10.7759/cureus.103727
“It is hypothesized that elevated CA-125 reflects peritoneal or pleural inflammation, as CA-125 is expressed by mesothelial cells lining these surfaces [4].”
InfluentialChacha, R., Maina, C., Murungi, E. K., Guantai, E. M., Ngugi, M. P., Ndirangu, E. G., Mugo, J., Njeru, S. N., & Kigondu, E. M. (2026) · Open Research Africa · doi:10.12688/openresafrica.16071.2
Extrapulmonary Tuberculosis Presenting as Chest Wall and Abdominal Fluid Collections
Yi, M., Altahan, O., Joglekar, M., Hasso, M., & Zervos, M. (2026) · Infectious Diseases in Clinical Practice · doi:10.1097/ipc.0000000000001554
Imaging in infective arthritis: A comprehensive review
Singh, J., & Rege, S. (2026) · Indian Journal of Musculoskeletal Radiology · doi:10.25259/ijmsr_62_2025
Hallazgos por imágenes de las presentaciones inusuales de la infección por tuberculosis
Gómez, V. G., Poveda, T. S., Paternina, M. A., & Naranjo, M. Z. (2025) · Revista colombiana de radiología · doi:10.53903/01212095.328
Ovarian Tuberculosis in An Adolescent: A Diagnostic Dilemma
Arif, M. H. M., Jalil, N. A. C., & Samsudin, A. H. Z. (2026) · Malaysian Journal of Paediatrics and Child Health · doi:10.51407/mjpch.v32i1.402
Development of Isoniazid–Pyrazole Hybrids as Potential Antitubercular Agents
Kadima, M. G., Singh, V., Kumar, G., Mishra, S., Seboletswe, P., Ankit, Kajee, A., Roquet, F., Kremer, L., Karpoormath, R. V., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27104385
“However, if left untreated, LTBI can progress to an active disease, making treatment significantly more challenging [4].”
Analytical Review of Diagnostic Methods of Female Genital and Peritoneal Tuberculosis
Соцкий, П. О., Sotskaya, O. L., & Safarian, M. D. (2026) · Tuberculosis and lung diseases · doi:10.58838/2075-1230-2026-104-2-110-120
Infertility Caused by Pelvic Tuberculosis: A Forgotten and Rare Diagnosis
Hashemi, M., & Dehghan, M. (2026) · Case Reports in Infectious Diseases · doi:10.1155/crdi/3837614
Imaging Findings of Testicular Tuberculosis: A Case Report and Pictorial Review
Sanchez, L., Jimenez, A. D., & Riascos, C. (2026) · Cureus · doi:10.7759/cureus.110738
Xu, X., Wang, Y., Li, L., Luo, Z., Liu, N., Wu, Y., Wang, C., Wang, B., Cui, E., Yu, L., et al. (2026) · Orthopaedic Surgery · doi:10.1111/os.70373
Imagerie des iléocolites aiguës
Laurent, V. (2025) · Elsevier eBooks · doi:10.1016/b978-2-294-78849-9.00012-5
A Case Report of Extrapulmonary Tuberculosis: A Potpourri of Imaging Manifestations
Chakravarty, R., Sahni, H., & Sarkar, N. (2026) · Cureus · doi:10.7759/cureus.114381
Navigating complex presentations of central nervous system tuberculosis: A two-case analysis
Boada-Garnica, J. A., Arias-Saavedra, A., Montes, M. I., Betancur, J. F., & Ramírez, B. (2026) · Radiology Case Reports · doi:10.1016/j.radcr.2026.07.060
“…the classical imaging findings, atypical presentations such as intraventricular tuberculomas, ependymal involvement, diffuse cerebritis, spinal pachymeningitis, extensive myelitis, or multifocal microabscesses may closely resemble inflammatory, infectious, or neoplastic disorders [ 3 ,9 ,10 ].”
Inflammatory Bowel Diseases and Infectious Agents: Herpes Viruses and Tuberculosis
Babayeva, G. H., Asadova, G. V., Musayev, J. S., Mahmudov, U. R., Verdiyev, E. K., Hasanov, R. A., Hasanov, R. H., Huseynov, H. M., Hasanova, A. I., & Abdullayeva, E. C. (2026) · IntechOpen eBooks · doi:10.5772/intechopen.1015416
Single-Cell Measurement Revolution: A New Paradigm in Tuberculosis Diagnosis
Ni, D., & Liu, G. (2026) · ACS Measurement Science Au · doi:10.1021/acsmeasuresciau.6c00245
Clinical outcomes of arthroscopic treatment for shoulder joint tuberculosis
Chen, S., Yang, Y., Chen, J., Zheng, F., Jin, H., Wang, W., Wang, D., Huang, Y., & Tang, X. (2026) · Journal of Shoulder and Elbow Surgery · doi:10.1016/j.jse.2026.09.002
Al‐Busaidi, O., Al-Subhi, A., & Busaidi, I. A. (2026) · International Journal of Mycobacteriology · doi:10.4103/ijmy.ijmy_106_26
Alfonso, M. Á. M., Olmedo, R., Samaniego, S., Martínez, L. F. R., & Gómez, M. J. (2026) · Revista Virtual de la Sociedad Paraguaya de Medicina Interna · doi:10.18004/rvspmi/2312-3893/2026.e13142623
Adult Appendicular Skeletal Infection
Khan, S. H. M., & Bloem, H. L. (2026) · Springer eBooks · doi:10.1007/978-3-031-66892-0_62
Zhou, X., Peng, S., Tan, R., Wang, J., Hu, H., Zhang, K., & Liu, A. (2026) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2026.1935536
Metadata
- Authors
- Rodriguez-Takeuchi, S. Y., Renjifo, M. E., & Medina, F. J.
- Affiliations
- Fundación Valle del Lili (CO)
- From the Department of Radiology, Fundación Valle del Lili–Universidad Icesi, Carrera 98 #18-49, Cali, Colombia.
- Venue
- Radiographics
- Published
- 2019-11
- Volume
- 39
- Issue
- 7
- Pages
- 2023-2037
- ISSN
- 0271-5333 (ISSN-L)
- 1527-1323
- OpenAlex
- W2988325760
- Cited by
- 328
- References
- 44
- Citations by year
- 2026: 27 · 2025: 49 · 2024: 63 · 2023: 68 · 2022: 70 · 2021: 36 · 2020: 13
- FWCI
- 6.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Radiographics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Diagnosis and treatment of tuberculosis
- Health Sciences › Medicine › Infectious Diseases › Infectious Diseases and Tuberculosis
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Keywords
- extrapulmonary tuberculosis, tuberculous lymphadenitis, disseminated tuberculosis, central nervous system tuberculosis, renal tuberculosis, urogenital tuberculosis, gastrointestinal tuberculosis, tuberculous peritonitis, spinal tuberculosis, synovitis, immunosuppression, pathophysiology
- MeSH terms
- Abscess, Diagnosis, Differential, Female, Humans, Magnetic Resonance Imaging, Male, Muscular Diseases, Risk, Tuberculoma, Tuberculosis, Tuberculosis, Lymph Node, Tuberculosis, Meningeal, Tuberculosis, Osteoarticular, Tuberculosis, Urogenital, Tuberculosis, Central Nervous System
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review