Cited by 505Opioid Use Disorder TreatmentNeuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on Behavior

The neurobiology of opioid dependence: implications for treatment

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Kosten, Thomas, George, Tony·2002·Science & Practice Perspectives

Abstract

Opioid tolerance, dependence, and addiction are all manifestations of brain changes resulting from chronic opioid abuse. The opioid abuser's struggle for recovery is in great part a struggle to overcome the effects of these changes. Medications such as methadone, LAAM, buprenorphine, and naltrexone act on the same brain structures and processes as addictive opioids, but with protective or normalizing effects. Despite the effectiveness of medications, they must be used in conjunction with appropriate psychosocial treatments.

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  • Craving is a central component of opioid use disorder and other substance use disorders.

    “A key component of OUD is the development of long-lasting drug craving (3–5), whether in the context of prescribed opioids, such as for analgesic purposes, or illicitly acquired heroin.”

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Authors
Kosten, T., & George, T.
Affiliations
Yale University (US)
Corresponding author
Kosten, Thomas
Venue
Science & Practice Perspectives
Published
2002-07
Volume
1
Issue
1
Pages
13-20
ISSN
  • 1930-4307 (ISSN-L)
  • 1930-4315
OpenAlex
W1997980357
Cited by
505
References
24
Citations by year
2026: 34 · 2025: 46 · 2024: 38 · 2023: 53 · 2022: 56 · 2021: 55 · 2020: 46 · 2019: 33 · 2018: 32 · 2017: 27 · 2016: 22 · 2015: 18 · 2014: 8 · 2013: 5 · 2012: 2
FWCI
1.75
Type
journal article
Language
en
Open access
Locations
  • Science & Practice Perspectives (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Drug Abuse (R01-DA-1-4039, P50 DA12762, K05‐DA00454, R01-DA-1-3672, K12 DA00167)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
opioid use disorder, opioid tolerance, neurobiology of addiction, methadone maintenance treatment, LAAM, buprenorphine, naltrexone, opioid antagonists, psychosocial interventions, addiction treatment
MeSH terms
Analgesics, Opioid, Brain, Humans, Models, Neurological, Narcotic Antagonists, Opioid-Related Disorders, Receptors, Opioid, Behavior, Addictive

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