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Ha, S., Kim, H., Kim, K. M., Kim, B. M., Kim, J., Son, M., Kim, D., Kim, M., Yoo, J., Yu, H. S., et al. (2024) · Aging Cell · doi:10.1111/acel.14184 · Cited by 25 · see citing works

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Fountoulakis, N., Miyamoto, Y., Pavkov, M. E., Karalliedde, J. J., & Maltese, G. (2024) · Diabetic Medicine · doi:10.1111/dme.15464 · Cited by 27 · see citing works

Understanding and targeting senescence in kidney disease

Chanvillard, L., Mason, T., & Ferenbach, D. A. (2025) · Clinical Kidney Journal · doi:10.1093/ckj/sfaf190 · Cited by 26 · see citing works

The Role of Apoptosis in the Pathogenic Mechanism of Critical States (Review)

Glukhov, A. I., Грызунова, Г. К., Usai, L., Алейникова, Т. Л., Chernikova, N. V., & Burt, A. Y. (2019) · General Reanimatology · doi:10.15360/1813-9779-2019-2-79-98 · Cited by 28 · see citing works

Pathogenesis and Therapeutic Perspectives of Tubular Injury in Diabetic Kidney Disease: An Update

Geng, J., Ma, S., Tang, H. R., & Zhang, C. (2025) · Biomedicines · doi:10.3390/biomedicines13061424 · Cited by 26 · see citing works

Hydrogen Indirectly Suppresses Increases in Hydrogen Peroxide in Cytoplasmic Hydroxyl Radical-Induced Cells and Suppresses Cellular Senescence

Sakai, T., Kurokawa, R., Hirano, S., & Imai, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020456 · Cited by 25 · see citing works

Inflammasome activation and metabolic remodelling in p16‐positive aging cells aggravates high‐fat diet‐induced lung fibrosis by inhibiting NEDD4L‐mediated K48‐polyubiquitin‐dependent degradation of SGK1

Gu, X., Meng, H., Peng, C., Lin, S., Li, B., Zhao, L., Yang, X., Wang, G., Cai, W., Zhou, J., et al. (2023) · Clinical and Translational Medicine · doi:10.1002/ctm2.1308 · Cited by 23 · see citing works

Role of FOXO1 in aldosterone-induced autophagy: A compensatory protective mechanism related to podocyte injury

Wang, B., Ding, W. Q., Zhang, M., Li, H., Guo, H., Lin, L.-L., Chen, J., & Gu, Y. (2016) · Oncotarget · doi:10.18632/oncotarget.9644 · Cited by 25 · see citing works

Mechanoregulation of Myofibroblast Fate and Cardiac Fibrosis

Kim, P., Chu, N., Davis, J., & Kim, D. (2017) · Advanced Biosystems · doi:10.1002/adbi.201700172 · Cited by 24 · see citing works

The interaction between cellular senescence and chronic kidney disease as a therapeutic opportunity

Zhao, J.-L., Qiao, X.-H., Mao, J., Liu, F., & Fu, H. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.974361 · Cited by 23 · see citing works

Urinary DcR2 is a novel biomarker for tubulointerstitial injury in patients with diabetic nephropathy

Chen, J., Zhang, W., Chen, K.-H., Lin, L.-R., Dai, H., Li, K., Zhang, J., Zheng, L., Fu, B.-Q., & He, Y. (2017) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00689.2016 · Cited by 23 · see citing works

Aging Lung: Molecular Drivers and Impact on Respiratory Diseases—A Narrative Clinical Review

Górski, P., Białas, A. J., & Piotrowski, W. J. (2024) · Antioxidants · doi:10.3390/antiox13121480 · Cited by 23 · see citing works

“Looping In” Mechanics: Mechanobiologic Regulation of the Nucleus and the Epigenome

Dai, E. N., Heo, S., & Mauck, R. L. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.202000030 · Cited by 20 · see citing works

Engineering Advanced In Vitro Models of Systemic Sclerosis for Drug Discovery and Development

Pieri, A. D., Korman, B. D., Jüngel, A., & Wuertz‐Kozak, K. (2021) · Advanced Biology · doi:10.1002/adbi.202000168 · Cited by 22 · see citing works

Renal aging and its consequences: navigating the challenges of an aging population

Zhang, M., Ni, H.-F., Lin, Y., Wang, K., He, T., Lan, Y., Han, Z., & Zuo, X. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1615681 · Cited by 22 · see citing works

Cellular Senescence: A Bridge Between Diabetes and Microangiopathy

Liu, J., Guo, B., Liu, Q., Zhu, G., Wang, Y., Wang, N., Yang, Y., & Fu, S. (2024) · Biomolecules · doi:10.3390/biom14111361 · Cited by 21 · see citing works

Effects of the Cytoplasm and Mitochondrial Specific Hydroxyl Radical Scavengers TA293 and mitoTA293 in Bleomycin-Induced Pulmonary Fibrosis Model Mice

Sakai, T., Takagaki, H., Yamagiwa, N., Ui, M., Hatta, S., & Imai, J. (2021) · Antioxidants · doi:10.3390/antiox10091398 · Cited by 17 · see citing works

Targeting senescence to prevent diabetic kidney disease: Exploring molecular mechanisms and potential therapeutic targets for disease management

Phillips, P. C. A., Branco, M. S. L. A., Cliff, C. L., Ward, J. K., Squires, P. E., & Hills, C. E. (2024) · Diabetic Medicine · doi:10.1111/dme.15408 · Cited by 16 · see citing works

Pharmacological Perturbation of Mechanical Contractility Enables Robust Transdifferentiation of Human Fibroblasts into Neurons

He, Z., Li, Y., Feng, G., Yuan, X., Lu, Z., Dai, M., Hu, Y., Zhang, Y., Zhou, Q., & Li, W. (2022) · Advanced Science · doi:10.1002/advs.202104682 · Cited by 16 · see citing works

Harnessing the Full Potential of Multi-Omic Analyses to Advance the Study and Treatment of Chronic Kidney Disease

Hill, C., Ávila-Palència, I., Maxwell, A. P., Hunter, R. F., & McKnight, A. J. (2022) · Frontiers in Nephrology · doi:10.3389/fneph.2022.923068 · Cited by 15 · see citing works

In Situ Regulation and Mechanisms of 3D Matrix Stiffness on the Activation and Reversion of Hepatic Stellate Cells

Chen, G., Deng, Y., Xia, B., & Lv, Y. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202202560 · Cited by 15 · see citing works

Artesunate Alleviates Kidney Fibrosis in Type 1 Diabetes with Periodontitis Rats via Promoting Autophagy and Suppression of Inflammation

Liang, C., Licheng, M., Chen, Y., Li, J., Wang, B., Ma, C., Yuan, Ž., & Nong, X. (2024) · ACS Omega · doi:10.1021/acsomega.4c00020 · Cited by 13 · see citing works

Identification and Validation of Glomeruli Cellular Senescence‐Related Genes in Diabetic Nephropathy by Multiomics

Tang, C., Yang, C., Wang, P., Li, L., Lin, Y., Yi, Q., Tang, F., Liu, L., Zhou, W., Liu, D., et al. (2023) · Advanced Biology · doi:10.1002/adbi.202300453 · Cited by 12 · see citing works

Impaired stemness in aging periodontal ligament stem cells is mediated by the progerin/endoplasmic reticulum stress/p53 axis

Zhang, X., Wang, Y., Wang, J., Zhang, Y., Li, R., Wang, X., Ge, X., Ye, Q., Ji, J., Fei, D., et al. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.10.029 · Cited by 12 · see citing works

The effects of macronutrients metabolism on cellular and organismal aging

Nehme, J., Altulea, A., Gheorghe, T., & Demaria, M. (2023) · Biomedical Journal · doi:10.1016/j.bj.2023.02.005 · Cited by 12 · see citing works

Cellular senescence and tumor promotion: Role of the Unfolded Protein Response.

Pluquet, O., & Abbadie, C. (2021) · Advances in Cancer Research · doi:10.1016/bs.acr.2021.01.001 · Cited by 8 · see citing works

Identifying Aging-Related Biomarkers and Immune Infiltration Features in Diabetic Nephropathy Using Integrative Bioinformatics Approaches and Machine-Learning Strategies

Liu, T., Zhuang, X., & Gao, J. (2023) · Biomedicines · doi:10.3390/biomedicines11092454 · Cited by 11 · see citing works

Senescent adipocytes and type 2 diabetes – current knowledge and perspective concepts

Kruczkowska, W., Gałęziewska, J., Kciuk, M., Gielecińska, A., Płuciennik, E., Pasieka, Z. W., Zhao, L.-Y., Yu, Y.-J., Kołat, D., & Kałuzińska‐Kołat, Ż. (2024) · BioMolecular Concepts · doi:10.1515/bmc-2022-0046 · Cited by 12 · see citing works

Regulating Lymphatic Vasculature in Fibrosis: Understanding the Biology to Improve the Modeling

Ruliffson, B. N. K., & Whittington, C. F. (2023) · Advanced Biology · doi:10.1002/adbi.202200158 · Cited by 10 · see citing works

Bmal1-deficient mouse fibroblast cells do not provide premature cellular senescence in vitro

Nakahata, Y., Yasukawa, S., Khaidizar, F. D., Shimba, S., Matsui, T., & Bessho, Y. (2018) · Chronobiology International · doi:10.1080/07420528.2018.1430038 · Cited by 11 · see citing works

The Role of Renal Cell Senescence in Diabetic Kidney Disease: Mechanisms and Therapeutic Advances

Yan, Z., Xu, J., Liu, T., Wang, L., Zhang, Q., Li, X., Lin, B., & Piao, C. (2025) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s543814 · Cited by 10 · see citing works

Organelle stress and glycation in kidney disease

Inagi, R. (2021) · Glycoconjugate Journal · doi:10.1007/s10719-021-09989-5 · Cited by 9 · see citing works

Harnessing Genomic Analysis to Explore the Role of Telomeres in the Pathogenesis and Progression of Diabetic Kidney Disease

Hill, C., Duffy, S., Coulter, T., Maxwell, A. P., & McKnight, A. J. (2023) · Genes · doi:10.3390/genes14030609 · Cited by 9 · see citing works

The role of Chinese herbal medicine in the treatment of diabetic nephropathy by regulating endoplasmic reticulum stress

Wei, M., Liu, X., Li, M., Tian, X. P., Feng, M., Pang, B., Fang, Z., & Wei, J.-P. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1174415 · Cited by 8 · see citing works

Targeting cellular senescence in diabetic kidney disease: potential of regenerative, cell-based therapies and other senotherapeutic approaches

Patel, H. A., Wang, J., Zinn, C. J., Learmonth, M., Bian, X., Jurk, D., Lerman, L. O., Wolfram, J., & Hickson, L. J. (2026) · Kidney International · doi:10.1016/j.kint.2025.10.019 · Cited by 8 · see citing works

P16INK4a deletion alleviates contrast-induced acute kidney injury by ameliorating renal cell apoptosis and suppressing inflammation and oxidative stress

Zhang, X., Huang, G., Zhang, Z., Wang, F., Liu, Q., Du, Y., Wang, X., & Gu, X. (2024) · Experimental Gerontology · doi:10.1016/j.exger.2024.112372 · Cited by 8 · see citing works

Novel insights into the activating transcription factor 4 in Alzheimer’s disease and associated aging-related diseases: Mechanisms and therapeutic implications

Zhang, N., Nao, J., Zhang, S., & Dong, X. (2024) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2024.101144 · Cited by 8 · see citing works

Endoplasmic reticulum and its role in diabetic nephropathy.

Dadras, F., & Khoshjou, F. (2015) · Iranian Journal of Kidney Diseases · Cited by 8 · see citing works

Featured Article: Deterioration of visual function mediated by senescence-associated endoplasmic reticulum stress in inflammatory tie2-TNF mice

Lenin, R. R., Nagy, P. G., Gentry, J., & Gangaraju, R. (2018) · Experimental Biology and Medicine · doi:10.1177/1535370218794915 · Cited by 7 · see citing works

Evolving insights into the identity and function of dark microglia

Flury, A. G., St‐Pierre, M., Ayata, P., & Tremblay, M. (2025) · Trends in Neurosciences · doi:10.1016/j.tins.2025.11.002 · Cited by 7 · see citing works

PTEN: A Novel Diabetes Nephropathy Protective Gene Related to Cellular Senescence

Li, K., Tang, H., Cao, X., Zhang, X., & Wang, X. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073088 · Cited by 6 · see citing works

Cellular Senescence in Kidney Diseases: From Bench to Clinic

Shu, S., Liu, J., Qian, Y., & Zhang, C. (2025) · The FASEB Journal · doi:10.1096/fj.202503532r · Cited by 5 · see citing works

Tunable hydrogel networks by varying secondary structures of hydrophilic peptoids provide viable 3D cell culture platforms for hMSCs

Pineda‐Hernandez, A., Castilla‐Casadiego, D. A., Morton, L. D., Giordano-Nguyen, S. A., Halwachs, K. N., & Rosales, A. M. (2025) · Biomaterials Science · doi:10.1039/d5bm00433k · Cited by 5 · see citing works

High levels of glucose induce epithelial-mesenchymal transition in renal proximal tubular cells through PERK-eIF2α pathway

Bao, Y., Ao, Y., Yi, B., & Batubayier, J. (2019) · Chinese Medical Journal · doi:10.1097/cm9.0000000000000157 · Cited by 5 · see citing works

Coming of age: could obesity-related metabolic complications be treated by targeting senescent cells?

Kasperová, B. J., Cinkajzlová, A., Horváth, L., Svoboda, P., Haluzı́k, M., & Hubáčková, S. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1622107 · Cited by 4 · see citing works

Celastrol attenuates diabetic kidney disease progression by repressing senescence of renal tubular epithelial cells

Zhang, Y., Sun, Z., Meng, W., Lei, S., Sun, J., Tang, Y., & Mu, X. (2025) · Frontiers in Aging · doi:10.3389/fragi.2025.1657947 · Cited by 3 · see citing works

Receptor for advanced glycation end-products promotes premature senescence of proximal tubular epithelial cells via activation of endoplasmic reticulum stress-dependent p21 signaling

Liu, J., Huang, K., Cai, G.-Y., Chen, X.-M., Yang, J.-R., Lin, L.-R., Yang, J., Huo, B.-G., Zhan, J., & He, Y.-N. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2013.10.002 · Cited by 181 · see citing works

Optineurin-mediated mitophagy protects renal tubular epithelial cells against accelerated senescence in diabetic nephropathy

Chen, K., Dai, H., Yuan, J., Chen, J., Lin, L., Zhang, W., Wang, L., Zhang, J., Li, K., & He, Y. (2018) · Cell Death & Disease · doi:10.1038/s41419-017-0127-z · Cited by 150 · see citing works

SP431DcR2 mediates senescent phenotype of tubular cell by interacting with PRDX1: a novel mechanism of renal fibrosis in diabetic nephropathy

Chen, J., Ling, W., Chen, J., & He, Y. (2019) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfz103.sp431

NAT10 inhibition alleviates renal tubular epithelial cell senescence by impeding ac4C acetylation of PAPP-A mRNA in diabetic nephropathy

Hu, M., Lv, L., Li, R. U. N. Z. H. I., Zhao, Z., Li, W., Wang, Y., Liu, Z., Lu, Y., & Zhou, S. (2026) · Cell Death and Disease · doi:10.1038/s41419-026-08970-0 · Cited by 1 · see citing works

Accelerated senescence in the kidneys of patients with type 2 diabetic nephropathy

Verzola, D., Gandolfo, M. T., Gaetani, G., Ferraris, A., Mangerini, R., Ferrario, F., Villaggio, B., Gianiorio, F., Tosetti, F., Weiss, U., et al. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.90302.2008 · Cited by 302 · see citing works