Regulation of Immunity and Inflammation by Hypoxia in Immunological Niches

Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients

Locatelli, F., Fishbane, S. N., Block, G. A., & Macdougall, I. C. (2017) · American Journal of Nephrology · doi:10.1159/000455166 · Cited by 4,834 · see citing works

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

Tannahill, G. M., Curtis, A. M., Adamik, J., Palsson-McDermott, E. M., McGettrick, A. F., Goel, G., Frezza, C., Bernard, N. J., Kelly, B., Foley, N. H., et al. (2013) · Nature · doi:10.1038/nature11986 · Cited by 4,176 · see citing works

Hypoxia-inducible factors in physiology and medicine

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A guide to immunometabolism for immunologists

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Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.

Kaelin, W. G., & Ratcliffe, P. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.04.009 · Cited by 3,251 · see citing works

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

Mills, E. L., Kelly, B., Logan, A., Costa, A. S. H., Varma, M., Bryant, C. E., Tourlomousis, P., Däbritz, J. H. M., Gottlieb, E., Latorre, I., et al. (2016) · Cell · doi:10.1016/j.cell.2016.08.064 · Cited by 2,291 · see citing works

Hypoxia and inflammation

Eltzschig, H. K., & Carmeliet, P. (2011) · New England Journal of Medicine · doi:10.1056/nejmra0910283 · Cited by 2,061 · see citing works

Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1α during hypoxia

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Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.

Semenza, G., Roth, P. H., Fang, H. M., & Wang, G. L. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31580-6 · Cited by 1,892 · see citing works

Impact of epoetin alfa on clinical end points in patients with chronic renal failure: A meta-analysis

Jones, M., Ibels, L. S., Schenkel, B., & Zagari, M. J. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.00450.x · Cited by 1,812 · see citing works

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

Dang, E. V., Barbi, J., Yang, H.-Y., Jinasena, D., Yu, H., Zheng, Y., Bordman, Z., Fu, J., Kim, Y., Yen, H.-R., et al. (2011) · Cell · doi:10.1016/j.cell.2011.07.033 · Cited by 1,595 · see citing works

HIF transcription factors, inflammation, and immunity

Palazon, A., Goldrath, A. W., Nizet, V., & Johnson, R. S. (2014) · Immunity · doi:10.1016/j.immuni.2014.09.008 · Cited by 1,195 · see citing works

Oxygen sensing and molecular adaptation to hypoxia

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HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

Corzo, C. A., Condamine, T., Lu, L., Cotter, M. J., Youn, J.-I., Cheng, P., Cho, H.-I., Celis, E., Quiceno, D. G., Padhya, T., et al. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20100587 · Cited by 1,173 · see citing works

Direct measurement of local oxygen concentration in the bone marrow of live animals

Spencer, J. A., Ferraro, F., Roussakis, E., Klein, A., Wu, J., Runnels, J. M., Zaher, W., Mortensen, L. J., Alt, C., Turcotte, R., et al. (2014) · Nature · doi:10.1038/nature13034 · Cited by 1,167 · see citing works

The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche

Simsek, T., Kocabas, F., Zheng, J., DeBerardinis, R. J., Mahmoud, A. I., Olson, E. N., Schneider, J. W., Zhang, C. C., & Sadek, H. A. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.07.011 · Cited by 1,101 · see citing works

Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients

Worlitzsch, D., Tarran, R., Ulrich, M., Schwab, U. E., Cekici, A., Meyer, K. C., Birrer, P., Bellon, G., Berger, J., Weiß, T., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci13870 · Cited by 1,100 · see citing works

Selective Activation of Inflammatory Pathways by Intermittent Hypoxia in Obstructive Sleep Apnea Syndrome

Ryan, S., Taylor, C. T., & McNicholas, W. T. (2005) · Circulation · doi:10.1161/circulationaha.105.556746 · Cited by 970 · see citing works

Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients

Worlitzsch, D., Tarran, R., Ulrich, M., Schwab, U., Cekici, A., Meyer, K. C., Birrer, P., Bellon, G., Berger, J., Weiss, T., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0213870 · Cited by 932 · see citing works

Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells

Takubo, K., Goda, N., Yamada, W., Iriuchishima, H., Ikeda, E., Kubota, Y., Shima, H., Johnson, R. S., Hirao, A., Suematsu, M., et al. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.06.020 · Cited by 891 · see citing works

Correlation between intraluminal oxygen gradient and radial partitioning of intestinal microbiota

Albenberg, L., Esipova, T. V., Judge, C. P., Bittinger, K., Chen, J., Laughlin, A., Grunberg, S., Baldassano, R. N., Lewis, J. D., Li, H., et al. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.07.020 · Cited by 886 · see citing works

Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia

Parmar, K., Mauch, P., Vergilio, J.-A., Sackstein, R., & Down, J. D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701152104 · Cited by 867 · see citing works

HIF1α and metabolic reprogramming in inflammation

Corcoran, S. E., & O'Neill, L. A. J. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84431 · Cited by 789 · see citing works

Prolyl hydroxylase-1 negatively regulates IκB kinase-β, giving insight into hypoxia-induced NFκB activity

Cummins, E. P., Berra, E., Comerford, K. M., Ginouves, A., Fitzgerald, K. T., Seeballuck, F., Godson, C., Nielsen, J. E., Moynagh, P., Pouyssegur, J., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602235103 · Cited by 788 · see citing works

Regulation of erythropoiesis by hypoxia-inducible factors

Haase, V. H. (2013) · Blood Reviews · doi:10.1016/j.blre.2012.12.003 · Cited by 787 · see citing works

A mechanism of hypoxia-mediated escape from adaptive immunity in cancer cells

Barsoum, I. B., Smallwood, C. A., Siemens, D. R., & Graham, C. H. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-0992 · Cited by 767 · see citing works

Succinate: a metabolic signal in inflammation

Mills, E., & O’Neill, L. A. J. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.11.008 · Cited by 741 · see citing works

The von Hippel–Lindau tumour suppressor protein: O2 sensing and cancer

Kaelin, W. G. (2008) · Nature reviews. Cancer · doi:10.1038/nrc2502 · Cited by 731 · see citing works

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation

Koivunen, P., Lee, S., Duncan, C. G., Lopez, G., Lu, G., Ramkissoon, S., Losman, J. A., Joensuu, P., Bergmann, U., Gross, S., et al. (2012) · Nature · doi:10.1038/nature10898 · Cited by 727 · see citing works

Targeting renal cell carcinoma with a HIF-2 antagonist

Chen, W., Hill, H., Christie, A., Kim, M. S., Holloman, E., Pavia-Jimenez, A., Homayoun, F., Ma, Y., Patel, N., Yell, P., et al. (2016) · Nature · doi:10.1038/nature19796 · Cited by 709 · see citing works

Redistribution of Intracellular Oxygen in Hypoxia by Nitric Oxide: Effect on HIF1α

Hagen, T., Taylor, C. T., Lam, F., & Moncada, S. (2003) · Science · doi:10.1126/science.1088805 · Cited by 704 · see citing works

Immunity, inflammation, and cancer: an eternal fight between good and evil

Shalapour, S., & Karin, M. (2015) · Journal of Clinical Investigation · doi:10.1172/jci80007 · Cited by 703 · see citing works

Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis

Karhausen, J., Furuta, G. T., Tomaszewski, J. E., Johnson, R. S., Colgan, S. P., & Haase, V. H. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200421086 · Cited by 655 · see citing works

Chronic Inflammation in Cancer Development

Multhoff, G., Molls, M., & Radons, J. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2011.00098 · Cited by 591 · see citing works

Autophagy, Inflammation, and Immunity: A Troika Governing Cancer and Its Treatment

Zhong, Z., Sánchez‐López, E., & Karin, M. (2016) · Cell · doi:10.1016/j.cell.2016.05.051 · Cited by 574 · see citing works

Cancer metabolism and the Warburg effect: the role of HIF-1 and PI3K

Courtnay, R., Ngo, D. C., Malik, N., Ververis, K., Tortorella, S. M., & Karagiannis, T. C. (2015) · Molecular Biology Reports · doi:10.1007/s11033-015-3858-x · Cited by 570 · see citing works

Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa

Clambey, E. T., McNamee, E. N., Westrich, J. A., Glover, L. E., Campbell, E. L., Jedlicka, P., de Zoeten, E. F., Cambier, J. C., Stenmark, K. R., Colgan, S. P., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202366109 · Cited by 560 · see citing works

Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts

Mole, D. R., Blancher, C., Copley, R. R., Pollard, P. J., Gleadle, J. M., Ragoussis, J., & Ratcliffe, P. J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m901790200 · Cited by 552 · see citing works

The hypoxic tumor microenvironment: A driving force for breast cancer progression

Semenza, G. L. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.05.036 · Cited by 535 · see citing works

Physiologic hypoxia and oxygen homeostasis in the healthy intestine. A Review in the Theme: Cellular Responses to Hypoxia

Zheng, L., Kelly, C. J., & Colgan, S. P. (2015) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00191.2015 · Cited by 488 · see citing works

The hematopoietic stem cell niche: Low in oxygen but a nice place to be

Eliasson, P., & Jönsson, J. (2009) · Journal of Cellular Physiology · doi:10.1002/jcp.21908 · Cited by 473 · see citing works

Transmigrating Neutrophils Shape the Mucosal Microenvironment through Localized Oxygen Depletion to Influence Resolution of Inflammation

Campbell, E. L., Bruyninckx, W. J., Kelly, C. J., Glover, L. E., McNamee, E. N., Bowers, B., Bayless, A. J., Scully, M. M., Saeedi, B. J., Golden‐Mason, L., et al. (2014) · Immunity · doi:10.1016/j.immuni.2013.11.020 · Cited by 472 · see citing works

Hypoxia-responsive transcription factors

Cummins, E. P., & Taylor, C. T. (2005) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-005-1413-7 · Cited by 462 · see citing works

Hypoxia: an alarm signal during intestinal inflammation

Colgan, S. P., & Taylor, C. T. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.39 · Cited by 461 · see citing works

O2 regulates stem cells through Wnt/β-catenin signalling

Mazumdar, J., O'Brien, W. T., Johnson, R. S., LaManna, J. C., Chavez, J. C., Klein, P. S., & Simon, M. C. (2010) · Nature Cell Biology · doi:10.1038/ncb2102 · Cited by 456 · see citing works

On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models

Cho, H., Du, X., Rizzi, J. P., Liberzon, E., Chakraborty, A. A., Gao, W., Carvo, I., Signoretti, S., Bruick, R. K., Josey, J. A., et al. (2016) · Nature · doi:10.1038/nature19795 · Cited by 451 · see citing works

Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44/42 MAPK and NF-κB

Frede, S., Stockmann, C., Freitag, P., & Fandrey, J. (2006) · Biochemical Journal · doi:10.1042/bj20051839 · Cited by 436 · see citing works

S-2-hydroxyglutarate regulates CD8(+) T-lymphocyte fate

Tyrakis, P. A., Palazon, A., Macias, D., Lee, K. L., Phan, A. T., Veliça, P., You, J., Chia, G. S., Sim, J., Doedens, A., et al. (2016) · Nature · doi:10.1038/nature20165 · Cited by 433 · see citing works

The mercurial nature of neutrophils: still an enigma in ARDS?

Williams, A. E., & Chambers, R. C. (2013) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00311.2013 · Cited by 418 · see citing works

The Hydroxylase Inhibitor Dimethyloxalylglycine Is Protective in a Murine Model of Colitis

Cummins, E. P., Seeballuck, F., Keely, S. J., Mangan, N. E., Callanan, J. J., Fallon, P. G., & Taylor, C. T. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.10.012 · Cited by 407 · see citing works

Noninvasive measurement of anatomic structure and intraluminal oxygenation in the gastrointestinal tract of living mice with spatial and spectral EPR imaging

He, G., Shankar, R. A., Chzhan, M., Samouilov, A., Kuppusamy, P., & Zweier, J. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.8.4586 · Cited by 383 · see citing works

Mucosal Protection by Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition

Robinson, A., Keely, S., Karhausen, J., Gerich, M. E., Furuta, G. T., & Colgan, S. P. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.09.033 · Cited by 368 · see citing works

NF ‐κB and HIF crosstalk in immune responses

D’Ignazio, L., Bandarra, D., & Rocha, S. (2015) · FEBS Journal · doi:10.1111/febs.13578 · Cited by 367 · see citing works

Ontogeny of early life immunity

Dowling, D. J., & Levy, O. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.04.007 · Cited by 365 · see citing works

Interdependent roles for hypoxia inducible factor and nuclear factor‐κB in hypoxic inflammation

Taylor, C. T. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.157669 · Cited by 354 · see citing works

Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation

Cosín‐Roger, J., Simmen, S., Melhem, H., Atrott, K., Frey-Wagner, I. M., Hausmann, M., de Vallière, C., Spalinger, M. R., Spielmann, P., Wenger, R. H., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00213-3 · Cited by 309 · see citing works

Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system

Cho, S. H., Raybuck, A. L., Stengel, K. R., Wei, M., Beck, T. C., Volanakis, E. J., Thomas, J. W., Hiebert, S. W., Haase, V. H., & Boothby, M. R. (2016) · Nature · doi:10.1038/nature19334 · Cited by 307 · see citing works

The tumor microenvironment in esophageal cancer

Lin, E. W., Karakasheva, T. A., Hicks, P. D., Bass, A. J., & Rustgi, A. K. (2016) · Oncogene · doi:10.1038/onc.2016.34 · Cited by 298 · see citing works

Oral Hypoxia–Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat (FG-4592) for the Treatment of Anemia in Patients with CKD

Provenzano, R., Besarab, A., Sun, C. H., Diamond, S. A., Durham, J. H., Cangiano, J. L., Aiello, J. R., Novak, J. E., Lee, T. T., Leong, R., et al. (2016) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.06890615 · Cited by 295 · see citing works

Oxygen sensing and hypoxia signalling pathways in animals: The implications of physiology for cancer

Ratcliffe, P. J. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.251470 · Cited by 294 · see citing works

HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond

Maxwell, P. H., & Eckardt, K. (2015) · Nature Reviews Nephrology · doi:10.1038/nrneph.2015.193 · Cited by 286 · see citing works

Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)

Cockman, M. E., Lancaster, D. E., Stolze, I. P., Hewitson, K. S., McDonough, M. A., Coleman, M. L., Coles, C. H., Yu, X., Hay, R. T., Ley, S. C., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606877103 · Cited by 285 · see citing works

Redox signaling in the gastrointestinal tract

Pérez, S., Taléns‐Visconti, R., Rius‐Pérez, S., Finamor, I., & Sastre, J. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.12.048 · Cited by 274 · see citing works

The EGLN-HIF O 2 -Sensing System: Multiple Inputs and Feedbacks

Ivan, M., & Kaelin, W. G. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.06.002 · Cited by 273 · see citing works

Hypoxia-inducible factor 3 biology: complexities and emerging themes

Duan, C. (2016) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00315.2015 · Cited by 269 · see citing works

L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH

Intlekofer, A. M., Wang, B., Liu, H., Shah, H., Carmona-Fontaine, C., Rustenburg, A. S., Salah, S., Gunner, M. R., Chodera, J. D., Cross, J. R., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2307 · Cited by 268 · see citing works

Adoptive Immunotherapy for Cancer or Viruses

Maus, M. V., Fraietta, J. A., Levine, B. L., Kalos, M. D., Zhao, Y., & June, C. H. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120136 · Cited by 265 · see citing works

The Journey from Discoveries in Fundamental Immunology to Cancer Immunotherapy

Miller, J. F. A. P., & Sadelain, M. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.03.007 · Cited by 243 · see citing works

Cycling hypoxia: A key feature of the tumor microenvironment

Michiels, C., Tellier, C., & Féron, O. (2016) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2016.06.004 · Cited by 239 · see citing works

Vadadustat, a novel oral HIF stabilizer, provides effective anemia treatment in nondialysis-dependent chronic kidney disease

Pérgola, P. E., Spinowitz, B., Hartman, C., Maroni, B. J., & Haase, V. H. (2016) · Kidney International · doi:10.1016/j.kint.2016.07.019 · Cited by 239 · see citing works

An Overview of the Intrathymic Intricacies of T Cell Development

Shah, D., & Zúñiga‐Pflücker, J. C. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302259 · Cited by 236 · see citing works

The hypoxia‐inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens

Loenarz, C., Coleman, M. L., Boleininger, A., Schierwater, B., Holland, P. W. H., Ratcliffe, P. J., & Schofield, C. J. (2010) · EMBO Reports · doi:10.1038/embor.2010.170 · Cited by 235 · see citing works

Nitric Oxide, Cytochrome C Oxidase, and the Cellular Response to Hypoxia

Taylor, C. T., & Moncada, S. (2010) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.181628 · Cited by 220 · see citing works

Interactions of innate and adaptive immunity in brain development and function

Filiano, A. J., Gadani, S. P., & Kipnis, J. (2014) · Brain Research · doi:10.1016/j.brainres.2014.07.050 · Cited by 217 · see citing works

Molecular mechanisms mediating metastasis of hypoxic breast cancer cells

Semenza, G. L. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.08.001 · Cited by 217 · see citing works

Hypoxia-dependent regulation of inflammatory pathways in immune cells

Taylor, C. T., Doherty, G. A., Fallon, P. G., & Cummins, E. P. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84433 · Cited by 217 · see citing works

The effect of hypoxia in development

Webster, W. S., & Abela, D. (2007) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.20102 · Cited by 213 · see citing works

Detection of hypoxia in human squamous cell carcinoma by EF5 binding.

Evans, S. M., Hahn, S. M., Pook, D. R., Jenkins, W. T., Chalian, A. A., Zhang, P. J., Stevens, C., Weber, R. S., Weinstein, G. S., Benjamin, I., et al. (2000) · PubMed · Cited by 190 · see citing works

Activation of Hypoxia Inducible Factor 1 Is a General Phenomenon in Infections with Human Pathogens

Werth, N., Beerlage, C., Rosenberger, C., Yazdi, A. S., Edelmann, M., Amr, A., Bernhardt, W. M., von Eiff, C., Becker, K., Schäfer, A., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011576 · Cited by 173 · see citing works

Oxygen metabolism and barrier regulation in the intestinal mucosa

Glover, L. E., Lee, J. S., & Colgan, S. P. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84429 · Cited by 172 · see citing works

Intermittent hypoxia is a key regulator of cancer cell and endothelial cell interplay in tumours

Toffoli, S., & Michiels, C. (2008) · FEBS Journal · doi:10.1111/j.1742-4658.2008.06454.x · Cited by 170 · see citing works

A Novel Hypoxia-Inducible Factor−Prolyl Hydroxylase Inhibitor (GSK1278863) for Anemia in CKD: A 28-Day, Phase 2A Randomized Trial

Brigandi, R. A., Johnson, B. M., Oei, C., Westerman, M. E., Olbina, G., de Zoysa, J., Roger, S. D., Sahay, M., Cross, N., McMahon, L. P., et al. (2016) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2015.11.021 · Cited by 170 · see citing works

Hypoxia-inducible factors: key regulators of myeloid cells during inflammation

Lin, N., & Simon, M. C. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84426 · Cited by 170 · see citing works

Targeting the HIF pathway in inflammation and immunity

Scholz, C. C., & Taylor, C. T. (2013) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2013.04.009 · Cited by 155 · see citing works

The role of HIF in immunity and inflammation

Cummins, E. P., Keogh, C. E., Crean, D., & Taylor, C. T. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2015.12.004 · Cited by 153 · see citing works

Immune Response Regulation in the Tumor Microenvironment by Hypoxia

Labiano, S., Palazón, A., & Melero, I. (2015) · Seminars in Oncology · doi:10.1053/j.seminoncol.2015.02.009 · Cited by 151 · see citing works

Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model

Bernhardt, W. M., Göttmann, U., Doyon, F., Buchholz, B., Câmpean, V., Schödel, J., Reisenbuechler, A., Klaus, S. J., Arend, M., Flippin, L. A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903978106 · Cited by 145 · see citing works

The impact of hypoxia on bacterial infection

Schaffer, K., & Taylor, C. T. (2015) · FEBS Journal · doi:10.1111/febs.13270 · Cited by 145 · see citing works

The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity

Masson, N., Singleton, R. S., Sekirnik, R., Trudgian, D. C., Ambrose, L. J. A., Miranda, M. X., Tian, Y., Kessler, B. M., Schofield, C. J., & Ratcliffe, P. J. (2012) · EMBO Reports · doi:10.1038/embor.2012.9 · Cited by 144 · see citing works

The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia

Koh, H. S., Chang, C. Y., Jeon, S.-B., Yoon, H. J., Ahn, Y.-H., Kim, H.-S., Kim, I.-H., Jeon, S. H., Johnson, R. S., & Park, E. J. (2015) · Nature Communications · doi:10.1038/ncomms7340 · Cited by 141 · see citing works

Ancient Atmospheres and the Evolution of Oxygen Sensing Via the Hypoxia-Inducible Factor in Metazoans

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Pharmacologic stabilization of HIF-1α increases hematopoietic stem cell quiescence in vivo and accelerates blood recovery after severe irradiation

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