The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Whole egg, but not egg white, ingestion induces mTOR colocalization with the lysosome after resistance exercise
Abstract
We have recently demonstrated that whole egg ingestion induces a greater muscle protein synthetic (MPS) response when compared with isonitrogenous egg white ingestion after resistance exercise in young men. Our aim was to determine whether whole egg or egg white ingestion differentially influenced colocalization of key regulators of mechanistic target of rapamycin complex 1 (mTORC1) as means to explain our previously observed divergent postexercise MPS response. In crossover trials, 10 healthy resistance-trained men (21 ± 1 yr; 88 ± 3 kg; body fat: 16 ± 1%; means ± SE) completed lower body resistance exercise before ingesting whole eggs (18 g protein, 17 g fat) or egg whites (18 g protein, 0 g fat). Muscle biopsies were obtained before exercise and at 120 and 300 min after egg ingestion to assess, by immunofluorescence, protein colocalization of key anabolic signaling molecules. After resistance exercise, tuberous sclerosis 2-Ras homolog enriched in brain (Rheb) colocalization decreased ( P < 0.01) at 120 and 300 min after whole egg and egg white ingestion with concomitant increases ( P < 0.01) in mTOR-Rheb colocalization. After resistance exercise, mTOR-lysosome-associated membrane protein 2 (LAMP2) colocalization significantly increased at 120 and 300 min only after whole egg ingestion ( P < 0.01), and mTOR-LAMP2 colocalization correlated with rates of MPS at rest and after exercise ( r = 0.40, P < 0.05). We demonstrated that the greater postexercise MPS response with whole egg ingestion is related in part to an enhanced recruitment of mTORC1-Rheb complexes to the lysosome during recovery. These data suggest nonprotein dietary factors influence the postexercise regulation of mRNA translation in human skeletal muscle.
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“despite providing equivalent total protein, whole eggs have been shown to more effectively activate mTORC1 [62] and support MyoPS after resistance exercise in young adults than egg whites [152].”
From Protein Requirements for Master Athletes: Just Older Versions of Their Younger Selves (2021) · cites this paper as [62]
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Cites
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
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Self-citationMoore, D. R., Robinson, M. J., Fry, J. L., Tang, J. E., Glover, E. I., Wilkinson, S. B., Prior, T., Tarnopolsky, M. A., & Phillips, S. M. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26401 · Cited by 973
Self-citationLysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex
Castellano, B. M., Thelen, A. M., Moldavski, O., Feltes, M., van der Welle, R. E. N., Mydock-McGrane, L., Jiang, X., van Eijkeren, R. J., Davis, O. B., Louie, S. M., et al. (2017) · Science · doi:10.1126/science.aag1417 · Cited by 562
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The role of skeletal muscle mTOR in the regulation of mechanical load‐induced growth
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Milk ingestion stimulates net muscle protein synthesis following resistance exercise
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Carbohydrate Does Not Augment Exercise-Induced Protein Accretion versus Protein Alone
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Cited by
Monteyne, A. J., Coelho, M. O., Porter, C., Abdelrahman, D. R., Jameson, T. S., Jackman, S. R., Blackwell, J. R., Finnigan, T. J., Stephens, F. B., Dirks, M. L., et al. (2020) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa092 · Cited by 110
Obesity Alters the Muscle Protein Synthetic Response to Nutrition and Exercise
Beals, J. W., Burd, N. A., Moore, D. R., & van Vliet, S. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00087 · Cited by 88
Self-citationVolek, J. S., Kackley, M. L., & Buga, A. (2024) · Current Nutrition Reports · doi:10.1007/s13668-024-00548-6 · Cited by 48
Protein Requirements for Master Athletes: Just Older Versions of Their Younger Selves
Moore, D. R. (2021) · Sports Medicine · doi:10.1007/s40279-021-01510-0 · Cited by 33
Self-citationMazzulla, M., Abou Sawan, S., Williamson, E., Hannaian, S. J., Volterman, K. A., West, D. W. D., & Moore, D. R. (2020) · The Journal of Nutrition · doi:10.1093/jn/nxz249 · Cited by 32
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Metadata
- Authors
- Abou Sawan, S., van Vliet, S., West, D. W. D., Beals, J. W., Paluska, S. A., Burd, N. A., & Moore, D. R.
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 2018-10-01
- Volume
- 315
- Issue
- 4
- Pages
- C537-C543
- ISSN
- 0363-6143
- 1522-1563
- Cited by
- 36
- References
- 14
- Language
- en
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