The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
The dual-specificity MAP kinase phosphatases: critical roles in development and cancer
Abstract
Intracellular signaling by mitogen-activated protein (MAP) kinases (MAPK) is involved in many cellular responses and in the regulation of various physiological and pathological conditions. Tight control of the localization and duration of extracellular-regulated kinase (ERK), c-Jun NH 2-terminal kinase (JNK), or p38 MAPK activity is thus a fundamental aspect of cell biology. Several members of the dual-specificity phosphatase (DUSPs) family are able to dephosphorylate MAPK isoforms with different specificity, cellular, and tissue localization. Understanding how these phosphatases are themselves regulated during development or in physiological and pathological conditions is therefore fundamental. Over the years, gene deletion and knockdown studies have completed initial in vitro studies and shed a new light on the global and specific roles of DUSPs in vivo. Whereas DUSP1, DUSP2, and DUSP10 appear as crucial players in the regulation of immune responses, other members of the family, like the ERK-specific DUSP6, were shown to play a major role in development. Recent findings on the involvement of DUSPs in cancer progression and resistance will also be discussed.
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Cites
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Cited by
ERK1/2 MAP kinases: Structure, function, and regulation
Roskoski, R. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.04.005 · Cited by 1,650
Sugiura, R., Satoh, R., & Takasaki, T. (2021) · Cells · doi:10.3390/cells10102509 · Cited by 369
p38 MAPK Signaling in Osteoblast Differentiation
Rodríguez-Carballo, E., Gámez, B., & Ventura, F. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00040 · Cited by 316
Targeting ERK1/2 protein-serine/threonine kinases in human cancers
Roskoski, R. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.01.039 · Cited by 308
DUSPs, to MAP kinases and beyond
Huang, C.-Y., & Tan, T.-H. (2012) · Cell & Bioscience · doi:10.1186/2045-3701-2-24 · Cited by 260
Metadata
- Authors
- Bermudez, O., Pagès, G., & Gimond, C.
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 2010-08
- Volume
- 299
- Issue
- 2
- Pages
- C189-C202
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- OpenAlex
- W2071900417
- Cited by
- 230
- References
- 11
- FWCI
- 7.92
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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