Hypoxia and cancer
Open accessAbstract
A major feature of solid tumours is hypoxia, decreased availability of oxygen, which increases patient treatment resistance and favours tumour progression. How hypoxic conditions are generated in tumour tissues and how cells respond to hypoxia are essential questions in understanding tumour progression and metastasis. Massive tumour-cell proliferation distances cells from the vasculature, leading to a deficiency in the local environment of blood carrying oxygen and nutrients. Such hypoxic conditions induce a molecular response, in both normal and neoplastic cells, that drives the activation of a key transcription factor; the hypoxia-inducible factor. This transcription factor regulates a large panel of genes that are exploited by tumour cells for survival, resistance to treatment and escape from a nutrient-deprived environment. Although now recognized as a major contributor to cancer progression and to treatment failure, the precise role of hypoxia signalling in cancer and in prognosis still needs to be further defined. It is hoped that a better understanding of the mechanisms implicated will lead to alternative and more efficient therapeutic approaches.
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HIF-1 is a master regulator of hypoxia and oxygen homeostasis.
“A master regulator of hypoxia and oxygen homeostasis is HIF-1 (26,27).”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [26]
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- Chiche J, Laferrière J, Trottier E, Roux D, Mazure N, Brahimi- Horn MC, Pouysségur J (2007) The hypoxia-induced tumor marker carbonic anhydrase IX plays a critical role in tumor microenvironmental pH homeostasis. Keystone Symposium Con- ference. Molecular Targets for Cancer. Abstract # 134, Whistler, British Columbia, 18-23 March
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- Authors
- Brahimi-Horn, M. C., Chiche, J., & Pouysségur, J.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Brahimi-Horn, M. Christiane
- Venue
- Journal of Molecular Medicine
- Published
- 2007-11-20
- Volume
- 85
- Issue
- 12
- Pages
- 1301-1307
- ISSN
- 0946-2716 (ISSN-L)
- 1432-1440
- OpenAlex
- W2151029652
- Cited by
- 765
- References
- 62
- Citations by year
- 2026: 15 · 2025: 31 · 2024: 60 · 2023: 49 · 2022: 58 · 2021: 65 · 2020: 36 · 2019: 25 · 2018: 31 · 2017: 39 · 2016: 42 · 2015: 44 · 2014: 30 · 2013: 53 · 2012: 38
- FWCI
- 2.91
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Molecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Institut National de la Santé et de la Recherche Médicale
- Centre National de la Recherche Scientifique
- Institut National Du Cancer
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Keywords
- tumor hypoxia, hypoxia-inducible factor, tumor progression, treatment resistance, metastasis, tumor vasculature, hypoxia signaling, tumor cell survival, tumor microenvironment, prognosis, therapeutic target
- MeSH terms
- Animals, Hypoxia, Antineoplastic Agents, Humans, Hydrogen-Ion Concentration, Neoplasm Metastasis, Neoplasms, Neovascularization, Pathologic, Oxygen, Phenotype, Prognosis, Signal Transduction, Cell Hypoxia, Cell Death, Angiogenesis Inhibitors, Cell Proliferation, Hypoxia-Inducible Factor 1
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