The DOI matches its Crossref record; 270 of the 271 references it cites were found in a registry or an index.
Mechanisms of normal and tumor-derived angiogenesis
Abstract
Often those diseases most evasive to therapeutic intervention usurp the human body's own cellular machinery or deregulate normal physiological processes for propagation. Tumor-induced angiogenesis is a pathological condition that results from aberrant deployment of normal angiogenesis, an essential process in which the vascular tree is remodeled by the growth of new capillaries from preexisting vessels. Normal angiogenesis ensures that developing or healing tissues receive an adequate supply of nutrients. Within the confines of a tumor, the availability of nutrients is limited by competition among actively proliferating cells, and diffusion of metabolites is impeded by high interstitial pressure (Jain RK. Cancer Res 47: 3039–3051, 1987). As a result, tumor cells induce the formation of a new blood supply from the preexisting vasculature, and this affords tumor cells the ability to survive and propagate in a hostile environment. Because both normal and tumor-induced neovascularization fulfill the essential role of satisfying the metabolic demands of a tissue, the mechanisms by which cancer cells stimulate pathological neovascularization mimic those utilized by normal cells to foster physiological angiogenesis. This review investigates mechanisms of tumor-induced angiogenesis. The strategies used by cancer cells to develop their own blood supply are discussed in relation to those employed by normal cells during physiological angiogenesis. With an understanding of blood vessel growth in both normal and abnormal settings, we are better suited to design effective therapeutics for cancer.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“This hypoxic stress acts as a potent inducer of angiogenic signaling, upregulating key factors such as vascular endothelial growth factor (VEGF) [51].”
From Modeling Tumor Microenvironment Complexity In Vitro: Spheroids as Physiologically Relevant Tumor Models and Strategies for Their Analysis (2025) · cites this paper as [51]
In the citing paper
“As the tumor expands beyond this size, the limited diffusion capacity results in the formation of hypoxic regions, which drive tumor dormancy [50,51].”
From Modeling Tumor Microenvironment Complexity In Vitro: Spheroids as Physiologically Relevant Tumor Models and Strategies for Their Analysis (2025) · cites this paper as [51]
In the citing paper
“Instead of triggering angiogenesis, some tumors co-opt existing vasculature and grow along the vessels [53][54][55][56], until the demand for nutrients and oxygen becomes too large and angiogenesis starts again [53,55].”
From Cancer-on-chip models for metastasis: importance of the tumor microenvironment (2024) · cites this paper as [53]
In the citing paper
“its presence is essential for initiation of the angiogenic program (76,77)”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [76]
In the citing paper
“VEGF-A is the only bona fide endothelial cell growth factor”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [76]
Citations
Cites
Angiogenesis in cancer and other diseases
Carmeliet, P., & Jain, R. K. (2000) · Nature · doi:10.1038/35025220 · Cited by 9,070
Angiogenesis in cancer, vascular, rheumatoid and other disease
Folkman, J. (1995) · Nature Medicine · doi:10.1038/nm0195-27 · Cited by 7,627
Risau, W. (1997) · Nature · doi:10.1038/386671a0 · Cited by 5,727
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
Shweiki, D., Itin, A., Soffer, D., & Keshet, E. (1992) · Nature · doi:10.1038/359843a0 · Cited by 4,617
What Is the Evidence That Tumors Are Angiogenesis Dependent?
Folkman, J. (1990) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/82.1.4 · Cited by 4,509
Endostatin: an endogenous inhibitor of angiogenesis and tumor growth
O'Reilly, M. S., Boehm, T., Shing, Y., Fukai, N., Vasios, G., Lane, W. S., Flynn, E., Birkhead, J. R., Olsen, B. R., & Folkman, J. (1997) · Cell · doi:10.1016/s0092-8674(00)81848-6 · Cited by 4,486
Tumors: Wounds That Do Not Heal
Flier, J. S., Underhill, L. H., & Dvorak, H. F. (1986) · New England Journal of Medicine · doi:10.1056/nejm198612253152606 · Cited by 4,391
Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid
Senger, D. R., Galli, S. J., Dvořàk, A. M., Perruzzi, C. A., Harvey, V. S., & Dvorak, H. F. (1983) · Science · doi:10.1126/science.6823562 · Cited by 3,969
Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
Shalaby, F., Rossant, J., Yamaguchi, T. P., Gertsenstein, M., Wu, X.-F., Breitman, M. L., & Schuh, A. C. (1995) · Nature · doi:10.1038/376062a0 · Cited by 3,931
Vascular-specific growth factors and blood vessel formation
Yancopoulos, G. D., Davis, S., Gale, N. W., Rudge, J. S., Wiegand, S. J., & Holash, J. (2000) · Nature · doi:10.1038/35025215 · Cited by 3,699
Flagged first, then by citations
1 of the 271 references couldn’t be matched to a known paper.
Research works printed but not linked: 32
- Ambs S, 1999, Cancer Res, 59, 5773
- Borgstrom P, 1996, Cancer Res, 56, 4032
- Clark RA, 1996, Am J Pathol, 148, 1407
- Compagni A, 2000, Cancer Res, 60, 7163
- Deroanne CF, 1997, Cancer Res, 57, 5590
- Dumont DJ, 1992, Oncogene, 7, 1471
- Dvorak HF, 1995, Am J Pathol, 146, 1029
- Esser S, 1998, J Cell Sci, 110, 2065
- Folkman J, 1988, Am J Pathol, 130, 393
- Gately S, 1996, Cancer Res, 56, 4887
- Goto F, 1993, Lab Invest, 69, 508
- Healy AM, 1992, Eur J Cell Biol, 59, 56
- Hughes S, 2000, Invest Ophthalmol Vis Sci, 41, 1217
- Jain RK., 1987, Cancer Res, 47, 3039
- Kitsukawa T, 1995, J Biol Chem, 121, 4309
- Kohn S, 1992, Lab Invest, 67, 596
- Korhonen J, 1994, Oncogene, 9, 395
- Luca M, 1997, Am J Pathol, 151, 1105
- Maglione D, 1993, Oncogene, 8, 925
- Merwin JR, 1991, Am J Pathol, 138, 37
- Millauer B, 1996, Cancer Res, 56, 1615
- Nicosia RF, 1994, Am J Pathol, 145, 1023
- Pajusola K, 1992, Cancer Res, 52, 5738
- Pierce GF, 1992, Am J Pathol, 140, 1375
- Senger DR, 1996, Am J Pathol, 149, 293
- Senger DR, 1986, Cancer Res, 46, 5629
- Takahashi Y, 1995, Cancer Res, 55, 3964
- Tanaka T, 1998, Cancer Res, 58, 3362
- Todaro GJ, 1990, Semin Cancer Biol, 1, 257
- Topp MS, 1995, Cancer Res, 55, 2173
- Vlodavsky I, 2000, Isr Med Assoc J, 2, 37
- Ziche M, 1982, J Natl Cancer Inst, 69, 475
Cited by
Sorted by citations
Items 701–800 of 808
Discovery and delivery of anti-angiogenic miRNAs for cancer treatment
Babae, N. (2013) · Utrecht University Repository (Utrecht University)
Gläser, J. D. (2009) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-5596
Angiogenesis in the nasal mucosa
Ahmed, S. K. (2013) · University of Birmingham Institutional Research Archive (University of Birmingham)
The role of mast cells in the microenvironment of tumors
Rabenhorst, A. (2012) · Kölner Universitäts PublikationsServer (Universität zu Köln)
Ligand-Directed AAVP to Deliver a Therapeutic Transgene to Neuroendocrine Tumors of the Pancreas
Smith, T. L. (2013) · Digital Commons-TMC (Texas Medical Center)
Li, C., Chen, J., Wang, Z., Zhang, B., Li, B., & Song, Y. (2006) · Chinese Journal of Cancer Research · doi:10.1007/s11670-006-0198-3
Kim, S. J., Lee, J. M., Kim, J. S., Kang, J. Y., Lee, S. H., Kim, S. C., Lee, S. Y., Kim, C. H., Ahn, J. H., Kwon, S. S., et al. (2008) · Tuberculosis & respiratory diseases · doi:10.4046/trd.2008.64.3.200
Néovascularisation de la plaque ostéochondrale : nouvelle cible thérapeutique de l’arthrose
Pesesse, L., Sanchez, C., & Henrotin, Y. E. (2010) · Revue du Rhumatisme · doi:10.1016/j.rhum.2010.05.004
Androgen-Independent Prostate Cancer - studies on angiogenesis and ADAMTS1
Gustavsson, H. (2009) · Gothenburg University Publications Electronic Archive (Gothenburg University)
PET Imaging of Tumor Integrin Expression
Cai, W., & Chen, X. S. (2006) · IEEE Computational Systems Bioinformatics Conference (CSB) · doi:10.1109/csbw.2005.105
Müller, S. A. (2009) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-14036
On the stimulatory effect of microglial cells on angiogenesis
Rymo, S. (2011) · Gothenburg University Publications Electronic Archive (Gothenburg University)
EFECTOS ANTICANCEROSOS DE POLIFENOLES NATURALES: PETEROSTILBENO Y QUERCETINA
Pastor, P. F. (2008) · TDX (Tesis Doctorals en Xarxa)
Tissue Engineering of Vascularized Adipose Tissue for Soft Tissue Reconstruction
Klein, S., Vykoukal, J. V., Prantl, L., & Dolderer, J. H. (2014) · Springer eBooks · doi:10.1007/978-3-642-45207-9_3
Endothelial Cell Replacement Therapy in the Critically Ill
Baudouin, S. (2003) · Springer eBooks · doi:10.1007/978-1-4757-5548-0_3
Babasola, I. O. (2012) · QSpace (Queen's University Library)
RIBAS, J. L. L., de Campos, M., & Capelozzi, V. L. (2004)
Novel Treatment Modalities for High-Risk Neuroblastoma : Studies in Animal Models
Fuchs, D. (2009) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Angiogenesis Related Remodeling and Reprogramming in Melanomas
Iyengar, B., & Internationals, O. (2015) · Investigative Dermatology and Venereology Research · doi:10.15436/2381-0858.15.003 · Cited by 1
Fibroblast Growth Factor Signaling in Vascular Development
Kovačević, I., Hoffmeister, M., & Oess, S. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2907-8_4
The Adrenergic System in Vascular Endothelial Cells
Ciccarelli, M., Sorriento, D., & Iaccarino, G. (2015) · Springer eBooks · doi:10.1007/978-3-319-13680-6_3
Oxygen Signaling in Physiological and Pathological Angiogenesis
Henze, A., & Mazzone, M. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2907-8_14
Targeting Tumor Associated Fibroblasts and Chemotherapy
Liao, D., & Reisfeld, R. A. (2011) · Springer eBooks · doi:10.1007/978-94-007-0659-0_21
Sharma, S. (2016) · Liverpool John Moores University · doi:10.24377/ljmu.t.00004481
Agha-Alinejad, H., Shokrollahi, F., & Matinhomaei, H. (2016) · Medical Journal of Tabriz University of Medical Sciences and Health Services
Angiogeneshämmare som behandling mot metastaser Var forskningen är idag och vart den är på väg
Grevby, C. J. (2013) · Epsilon Archive for Student Projects (University of Southampton)
Angiogenesis in Gynecologic Cancers
Growdon, W., Foster, R., & Bradford, L. S. (2013) · CRC Press eBooks · doi:10.1201/b14842-11
p27kip1 and p57Kip2 (CDKN1B and CDKN1C)
Salajegheh, A. (2016) · Springer eBooks · doi:10.1007/978-3-319-28140-7_34
Serum platelet-derived growth factor-BB in adult patients with aggressive non-Hodgkin's lymphoma
Azmy, E., Youssef, L. F., Halim, A. A. F., Rabie, A., & El-Gayar, A. M. (2012) · The Egyptian Journal of Haematology · doi:10.7123/01.ejh.0000415411.50251.80
STEM CELL AND HYPOXIA-BASED APPROACHES TO ENGINEERING BLOOD VESSELS
Kusuma, S. (2014)
Heterogeneity of Tie2 Expression in Tumor
Fathers, K. E., Stone, C., Minhas, K., Greenwood, J. D., Dumont, D., & Coomber, B. L. (2005)
Klinika Chirurgii Onkologicznej, U. C. K., Król, K., & Sznurkowski, J. J. (2016) · Ginekologia Onkologiczna/Current Gynecologic Oncology · doi:10.15557/cgo.2016.0019
Kalliokoski, S., Sulic, A., Korponay-Szabo, I. R., Szondy, Z., Frías, R., Perez, M. A., Martucciello, S., Roivainen, A., Pelliniemi, L. J., Esposito, C., et al. (2014) · PLoS ONE · doi:10.1371/annotation/a0040512-ea12-47b4-943b-2e68d665a851
Chronic Hypoxia Induces Epigenetic Modifications in the Fetal Rat Heart
Patterson, A. J. (2011) · The Scholars Repository - LLU (Loma Linda University)
Tremmel, M. (2009) · heiDOK (Heidelberg University) · doi:10.11588/heidok.00009814
Pós-Graduação, P. D. (2014)
A novel peptide derived from the functional domain of AGGF1 has anti-angiogenic activity
Pasupuleti, V. (2011) · OhioLink ETD Center (Ohio Library and Information Network)
Validation and Mechanism Studies of Novel Therapeutic Compounds Modulating Angiogenesis
Tat, J. (2013) · TSpace (University of Toronto)
Szpera-Goździewicz, A., Goździewicz, T., Wirstlein, P. K., Wender-Ożegowska, E., & Bręborowicz, G. H. (2017) · Polskie Archiwum Medycyny Wewnętrznej · doi:10.20452/pamw.4138
Chintalapati, M. (2006) · Louisiana State University · doi:10.31390/gradschool_theses.2153
Methods to Study Angiogenesis in a Mouse Model of Prostate Cancer
Pedrosa, A., Trindade, A., & Duarte, A. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7845-8_2
Platelet-Derived Growth Factor Receptor (PDGF-R) as the Target for Herbal-Based Anticancer Agents
Ramamoorthy, M. D., & Dhiraviam, K. N. (2018) · Springer eBooks · doi:10.1007/978-981-10-8064-7_17
우선민, & Kwon, T. K. (2018) · JoLS Journal of Life Sciences
The Value of Anti-angiogenics in Breast Cancer Therapy
Banys-Paluchowski, M. J., Fehm, T. N., & Müller, V. (2019) · Springer eBooks · doi:10.1007/978-3-319-33673-2_24
Influence of VEGF deprivation upon vascular formation by endothelium in the presence of macrophages
Козырева, А. Р., Lvova, T. Y., Markova, K. L., Симбирцев, А. С., Ischenko, A. M., Selkov, S. А., & Соколов, Д. И. (2020) · Medical Immunology (Russia) · doi:10.15789/1563-0625-iov-1894
Toward the patient-centred development of cancer therapeutics: A focus on nanomedicines
Freeman, M. W. (2018) · TSpace (University of Toronto)
Cancer Stem Cells and Therapeutic Angiogenesis
Bhagavatheeswaran, S., & Balakrishnan, A. (2020) · Springer eBooks · doi:10.1007/978-981-15-5120-8_11
A talidomida como agente antiangiogênico no câncer de mama
Hable, J. Y. S., Heller, H. L., & de Farias, L. R. (2021) · Programa de Iniciação Científica - PIC/UniCEUB - Relatórios de Pesquisa · doi:10.5102/pic.n0.2019.7529
EGFL7 inhibits tumor angiogenesis via its Emilin-like domain
Kadam, A. N. (2017) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3rx93w1s
Polymer ultrasound contrast agents for targeted drug and gene delivery
Cochran, M., & Wheatley, M. A. (2012) · doi:10.17918/etd-7001
Yoo, S., You, D. H., Lee, J., Hong, H. C., & Lee, S. J. (2022) · medRxiv · doi:10.1101/2021.12.30.21267814
Weinstein, B. M. (2003) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1012571.186233
Salajegheh, A. (2016) · Springer eBooks · doi:10.1007/978-3-319-28140-7_17
Vascular and Stromal Contributions to Tumor Bone-Homing: Focus on Multiple Myeloma
Federico, C., Sacco, A., Belotti, A., Ribolla, R., Cancelli, V., Giacomini, A., Ronca, R., Chiarini, M., Imberti, L., Marini, M., et al. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.11240-1
Zalev, J., Richards, L. M., Clingman, B. A., Harris, J., Cantu, E., Menezes, G. L. G., Avila, C., Bertrand, A., Saenz, X., Miller, S., et al. (2022) · doi:10.32920/21290946
Endothelial Cell Reactions to Oxygen: Implications for Cancer
de Oliveira, R. L., & Mazzone, M. (2014) · Springer eBooks · doi:10.1007/978-2-8178-0466-8_12
Photoacoustic Imaging for Monitoring Vascular Disrupting Agents
Fadhel, M. N. (2023) · doi:10.32920/23325650.v1
Photoacoustic Imaging for Monitoring Vascular Disrupting Agents
Fadhel, M. N. (2023) · doi:10.32920/23325650
Ceylan, H. K., Meydan, C., Nalbantsoy, A., & Elibol, M. (2024) · Türk doğa ve fen dergisi :/Türk doğa ve fen dergisi · doi:10.46810/tdfd.1474399
Targeting long non-coding RNA RP11-502I4.3 delays the trend of angiogenesis in diabetic retinopathyPreprint
Zeng, L., Wu, Y., Zhu, L., He, J., Yuan, Y., Wang, X., Tang, K., & Tan, W. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.15.618482
Mast Cells in and Their Cellular Interactions Within the Tumor Environment
Jackson, C. W., Reji, M. A., Pratt, C. M., Nguyen, S. M. T., & Krishnaswamy, G. A. (2022) · Springer eBooks · doi:10.1007/978-3-030-80962-1_21-1
The Blood-Brain Barrier Disruption Methods for Drug Delivery
Amini, M., & Banu, M. A. (2025) · Springer eBooks · doi:10.1007/978-3-031-80173-0_5
Mast Cells in and Their Cellular Interactions Within the Tumor Environment
Jackson, C. W., Reji, M. A., Pratt, C. M., Nguyen, S. M. T., & Krishnaswamy, G. A. (2025) · Springer eBooks · doi:10.1007/978-3-032-00749-0_21
Long, W., Zhou, M., Han, X., & Wang, H. (2025) · Asian Journal of Surgery · doi:10.1016/j.asjsur.2025.09.212
Osório, C. (2011) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · doi:10.34626/qe3m-0107
Blin, J. A., Hamid, R. A., & Khaza’ai, H. (2021) · Figshare · doi:10.6084/m9.figshare.14850623
Blin, J. A., Hamid, R. A., & Khaza’ai, H. (2021) · Figshare · doi:10.6084/m9.figshare.14850626
Manoharan, S., Venkatesan, V., & Perumal, E. (2026) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-026-05052-y
AI ‐assisted design of a VEGFR2 agonistic peptide that promotes angiogenesis and wound repair
Yasmeen, F., Ramachandran, R., Pirzada, R. H., CHOI, B. I. W., Seo, H., Kim, W., Kim, M. S., & Choi, S. (2026) · Protein Science · doi:10.1002/pro.70529
Epigenetics in angiogenesis, gastrointestinal cancer progression and its clinical significance
Chandana, A. N., & Bhagya, N. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-27765-8.00012-6
Tie1 et la transition endothélio-mésenchymateuse
Garcia, J. (2013) · theses.fr (ABES) · doi:10.70675/063d32edz5c5cz44e7zb912z0fa2bc96180b
Synthèse et évaluation angiogénique d'analogues du M6P
Mintsa, L. M. (2015) · theses.fr (ABES) · doi:10.70675/10d7ccd4z8129z40ddz933dz0157efb5dbcf
Contribution à l'étude du rôle de CD146 soluble dans les pathologies angiogéniques
Stalin, J. (2014) · theses.fr (ABES) · doi:10.70675/987330a7zf9b1z4179z90fbzf2c1119eb37b
Les nanoparticules à visée théranostique en oncologie : évaluation de leur innocuité et efficacité
Corréard, F. (2015) · theses.fr (ABES) · doi:10.70675/b791757az8695z49e5z8a01z1edee2d8ca4f
Le syndrome de Rendu-Osler-Weber : aspects génétiques, moléculaires et épidémiologiques
Din, F. A. E. (2015) · theses.fr (ABES) · doi:10.70675/2bea4075z05b5z47d5zbbd3z3f6caf32edd8
Magalon, J. (2018) · doi:10.70675/917579acze581z4bfbzb10czc6d5c3150e9d
Metadata
- Authors
- Papetti, M., & Herman, I. M.
- Affiliations
- Tufts University (US)
- ORCID
- Herman, Ira M.
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 2002-05-01
- Volume
- 282
- Issue
- 5
- Pages
- C947-C970
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- OpenAlex
- W2050499474
- Cited by
- 809
- References
- 271
- Citations by year
- 2026: 11 · 2025: 15 · 2024: 19 · 2023: 33 · 2022: 38 · 2021: 32 · 2020: 36 · 2019: 28 · 2018: 20 · 2017: 41 · 2016: 36 · 2015: 45 · 2014: 42 · 2013: 46 · 2012: 41
- FWCI
- 2.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Cell Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01gm055110-04)
- National Eye Institute (R01EY009033, EY09033)
- National Institute of General Medical Sciences (GM55110)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK034928)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
- Physical Sciences › Mathematics › Modeling and Simulation › Mathematical Biology Tumor Growth
- Keywords
- tumor angiogenesis, physiological angiogenesis, tumor blood supply, vascular remodeling, capillary proliferation, interstitial fluid pressure, tumor microenvironment, cancer metabolism
- MeSH terms
- Blood Vessels, Growth Substances, Humans, Models, Cardiovascular, Neoplasms, Neovascularization, Pathologic, Proteins, Receptors, Cell Surface, Neovascularization, Physiologic, Receptor Protein-Tyrosine Kinases, Angiopoietin-2, Receptors, TIE
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review