The life and times of cellular senescence in skeletal muscle: Friend or foe for homeostasis and adaptation?

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477 · see citing works

The senescence-associated secretory phenotype: the dark side of tumor suppression

Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206 · see citing works

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766 · see citing works

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670 · see citing works

Cellular Senescence: Defining a Path Forward

Gorgoulis, V., Adams, P. D., Alimonti, A., Bennett, D. C., Bischof, O., Bishop, C., Campisi, J., Collado, M., Evangelou, K., Ferbeyre, G., et al. (2019) · Cell · doi:10.1016/j.cell.2019.10.005 · Cited by 3,225 · see citing works

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

Baker, D. J., Childs, B. G., Durik, M., Wijers, M. E., Sieben, C. J., Zhong, J., A. Saltness, R., Jeganathan, K. B., Verzosa, G. C., Pezeshki, A., et al. (2016) · Nature · doi:10.1038/nature16932 · Cited by 2,891 · see citing works

A DNA damage checkpoint response in telomere-initiated senescence

Fagagna, F. D. D., Reaper, P. M., Clay-Farrace, L., Fiegler, H., Carr, P., von Zglinicki, T., Saretzki, G., Carter, N. P., & Jackson, S. P. (2003) · Nature · doi:10.1038/nature02118 · Cited by 2,855 · see citing works

p21 in cancer: Intricate networks and multiple activities

Abbas, T., & Dutta, A. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2657 · Cited by 2,712 · see citing works

Hallmarks of Cellular Senescence

Hernandez-Segura, A., Nehme, J., & Demaria, M. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.02.001 · Cited by 2,605 · see citing works

Senolytics improve physical function and increase lifespan in old age

Xu, M., Pirtskhalava, T., Farr, J. N., Weigand, B. M., Palmer, A. K., Weivoda, M. M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0092-9 · Cited by 2,287 · see citing works

Cellular senescence in ageing: from mechanisms to therapeutic opportunities

Di Micco, R., Krizhanovsky, V., Baker, D., & d’Adda di Fagagna, F. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00314-w · Cited by 2,277 · see citing works

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

Demaria, M., Ohtani, N., Youssef, S. A., Rodier, F., Toussaint, W., Mitchell, J. R., Laberge, R.-M., Vijg, J., Van Steeg, H., Dollé, M. E. T., et al. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.11.012 · Cited by 2,045 · see citing works

Senolytic drugs: from discovery to translation

Kirkland, J. L., & Tchkonia, T. (2020) · Journal of Internal Medicine · doi:10.1111/joim.13141 · Cited by 1,227 · see citing works

Targeting cellular senescence prevents age-related bone loss in mice

Farr, J. N., Xu, M., Weivoda, M. M., Monroe, D. G., Fraser, D. G., Onken, J. L., Negley, B. A., Sfeir, J. G., Ogrodnik, M. B., Hachfeld, C. M., et al. (2017) · Nature Medicine · doi:10.1038/nm.4385 · Cited by 1,182 · see citing works

Senescence and the SASP: many therapeutic avenues

Birch, J., & Gil, J. (2020) · Genes & Development · doi:10.1101/gad.343129.120 · Cited by 1,177 · see citing works

Cellular senescence: the good, the bad and the unknown

Huang, W., Hickson, L. J., Eirin, A., Kirkland, J. L., & Lerman, L. O. (2022) · Nature Reviews Nephrology · doi:10.1038/s41581-022-00601-z · Cited by 1,150 · see citing works

Correlation of Terminal Cell Cycle Arrest of Skeletal Muscle with Induction of p21 by MyoD

Halevy, O., Novitch, B. G., Spicer, D. B., Skapek, S. X., Rhee, J., Hannon, G. J., Beach, D., & Lassar, A. B. (1995) · Science · doi:10.1126/science.7863327 · Cited by 1,139 · see citing works

A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues

Saul, D., Kosinsky, R. L., Atkinson, E. J., Doolittle, M. L., Zhang, X., LeBrasseur, N. K., Pignolo, R. J., Robbins, P. D., Niedernhofer, L. J., Ikeno, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32552-1 · Cited by 1,060 · see citing works

Lamin B1 loss is a senescence-associated biomarker

Freund, A., Laberge, R.-M., Demaria, M., & Campisi, J. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-10-0884 · Cited by 1,046 · see citing works

Cellular senescence: a translational perspective

Kirkland, J. L., & Tchkonia, T. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.04.013 · Cited by 1,013 · see citing works

Geriatric muscle stem cells switch reversible quiescence into senescence

Sousa-Victor, P., Gutarra, S., García-Prat, L., Rodriguez-Ubreva, J., Ortet, L., Ruiz-Bonilla, V., Jardí, M., Ballestar, E., González, S., Serrano, A. L., et al. (2014) · Nature · doi:10.1038/nature13013 · Cited by 1,010 · see citing works

Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model

Zhang, P., Kishimoto, Y., Grammatikakis, I., Gottimukkala, K., Cutler, R. G., Zhang, S., Abdelmohsen, K., Bohr, V. A., Misra Sen, J., Gorospe, M., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0372-9 · Cited by 977 · see citing works

Regulation of Muscle Growth and Regeneration by the Immune System

Tidball, J. G. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2016.150 · Cited by 740 · see citing works

BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice

Baker, D. J., Jeganathan, K. B., Cameron, J. D., Thompson, M., Juneja, S., Kopecka, A., Kumar, R., Jenkins, R. B., de Groen, P. C., Roche, P., et al. (2004) · Nature Genetics · doi:10.1038/ng1382 · Cited by 731 · see citing works

DNA damage response and cellular senescence in tissues of aging mice

Wang, C., Jurk, D., Maddick, M., Nelson, G., Martin‐Ruiz, C., & Von Zglinicki, T. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00481.x · Cited by 696 · see citing works

Targeting senescent cells alleviates obesity-induced metabolic dysfunction

Palmer, A. K., Xu, M., Zhu, Y., Pirtskhalava, T., Weivoda, M. M., Hachfeld, C. M., Prata, L. G., van Dijk, T. H., Verkade, E., Casaclang‐Verzosa, G., et al. (2019) · Aging Cell · doi:10.1111/acel.12950 · Cited by 658 · see citing works

Targeting cellular senescence with senotherapeutics: senolytics and senomorphics

Zhang, L. J., Pitcher, L. E., Prahalad, V., Niedernhofer, L. J., & Robbins, P. D. (2022) · FEBS Journal · doi:10.1111/febs.16350 · Cited by 648 · see citing works

Muscle type and fiber type specificity in muscle wasting

Ciciliot, S., Rossi, C. A., Dyar, K. A., Blaauw, B., & Schiaffino, S. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.05.016 · Cited by 626 · see citing works

Accumulation of senescent cells in Mitotic tissue of aging primates

Jeyapalan, J. C., Ferreira, M., Sedivy, J. M., & Herbig, U. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.008 · Cited by 571 · see citing works

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

Ogrodnik, M., Zhu, Y., Langhi, L. G. P., Tchkonia, T., Krüger, P., Fielder, E., Victorelli, S., Ruswhandi, R. A., Giorgadze, N., Pirtskhalava, T., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2018.12.008 · Cited by 536 · see citing works

Length-independent telomere damage drives post-mitotic cardiomyocyte senescence

Anderson, R., Lagnado, A., Maggiorani, D., Walaszczyk, A., Dookun, E., Chapman, J., Birch, J., Salmonowicz, H., Ogrodnik, M., Jurk, D., et al. (2019) · The EMBO Journal · doi:10.15252/embj.2018100492 · Cited by 532 · see citing works

The Flaws and Human Harms of Animal Experimentation

AKHTAR, A. (2015) · Cambridge Quarterly of Healthcare Ethics · doi:10.1017/s0963180115000079 · Cited by 527 · see citing works

p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes

Davalos, A. R., Kawahara, M., Malhotra, G. K., Schaum, N., Huang, J., Ved, U., Beausejour, C. M., Coppe, J.-P., Rodier, F., & Campisi, J. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201206006 · Cited by 439 · see citing works

Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration

Moiseeva, V., Cisneros, A., Sica, V., Deryagin, O., Lai, Y., Jung, S., Andrés, E., An, J., Segalés, J., Ortet, L., et al. (2023) · Nature · doi:10.1038/s41586-022-05535-x · Cited by 423 · see citing works

Telomeres and cell senescence—size matters not

Victorelli, S., & Passos, J. F. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.03.027 · Cited by 413 · see citing works

p21CIP1 and p57KIP2 control muscle differentiation at the myogenin stepPreprint

Zhang, P., Wong, C., Liu, D., Finegold, M. J., Harper, J. W., & Elledge, S. J. (1999) · Genes & Development · doi:10.1101/gad.13.2.213 · Cited by 409 · see citing works

p16(Ink4a) and senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli

Hall, B. M., Balan, V., Gleiberman, A. S., Strom, E., Krasnov, P., Virtuoso, L. P., Rydkina, E., Vujcic, S., Balan, K., Gitlin, I. I., et al. (2017) · Aging · doi:10.18632/aging.101268 · Cited by 407 · see citing works

Associations of Muscle Mass and Strength with All-Cause Mortality among US Older Adults

LI, R., XIA, J., ZHANG, X., GATHIRUA-MWANGI, W. G., GUO, J., LI, Y., MCKENZIE, S., & SONG, Y. (2018) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001448 · Cited by 398 · see citing works

Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues

Georgakopoulou, E., Tsimaratou, K., Evangelou, K., Fernandez, M.-P., Zoumpourlis, V, Trougakos, I., Kletsas, D., Bartek, J., Serrano, M., & Gorgoulis, V. (2012) · Aging · doi:10.18632/aging.100527 · Cited by 390 · see citing works

Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells

Hall, B. M., Balan, V., Gleiberman, A. S., Strom, E., Krasnov, P., Virtuoso, L. P., Rydkina, E., Vujcic, S., Balan, K., Gitlin, I., et al. (2016) · Aging · doi:10.18632/aging.100991 · Cited by 357 · see citing works

Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice

Yousefzadeh, M. J., Zhao, J., Bukata, C., Wade, E. A., McGowan, S. J., Angelini, L. A., Bank, M. P., Gurkar, A. U., McGuckian, C. A., Calubag, M. F., et al. (2020) · Aging Cell · doi:10.1111/acel.13094 · Cited by 331 · see citing works

Myonuclei acquired by overload exercise precede hypertrophy and are not lost on detraining

Bruusgaard, J. C., Johansen, I. B., Egner, I. M., Rana, Z. A., & Gundersen, K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913935107 · Cited by 327 · see citing works

CYTOLOGICAL STUDIES OF FIBER TYPES IN SKELETAL MUSCLE

GAUTHIER, G. F., & Padykula, H. A. (1966) · The Journal of Cell Biology · doi:10.1083/jcb.28.2.333 · Cited by 319 · see citing works

Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent

Chang, B.-D., Swift, M. E., Shen, M., Fang, J., Broude, E. V., & Roninson, I. B. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012602599 · Cited by 312 · see citing works

Injury-Induced Senescence Enables In Vivo Reprogramming in Skeletal Muscle

Chiche, A., Le Roux, I., von Joest, M., Sakai, H., Aguín, S. B., Cazin, C., Salam, R., Fiette, L., Alegria, O., Flamant, P., et al. (2017) · Cell Stem Cell · doi:10.1016/j.stem.2016.11.020 · Cited by 295 · see citing works

Therapy-Induced Senescence: An “Old” Friend Becomes the Enemy

Saleh, T., Bloukh, S., Carpenter, V. J., Alwohoush, E., Bakeer, J., Darwish, S., Azab, B., & Gewirtz, D. A. (2020) · Cancers · doi:10.3390/cancers12040822 · Cited by 289 · see citing works

Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation

Brenner, A. J., Stampfer, M. R., & Aldaz, C. M. (1998) · Oncogene · doi:10.1038/sj.onc.1201919 · Cited by 272 · see citing works

Monocyte/macrophage interactions with myogenic precursor cells during skeletal muscle regeneration

Saclier, M., Cuvellier, S., Magnan, M., Mounier, R., & Chazaud, B. (2013) · FEBS Journal · doi:10.1111/febs.12166 · Cited by 248 · see citing works

The bystander effect contributes to the accumulation of senescent cells in vivo

da Silva, P. F. L., Ogrodnik, M., Kucheryavenko, O., Glibert, J., Miwa, S., Cameron, K., Ishaq, A., Saretzki, G., Nagaraja‐Grellscheid, S., Nelson, G., et al. (2019) · Aging Cell · doi:10.1111/acel.12848 · Cited by 247 · see citing works

Shared Resistance to Aging and ALS in Neuromuscular Junctions of Specific Muscles

Valdez, G., Tapia, J. C., Lichtman, J. W., Fox, M. A., & Sanes, J. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034640 · Cited by 216 · see citing works

Replicative Senescence and Cell Immortality: The Role of Telomeres and Telomerase

Chiu, C. P., & Harley, C. B. (1997) · Experimental Biology and Medicine · doi:10.3181/00379727-214-44075 · Cited by 214 · see citing works

Characterization of cellular senescence in aging skeletal muscle

Zhang, X., Habiballa, L., Aversa, Z., Ng, Y. E., Sakamoto, A. E., Englund, D. A., Pearsall, V. M., White, T. A., Robinson, M. M., Rivas, D. A., et al. (2022) · Nature Aging · doi:10.1038/s43587-022-00250-8 · Cited by 206 · see citing works

Exercise enhances skeletal muscle regeneration by promoting senescence in fibro-adipogenic progenitors

Saito, Y., Chikenji, T. S., Matsumura, T., Nakano, M., & Fujimiya, M. (2020) · Nature Communications · doi:10.1038/s41467-020-14734-x · Cited by 196 · see citing works

Cellular Senescence in Postmitotic Cells: Beyond Growth Arrest

Sapieha, P., & Mallette, F. A. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.03.003 · Cited by 193 · see citing works

Senotherapeutics for healthy ageing

Niedernhofer, L. J., & Robbins, P. D. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.44 · Cited by 190 · see citing works

Sentinel <i>p16</i> ^INK4a+ cells in the basement membrane form a reparative niche in the lung

Reyes, N. S., Krasilnikov, M., Allen, N. C., Lee, J. Y., Hyams, B., Zhou, M., Ravishankar, S., Cassandras, M., Wang, C., Khan, I., et al. (2022) · Science · doi:10.1126/science.abf3326 · Cited by 181 · see citing works

Senescence in Post-Mitotic Cells: A Driver of Aging?

von Zglinicki, T., Wan, T., & Miwa, S. (2021) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2020.8048 · Cited by 170 · see citing works

A cellular memory mechanism aids overload hypertrophy in muscle long after an episodic exposure to anabolic steroids

Egner, I. M., Bruusgaard, J. C., Eftestøl, E., & Gundersen, K. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.264457 · Cited by 159 · see citing works

Mice Fed Rapamycin Have an Increase in Lifespan Associated with Major Changes in the Liver Transcriptome

Fok, W. C., Chen, Y., Bokov, A. F., Zhang, Y., Salmon, A. B., Diaz, V., Javors, M. A., Wood, W. H., Zhang, Y., Becker, K. G., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0083988 · Cited by 145 · see citing works

Exercise reduces circulating biomarkers of cellular senescence in humans

Englund, D. A., Sakamoto, A. E., Fritsche, C. M., Heeren, A. A., Zhang, X., Kotajarvi, B. R., Lecy, D. R., Yousefzadeh, M. J., Schafer, M. J., White, T. A., et al. (2021) · Aging Cell · doi:10.1111/acel.13415 · Cited by 125 · see citing works

Sudan Black B, The Specific Histochemical Stain for Lipofuscin: A Novel Method to Detect Senescent Cells

Evangelou, K., & Gorgoulis, V. G. (2017) · Methods in Molecular Biology · doi:10.1007/978-1-4939-6670-7_10 · Cited by 124 · see citing works

Is Senescence-Associated β-Galactosidase a Reliable in vivo Marker of Cellular Senescence During Embryonic Development?

de Mera‐Rodríguez, J. A., Álvarez‐Hernán, G., Gañán, Y., Martín‐Partido, G., Rodríguez‐León, J., & Francisco‐Morcillo, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.623175 · Cited by 123 · see citing works

Effects of Aging on Type II Muscle Fibers: A Systematic Review of the Literature

Brunner, F., Schmid, A. B., Sheikhzadeh, A., Nordin, M. C., Yoon, J., & Frankel, V. H. (2007) · Journal of Aging and Physical Activity · doi:10.1123/japa.15.3.336 · Cited by 117 · see citing works

p21 is essential for normal myogenic progenitor cell function in regenerating skeletal muscle

Hawke, T. J., Meeson, A. P., Jiang, N., Graham, S. M., Hutcheson, K. A., DiMaio, J. M., & Garry, D. J. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00055.2003 · Cited by 110 · see citing works

Deletion of SA β‐Gal+ cells using senolytics improves muscle regeneration in old mice

Dungan, C. M., Murach, K. A., Zdunek, C. J., Tang, Z. J., Nolt, G. L., Brightwell, C. R., Hettinger, Z. R., Englund, D. A., Liu, Z., Fry, C. S., et al. (2021) · Aging Cell · doi:10.1111/acel.13528 · Cited by 105 · see citing works

Elevated myonuclear density during skeletal muscle hypertrophy in response to training is reversed during detraining

Dungan, C. M., Murach, K. A., Frick, K. K., Jones, S. R., Crow, S. E., Englund, D. A., Vechetti, I. J., Figueiredo, V. C., Levitan, B. M., Satin, J., et al. (2019) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00050.2019 · Cited by 103 · see citing works

Increase in relative skeletal muscle mass over time and its inverse association with metabolic syndrome development: a 7-year retrospective cohort study

Kim, G., Lee, S., Jun, J. E., Lee, Y., Ahn, J., Bae, J. C., Jin, S., Hur, K. Y., Jee, J. H., Lee, M., et al. (2018) · Cardiovascular Diabetology · doi:10.1186/s12933-018-0659-2 · Cited by 98 · see citing works

Effects of training, detraining, and retraining on strength, hypertrophy, and myonuclear number in human skeletal muscle

Psilander, N., Eftestøl, E., Cumming, K. T., Juvkam, I., Ekblom, M. M., Sunding, K., Wernbom, M., Holmberg, H.-C., Ekblom, B., Bruusgaard, J. C., et al. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00917.2018 · Cited by 95 · see citing works

Skeletal muscle aging, cellular senescence, and senotherapeutics: current knowledge and future directions

Englund, D. A., Zhang, X., Aversa, Z., & LeBrasseur, N. K. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111595 · Cited by 94 · see citing works

Muscle memory: myonuclear accretion, maintenance, morphology, and miRNA levels with training and detraining in adult mice

Murach, K. A., Mobley, C. B., Zdunek, C. J., Frick, K. K., Jones, S. R., McCarthy, J. J., Peterson, C. A., & Dungan, C. M. (2020) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12617 · Cited by 93 · see citing works

p21 induces a senescence program and skeletal muscle dysfunction

Englund, D. A., Jolliffe, A., Aversa, Z., Zhang, X., Sturmlechner, I., Sakamoto, A. E., Zeidler, J. D., Warner, G. M., McNinch, C., White, T. A., et al. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101652 · Cited by 90 · see citing works

Cellular senescence-mediated exacerbation of Duchenne muscular dystrophy

Sugihara, H., Teramoto, N., Nakamura, K., Shiga, T., Shirakawa, T., Matsuo, M., Ogasawara, M., Nishino, I., Matsuwaki, T., Nishihara, M., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-73315-6 · Cited by 85 · see citing works

Induction of Cellular Senescence by Doxorubicin Is Associated with Upregulated miR-375 and Induction of Autophagy in K562 Cells

Yang, M., Lin, P., Liu, Y., Hsiao, H., Yang, W.-C., Hsu, J.-F., Hsu, C., & Lin, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037205 · Cited by 82 · see citing works

Dasatinib plus quercetin prevents uterine age-related dysfunction and fibrosis in mice

Cavalcante, M. B., Saccon, T. D., Nunes, A. D. C., Kirkland, J. L., Tchkonia, T., Schneider, A., & Masternak, M. M. (2020) · Aging · doi:10.18632/aging.102772 · Cited by 80 · see citing works

Myonuclear content regulates cell size with similar scaling properties in mice and humans

Hansson, K., Eftestøl, E., Bruusgaard, J. C., Juvkam, I. S., Cramer, A., Malthe‐Sørenssen, A., Millay, D. P., & Gundersen, K. (2020) · Nature Communications · doi:10.1038/s41467-020-20057-8 · Cited by 79 · see citing works

Nucleus Type-Specific DNA Methylomics Reveals Epigenetic “Memory” of Prior Adaptation in Skeletal Muscle

Wen, Y., Dungan, C. M., Mobley, C. B., Valentino, T. R., von Walden, F., & Murach, K. A. (2021) · Function · doi:10.1093/function/zqab038 · Cited by 77 · see citing works

Beta-galactosidase staining on bone marrow. The osteoclast pitfall.

Kopp, H., Hooper, A. T., Shmelkov, S. V., & Rafii, S. (2007) · PubMed · doi:10.14670/hh-22.971 · Cited by 76 · see citing works

Senolytic treatment rescues blunted muscle hypertrophy in old mice

Dungan, C. M., Figueiredo, V. C., Wen, Y., VonLehmden, G. L., Zdunek, C. J., Thomas, N. T., Mobley, C. B., Murach, K. A., Brightwell, C. R., Long, D. E., et al. (2022) · GeroScience · doi:10.1007/s11357-022-00542-2 · Cited by 65 · see citing works

Skeletal Muscle Mass as a Mortality Predictor among Nonagenarians and Centenarians: A Prospective Cohort Study

Wang, H., Hai, S., Liu, Y., Liu, Y., & Dong, B. (2019) · Scientific Reports · doi:10.1038/s41598-019-38893-0 · Cited by 63 · see citing works

Exercise Counters the Age-Related Accumulation of Senescent Cells

Zhang, X., Englund, D. A., Aversa, Z., Jachim, S. K., White, T. A., & LeBrasseur, N. K. (2022) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000302 · Cited by 63 · see citing works

Reduced Life- and Healthspan in Mice Carrying a Mono-Allelic BubR1 MVA Mutation

Wijshake, T., Malureanu, L. A., Baker, D. J., Jeganathan, K. B., van de Sluis, B., & van Deursen, J. M. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003138 · Cited by 59 · see citing works

In vivo analysis of γH2AX+ cells in skeletal muscle from aged and obese humans

Dungan, C. M., Peck, B. D., Walton, R. G., Huang, Z., Bamman, M. M., Kern, P. A., & Peterson, C. A. (2020) · The FASEB Journal · doi:10.1096/fj.202000111rr · Cited by 57 · see citing works

Cisplatin-induced premature senescence with concomitant reduction of gap junctions in human fibroblasts

Zhao, W., Lin, Z. X., & Zhang, Z. (2004) · Cell Research · doi:10.1038/sj.cr.7290203 · Cited by 51 · see citing works

Senolytic elimination of senescent macrophages restores muscle stem cell function in severely dystrophic muscle

Liu, L., Yue, X., Sun, Z., Hambright, W. S., Feng, Q., Cui, Y., Huard, J., Robbins, P. D., Wang, Z., & Mu, X. (2022) · Aging · doi:10.18632/aging.204275 · Cited by 49 · see citing works

Muscle injury induces a transient senescence‐like state that is required for myofiber growth during muscle regeneration

Young, L. V., Wakelin, G., Cameron, A., Springer, S. A., Ross, J. P., Wolters, G., Murphy, J. P., Arsenault, M. G., Ng, S. Y., Collao, N., et al. (2022) · The FASEB Journal · doi:10.1096/fj.202200289rr · Cited by 46 · see citing works

HMGB1 orchestrates STING-mediated senescence via TRIM30α modulation in cancer cells

Lee, J., Park, I. H., Kwak, M. S., Rhee, W. J., Kim, S. H., & Shin, J. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00409-z · Cited by 42 · see citing works

Skeletal Muscle Nuclei in Mice are not Post-mitotic

Borowik, A., Davidyan, A., Peelor, F. F., Volovičeva, E., Doidge, S. M., Bubak, M. P., Mobley, C. B., McCarthy, J. J., Dupont‐Versteegden, E. E., & Miller, B. F. (2022) · Function · doi:10.1093/function/zqac059 · Cited by 41 · see citing works

Reduced stem cell aging in exercised human skeletal muscle is enhanced by ginsenoside Rg1

Lee, T. X. Y., Wu, J., Jean, W., Condello, G., AlKhatib, A. H., Hsieh, C.-C., Hsieh, Y., Huang, C., & Kuo, C. (2021) · Aging · doi:10.18632/aging.203176 · Cited by 33 · see citing works

Linking skeletal muscle aging with osteoporosis by lamin A/C deficiency

Xiong, L., Zhao, K., Cao, Y. W., Guo, H.-H., Pan, J., Yang, X., Ren, X., Mei, L., & Xiong, W. (2020) · PLoS Biology · doi:10.1371/journal.pbio.3000731 · Cited by 31 · see citing works

“Muscle memory” not mediated by myonuclear number? Secondary analysis of human detraining data

Murach, K. A., Dungan, C. M., Dupont‐Versteegden, E. E., McCarthy, J. J., & Peterson, C. A. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00506.2019 · Cited by 27 · see citing works

Loss of dystrophin expression in skeletal muscle is associated with senescence of macrophages and endothelial cells

Young, L. V., Morrison, W., Campbell, C., Moore, E. C., Arsenault, M. G., Dial, A. G., Ng, S. Y., Bellissimo, C. A., Perry, C. G. R., Ljubicic, V., et al. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00397.2020 · Cited by 21 · see citing works

Removal of p16INK4 Expressing Cells in Late Life has Moderate Beneficial Effects on Skeletal Muscle Function in Male Mice

Guzman, S. D., Judge, J., Shigdar, S. M., Paul, T. A., Davis, C. S., Macpherson, P. C. D., Markworth, J. F., Remmen, H. V., Richardson, A. G., McArdle, A., et al. (2022) · Frontiers in Aging · doi:10.3389/fragi.2021.821904 · Cited by 13 · see citing works

Lipid Deposition in Different Fiber Types of Skeletal Muscle of Periparturient Dairy Cows

Roberts, C. J., Turfrey, B. A., & Bland, A. P. (1983) · Veterinary Pathology · doi:10.1177/030098588302000103 · Cited by 10 · see citing works

Mitochondrial dysfunction in age-related sarcopenia: mechanistic insights, diagnostic advances, and therapeutic prospects

Huang, Y., Wang, C., Cui, H., Sun, G., Qi, X., & Yao, X. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1590524 · Cited by 45 · see citing works

Restoration of epigenetic impairment in the skeletal muscle and chronic inflammation resolution as a therapeutic approach in sarcopenia.

Livshits, G., & Kalinkovich, A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102267 · Cited by 37 · see citing works

The roles of miRNAs in adult skeletal muscle satellite cells

Koopmans, P. J., Ismaeel, A., Goljanek‐Whysall, K., & Murach, K. A. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.10.403 · Cited by 22 · see citing works

At the Nexus Between Epigenetics and Senescence: The Effects of Senolytic ( BI01 ) Administration on DNA Methylation Clock Age and the Methylome in Aged and Regenerated Skeletal Muscle

Chambers, T. L., Wells, J. M., Koopmans, P. J., da Silva, F. M., Malik, Z. B., Greene, N. P., Filareto, A., Franti, M., Sini, P., Weinstabl, H., et al. (2025) · Aging Cell · doi:10.1111/acel.70068 · Cited by 14 · see citing works

Resistance training suppresses accumulation of senescent fibro-adipogenic progenitors and senescence-associated secretory phenotype in aging rat skeletal muscle

Hung, Y., Sato, A., Takino, Y., Ishigami, A., & Machida, S. (2024) · GeroScience · doi:10.1007/s11357-024-01338-2 · Cited by 10 · see citing works

SenMayo transcriptomic senescence panel highlights glial cells in the ageing mouse and human retina

Suresh, S., Karthik, G., Ouyang, J. F., Chrysostomou, V., Tang, S. A., Petretto, E. G., Crowston, J. G., & Bell, K. C. (2024) · npj Aging · doi:10.1038/s41514-024-00187-9 · Cited by 10 · see citing works

Brain aging: Unlocking personalized strategies for cognitive resilience

Saliev, T. M. (2025) · Brain Network Disorders · doi:10.1016/j.bnd.2025.09.002 · Cited by 7 · see citing works

The impact of cellular senescence on aging skeletal muscle

Kamal, M. J., Bevington, R. T., Johnson, A., & Parise, G. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1719279 · Cited by 5 · see citing works

Metabolic reprogramming in diabetes and other endocrine and metabolic disorders: exploring the Warburg effect, ketones, and SGLT2 inhibitors

Carrera‐Bastos, P., Muskiet, M. H. A., Ordóñez, F. M., Pruimboom, L., Lucía, A., Luque, R. M., & Muskiet, F. A. J. (2025) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-025-09996-z · Cited by 5 · see citing works

Murine Myoblasts Exposed to SYUIQ-5 Acquire Senescence Phenotype and Differentiate into Sarcopenic-Like Myotubes, an In Vitro Study

Gerosa, L., Malvandi, A. M., Gomarasca, M., Verdelli, C., Sansoni, V., Faraldi, M., Ziemann, E., Olivieri, F., Banfi, G., & Lombardi, G. (2024) · The Journals of Gerontology Series A · doi:10.1093/gerona/glae022 · Cited by 2 · see citing works

Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators

Muñoz López, M., López-Gil, J. F., Ramírez de la piscina Viúdez, X., Baz-Valle, E., & Tornero Aguilera, J. F. (2026) · Cells · doi:10.3390/cells15111041 · Cited by 1 · see citing works

Senescence as a regulatory mechanism in skeletal muscle repair in young mice

Johnson, A., Bevington, R. T., & Parise, G. (2026) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00154.2026 · Cited by 1 · see citing works

Exploring frontiers in musculoskeletal biology and bioengineering

Hawke, T. J., & Zaucke, F. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00037.2024 · Cited by 1 · see citing works

In vitro mitochondrial and myogenic gene expression is influenced by formoterol in human myotubes

Zumbro, E. L., Duplanty, A. A., Gordon, R. A., Guerin, G. D., Brisebois, M. F., Sokoloski, M. L., & Rigby, B. R. (2023) · Bulletin of the National Research Centre/Bulletin of the National Research Center · doi:10.1186/s42269-023-01154-2

From promise to success: AJP-Cell Physiology’s journey of accomplishments and future vision

Schaefer, L. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00009.2024

Connective tissue dysplasia and pathogenetic mechanisms as a factor in impaired musculoskeletal adaptation in youth: a sports medicine review

Sankova, M. V., Ачкасов, Е. Е., Achkasov, E., Schamas-Esposel, M., Sankov, A. V., Orliuk, M., Redina, S., Oganesyan, M. V., Zharikova, T. M., Pontes‐Silva, A., et al. (2025) · Sport Sciences for Health · doi:10.1007/s11332-025-01474-y

Characterizing mitochondrial phenotypes and MERCS in aged human skeletal muscle myoblasts

Unten, Y., Takafuji, K., Masukagami, Y., Shiiba, I., Horiuchi, K., Husník, F., Yanagi, S., Tateishi, N., & Suzuki, T. (2026) · PLoS ONE · doi:10.1371/journal.pone.0343604

Muscle satellite cells and aging

Johnson, A., Bevington, R. T., Rumelski, S., Kassamali, N., & Parise, G. (2026) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00232.2026

Fehlgeleitete interzelluläre Kommunikation beim Altern und bei chronischen Entzündungen

Großkopf, A., Saemann, L., & Simm, A. (2026) · Zeitschrift für Gerontologie und Geriatrie · doi:10.1007/s00391-026-02619-5

Aging of Skeletal Muscle: From Molecular Mechanisms to Therapeutic Interventions

Liu, T., & Hu, Y. (2026) · MedComm · doi:10.1002/mco2.70995

Aquaporin‐4 Orchestrates Muscle Cell Differentiation and Satellite Cell Preservation: A Novel Target in Age‐Related Muscle Decline

Girón, M. D. S. C., Manzano, M., Pereira, S. L., Reinoso, A., Burgio, C., Montero-Martin, N., Jiménez-Jiménez, G., Argilés, J. M. A., Rueda, R., López-Pedrosa, J. M., et al. (2026) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.70412

Skeletal muscle aging, cellular senescence, and senotherapeutics: current knowledge and future directions

Englund, D. A., Zhang, X., Aversa, Z., & LeBrasseur, N. K. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111595 · Cited by 94 · see citing works

Diverse Roles of Cellular Senescence in Skeletal Muscle Inflammation, Regeneration, and Therapeutics

Saito, Y., & Chikenji, T. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.739510 · Cited by 48 · see citing works

Cellular Senescence in Skeletal Muscle Aging

Li, Y., & Wang, H. (2026) · Endocrinology and Metabolism · doi:10.3803/enm.2025.2816 · Cited by 8 · see citing works

Cellular senescence in skeletal muscle: myogenic and nonmyogenic cell populations, mechanisms, and therapeutic opportunities

Παπανικολάου, Κ., Yadav, A., Mankowski, R. T., Alexander, M. S., Gamboa, J. L., Thalacker‐Mercer, A. E., Dungan, C. M., & Englund, D. A. (2026) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00876.2025 · Cited by 2 · see citing works

The impact of cellular senescence on aging skeletal muscle

Kamal, M. J., Bevington, R. T., Johnson, A., & Parise, G. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1719279 · Cited by 5 · see citing works