Cellular senescence-mediated exacerbation of Duchenne muscular dystrophy
Open accessAbstract
Duchenne muscular dystrophy (DMD) is a progressive disease characterised by chronic muscle degeneration and inflammation. Our previously established DMD model rats (DMD rats) have a more severe disease phenotype than the broadly used mouse model. We aimed to investigate the role of senescence in DMD using DMD rats and patients. Senescence was induced in satellite cells and mesenchymal progenitor cells, owing to the increased expression of CDKN2A, p16- and p19-encoding gene. Genetic ablation of p16 in DMD rats dramatically restored body weight and muscle strength. Histological analysis showed a reduction of fibrotic and adipose tissues invading skeletal muscle, with increased muscle regeneration. Senolytic drug ABT263 prevented loss of body weight and muscle strength, and increased muscle regeneration in rats even at 8 months-the late stage of DMD. Moreover, senescence markers were highly expressed in the skeletal muscle of DMD patients. In situ hybridization of CDKN2A confirmed the expression of it in satellite cells and mesenchymal progenitor cells in patients with DMD. Collectively, these data provide new insights into the integral role of senescence in DMD progression.
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Senotherapy has proven to be effective in a rat model of Duchenne muscular dystrophy.
“Senotherapy has also proven to be effective in a rat model of Duchenne muscular dystrophy, 29 a progressive disease characterised by chronic muscle degeneration and inflammation.”
From The costs and benefits of senotherapeutics for human health (2022) · cites this paper as [29]
In children and young adults (3 to 33 years of age) affected by Duchene muscular dystrophy (DMD), p16 is evident in skeletal biopsy specimens while absent in age-matched peers without the disease.
“In children and young adults (3 to 33 years of age) affected by Duchene muscular dystrophy (DMD), p16 is evident in skeletal biopsy specimens while absent in age-matched peers without the disease (Sugihara et al., 2020).”
From Skeletal muscle aging, cellular senescence, and senotherapeutics: current knowledge and future directions (2021) · cites this paper as Sugihara et al., 2020
In situ hybridization for CDKN2A mRNA suggest heightened expression in both satellite cells and FAPs in DMD.
“Interesting, in situ hybridization for CDKN2A mRNA suggest heightened expression in both satellite cells and FAPs.”
From Skeletal muscle aging, cellular senescence, and senotherapeutics: current knowledge and future directions (2021) · cites this paper as Sugihara et al., 2020
Disease progression, marked by loss of body weight, skeletal muscle strength, and muscle fiber degeneration, was attenuated by ABT263 in the DMD rat model.
“Moreover, disease progression, marked by loss of body weight, skeletal muscle strength, and muscle fiber degeneration, was attenuated by ABT263.”
From Skeletal muscle aging, cellular senescence, and senotherapeutics: current knowledge and future directions (2021) · cites this paper as Sugihara et al., 2020
In the DMD rat model, two cycles of 7 days of ABT263 separated by two weeks at a relatively late stage of disease (8 months) significantly reduced the expression of senescence markers in skeletal muscle, including p16, p19, p21, and a subset of SASP factors, compared to vehicle.
“Notably, in the DMD rat model, two cycles of 7 days of ABT263 separated by two weeks at a relatively late stage of disease (8 months) significantly reduced the expression of senescence markers in skeletal muscle, including p16, p19, p21, and a subset of SASP factors, compared to vehicle (Sugihara et al., 2020).”
From Skeletal muscle aging, cellular senescence, and senotherapeutics: current knowledge and future directions (2021) · cites this paper as Sugihara et al., 2020
Modest yet beneficial effects on muscle fiber size were observed in the DMD rat model treated with ABT263.
“Modest yet beneficial effects on muscle fiber size were observed.”
From Skeletal muscle aging, cellular senescence, and senotherapeutics: current knowledge and future directions (2021) · cites this paper as Sugihara et al., 2020
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Cellular senescence and senolytics: the path to the clinic
Chaib, S., Tchkonia, T., & Kirkland, J. L. (2022) · Nature Medicine · doi:10.1038/s41591-022-01923-y · Cited by 1,105 · see citing works
Molecular Mechanisms of Inflammation in Sarcopenia: Diagnosis and Therapeutic Update
Jiménez-Gutiérrez, G. E., Martínez-Gómez, L. E., Martínez-Armenta, C., Pineda, C., Martínez‐Nava, G. A., & López-Reyes, A. G. (2022) · Cells · doi:10.3390/cells11152359 · Cited by 243 · see citing works
The costs and benefits of senotherapeutics for human health
Raffaele, M., & Vinciguerra, M. (2022) · The Lancet Healthy Longevity · doi:10.1016/s2666-7568(21)00300-7 · Cited by 140 · see citing works
Senolytics for Cancer Therapy: Is All that Glitters Really Gold?
Carpenter, V. J., Saleh, T., & Gewirtz, D. A. (2021) · Cancers · doi:10.3390/cancers13040723 · Cited by 124 · see citing works
Role of cellular senescence in inflammation and regeneration
Saito, Y., Yamamoto, S., & Chikenji, T. (2024) · Inflammation and Regeneration · doi:10.1186/s41232-024-00342-5 · Cited by 117 · see citing works
Englund, D. A., Zhang, X., Aversa, Z., & LeBrasseur, N. K. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111595 · Cited by 94 · see citing works
Emerging insights in senescence: pathways from preclinical models to therapeutic innovations
Mansfield, L., Ramponi, V., Gupta, K., Stevenson, T., Mathew, A. B., Barinda, A. J., Herbstein, F., & Morsli, S. (2024) · npj Aging · doi:10.1038/s41514-024-00181-1 · Cited by 91 · see citing works
Satellite cell contribution to disease pathology in Duchenne muscular dystrophy
Kodippili, K., & Rudnicki, M. A. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1180980 · Cited by 61 · see citing works
Cardone, N., Taglietti, V., Baratto, S., Kefi, K., Periou, B., Gitiaux, C., Barnérias, C., Lafuste, P., Leturcq, F., Nectoux, J., et al. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01657-z · Cited by 52 · see citing works
Careccia, G., Mangiavini, L., & Cirillo, F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010512 · Cited by 59 · see citing works
Diverse Roles of Cellular Senescence in Skeletal Muscle Inflammation, Regeneration, and Therapeutics
Saito, Y., & Chikenji, T. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.739510 · Cited by 48 · see citing works
Taglietti, V., Kefi, K., Rivera, L., Bergiers, O., Cardone, N., Coulpier, F., Gioftsidi, S., Drayton‐Libotte, B., Hou, C., Authier, F., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.add5275 · Cited by 39 · see citing works
Focus on senescence: Clinical significance and practical applications
Boccardi, V., Orr, M. E., Polidori, M. C., Ruggiero, C., & Mecocci, P. (2024) · Journal of Internal Medicine · doi:10.1111/joim.13775 · Cited by 40 · see citing works
Murine models of Duchenne muscular dystrophy: is there a best model?
Swiderski, K., & Lynch, G. S. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00212.2021 · Cited by 37 · see citing works
Empowering Muscle Stem Cells for the Treatment of Duchenne Muscular Dystrophy
Filippelli, R. L., & Chang, N. C. (2021) · Cells Tissues Organs · doi:10.1159/000514305 · Cited by 35 · see citing works
Context‐dependent roles of cellular senescence in normal, aged, and disease states
Moiseeva, V., Cisneros, A., Cobos, A. C., Tarrega, A. B., Oñate, C. S., Perdiguero, E., Serrano, A. L., & Muñoz‐Cánoves, P. (2023) · The FEBS Journal · doi:10.1111/febs.16573 · Cited by 34 · see citing works
Adipose tissue in older individuals: a contributing factor to sarcopenia
Wang, T., Zhou, D., & Hong, Z. (2024) · Metabolism · doi:10.1016/j.metabol.2024.155998 · Cited by 35 · see citing works
Identification and Validation of Aging-Related Genes in Idiopathic Pulmonary Fibrosis
He, J., & Li, X. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.780010 · Cited by 31 · see citing works
Butyrate promotes C2C12 myoblast proliferation by activating ERK/MAPK pathway
Guan, L., Cao, Z., Pan, Z., Zhao, C., Xue, M., Yang, F., & Chen, J. (2023) · Molecular Omics · doi:10.1039/d2mo00256f · Cited by 30 · see citing works
From cyclins to CDKIs: Cell cycle regulation of skeletal muscle stem cell quiescence and activation
Mademtzoglou, D., & Relaix, F. (2022) · Experimental Cell Research · doi:10.1016/j.yexcr.2022.113275 · Cited by 32 · see citing works
Granet, J. A., Robertson, R., Cusmano, A. A., Filippelli, R. L., Lorenz, T. O., Li, S., Yaqubi, M., Stratton, J. A., & Chang, N. C. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07755-1 · Cited by 28 · see citing works
Nie, C., Wang, B., Fan, M., Wang, Y., Sun, Y., Qian, H., Li, Y., & Wang, L. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c05246 · Cited by 26 · see citing works
Fujikura, Y., Sugihara, H., Hatakeyama, M., Oishi, K., & Yamanouchi, K. (2021) · The FASEB Journal · doi:10.1096/fj.202100629r · Cited by 24 · see citing works
Self-citationDungan, C. M., Wells, J. M., & Murach, K. A. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00553.2022 · Cited by 21 · see citing works
Bioactive lipid mediator class switching regulates myogenic cell progression and muscle regeneration
Fabre, P., Molina, T., Larose, J., Greffard, K., Généreux-Gamache, G., Deprez, A., Mokhtari, I., Pellerito, O., Duchesne, É., Dort, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60586-8 · Cited by 21 · see citing works
Understanding the development of sarcopenic obesity
Gross, D. C., Cheever, C. R., & Batsis, J. A. (2023) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2023.2267672 · Cited by 19 · see citing works
Dowling, P., Swandulla, D., & Ohlendieck, K. (2023) · European Journal of Translational Myology · doi:10.4081/ejtm.2023.11856 · Cited by 18 · see citing works
Phosphate and Cellular Senescence
Hu, M. C., & Moe, O. W. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-91623-7_7 · Cited by 18 · see citing works
Nunes, J. M., Kell, L., Slaghekke, A., Wüst, R. C. I., Fielding, B. C., Kell, D. B., & Pretorius, E. (2026) · Cell Death and Disease · doi:10.1038/s41419-025-08162-2 · Cited by 18 · see citing works
Dowling, P., Gargan, S., Zweyer, M., Swandulla, D., & Ohlendieck, K. (2023) · Biomolecules · doi:10.3390/biom13071108 · Cited by 15 · see citing works
Kirchner, V. A., Badshah, J. S., Hong, S. K., Martinez, O. M., Pruett, T. L., & Niedernhofer, L. J. (2023) · Transplantation · doi:10.1097/tp.0000000000004838 · Cited by 15 · see citing works
Ryanodine receptor dysfunction causes senescence and fibrosis in Duchenne dilated cardiomyopathy
Souidi, M., Resta, J., Dridi, H., Sleiman, Y., Reiken, S. R., Formoso, K., Colombani, S., Amédro, P., Meyer, P., Charrabi, A., et al. (2024) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13411 · Cited by 15 · see citing works
Suppression of MyoD induces spontaneous adipogenesis in skeletal muscle progenitor cell culture
Yamanouchi, K., Nakamura, K., Takeuchi, S., Hosoyama, T., Matsuwaki, T., & Nishihara, M. (2021) · Animal Science Journal · doi:10.1111/asj.13573 · Cited by 15 · see citing works
Self-citationTranslating cellular senescence research into clinical practice for metabolic disease
Chaib, S., Palmer, A. K., Wyles, S. P., Musi, N., Kirkland, J. L., & Tchkonia, T. (2025) · Nature Reviews Endocrinology · doi:10.1038/s41574-025-01187-9 · Cited by 14 · see citing works
Silver electroceutical technology to treat sarcopenia
Kim, M. Y., Shin, H. Y., Cho, S. C., Yang, S., Intisar, A., Woo, H. J., Choi, Y.-S., You, C., Kang, J., Lee, Y., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2300036120 · Cited by 13 · see citing works
Sharma, A. R., Chatterjee, S., Lee, Y., & Lee, S. (2023) · Aging and Disease · doi:10.14336/ad.2023.00903 · Cited by 15 · see citing works
Yamanouchi, K., Tanaka, Y., Ikeda, M., Kato, S., Okino, R., Nishi, H., Hakuno, F., Takahashi, S., CHAMBERS, J. K., Matsuwaki, T., et al. (2022) · Skeletal Muscle · doi:10.1186/s13395-022-00307-7 · Cited by 11 · see citing works
Self-citationImmunoproteasome Inhibition Ameliorates Aged Dystrophic Mouse Muscle Environment
Tripodi, L., Molinaro, D., Fortunato, F., Mella, C., Cassani, B., Torrente, Y., & Farini, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314657 · Cited by 10 · see citing works
Body Composition and Senescence: Impact of Polyphenols on Aging-Associated Events
dos Santos, T. W., Pereira, Q. C., Fortunato, I. M., Oliveira, F. D. S., Alvarez, M. C., & Ribeiro, M. L. (2024) · Nutrients · doi:10.3390/nu16213621 · Cited by 10 · see citing works
Xie, Z., Liu, C., Sun, C., Lu, Y., Wu, S., Liu, Y., Wang, Q., Wan, Y., Wang, Y., Yu, M., et al. (2023) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13410 · Cited by 7 · see citing works
Ivabradine ameliorates cardiomyopathy progression in a Duchenne muscular dystrophy model rat
Tochinai, R., Kimura, K., Saika, T., Fujii, W., Morita, H., Nakanishi, K., Tsuru, Y., Sekizawa, S., Yamanouchi, K., & Kuwahara, M. (2023) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.23-0087 · Cited by 7 · see citing works
Self-citationCell therapy for Duchenne muscular dystrophy: promises, challenges, and controversies
Łoboda, A., & Dulak, J. (2025) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-025-05904-5 · Cited by 7 · see citing works
Fujikura, Y., Kimura, K., Yamanouchi, K., Sugihara, H., Hatakeyama, M., Zhuang, H., Abe, T., Daimon, M., Morita, H., Komuro, I., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-15934-9 · Cited by 7 · see citing works
Self-citationInterplay between Pitx2 and Pax7 temporally governs specification of extraocular muscle stem cells
Kuriki, M., Korb, A., Comai, G., & Tajbakhsh, S. (2024) · PLoS Genetics · doi:10.1371/journal.pgen.1010935 · Cited by 6 · see citing works
Kepreotis, S., Oh, J. G., Park, M. N., Yoo, J., Lee, C., Mercola, M. A., Hajjar, R. J., & Jeong, D. (2024) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2024.102174 · Cited by 6 · see citing works
Gao, Z., Lu, A., Daquinag, A. C., Yu, Y., Huard, M., Tseng, C., Gao, X., Huard, J., & Kolonin, M. G. (2021) · Biomolecules · doi:10.3390/biom11101519 · Cited by 6 · see citing works
The rise of rat models for Duchenne muscular dystrophy and therapeutic evaluations
Relaix, F., Lafuste, P., Taglietti, V., & Tiret, L. (2025) · Skeletal Muscle · doi:10.1186/s13395-025-00395-1 · Cited by 5 · see citing works
Loss of the matrix metalloproteinase-10 causes premature features of aging in satellite cells
Bobadilla, M., Orbe, J., Abizanda, G., Machado, F. J. D., Vilas‐Zornoza, A., Ullate‐Agote, A., Extramiana, L., Churio, A. B., Aranguren, X. L., Cantero, G., et al. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1128534 · Cited by 5 · see citing works
Cojocaru, A. I., Kefi, K., Masson, J.-D., Tiret, L., Relaix, F., & Taglietti, V. (2025) · Skeletal Muscle · doi:10.1186/s13395-025-00381-7 · Cited by 4 · see citing works
Kihara, Y., Tanaka, Y., Ikeda, M., Homma, J., Takagi, R., Ishigaki, K., Yamanouchi, K., Honda, H., Nagata, S., & Yamato, M. (2022) · Regenerative Therapy · doi:10.1016/j.reth.2022.10.003 · Cited by 4 · see citing works
Self-citationMuscle stem cell dysfunction in rhabdomyosarcoma and muscular dystrophy
Robertson, R., Li, S., Filippelli, R. L., & Chang, N. C. (2024) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2024.01.019 · Cited by 4 · see citing works
Stem/progenitor cell-based therapy for Duchenne muscular dystrophy
Tominari, T., Sathyaprakash, C., & Aoki, Y. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1640275 · Cited by 3 · see citing works
Teramoto, N., Ikeda, M., Sugihara, H., Shiga, T., Matsuwaki, T., Nishihara, M., Uchida, K., & Yamanouchi, K. (2021) · Journal of Veterinary Medical Science · doi:10.1292/jvms.21-0243 · Cited by 3 · see citing works
Self-citationDonandt, T., Hintze, S., Krause, S., Wolf, E., Schoser, B. G. H., Walter, M. C., & Meinke, P. (2022) · Life · doi:10.3390/life12101668 · Cited by 3 · see citing works
Fujikura, Y., Yamanouchi, K., Sugihara, H., Hatakeyama, M., Abe, T., Ato, S., & Oishi, K. (2022) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2022.101378 · Cited by 3 · see citing works
Self-citationNakamura, K., Kanou, M., Fujii, W., Kouzaki, K., Jimbo, T., Yamanouchi, K., Nakazato, K., Ueda, H., Hirata, J., & Yamana, K. (2025) · Human Molecular Genetics · doi:10.1093/hmg/ddaf028 · Cited by 3 · see citing works
Self-citationΠαπανικολάου, Κ., Yadav, A., Mankowski, R. T., Alexander, M. S., Gamboa, J. L., Thalacker‐Mercer, A. E., Dungan, C. M., & Englund, D. A. (2026) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00876.2025 · Cited by 2 · see citing works
Vorwald, M. E., Krishna, S., Lee, J. H., Roths, M. S., Valentine, R. J., & Selsby, J. T. (2026) · The Journal of Physiology · doi:10.1113/jp289832 · Cited by 2 · see citing works
Lam, P. M. W., Zygmunt, D. A., Ashbrook, A., Bennett, M., Vetter, T. A., & Martin, P. T. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.06.028 · Cited by 2 · see citing works
A new dystrophin-deficient rat model mirroring exon skipping in patients with DMD exon 45 deletions
Wang, T., Daoud, C., Dubois, A., Corre, G., Bellec, J., Bovolenta, M., Philidet, L., Dorval, A., Bourg, N., Roudaut, C., et al. (2026) · Disease Models & Mechanisms · doi:10.1242/dmm.052578 · Cited by 2 · see citing works
New Horizons in Myotonic Dystrophy Type 1: Cellular Senescence as a Therapeutic Target
Légaré, C., Berglund, J. A., Duchesne, É., & Dumont, N. A. (2024) · BioEssays · doi:10.1002/bies.202400216 · Cited by 1 · see citing works
Cellular Senescence in Skeletal Muscle: Age, Sarcopenia, Therapy
Плехова, Н. Г., Андреевна, Н. П., Voro, A. N., Korolev, D. V., & Шуматов, В. Б. (2025) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093025030147 · Cited by 1 · see citing works
Gao, X., Ruzbarsky, J. J., Huard, M., Sajedi, S., Shyu, P. T., Xiao, Z., Force, B. S., White, S., Ayers, J. D., Wang, B., et al. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.108016 · Cited by 1 · see citing works
Senescence dynamics define therapeutic windows for Duchenne muscular dystrophy in DBA/2-mdx mice
Calls, A., Tàrrega, A. B., Cisneros, A., Rommelfanger, M., Campanario, S., Grima-Terrén, M., Ramírez‐Pardo, I., Moiseeva, V., Lukesova, V., Andrés, E., et al. (2026) · Skeletal Muscle · doi:10.1186/s13395-026-00426-5 · Cited by 1 · see citing works
Senescence as a regulatory mechanism in skeletal muscle repair in young mice
Johnson, A., Bevington, R. T., & Parise, G. (2026) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00154.2026 · Cited by 1 · see citing works
Bouchereau, W., Chenane, L., Weiss‐Gayet, M., Lessard, L., Cardona, Y., Mounier, R., Gallay, L., Allenbach, Y., Benvéniste, O., Corpet, A., et al. (2026) · NAR Molecular Medicine · doi:10.1093/narmme/ugag022 · Cited by 1 · see citing works
Tongue muscle is protected from dystrophic changes in the Duchenne Muscular Dystrophy RatPreprint
Yamanouchi, K., Tanaka, Y., Ikeda, M., Kato, S., CHAMBERS, J. K., Matsuwaki, T., & Uchida, K. (2022) · Research Square · doi:10.21203/rs.3.rs-1379508/v1
Self-citationClearance of senescent cells: potent anti-aging approach
Ferreira, J., & Deamer, A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90235-9.00002-1
Interplay between Pitx2 and Pax7 temporally governs specification of extraocular muscle progenitorsPreprint
Kuriki, M., Comai, G., & Tajbakhsh, S. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.24.554745
A Global, and Orbital, View of Extraocular Muscles
Comai, G., & Tajbakhsh, S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-13820-1.00143-2
Liu, M., Chatterjee, S., Wu, J., Kashaniasl, Z., Kumar, A., Lin, C., & Darabi, R. (2025) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2025.101515
Yamaguchi, R., Ikeda, M., Takeuchi, S., Nakamura, K., Kurmangaliyeva, A., Teramoto, N., Sugihara, H., Kikawa, C., Matsuwaki, T., Nishihara, M., et al. (2025) · Animal Science Journal · doi:10.1111/asj.70097
Self-citationMeneses‐Valdés, R., Gallero, S., Hentze, J., Nielsen, S. F., Nielsen, J., Jaimovich, E., Henríquez‐Olguín, C., & Jensen, T. E. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.19.671046
Kihara, Y., Ikeda, M., Takagi, R., Ishigaki, K., Yamanouchi, K., Nagata, S., & Yamato, M. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04594-x
Self-citationCardone, N., Taglietti, V., Baratto, S., Kefi, K., Periou, B., Gitiaux, C., Barnérias, C., Lafuste, P., Leturcq, F., Nectoux, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26628973
Therapeutic strategies targeting muscle stem cells in satellite cell-opathies
Garcia, P., Mokhtari, I., & Dumont, N. A. (2026) · Journal of Neuromuscular Diseases · doi:10.1177/22143602251414570
Morel, V. (2021) · theses.fr (ABES) · doi:10.70675/31e506dazce13z4d4cz8c40z9823077c170b
Dotou, M. (2023) · theses.fr (ABES) · doi:10.70675/ea22a042z96ccz45fdz9667z82a8825cb567
Kajabadi, N., Narasimhan, A., Chen, G., Yi, L., Rodríguez‐Rodríguez, C., Coccimiglio, I. F., Huang, T., Rendeiro, M. M., Yamanouchi, K., Häfeli, U. O., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.29.728674
Self-citationYe, Z. H., Chen, S., Rui, J., Tang, L., Wang, T., & Fan, Q. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.06.038
Duchenne muscular dystrophy: from gene to gene-ius therapies
Muchir, A., Musarò, A., & Chamberlain, J. S. (2026) · Skeletal Muscle · doi:10.1186/s13395-026-00439-0
Swallowing Dysfunction and Histopathological Changes in a Rat Model of Duchenne Muscular Dystrophy
Kitano, M., Ohnishi, H., Tamura, K., Mizuno, K., Hayashi, Y., Okuyama, H., Yoshimatsu, M., Sato, M., Kawai, Y., Sakurai, H., et al. (2026) · Dysphagia · doi:10.1007/s00455-026-10991-y
Self-citationSkeletal Muscle Aging Is a Significant Contributor to Systemic Aging
Li, M.-M., Liu, X., Li, Y., Li, H., Wang, Y., Qiu, K., & Kong, W. (2026) · Biomolecules · doi:10.3390/biom16101527
- Authors
- Sugihara, H., Teramoto, N., Nakamura, K., Shiga, T., Shirakawa, T., Matsuo, M., Ogasawara, M., Nishino, I., Matsuwaki, T., Nishihara, M., & Yamanouchi, K.
- Affiliations
- The University of Tokyo (JP)
- Kobe Gakuin University (JP)
- National Center of Neurology and Psychiatry (JP)
- Corresponding author
- Yamanouchi, Keitaro
- ORCID
- Venue
- Scientific Reports
- Published
- 2020-10-12
- Volume
- 10
- Issue
- 1
- Pages
- 16385-16385
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC7550355
- OpenAlex
- W3092172736
- Cited by
- 85
- References
- 80
- Citations by year
- 2026: 13 · 2025: 16 · 2024: 12 · 2023: 17 · 2022: 17 · 2021: 10
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Intramural Research Grantor Neurological and Psychiatric Disorders of NCNP (29-4)
- Japan Society for the Promotion of Science KAKENHI Grants (15K14883)
- Japan Agency for Medical Research and Development (JP18nk0101342)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Genetics › Neurogenetic and Muscular Disorders Research
- Keywords
- Duchenne muscular dystrophy, cellular senescence, p16, CDKN2A, senolytic therapy, navitoclax, satellite cells, mesenchymal progenitor cells, muscle regeneration, muscle fibrosis, muscle strength, skeletal muscle
- MeSH terms
- Animals, Cells, Cultured, Disease Models, Animal, Humans, Mutation, Regeneration, Dystrophin, Cellular Senescence, Muscle, Skeletal, Cyclin-Dependent Kinase Inhibitor p16, Muscular Dystrophy, Duchenne, Satellite Cells, Skeletal Muscle, Mice, Rats, Mesenchymal Stem Cells
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