Polyamines regulate E-cadherin transcription through c-Myc modulating intestinal epithelial barrier function
Open accessAbstract
The integrity of the intestinal epithelial barrier depends on intercellular junctions that are highly regulated by numerous extracellular and intracellular factors. E-cadherin is found primarily at the adherens junctions in the intestinal mucosa and mediates strong cell-cell contacts that have a functional role in forming and regulating the epithelial barrier. Polyamines are necessary for E-cadherin expression, but the exact mechanism underlying polyamines remains elusive. The current study was performed to determine whether polyamines induce E-cadherin expression through the transcription factor c-Myc and whether polyamine-regulated E-cadherin plays a role in maintenance of the epithelial barrier integrity. Decreasing cellular polyamines reduced c-Myc and repressed E-cadherin transcription as indicated by a decrease in levels of E-cadherin promoter activity and its mRNA. Forced expression of the c-myc gene by infection with adenoviral vector containing c-Myc cDNA stimulated E-cadherin promoter activity and increased E-cadherin mRNA and protein levels in polyamine-deficient cells. Experiments using different E-cadherin promoter mutants revealed that induction of E-cadherin transcription by c-Myc was mediated through the E-Pal box located at the proximal region of the E-cadherin promoter. Decreased levels of E-cadherin in polyamine-deficient cells marginally increased basal levels of paracellular permeability but, remarkably, potentiated H(2)O(2)-induced epithelial barrier dysfunction. E-cadherin silencing by transfection with its specific small interfering RNA also increased vulnerability of the epithelial barrier to H(2)O(2). These results indicate that polyamines enhance E-cadherin transcription by activating c-Myc, thus promoting function of the epithelial barrier.
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Polyamines enhance gut barrier integrity through inducing E-cadherin, the cell-cell adhesion protein, in a c-Myc-dependent manner.
“Polyamines enhance gut barrier integrity through inducing E-cadherin, the cell-cell adhesion protein in c-Myc–dependent manner.126”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [126]
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Cites
Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis
Gumbiner, B. M. (1996) · Cell · doi:10.1016/s0092-8674(00)81279-9 · Cited by 3,471 · see citing works
The tight junction: a multifunctional complex
Schneeberger, E. E., & Lynch, R. D. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00558.2003 · Cited by 1,401 · see citing works
The cell-cell adhesion molecule E-cadherin
Roy, F. M. V., & Berx, G. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8281-1 · Cited by 1,330 · see citing works
Polyamines and cancer: old molecules, new understanding
Gerner, E. W., & Meyskens, F. L. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1454 · Cited by 1,163 · see citing works
Balda, M. S., Whitney, J. A., Flores, C., González, S., Cereijido, M., & Matter, K. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.134.4.1031 · Cited by 876 · see citing works
Eger, A., Aigner, K., Sonderegger, S., Dampier, B., Oehler, S., Schreiber, M., Berx, G., Cano, A., Beug, H., & Foisner, R. (2005) · Oncogene · doi:10.1038/sj.onc.1208429 · Cited by 808 · see citing works
Gumbiner, B., Stevenson, B., & Grimaldi, A. (1988) · The Journal of cell biology · doi:10.1083/jcb.107.4.1575 · Cited by 799 · see citing works
Quaroni, A., Wands, J. R., Trelstad, R. L., & Isselbacher, K. J. (1979) · The Journal of Cell Biology · doi:10.1083/jcb.80.2.248 · Cited by 778 · see citing works
Peinado, H., Ballestar, E., Esteller, M., & Cano, A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.24.1.306-319.2004 · Cited by 766 · see citing works
Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases
Casero, R. A., & Marton, L. J. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2243 · Cited by 752 · see citing works
Tight Junctions and Cell Polarity
Shin, K., Fogg, V. C., & Margolis, B. L. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010305.104219 · Cited by 745 · see citing works
Critical Values for Duncan's New Multiple Range Test
Harter, H. L. (1960) · Biometrics · doi:10.2307/2527770 · Cited by 648 · see citing works
The cadherin superfamily: diversity in form and function
Angst, B. D., Marcozzi, C., & Magee, A. I. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.4.629 · Cited by 619 · see citing works
MEMBRANE-ASSOCIATED GUANYLATE KINASES REGULATE ADHESION AND PLASTICITY AT CELL JUNCTIONS
Funke, L., Dakoji, S., & Bredt, D. S. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133339 · Cited by 469 · see citing works
Rao, R., Basuroy, S., Rao, V. U., KARNAKY, K. J., & Gupta, A. K. (2002) · Biochemical Journal · doi:10.1042/bj20011804 · Cited by 402 · see citing works
Inflammatory bowel disease is associated with changes of enterocytic junctions
Gaßler, N., Rohr, C. M., Schneider, A., Kartenbeck, J., Bach, A., Obermüller, N., Otto, H. F., & Autschbach, F. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.281.1.g216 · Cited by 363 · see citing works
Nusrat, A., von Eichel-Streiber, C., Turner, J. R., Verkade, P., Madara, J., & Parkos, C. A. (2001) · Infection and Immunity · doi:10.1128/iai.69.3.1329-1336.2001 · Cited by 352 · see citing works
Mammalian tight junctions in the regulation of epithelial differentiation and proliferation
Matter, K., Aijaz, S., Tsapara, A., & Balda, M. S. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.08.003 · Cited by 313 · see citing works
The Molecular Physiology of Tight Junction Pores
Itallie, C. M. V., & Anderson, J. M. (2004) · Physiology · doi:10.1152/physiol.00027.2004 · Cited by 298 · see citing works
Expression from the human occludin promoter is affected by tumor necrosis factor α and interferon γ
Mankertz, J., Tavalali, S., Schmitz, H., Mankertz, A., Riecken, E. O., Fromm, M., & Schulzke, J. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.11.2085 · Cited by 287 · see citing works
Capaldo, C., & Macara, I. G. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-05-0471 · Cited by 258 · see citing works
Oncogenic Raf-1 Disrupts Epithelial Tight Junctions via Downregulation of Occludin
Li, D., & Mrsny, R. J. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.148.4.791 · Cited by 233 · see citing works
Celano, P., Baylin, S. B., & Casero, R. A. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)81881-6 · Cited by 217 · see citing works
Behrens, J., Löwrick, O., Klein‐Hitpaß, L., & Birchmeier, W. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.24.11495 · Cited by 213 · see citing works
Regulatory mechanisms controlling human E-cadherin gene expression
Liu, Y., Lee, W.-W., Wang, C., Chao, T.-H., Chen, Y., & Chen, J. H. (2005) · Oncogene · doi:10.1038/sj.onc.1208991 · Cited by 209 · see citing works
Fujimori, T., & Takeichi, M. (1993) · Molecular Biology of the Cell · doi:10.1091/mbc.4.1.37 · Cited by 200 · see citing works
Batsché, É., Muchardt, C., Behrens, J., Hurst, H. C., & Crémisi, C. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.7.3647 · Cited by 161 · see citing works
Nejsum, L. N., & Nelson, W. J. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200705094 · Cited by 154 · see citing works
Guo, X., Rao, J. N., Liu, L., Zou, T.-T., Turner, D. J., Bass, B. L., & Wang, J.-Y. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00015.2003 · Cited by 153 · see citing works
Self-citationMechanisms Identified in the Transcriptional Control of Epithelial Gene Expression
Hennig, G., Löwrick, O., Birchmeier, W., & Behrens, J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.1.595 · Cited by 136 · see citing works
Angst, B. D., Marcozzi, C., & Magee, A. I. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.4.625 · Cited by 133 · see citing works
E-cadherin Is a WT1 Target Gene
Hosono, S., Groß, I., English, M. A., Hajra, K. M., Fearon, E. R., & Licht, J. D. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.15.10943 · Cited by 131 · see citing works
Zou, T., Mazan-Mamczarz, K., Rao, J. N., Liu, L., Marasa, B. S., Zhang, A., Xiao, L., Pullmann, R., Gorospe, M., & Wang, J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602344200 · Cited by 128 · see citing works
Self-citationOccludin Modulates Transepithelial Migration of Neutrophils
Huber, D., Balda, M. S., & Matter, K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.8.5773 · Cited by 126 · see citing works
Activated Androgen Receptor Downregulates E-Cadherin Gene Expression and Promotes Tumor Metastasis
Liu, Y.-N., Liu, Y., Lee, H.-J., Hsu, Y.-H., & Chen, J.-H. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00449-08 · Cited by 123 · see citing works
Regulation of endothelial barrier function and growth by VE-cadherin, plakoglobin, and β-catenin
Venkiteswaran, K., Xiao, K., Summers, S., Calkins, C. C., Vincent, P. A., Pumiglia, K. M., & Kowalczyk, A. P. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00417.2001 · Cited by 121 · see citing works
Wang, J. Y., McCormack, S. A., Viar, M. J., Wang, H., Tzen, C., Scott, R. E., & Johnson, L. R. (1993) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1993.265.2.g331 · Cited by 120 · see citing works
Self-citationZou, T., Rao, J. N., Guo, X., Liu, L., Zhang, H. M., Strauch, E. D., Bass, B. L., & Wang, J. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00480.2003 · Cited by 113 · see citing works
Self-citationChen, J., Rao, J. N., Zou, T., Liu, L., Marasa, B. S., Xiao, L., Zeng, X., Turner, D. J., & Wang, J.-Y. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00201.2007 · Cited by 107 · see citing works
Self-citationRao, J. N., Platoshyn, O., Li, L., Guo, X., Golovina, V. A., Yuan, J. X. ‐., & Wang, J. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00361.2001 · Cited by 107 · see citing works
Self-citationLi, L., Rao, J. N., Bass, B. L., & Wang, J. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.280.5.g992 · Cited by 105 · see citing works
Self-citationZhang, H. M., Rao, J. N., Guo, X., Liu, L., Zou, T., Turner, D. J., & Wang, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m314337200 · Cited by 104 · see citing works
Self-citationPolyamines modulate transcription but not posttranscription of c-myc and c-jun in IEC-6 cells
Patel, A. R., & Wang, J. Y. (1997) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1997.273.3.c1020 · Cited by 102 · see citing works
Self-citationPolyamines and the Intestinal Tract
Seiler, N., & Raul, F. (2007) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360701250016 · Cited by 93 · see citing works
Guo, X., Rao, J. N., Liu, L., Zou, T., Keledjian, K. M., Boneva, D., Marasa, B. S., & Wang, J.-Y. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00407.2004 · Cited by 93 · see citing works
Self-citationStimulation of proximal small intestinal mucosal growth by luminal polyamines
Wang, J. Y., McCormack, S. A., Viar, M. J., & Johnson, L. R. (1991) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1991.261.3.g504 · Cited by 92 · see citing works
Self-citationDownregulation of E-cadherin in the reparative epithelium of the human gastrointestinal tract.
Hanby, A. M., Chinery, R., Poulsom, R., Playford, R. J., & Pignatelli, M. N. (1996) · Europe PMC (PubMed Central) · Cited by 83 · see citing works
Chen, J., Xiao, L., Rao, J. N., Zou, T., Liu, L., Bellavance, E. C., Gorospe, M., & Wang, J. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-02-0175 · Cited by 80 · see citing works
Self-citationXiao, L., Rao, J. N., Zou, T., Liu, L., Marasa, B. S., Chen, J., Turner, D. J., Zhou, H., Gorospe, M., & Wang, J. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-07-0675 · Cited by 79 · see citing works
Self-citationE-cadherin is a novel transcriptional target of the KLF6 tumor suppressor
DiFeo, A. V., Narla, G., Camacho‐Vanegas, O., Nishio, H., Rose, S. L., Buller, R. E., Friedman, S. L., Walsh, M. J., & Martignetti, J. A. (2006) · Oncogene · doi:10.1038/sj.onc.1209611 · Cited by 78 · see citing works
Man, Y., Hart, V. J., Ring, C. J. A., Sanjar, S., & West, M. R. (2000) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.23.5.4046 · Cited by 69 · see citing works
Expression of protooncogenes c-fos and c-myc in healing of gastric mucosal stress ulcers
Wang, J. Y., & Johnson, L. R. (1994) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1994.266.5.g878 · Cited by 68 · see citing works
Self-citationPolyamines and mRNA stability in regulation of intestinal mucosal growth
Wang, J.-Y. (2007) · Amino Acids · doi:10.1007/s00726-007-0518-z · Cited by 66 · see citing works
Self-citationLiu, L., Li, L., Rao, J. N., Zou, T., Zhang, H. M., Boneva, D., Bernard, M. S., & Wang, J.-Y. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00326.2004 · Cited by 61 · see citing works
Self-citationLiu, L., Guo, X., Rao, J. N., Zou, T., Marasa, B. S., Chen, J., Greenspon, J., Casero, R. A., & Wang, J. (2006) · Biochemical Journal · doi:10.1042/bj20060217 · Cited by 59 · see citing works
Self-citationTavalali, S., Schmitz, H., Fromm, M., Schulzke, J.-D., & Mankertz, J. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)84547-3 · Cited by 58 · see citing works
Rao, J. N., Liu, L., Zou, T., Marasa, B. S., Boneva, D., Wang, S. R., Malone, D. L., Turner, D. J., & Wang, J. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00282.2006 · Cited by 51 · see citing works
Self-citationXiao, L., Rao, J. N., Zou, T., Liu, L., Marasa, B. S., Chen, J., Turner, D. J., Passaniti, A., & Wang, J. (2007) · Biochemical Journal · doi:10.1042/bj20061436 · Cited by 50 · see citing works
Self-citationRao, J. N., Liu, S. V., Zou, T., Liu, L., Xiao, L., Zhang, X., Bellavance, E. C., Yuan, J. X. ‐., & Wang, J. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00232.2008 · Cited by 48 · see citing works
Self-citationMeeting of cell-cell adhesion, communication and signalling at the junction
Nelson, W. J. (1996) · Trends in Cell Biology · doi:10.1016/0962-8924(96)30040-8 · Cited by 5 · see citing works
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Gut microbiota, metabolites and host immunity
Rooks, M. G., & Garrett, W. S. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.42 · Cited by 3,409 · see citing works
Postler, T. S., & Ghosh, S. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.05.008 · Cited by 876 · see citing works
“Conversely, blocking endogenous production of polyamines with a chemical inhibitor of ornithine decarboxylase negatively affects maintenance, repair, and function of the intestinal epithelium, although it is not clear if or how this relates to dietary and microbially derived polyamine absorption (Chen et al., 2007; Gu…”
BackgroundModulation of cellular function by polyamines
Igarashi, K., & Kashiwagi, K. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.07.009 · Cited by 852 · see citing works
Regulation of Intestinal Barrier Function by Microbial Metabolites
Ghosh, S., Whitley, C. S., Haribabu, B., & Jala, V. R. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.02.007 · Cited by 835 · see citing works
Mammalian polyamine metabolism and function
Pegg, A. E. (2009) · IUBMB Life · doi:10.1002/iub.230 · Cited by 786 · see citing works
Bridging intestinal immunity and gut microbiota by metabolites
Wang, G., Huang, S., Wang, Y., Cai, S., Yu, H., Liu, H., Zeng, X., Zhang, G., & Qiao, S. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03190-6 · Cited by 299 · see citing works
Metabolites of Dietary Protein and Peptides by Intestinal Microbes and their Impacts on Gut
Fan, P. F., Li, L., Rezaei, A., Eslamfam, S., Che, D., & Ma, X. (2015) · Current Protein and Peptide Science · doi:10.2174/1389203716666150630133657 · Cited by 233 · see citing works
Dietary and Gut Microbiota Polyamines in Obesity- and Age-Related Diseases
Ramos-Molina, B., Queipo-Ortuño, M. I., Lambertos, A., Tinahones, F. J., & Peñafiel, R. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00024 · Cited by 226 · see citing works
Cohen, L. J., Cho, J. H., Gevers, D., & Chu, H. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.03.017 · Cited by 201 · see citing works
Zhang, Y., Chen, R., Zhang, D., Qi, S., & Liu, Y. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114295 · Cited by 210 · see citing works
FOXM1 (Forkhead box M1) in Tumorigenesis
Wierstra, I. (2013) · Advances in cancer research · doi:10.1016/b978-0-12-407190-2.00016-2 · Cited by 183 · see citing works
The functional role of polyamines in eukaryotic cells
Igarashi, K., & Kashiwagi, K. (2018) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2018.12.012 · Cited by 149 · see citing works
den Bossche, J. V., Lamers, W. H., Köhler, E. S., Geuns, J. M. C., Alhonen, L. I., Uimari, A., Pirnes-Karhu, S., Overmeire, E. V., Morias, Y., Brys, L., et al. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0911453 · Cited by 145 · see citing works
The gut ecosystem and immune tolerance
Shao, T., Hsu, R., Rafizadeh, D. L., Wang, L., Bowlus, C. L., Kumar, N., Mishra, J., Timilsina, S., Ridgway, W. M., Gershwin, M. E., et al. (2023) · Journal of Autoimmunity · doi:10.1016/j.jaut.2023.103114 · Cited by 136 · see citing works
Yu, T., Wang, P., Rao, J. N., Zou, T., Liu, L., Xiao, L., Gorospe, M., & Wang, J. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr567 · Cited by 104 · see citing works
Self-citationNakamura, A., Ooga, T., & Matsumoto, M. (2018) · Gut Microbes · doi:10.1080/19490976.2018.1494466 · Cited by 100 · see citing works
Polyamines and Gut Mucosal Homeostasis.
Timmons, J. A., Chang, E. T., Wang, J., & Rao, J. N. (2012) · PubMed · Cited by 97 · see citing works
Self-citationThe Molecular and Physiological Effects of Protein-Derived Polyamines in the Intestine
Bekebrede, A. F., Keijer, J., Gerrits, W. J. J., & de Boer, V. C. J. (2020) · Nutrients · doi:10.3390/nu12010197 · Cited by 92 · see citing works
Polyamines in Gut Epithelial Renewal and Barrier Function
Rao, J. N., Xiao, L., & Wang, J. (2020) · Physiology · doi:10.1152/physiol.00011.2020 · Cited by 85 · see citing works
Self-citationGut-microbiota derived bioactive metabolites and their functions in host physiology
Debnath, N., Kumar, R., Kumar, A., Mehta, P. K., & Yadav, A. K. (2021) · Biotechnology and Genetic Engineering Reviews · doi:10.1080/02648725.2021.1989847 · Cited by 77 · see citing works
Rao, J. N., Rathor, N., Zhuang, R., Zou, T., Liu, L., Xiao, L., Turner, D. J., & Wang, J. (2012) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00120.2012 · Cited by 69 · see citing works
Self-citationGut/rumen-mammary gland axis in mastitis: Gut/rumen microbiota–mediated “gastroenterogenic mastitis”
Hu, X., He, Z., Zhao, C., He, Y., Qiu, M., Xiang, K., Zhang, N., & Fu, Y. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2023.02.009 · Cited by 70 · see citing works
Health promoting activities of probiotics
Tang, C., & Lu, Z. (2019) · Journal of Food Biochemistry · doi:10.1111/jfbc.12944 · Cited by 66 · see citing works
Microbial Metabolite Regulation of Epithelial Cell-Cell Interactions and Barrier Function
Ornelas, A., Dowdell, A. S., Lee, J. S., & Colgan, S. P. (2022) · Cells · doi:10.3390/cells11060944 · Cited by 64 · see citing works
Wang, P., Rao, J. N., Zou, T., Liu, L., Xiao, L., Yu, T., Turner, D. J., Gorospe, M., & Wang, J. (2009) · Biochemical Journal · doi:10.1042/bj20091459 · Cited by 60 · see citing works
Self-citationBrand, E. C., Klaassen, M. A. Y., Gaćeša, R., Vila, A. V., Ghosh, H., de Zoete, M. R., Boomsma, D. I., Hoentjen, F., Horje, C. S. H. T., van de Meeberg, P. C., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2021.01.030 · Cited by 57 · see citing works
Rediscovering ACE: novel insights into the many roles of the angiotensin-converting enzyme
González-Villalobos, R. A., Shen, X. Z., Bernstein, E. A., Janjulia, T., Taylor, B. L., Giani, J. F., Blackwell, W.-L. B., Shah, K. H., Shi, P. D., Fuchs, S., et al. (2013) · Journal of Molecular Medicine · doi:10.1007/s00109-013-1051-z · Cited by 56 · see citing works
Pradhan, B., Guha, D., Naik, A. K., Banerjee, A., Tambat, S., Chawla, S., Senapati, S., & Aich, P. (2018) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-018-9436-5 · Cited by 56 · see citing works
Microbiota-Associated Metabolites and Related Immunoregulation in Colorectal Cancer
Chen, Y., & Chen, Y. (2021) · Cancers · doi:10.3390/cancers13164054 · Cited by 54 · see citing works
Gastrointestinal immune and microbiome changes during parenteral nutrition
Pierre, J. F. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00321.2016 · Cited by 54 · see citing works
Anti-inflammatory Gut Microbial Pathways Are Decreased During Crohn’s Disease Exacerbations
Klaassen, M. A. Y., Imhann, F., Collij, V., Fu, J., Wijmenga, C., Zhernakova, A., Dijkstra, G. D. H., Festen, E. A. M., Gaćeša, R., Vila, A. V., et al. (2019) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjz077 · Cited by 52 · see citing works
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Schreiber, F., Balas, I., Robinson, M. J., & Bakdash, G. (2024) · Cells · doi:10.3390/cells13060477 · Cited by 54 · see citing works
Probiotics: Comprehensive Exploration of the Growth Promotion Mechanisms in Shrimps
Goh, J. X. H., Tan, L. T., Law, J. W., Khaw, K. Y., Zengin, G., Chan, K., Letchumanan, V., Lee, L., & Goh, B. H. (2023) · Progress In Microbes & Molecular Biology · doi:10.36877/pmmb.a0000324 · Cited by 50 · see citing works
Microbial metabolites and graft versus host disease
Riwes, M. M., & Reddy, P. (2017) · American Journal of Transplantation · doi:10.1111/ajt.14443 · Cited by 50 · see citing works
“Osteomicrobiology”: The Nexus Between Bone and Bugs
Bhardwaj, A., Sapra, L., Tiwari, A., Mishra, P. K., Sharma, S., & Srivastava, R. K. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.812466 · Cited by 50 · see citing works
L-Arginine Pretreatment Reduces Intestinal Mucositis as Induced by 5-FU in Mice
Leocádio, P. C. L., Antunes, M. M., Teixeira, L. G., Leonel, A. J., Alvarez-Leite, J. I., Machado, D. C. C., Generoso, S. D. V., Cardoso, V. N., & Correia, M. I. T. D. (2015) · Nutrition and Cancer · doi:10.1080/01635581.2015.1004730 · Cited by 49 · see citing works
Köhler, N., & Zeiser, R. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2018.03179 · Cited by 49 · see citing works
Cerdó, T., Diéguez, E., & Campoy, C. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00188.2019 · Cited by 48 · see citing works
Zhang, C., Zhen, Y., Weng, Y., Lin, J., Xu, X., Ma, J., Zhong, Y., & Wang, M. (2025) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-025-01193-x · Cited by 48 · see citing works
Role of polyamines in intestinal mucosal barrier function
Nakamura, A., & Matsumoto, M. (2025) · Seminars in Immunopathology · doi:10.1007/s00281-024-01035-4 · Cited by 45 · see citing works
Yu, T., Gu, B.-L., Yan, J., Zhu, J., Yan, W., Chen, J., Qian, L., & Cai, W. (2015) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00112.2015 · Cited by 42 · see citing works
Self-citationChen, Z.-H., Yuan, X., Tu, T.-T., Wang, L., Mao, Y.-H., Luo, Y., Qiu, S., & Song, A.-X. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.131910 · Cited by 37 · see citing works
Liu, L., Rao, J. N., Zou, T., Xiao, L., Smith, A. D., Zhuang, R., Turner, D. J., & Wang, J. (2011) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00341.2011 · Cited by 36 · see citing works
Self-citationRole of the Microbiome in Mediating Health Effects of Dietary Components
Gong, L., Wen, T., & Wang, J. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b08231 · Cited by 32 · see citing works
Self-citationKwon, M. S., Chung, H. K., Xiao, L., Yu, T., Wang, S. R., Piao, J., Rao, J. N., Gorospe, M., & Wang, J. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00597.2020 · Cited by 31 · see citing works
Self-citationMicrobes with higher metabolic independence are enriched in human gut microbiomes under stressPreprint
Veseli, I., Chen, Y. T., Schechter, M. S., Vanni, C., Fogarty, E. C., Watson, A. R., Jabrì, B., Blekhman, R., Willis, A. D., Yu, M., et al. (2023) · eLife · doi:10.7554/elife.89862 · Cited by 32 · see citing works
Polysaccharides to postbiotics: Nurturing bone health via modulating “gut-immune axis”
Yadav, S., Sapra, L., & Srivastava, R. K. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.134655 · Cited by 27 · see citing works
Microbes with higher metabolic independence are enriched in human gut microbiomes under stress
Veseli, I., Chen, Y. T., Schechter, M. S., Vanni, C., Fogarty, E. C., Watson, A. R., Jabrì, B., Blekhman, R., Willis, A. D., Yu, M., et al. (2025) · eLife · doi:10.1101/2023.05.10.540289 · Cited by 26 · see citing works
Small noncoding vault RNA2‐1 disrupts gut epithelial barrier function via interaction with HuR
Ma, X., Xiao, L., Wen, S. J., Yu, T., Sharma, S., Chung, H. K., Warner, B., Mallard, C. G., Rao, J. N., Gorospe, M., et al. (2022) · EMBO Reports · doi:10.15252/embr.202254925 · Cited by 22 · see citing works
Self-citationUnderstanding the Effects of Metabolites on the Gut Microbiome and Severe Acute Pancreatitis
Ye, S., Si, C., Deng, J., Chen, X., Kong, L., Zhou, X., & Wang, W. (2021) · BioMed Research International · doi:10.1155/2021/1516855 · Cited by 21 · see citing works
Rodriguez, J., Olivares, M., & Delzenne, N. M. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900481 · Cited by 20 · see citing works
Sun, L., Chen, L., Lin, Z., Qin, Y., Zhang, J., Yang, J., Ma, J., Ye, T., & Li, W. (2011) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.2011.01367.x · Cited by 20 · see citing works
Kitase, Y., & Shuler, C. F. (2013) · The International Journal of Developmental Biology · doi:10.1387/ijdb.120117yk · Cited by 19 · see citing works
Wang, P., Wang, S. R., Xiao, L., Chen, J., Wang, J., & Rao, J. N. (2017) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00330.2016 · Cited by 19 · see citing works
Self-citationGierse, L. C., Meene, A., Schultz, D., Schwaiger, T., Karte, C., Schröder, C., Wang, H., Wünsche, C., Methling, K., Kreikemeyer, B., et al. (2020) · Microorganisms · doi:10.3390/microorganisms8121887 · Cited by 17 · see citing works
Yun, Y., Baek, A., & Kim, D. (2021) · BMB Reports · doi:10.5483/bmbrep.2021.54.5.211 · Cited by 15 · see citing works
Constitutive gray hair in mice induced by melanocyte‐specific deletion of c‐Myc
Pshenichnaya, I., Schouwey, K., Armaro, M., Larue, L., Knoepfler, P. S., Eisenman, R. N., Trumpp, A., Delmas, V., & Beermann, F. (2012) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2012.00998.x · Cited by 14 · see citing works
Sending signals – The microbiota’s contribution to intestinal epithelial homeostasis
Goyal, S., Tsang, D. K. L., Maisonneuve, C., & Girardin, S. E. (2020) · Microbes and Infection · doi:10.1016/j.micinf.2020.10.009 · Cited by 14 · see citing works
The Roles of Polyamines in Intestinal Development and Function in Piglets
Tan, B., Xiao, D., Wang, J., & Tan, B. (2024) · Animals · doi:10.3390/ani14081228 · Cited by 12 · see citing works
Self-citationCortés, A., Martin, J. C., Rosa, B. A., Stark, K. A., Clare, S., McCarthy, C. A., Harcourt, K., Brandt, C., Tolley, C., Lawley, T. D., et al. (2022) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0010878 · Cited by 12 · see citing works
Johansson, C.-C., Gennemark, P., Artursson, P., Äbelö, A., Ashton, M., & Jansson‐Löfmark, R. (2013) · Journal of Pharmacokinetics and Pharmacodynamics · doi:10.1007/s10928-012-9293-x · Cited by 12 · see citing works
Gerson, K. D., Liao, J., McCarthy, C., Burris, H. H., Korem, T., Levy, M., Ravel, J., & Elovitz, M. A. (2021) · Scientific Reports · doi:10.1038/s41598-021-02304-0 · Cited by 11 · see citing works
Soft TCPTP Agonism—Novel Target to Rescue Airway Epithelial Integrity by Exogenous Spermidine
Ghisalberti, C. A., Borzı̀, R. M., Cetrullo, S., Flamigni, F., & Cairo, G. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00147 · Cited by 11 · see citing works
Wang, X., Guo, S., Zhou, X., Wang, Y., Zhang, T., & Chen, R. (2021) · International Journal of General Medicine · doi:10.2147/ijgm.s339504 · Cited by 10 · see citing works
Zhao, G., Li, H., Huang, L., Cheng, Y., Liu, J., Song, R., & Wang, X. (2025) · Frontiers in Veterinary Science · doi:10.3389/fvets.2025.1589900 · Cited by 7 · see citing works
Effects of gut bacteria and their metabolites on gut health of animals
Hao, Z., Ding, X., & Wang, J. (2024) · Advances in applied microbiology · doi:10.1016/bs.aambs.2024.02.007 · Cited by 7 · see citing works
Self-citationLi, W., Huang, M., Wen-Gang, L., Chen, X., Shen, M., Li, X., Wang, R., & Ke, C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0135251 · Cited by 7 · see citing works
Mafe, A. N., & Büsselberg, D. (2026) · Nutrients · doi:10.3390/nu18040578 · Cited by 5 · see citing works
Bailey, S., & Fraser, K. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1229796 · Cited by 6 · see citing works
Clinical Significance of Topical Spermidine Hyaluronate in Vestibulodynia: An Early Appraisal
Murina, F., & Ghisalberti, C. (2023) · Open Journal of Obstetrics and Gynecology · doi:10.4236/ojog.2023.1312167 · Cited by 5 · see citing works
Zhang, C., Virk, A. K., KHAN, I. A., & Qin, H. (2020) · Springer eBooks · doi:10.1007/978-981-15-4759-1_2 · Cited by 5 · see citing works
Orlando, A., Linsalata, M., D’Attoma, B., & Russo, F. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.06.055 · Cited by 5 · see citing works
The gut–bone axis: microbial metabolism and nutritional interventions for bone health
Rodriguez-Bryant, A., Papageorgiou, M., Horcajada, M.-N., Biver, E., Ferrari, S., & Bonnet, N. (2026) · Gut Microbes · doi:10.1080/19490976.2026.2675093 · Cited by 4 · see citing works
Rathor, N., Chung, H. K., Song, J., Wang, S. R., Wang, J., & Rao, J. N. (2021) · Physiological Reports · doi:10.14814/phy2.14864 · Cited by 4 · see citing works
Self-citationPhysiological and Pathological Inflammation at the Mucosal Frontline
Kurashima, Y., & Kiyono, H. (2016) · Springer eBooks · doi:10.1007/978-4-431-56068-5_43 · Cited by 3 · see citing works
Yu, X., Xin, S., Liu, X., Pan, L., Shi, W., Li, Y., Wang, H., Lu, X., Gao, H., & Xu, J. (2025) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl27929 · Cited by 3 · see citing works
Wang, J., Lv, Z.-Y., Li, P., Zhang, Y., Li, X., & Shen, D.-F. (2024) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-024-05060-7 · Cited by 2 · see citing works
Self-citationGut microbiota and gut-derived metabolites in defining multiple sclerosis phenotypic continuum
Montini, F., Mangalam, A. K., Zeydan, B., Murray, J., & Kantarci, O. H. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1858047 · Cited by 1 · see citing works
Parenteral Nutrition Modeling and Research Advances
Kumari, R., Henry, L. M., & Pierre, J. F. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.101692 · Cited by 1 · see citing works
The inflammation during colorectal cancer: A friend or a foe?
Medina-Andrade, I., Olguín, J. E., Rodríguez, T., & Terrazas, L. I. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822028-3.00003-0 · Cited by 1 · see citing works
Metabolism of the challenged intestinal epithelial cell
Bekebrede, A. F. (2023) · doi:10.18174/578215 · Cited by 1 · see citing works
MOLECULAR ASPECTS OF ENDOTHELIAL CELL FUNCTION AND HYPOXIA-DEPENDENT TUMOR ANGIOGENESIS
Kucharzewska, P. (2011)
Functional relevance of epigenetic modifications in inflammatory bowel disease
Feng, Z. (2013) · Multimedialen Archiv und Publikationsserver der Christian-Albrechts-Universität zu Kiel (Christian-Albrechts-Universität zu Kiel)
Unravelling gene regulation in the epidermis during differentiation
Rahim, A. B. A. (2018) · doi:10.32657/10356/75891
Mikrobiom – Bedeutung für die Manifestation des Diabetes
Henneke, L., & Laudes, M. (2021) · Der Diabetologe · doi:10.1007/s11428-021-00716-0
Parker, G. A., & Papenfuss, T. L. (2017) · Molecular and integrative toxicology · doi:10.1007/978-3-319-47377-2_1
The gut microbiome in the onset and progression of Inflammatory Bowel Diseases
Klaassen, M. A. Y. (2024) · doi:10.33612/diss.909058157
Homéostasie de la Barrière Intestinale : rôle des métabolites bactériens
Liquard, R., Oukacha, K., Seksik, P., Sauvonnet, N., Thenet, S., & Carrière, V. (2025) · Cahiers de Nutrition et de Diététique · doi:10.1016/j.cnd.2025.11.002
Topical Spermidine Hyaluronate (Spd-HA) in Vulvovaginal Atrophy: A Preliminary Study
Porcari, I., Maini, M. C., Ghisalberti, C. A., Tezze, C., Trimarchi, E., Graziottin, A., Bosco, M., Casprini, C., Garzon, S., & Uccella, S. (2025) · Medicina · doi:10.3390/medicina61122104
Predominant miRNAs in Animal-Source Foods and Bioinformatic Analysis
Ilori, O. A., Santis, G. D., Cannataro, R., Tucci, P., & Cione, E. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48020237
Kaminski, L. (2018) · theses.fr (ABES) · doi:10.70675/7f6ae88bz4f3cz49d3zafcdz8682254b2be3
Cherrak, Y. (2020) · theses.fr (ABES) · doi:10.70675/50fe6f7bz2852z46e8z8c69z34c04bfce736
Polyamines in Gut Mucosal Repair and Injury-Associated Diseases
Warner, B., Xiao, L., & Wang, J.-Y. (2026) · IntechOpen eBooks · doi:10.5772/intechopen.1015566
Self-citationPolyamines and Epithelial Barrier Loss During HIV Infection
Mahalingam, S. S., Cameron, C. M., Richardson, B., Cameron, M. J., da Silva, A. P., Pinto, A., Tamilselvan, B., Jayaraman, S., Jacobson, J. M., Yendewa, G. A., et al. (2026) · Pathogens · doi:10.3390/pathogens15101069
- Authors
- Liu, L., Guo, X., Rao, J. N., Zou, T., Xiao, L., Yu, T., Timmons, J. A., Turner, D. J., & Wang, J.-Y.
- Affiliations
- University of Maryland, Baltimore (US)
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 2009-04
- Volume
- 296
- Issue
- 4
- Pages
- C801-C810
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- PMC
- PMC2670658
- OpenAlex
- W2149359487
- Cited by
- 94
- References
- 60
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 7 · 2023: 8 · 2022: 5 · 2021: 12 · 2020: 8 · 2019: 7 · 2018: 5 · 2017: 6 · 2016: 3 · 2015: 4 · 2013: 5 · 2012: 4
- FWCI
- 1.47
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Physiology-Cell Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (T32DK067872, R01DK061972, (DK-57819, R01DK068491, DK-61972, R01DK057819, DK-68491)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Keywords
- polyamines, E-cadherin, c-Myc, intestinal epithelial barrier, adherens junctions, E-cadherin promoter, paracellular permeability, transcriptional regulation, cell-cell adhesion
- MeSH terms
- Eflornithine, Animals, Cell Line, Enzyme Inhibitors, Epithelial Cells, Humans, Hydrogen Peroxide, Intercellular Junctions, Intestinal Mucosa, Mutation, Ornithine Decarboxylase, Permeability, Polyamines, Promoter Regions, Genetic, RNA, Messenger, Transcription, Genetic, Transfection, Antigens, CD, Cadherins, Proto-Oncogene Proteins c-myc, RNA Interference, RNA, Small Interfering, Rats, Ornithine Decarboxylase Inhibitors
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