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Critical Role of Astrocytic Polyamine and GABA Metabolism in Epileptogenesis

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The Oncobiome in Gastroenteric and Genitourinary Cancers

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Bacterial infection reinforces host metabolic flux from arginine to spermine for NLRP3 inflammasome evasion

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Dysregulation along the gut microbiota-immune system axis after oral exposure to titanium dioxide nanoparticles: A possible environmental factor promoting obesity-related metabolic disorders

Lamas, B., Evariste, L., & Houdeau, É. (2023) · Environmental Pollution · doi:10.1016/j.envpol.2023.121795 · Cited by 29 · see citing works

A comprehensive review for gut microbes: technologies, interventions, metabolites and diseases

Qi, C., Wang, P., Fu, T., Lu, M., Cai, Y., Chen, X., & Cheng, L. (2020) · Briefings in Functional Genomics · doi:10.1093/bfgp/elaa029 · Cited by 28 · see citing works

Interaction of gut microbiota with the tumor microenvironment: A new strategy for antitumor treatment and traditional Chinese medicine in colorectal cancer

Li, T., Han, L., Ma, S., Lin, W., Ba, X. W., Yan, J., Huang, Y., Tu, S., & Qin, K. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1140325 · Cited by 27 · see citing works

Arginase 2 and Polyamines in Human Pancreatic Beta Cells: Possible Role in the Pathogenesis of Type 2 Diabetes

Marselli, L., Bosi, E., Luca, C. D., Guerra, S. D., Tesi, M., Suleiman, M., & Marchetti, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212099 · Cited by 26 · see citing works

Effects of Spermidine on Gut Microbiota Modulation in Experimental Abdominal Aortic Aneurysm Mice

Liu, S., Liu, Y., Zhao, J., Yang, P., Wang, W., & Liao, M. (2022) · Nutrients · doi:10.3390/nu14163349 · Cited by 26 · see citing works

The Spermine Oxidase/Spermine Axis Coordinates ATG5‐Mediated Autophagy to Orchestrate Renal Senescence and Fibrosis

Luo, D., Xiaohui, L., Li, H., Li, Y., Wang, Y., Jiang, S., Li, G., Xu, Y., Wu, K., Dou, X., et al. (2024) · Advanced Science · doi:10.1002/advs.202306912 · Cited by 25 · see citing works

Correlation of polyamines, acrolein-conjugated lysine and polyamine metabolic enzyme levels with age in human liver

Uemura, T., Akasaka, Y., & Ikegaya, H. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e05031 · Cited by 25 · see citing works

Microbiome mediation of animal life histories via metabolites and insulin‐like signalling

Warne, R. W., & Dallas, J. W. (2022) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12833 · Cited by 24 · see citing works

Characterization of the Small Bowel Microbiome Reveals Different Profiles in Human Subjects Who Are Overweight or Have Obesity

Leite, G., Barlow, G. M., Rashid, M. A., Hosseini, A., Cohrs, D., Parodi, G., Morales, W., Weitsman, S. R., Rezaie, A. R., Pimentel, M., et al. (2024) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000002790 · Cited by 25 · see citing works

Modulation of the Neuro–Cancer Connection by Metabolites of Gut Microbiota

Mafe, A. N., & Büsselberg, D. (2025) · Biomolecules · doi:10.3390/biom15020270 · Cited by 24 · see citing works

Gender-Related Differences on Polyamine Metabolome in Liquid Biopsies by a Simple and Sensitive Two-Step Liquid-Liquid Extraction and LC-MS/MS

Samarra, I., Ramos‐Molina, B., Queipo‐Ortuño, M. I., Tinahones, F. J., Arola, L., Delpino-Rius, A., Herrero, P., & Canela-Canela, N. (2019) · Biomolecules · doi:10.3390/biom9120779 · Cited by 24 · see citing works

Nicotinamide Riboside-Conditioned Microbiota Deflects High-Fat Diet-Induced Weight Gain in Mice

Lozada-Fernández, V. V., deLeon, O., Kellogg, S. L., Saravia, F. L., Hadiono, M. A., Atkinson, S. N., Grobe, J. L., & Kirby, J. R. (2022) · mSystems · doi:10.1128/msystems.00230-21 · Cited by 23 · see citing works

Next-generation prebiotics: Maillard-conjugates of 2′-fucosyllactose and lactoferrin hydrolysates beneficially modulate gut microbiome composition and health promoting activity in a murine model

Peled, S., Freilich, S., Hanani, H., Kashi, Y., & Livney, Y. D. (2023) · Food Research International · doi:10.1016/j.foodres.2023.113830 · Cited by 23 · see citing works

New Insights into Identification, Distribution, and Health Benefits of Polyamines and Their Derivatives

Qiao, J., Cai, W., Wang, K., Haubruge, É., Dong, J. N., El-Seedi, H. R., Xu, X., & Zhang, H. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c08556 · Cited by 23 · see citing works

Interrelationship of myo-inositol pathways with systemic metabolic conditions in two strains of high-performance laying hens during their productive life span

Gonzalez-Uarquin, F., Sommerfeld, V., Rodehutscord, M., & Huber, K. (2021) · Scientific Reports · doi:10.1038/s41598-021-84169-x · Cited by 23 · see citing works

Spermidine at supraphysiological doses induces oxidative stress and granulosa cell apoptosis in mouse ovaries

Jiang, D., Jiang, Y., Long, S., Chen, Z., Li, Y., Mo, G., Bai, L., Hao, X., Yan, Y., Li, L., et al. (2021) · Theriogenology · doi:10.1016/j.theriogenology.2021.03.026 · Cited by 23 · see citing works

Identification of metabolites produced by six gut commensal Bacteroidales strains using non-targeted LC-MS/MS metabolite profiling

Fernández-Cantos, M. V., Babu, A. F., Hanhineva, K., & Kuipers, O. P. (2024) · Microbiological Research · doi:10.1016/j.micres.2024.127700 · Cited by 22 · see citing works

Liquid chromatography-tandem mass spectrometry based quantification of arginine metabolites including polyamines in different sample matrices

Langner, M., Mateska, I., Bechmann, N., Wielockx, B., Chavakis, T., Alexaki, V. I., & Peitzsch, M. (2022) · Journal of Chromatography A · doi:10.1016/j.chroma.2022.463021 · Cited by 22 · see citing works

Understanding the Effects of Metabolites on the Gut Microbiome and Severe Acute Pancreatitis

Ye, S., Si, C., Deng, J., Chen, X., Kong, L., Zhou, X., & Wang, W. (2021) · BioMed Research International · doi:10.1155/2021/1516855 · Cited by 21 · see citing works

The role of microbial metabolites in endocrine tumorigenesis: From the mechanistic insights to potential therapeutic biomarkers

Zhang, Y., Tang, N., Zhou, H., & Zhu, Y. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116218 · Cited by 20 · see citing works

Implication of the Gut Microbiota in Metabolic Inflammation Associated with Nutritional Disorders and Obesity

Rodriguez, J., Olivares, M., & Delzenne, N. M. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900481 · Cited by 20 · see citing works

Amelioration of Non-Alcoholic Steatohepatitis by Atractylodes macrocephala Polysaccharide, Chlorogenic Acid, and Geniposide Combination Is Associated With Reducing Endotoxin Gut Leakage

Leng, J., Tian, H., Fang, Y., Hu, Y., & Peng, J. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.827516 · Cited by 19 · see citing works

Spermidine activates adipose tissue thermogenesis through autophagy and fibroblast growth factor 21

Ni, Y., Zheng, L., Zhang, L., Li, J., Pan, Y., Du, H., Wang, Z., & Fu, Z. (2024) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2024.109569 · Cited by 19 · see citing works

Deciphering relationship between depression and microbial molecules based on multi-omics: A case study of Chaigui Granules

Wang, Q., Zhao, Y.-X., Qin, X., & Tian, J. (2024) · Chinese Herbal Medicines · doi:10.1016/j.chmed.2023.12.003 · Cited by 19 · see citing works

Increased hepatic putrescine levels as a new potential factor related to the progression of metabolic dysfunction‐associated steatotic liver disease

Núñez‐Sánchez, M. Á., Martínez‐Sánchez, M. A., Sierra‐Cruz, M., Lambertos, A., Rico‐Chazarra, S., Oliva‐Bolarín, A., Román, A. B., Yuste, J. E., Martínez, C. M., Mika, A., et al. (2024) · The Journal of Pathology · doi:10.1002/path.6330 · Cited by 19 · see citing works

Bridging two worlds: Host Microbiota crosstalk in health and dysregulation

Sanam, M., Hossain, C. F. T. Z., Hyder, T. B., Tarannum, R., Oishi, J. F., Rahman, K. A., Islam, S., Bulbul, N., Jime, J. S., Shishir, M. A., et al. (2025) · Innate Immunity · doi:10.1177/17534259251392993 · Cited by 19 · see citing works

Fecal microbiota and inflammatory and antioxidant status of obese and lean dogs, and the effect of caloric restriction

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Spermidine prevents high glucose‐induced senescence in HT‐22 cells by upregulation of CB1 receptor

Zhu, W., Xiao, F., Tang, Y., Zou, W., Li, X., Zhang, P., Wang, A., & Tang, X. (2018) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12955 · Cited by 18 · see citing works

Synbiotic Effect of Whole Grape Seed Flour and Newly Isolated Kefir Lactic Acid Bacteria on Intestinal Microbiota of Diet-Induced Obese Mice

Seo, K., Kim, D., YOKOYAMA, W. H., & Kim, H. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c01240 · Cited by 18 · see citing works

Effect of stress factors on the production of biogenic amines by lactic acid bacteria isolated from fermented Mexican foods (cheese and beer)

Ovalle-Marmolejo, X. Y., Redondo-Solano, M., Granados-Chinchilla, F., Miranda‐Castilleja, D. E., & Arvizu‐Medrano, S. M. (2022) · Food Control · doi:10.1016/j.foodcont.2022.109553 · Cited by 17 · see citing works

SLC3A2 and SLC7A2 Mediate the Exogenous Putrescine-Induced Adipocyte Differentiation

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Change in serum polyamine metabolome pattern after bariatric surgery in obese patients with metabolic syndrome

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Putrescine as a Novel Biomarker of Maternal Serum in First Trimester for the Prediction of Gestational Diabetes Mellitus: A Nested Case-Control Study

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Effect of a lifestyle intervention program with energy-restricted Mediterranean diet and exercise on the serum polyamine metabolome in individuals at high cardiovascular disease risk: a randomized clinical trial

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Gut Microbiota Alterations in Trace Amine-Associated Receptor 9 (TAAR9) Knockout Rats

Zhukov, I. S., Vaganova, A. N., Murtazina, R. Z., Alferova, L. S., Ермоленко, Е. И., & Gainetdinov, R. R. (2022) · Biomolecules · doi:10.3390/biom12121823 · Cited by 16 · see citing works

Polyamines and Longevity in Mammals

Matsumoto, M. (2014) · Springer eBooks · doi:10.1007/978-4-431-55212-3_21 · Cited by 3 · see citing works

Polyamine signaling in obesity: Microbiota-mediated spermidine and putrescine pathways in inflammation and metabolic homeostasis

Saxena, S., Ahmed, I., Jha, R. K., Kumar, N., Saxena, M., Chakrabarty, S., Choudhary, R. K., Ahuja, D., Kumar, M. V., & Bhattacharjee, A. (2026) · Obesity Medicine · doi:10.1016/j.obmed.2026.100745

Polyamines

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Gut microbiota and anti-aging: Focusing on spermidine

Yu, L., Pan, J., Guo, M., Duan, H., Zhang, H., Narbad, A., Zhai, Q., Tian, F., & Chen, W. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2224867 · Cited by 62 · see citing works

Spermine and gene methylation: a mechanism of lifespan extension induced by polyamine-rich diet

Soda, K. (2019) · Amino Acids · doi:10.1007/s00726-019-02733-2 · Cited by 41 · see citing works