The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Persistent increase in glucose uptake by rat skeletal muscle following exercise
Abstract
The effect of a bout of exercise on glucose uptake and glycogen synthesis in skeletal muscle was examined using a perfused rat hindlimb preparation. Rats were subjected to a bout of swimming. The exercise stress was moderate as reflected in a reduction of muscle glycogen concentration of only 50%. Glucose uptake and glycogen synthesis were measured in perfused hindlimb muscles for a 30-min period beginning approximately 60 min following the exercise. The rate of glucose uptake in the absence of insulin was 10-fold higher in hindlimbs of exercised animals than in the controls. The rate of glucose uptake was also higher in exercised than in control muscles in the presence of 50 microunits/ml or 10 mU/ml of insulin, but these differences were smaller than that found in the absence of insulin. Conversion to glycogen was the major pathway for disposal of the glucose taken up by muscle. The rate of glycogen accumulation in the exercised plantaris muscles was greater than in the control muscles both in the absence and presence of insulin.
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“A single bout of muscle contraction increases insulin sensitivity in perfused hindquarters of healthy animals (242, 255, 434) and in the whole body of healthy humans (230, 343).”
From Lack of Exercise Is a Major Cause of Chronic Diseases (2012) · cites this paper as [255]
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Cites
HINDLIMB MUSCLE FIBER POPULATIONS OF FIVE MAMMALS
Ariano, M. A., Edgerton, V. R., & Armstrong, R. B. (1973) · Journal of Histochemistry & Cytochemistry · doi:10.1177/21.1.51 · Cited by 1,118
[7] Chemical procedures for analysis of polysaccharides
Hassid, W. Z., & Abraham, S. (1957) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(57)03345-5 · Cited by 712
Evaluation of the isolated perfused rat hindquarter for the study of muscle metabolism
Ruderman, N. B., Houghton, C. R. S., & Hems, R. (1971) · Biochemical Journal · doi:10.1042/bj1240639 · Cited by 446
Glycogen Synthetase Activity in Skeletal Muscle
Danforth, W. H. (1965) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)45214-8 · Cited by 435
Rennie, M. J., & Holloszy, J. O. (1977) · Biochemical Journal · doi:10.1042/bj1680161 · Cited by 240
Self-citationBerger, M., Hagg, S., & Ruderman, N. B. (1975) · Biochemical Journal · doi:10.1042/bj1460231 · Cited by 211
Substrate depletion in different types of muscle and in liver during prolonged running
Baldwin, K., Reitman, J., Terjung, R. L., Winder, W. W., & Holloszy, J. O. (1973) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1973.225.5.1045 · Cited by 134
Self-citationGlycogen repletion in different types of muscle and in liver after exhausting exercise
Terjung, R. L., Baldwin, K., Winder, W. W., & Holloszy, J. O. (1974) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1974.226.6.1387 · Cited by 120
Self-citationRole of extramuscular energy sources in the metabolism of the exercising dog.
Paul, P., & Issekutz, B., Jr. (1967) · Journal of Applied Physiology · doi:10.1152/jappl.1967.22.4.615 · Cited by 91
Human Forearm Muscle Metabolism During Exercise: IV. Glucose Uptake at Different Work Intensities
Wahren, J. (1970) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365517009049194 · Cited by 36
Glucose Uptake by the Isolated Perfused Rat Hind Limb during Rest and Exercise
Szabo, A., Mahler, R., & Szabó, O. (1969) · Hormone and Metabolic Research · doi:10.1055/s-0028-1095147 · Cited by 15
Benis, A. M., Chien, S., Usami, S., & Jan, K.-M. (1973) · Journal of Applied Physiology · doi:10.1152/jappl.1973.34.3.383 · Cited by 11
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Lack of Exercise Is a Major Cause of Chronic Diseases
Booth, F. W., Roberts, C. K., & Laye, M. J. (2012) · Comprehensive Physiology · doi:10.1002/cphy.c110025 · Cited by 2,575
Colberg, S. R., Sigal, R. J., Fernhall, B., Regensteiner, J. G., Blissmer, B. J., Rubin, R. R., Chasan-Taber, L., Albright, A. L., & Braun, B. (2010) · Diabetes Care · doi:10.2337/dc10-9990 · Cited by 1,955
“Muscular BG uptake remains elevated postexercise, with the contraction-mediated pathway persisting for several hours (86,119) and insulinmediated uptake for longer (9,33,141, 226).”
Exercise, Glucose Transport, and Insulin Sensitivity
Goodyear, L. J., & Kahn, B. B. (1998) · Annual Review of Medicine · doi:10.1146/annurev.med.49.1.235 · Cited by 1,056
Molecular and cellular adaptation of muscle in response to exercise: perspectives of various models
Booth, F. W., & Thomason, D. B. (1991) · Physiological Reviews · doi:10.1152/physrev.1991.71.2.541 · Cited by 703
(2010) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181eeb61c · Cited by 567
Metadata
- Authors
- Ivy, J. L., & Holloszy, J. O.
- ORCID
- Ivy, J. L.
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 1981-11-01
- Volume
- 241
- Issue
- 5
- Pages
- C200-C203
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- OpenAlex
- W2237508147
- Cited by
- 185
- References
- 12
- Citations by year
- 2025: 3 · 2023: 1 · 2022: 3 · 2020: 3 · 2019: 1 · 2018: 2 · 2016: 5 · 2015: 3 · 2014: 3 · 2013: 2 · 2012: 6
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Cell Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Keywords
- physical activity, skeletal muscle, glucose uptake, glycogen synthesis, insulin, plantaris muscle, hindlimb perfusion, swimming training, glucose disposal, glycogen accumulation
- MeSH terms
- Animals, Biological Transport, Active, Physical Exertion, Female, Glucose, Glycogen, Insulin, Lactates, Muscles, Rats, Inbred Strains, Lactic Acid, Rats
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