The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Dissociation of effects of insulin and contraction on glucose transport in rat epitrochlearis muscle
Abstract
The effects of insulin and contraction on glucose transport and metabolism were investigated in rat epitrochlearis muscles in vitro. Insulin dose-response curves showed a threshold (approximately 50 microunits/ml) and saturation-type (approximately 1 mU/ml) kinetics, whereas isometric contraction activated glucose transport and metabolism in a linear fashion with no evidence of a threshold. Insulin and contraction increased the apparent maximal rate of uptake of the hexose transport system with minimal effect on its apparent Km. The stimulatory effects of insulin and contraction were additive; similar results were obtained with 2-deoxy-D-glucose. Contraction stimulated glucose transport in three different preparations of muscles depleted of insulin: 1) exhaustively washed for 2 h, 2) rats infused with anti-insulin serum, and 3) chronically (streptozotocin-induced) diabetic rats. Prostaglandin E2 augmented the effect of a submaximal concentration of insulin on glucose transport without exerting any effect by itself but had no effect on contraction-augmented glucose transport. It is concluded that insulin and contraction activate glucose transport and metabolism via independent mechanisms.
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Substrate Turnover during Prolonged Exercise in Man
Ahlborg, G., Felig, P., Hagenfeldt, L., Hendler, R., & Wahren, J. (1974) · Journal of Clinical Investigation · doi:10.1172/jci107645 · Cited by 786
Muscle Glucose Metabolism following Exercise in the Rat
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Karnieli, E., Zarnowski, M. J., Hissin, P. J., Simpson, I. A., Salans, L. B., & Cushman, S. W. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)69319-1 · Cited by 456
Mechanisms of the ability of insulin to activate the glucose-transport system in rat adipocytes
Olefsky, J. M. (1978) · Biochemical Journal · doi:10.1042/bj1720137 · Cited by 229
Studies of Tissue Permeability
Holloszy, J. O., & Narahara, H. T. (1965) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)97170-x · Cited by 222
Berger, M., Hagg, S., & Ruderman, N. B. (1975) · Biochemical Journal · doi:10.1042/bj1460231 · Cited by 212
Exercise and Diabetes Mellitus
Vranic, M., & Berger, M. (1979) · Diabetes · doi:10.2337/diab.28.2.147 · Cited by 212
Persistent increase in glucose uptake by rat skeletal muscle following exercise
Ivy, J. L., & Holloszy, J. O. (1981) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1981.241.5.c200 · Cited by 185
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Exercise, GLUT4, and skeletal muscle glucose uptake
Richter, E. A., & Hargreaves, M. (2013) · Physiological Reviews · doi:10.1152/physrev.00038.2012 · Cited by 1,407
Exercise, Glucose Transport, and Insulin Sensitivity
Goodyear, L. J., & Kahn, B. B. (1998) · Annual Review of Medicine · doi:10.1146/annurev.med.49.1.235 · Cited by 1,056
Regulatory role for the arginine–nitric oxide pathway in metabolism of energy substrates
Jobgen, W. S., Fried, S. K., Fu, W. J., Meininger, C. J., & Wu, G. (2006) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.12.001 · Cited by 710
Invited Review: Effects of acute exercise and exercise training on insulin resistance
Henriksen, E. J. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01219.2001 · Cited by 535
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Holloszy, J. O. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00123.2005 · Cited by 494
Metadata
- Authors
- Nesher, R., Karl, I. E., & Kipnis, D. M.
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 1985-09-01
- Volume
- 249
- Issue
- 3
- Pages
- C226-C232
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- OpenAlex
- W2296784018
- Cited by
- 257
- References
- 19
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nesher, R., Karl, I. E., & Kipnis, D. M. (1985). Dissociation of effects of insulin and contraction on glucose transport in rat epitrochlearis muscle. American Journal of Physiology-Cell Physiology. https://doi.org/10.1152/ajpcell.1985.249.3.c226
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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