Exercise, GLUT4, and skeletal muscle glucose uptake

Richter, Erik A.; Hargreaves, Mark

doi:10.1152/physrev.00038.2012

Cited by 1,407Metabolism, Diabetes, and CancerCardiovascular and exercise physiologyAdipose Tissue and Metabolism

Exercise, GLUT4, and skeletal muscle glucose uptake

Richter, Erik A., Hargreaves, Mark·2013·Physiological Reviews

DOI 10.1152/physrev.00038.2012

Open this paper in CoChat — free account

Abstract

Glucose is an important fuel for contracting muscle, and normal glucose metabolism is vital for health. Glucose enters the muscle cell via facilitated diffusion through the GLUT4 glucose transporter which translocates from intracellular storage depots to the plasma membrane and T-tubules upon muscle contraction. Here we discuss the current understanding of how exercise-induced muscle glucose uptake is regulated. We briefly discuss the role of glucose supply and metabolism and concentrate on GLUT4 translocation and the molecular signaling that sets this in motion during muscle contractions. Contraction-induced molecular signaling is complex and involves a variety of signaling molecules including AMPK, Ca 2+ , and NOS in the proximal part of the signaling cascade as well as GTPases, Rab, and SNARE proteins and cytoskeletal components in the distal part. While acute regulation of muscle glucose uptake relies on GLUT4 translocation, glucose uptake also depends on muscle GLUT4 expression which is increased following exercise. AMPK and CaMKII are key signaling kinases that appear to regulate GLUT4 expression via the HDAC4/5-MEF2 axis and MEF2-GEF interactions resulting in nuclear export of HDAC4/5 in turn leading to histone hyperacetylation on the GLUT4 promoter and increased GLUT4 transcription. Exercise training is the most potent stimulus to increase skeletal muscle GLUT4 expression, an effect that may partly contribute to improved insulin action and glucose disposal and enhanced muscle glycogen storage following exercise training in health and disease.

Integrity signals

Registry

Crossref · 10.1152/physrev.00038.2012

Cites

343 of 343 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Regular endurance exercise exerts beneficial effects on glycemic control via activation of the contraction-mediated (insulin independent) glucose uptake signaling pathway.
“Regular endurance exercise has been shown to exert beneficial effects on glycemic control via the activation of the contraction-mediated (insulin independent) glucose uptake signaling pathway [22].”
From Exercise mitigates sleep-loss-induced changes in glucose tolerance, mitochondrial function, sarcoplasmic protein synthesis, and diurnal rhythms (2021) · cites this paper as [22]
Exercise is known to acutely increase skeletal muscle Glut4 mRNA.
“While exercise is known to acutely increase skeletal muscle Glut4 mRNA [22]”
From Exercise mitigates sleep-loss-induced changes in glucose tolerance, mitochondrial function, sarcoplasmic protein synthesis, and diurnal rhythms (2021) · cites this paper as [22]
The absence of an increase in Glut4 mRNA in the SR+EX group may be explained by the timing of the muscle sample, collected 48 h post the final exercise session, by which time Glut4 mRNA expression may have returned to baseline levels.
“This may be explained by the timing of our muscle sample, which was collected 48 h post the final exercise session, by which time Glut4 mRNA expression may have returned to baseline levels [22,51].”
From Exercise mitigates sleep-loss-induced changes in glucose tolerance, mitochondrial function, sarcoplasmic protein synthesis, and diurnal rhythms (2021) · cites this paper as [22]
The acute effects of exercise on glycemic control are known to persist for up to 48 h.
“which are known to persist for up to 48 h [22].”
From Exercise mitigates sleep-loss-induced changes in glucose tolerance, mitochondrial function, sarcoplasmic protein synthesis, and diurnal rhythms (2021) · cites this paper as [22]

1 retracted

ATP consumption by sarcoplasmic reticulum Ca2+ pumps accounts for 50% of resting metabolic rate in mouse fast and slow twitch skeletal muscle
Norris, S. M., Bombardier, É., Smith, I. C. P., Vigna, C., & Tupling, A. R. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00479.2009 · Cited by 31 · see citing works
Retracted
The selectivity of protein kinase inhibitors: a further update
Bain, J., Plater, L., Elliott, M., Shpiro, N., Hastie, C. J., McLauchlan, H., Klevernic, I. V., Arthur, J. S. C., Alessi, D. R., & Cohen, P. (2007) · Biochemical Journal · doi:10.1042/bj20070797 · Cited by 2,537 · see citing works
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy
Hardie, D. G. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2249 · Cited by 2,207 · see citing works
Physiological adaptations to low-volume, high-intensity interval training in health and disease
Gibala, M. J., Little, J. P., MacDonald, M. J., & Hawley, J. A. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2011.224725 · Cited by 1,744 · see citing works
Diet, muscle glycogen and physical performance.
Bergström, J., Hermansen, L., Hultman, E., & Saltin, B. (1967) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1967.tb03720.x · Cited by 1,740 · cited 1× · see citing works
“Thus mice, which do not express glycogen synthase and therefore have no muscle glycogen, are able to run as well as WT mice (230), whereas there is no doubt that low muscle glycogen in humans limits performance (23).”
Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase
Hawley, S. A., Pan, D. A., Mustard, K. J., Ross, L., Bain, J., Edelman, A. M., Frenguelli, B. G., & Hardie, D. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.009 · Cited by 1,589 · see citing works
The Ras superfamily at a glance
Wennerberg, K., Rossman, K. L., & Der, C. J. (2005) · Journal of Cell Science · doi:10.1242/jcs.01660 · Cited by 1,549 · see citing works
The GLUT4 Glucose Transporter
Huang, S., & Czech, M. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.03.006 · Cited by 1,399 · see citing works
Maximal perfusion of skeletal muscle in man.
Andersen, P., & Saltin, B. (1985) · The Journal of Physiology · doi:10.1113/jphysiol.1985.sp015794 · Cited by 1,250 · see citing works
AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle
Merrill, G. F., Kurth, E. J., Hardie, D. G., & Winder, W. W. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.6.e1107 · Cited by 1,027 · see citing works
The Ca2+/Calmodulin-dependent Protein Kinase Kinases Are AMP-activated Protein Kinase Kinases
Hurley, R. L., Anderson, K. A., Franzone, J. M., Kemp, B. E., Means, A. R., & Witters, L. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503824200 · Cited by 1,021 · see citing works
Insulin-stimulated Phosphorylation of a Rab GTPase-activating Protein Regulates GLUT4 Translocation
Sano, H., Kane, S., Sano, E., Mı̂inea, C. P., Asara, J. M., Lane, W. S., Garner, C. W., & Lienhard, G. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c300063200 · Cited by 964 · see citing works
A Role for AMP-Activated Protein Kinase in Contraction- and Hypoxia-Regulated Glucose Transport in Skeletal Muscle
Mu, J., Brozinick, J. T., Valladares, O., Bucan, M., & Birnbaum, M. J. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00251-9 · Cited by 924 · see citing works
Handbook of Physiology. Section 12. Exercise: Regulation and Integration of Multiple Systems
Coast, J. R. (1997) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199703000-00021 · Cited by 915 · see citing works
Molecular cloning and characterization of an insulin-regulatable glucose transporter
James, D. E., Strube, M., & Muecdler, M. (1989) · Nature · doi:10.1038/338083a0 · Cited by 909 · see citing works
Management of cellular energy by the AMP‐activated protein kinase system
Hardie, D. G., Scott, J. W., Pan, D. A., & Hudson, E. R. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00560-x · Cited by 855 · see citing works
Exercise : regulation and integration of multiple systems
Rowell, L. B., & Shepherd, J. T. (1996) · Medical Entomology and Zoology · Cited by 810 · see citing works
Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise
Winder, W. W., & Hardie, D. G. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.270.2.e299 · Cited by 799 · see citing works
Substrate Turnover during Prolonged Exercise in Man
Ahlborg, G., Felig, P., Hagenfeldt, L., Hendler, R., & Wahren, J. (1974) · Journal of Clinical Investigation · doi:10.1172/jci107645 · Cited by 786 · see citing works
Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance
Zisman, A., Peroni, O. D., Abel, E. D., Michael, M. D., Mauvais-Jarvis, F., Lowell, B. B., Wojtaszewski, J. F. P., Hirshman, M. F., Virkamaki, A., Goodyear, L. J., et al. (2000) · Nature Medicine · doi:10.1038/78693 · Cited by 743 · see citing works
Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade
Sanders, M. J., Grondin, P., Hegarty, B. D., Snowden, M. A., & Carling, D. (2007) · Biochemical Journal · doi:10.1042/bj20061520 · Cited by 667 · see citing works
Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1
Michael, L. F., Wu, Z., Cheatham, R. B., Puigserver, P., Adelmant, G., Lehman, J. J., Kelly, D. P., & Spiegelman, B. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.061035098 · Cited by 663 · see citing works
AMPK is a direct adenylate charge-regulated protein kinase
Oakhill, J. S., Steel, R., Chen, Z.-P., Scott, J. W., Ling, N., Tam, S., & Kemp, B. E. (2011) · Science · doi:10.1126/science.1200094 · Cited by 612 · see citing works
A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis
Carling, D., Zammit, V. A., & Hardie, D. G. (1987) · FEBS Letters · doi:10.1016/0014-5793(87)80292-2 · Cited by 599 · see citing works
Glucose metabolism during leg exercise in man
Wahren, J., Felig, P., Ahlborg, G., & Jorfeldt, L. (1971) · Journal of Clinical Investigation · doi:10.1172/jci106772 · Cited by 598 · see citing works
Identification of a novel gene encoding an insulin-responsive glucose transporter protein
Birnbaum, M. J. (1989) · Cell · doi:10.1016/0092-8674(89)90968-9 · Cited by 598 · see citing works
Knockout of the α2 but Not α1 5′-AMP-activated Protein Kinase Isoform Abolishes 5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranosidebut Not Contraction-induced Glucose Uptake in Skeletal Muscle
Jørgensen, S. B., Viollet, B., Andreelli, F., Frøsig, C., Birk, J. B., Schjerling, P., Vaulont, S., Richter, E. A., & Wojtaszewski, J. F. P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m306205200 · Cited by 553 · see citing works
Self-citation
Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction
Sakamoto, K., McCarthy, A., Smith, D. P., Green, K. A., Hardie, D. G., Ashworth, A., & Alessi, D. R. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600667 · Cited by 544 · see citing works
A Method to Identify Serine Kinase Substrates
Kane, S., Sano, H., Liu, S. C. H., Asara, J. M., Lane, W. S., Garner, C. C., & Lienhard, G. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200198200 · Cited by 529 · see citing works
Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5
McKinsey, T. A., Zhang, C. L., & Olson, E. N. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.260501497 · Cited by 520 · see citing works
Contraction stimulates translocation of glucose transporter GLUT4 in skeletal muscle through a mechanism distinct from that of insulin
Lund, S., Holman, G. D., Schmitz, O., & Pedersen, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.13.5817 · Cited by 492 · see citing works
Carbohydrate feeding during prolonged strenuous exercise can delay fatigue
Coyle, E. F., Hagberg, J. M., Hurley, B. F., Martin, W. H., Ehsani, A. A., & Holloszy, J. O. (1983) · Journal of Applied Physiology · doi:10.1152/jappl.1983.55.1.230 · Cited by 487 · see citing works
Dissecting the Role of 5′-AMP for Allosteric Stimulation, Activation, and Deactivation of AMP-activated Protein Kinase
Suter, M., Riek, U., Tuerk, R. D., Schlattner, U., Wallimann, T., & Neumann, D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606357200 · Cited by 479 · see citing works
Exercise induces recruitment of the “insulin-responsive glucose transporter”. Evidence for distinct intracellular insulin- and exercise-recruitable transporter pools in skeletal muscle.
Douen, A. G., Ramlal, T., Rastogi, S., Bilan, P. J., Cartee, G. D., Vranić, M., Holloszy, J. O., & Klip, A. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77362-6 · Cited by 473 · see citing works
AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5
McGee, S. L., van Denderen, B. J. W., Howlett, K. F., Mollica, J., Schertzer, J. D., Kemp, B. E., & Hargreaves, M. (2008) · Diabetes · doi:10.2337/db07-0843 · Cited by 455 · see citing works
Self-citation
AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain
Mîinea, C. P., Sano, H., Kane, S., Sano, E., Fukuda, M., Peränen, J., Lane, W. S., & Lienhard, G. E. (2005) · Biochemical Journal · doi:10.1042/bj20050887 · Cited by 449 · see citing works
Isoform‐specific and exercise intensity‐dependent activation of 5′‐AMP‐activated protein kinase in human skeletal muscle
Wojtaszewski, J. F. P., Nielsen, P., Hansen, B. F., Richter, E. A., & Kiens, B. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.t01-1-00221.x · Cited by 435 · see citing works
Self-citation
Glucose transporter protein content and glucose transport capacity in rat skeletal muscles
Henriksen, E. J., Bourey, R. E., Rodnick, K. J., Koranyi, L. I., Permutt, M. A., & Holloszy, J. O. (1990) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1990.259.4.e593 · Cited by 435 · see citing works
Exercise induces rapid increases in GLUT4 expression, glucose transport capacity, and insulin-stimulated glycogen storage in muscle.
Ren, J., Semenkovich, C. F., Gulve, E. A., Gao, J. H., & Holloszy, J. O. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36636-x · Cited by 416 · see citing works
Histone deacetylase degradation andMEF2 activation promote the formation of slow-twitch myofibers
Potthoff, M. J., Wu, H., Arnold, M., Shelton, J. M., Backs, J., McAnally, J., Richardson, J. A., Bassel‐Duby, R., & Olson, E. N. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31960 · Cited by 416 · see citing works
Synergistic interaction between exercise and insulin on peripheral glucose uptake.
DeFronzo, R. A., Ferrannini, E., Sato, Y., Felig, P., & Wahren, J. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110399 · Cited by 415 · see citing works
Acute exercise induces GLUT4 translocation in skeletal muscle of normal human subjects and subjects with type 2 diabetes
Kennedy, J. W., Hirshman, M. F., Gervino, E. V., Ocel, J. V., Forse, R. A., Hoenig, S. J., Aronson, D., Goodyear, L. J., & Horton, E. S. (1999) · Diabetes · doi:10.2337/diabetes.48.5.1192 · Cited by 415 · see citing works
JNK and Tumor Necrosis Factor-α Mediate Free Fatty Acid-induced Insulin Resistance in 3T3-L1 Adipocytes
Nguyen, M. T. A., Satoh, H., Favelyukis, S., Babendure, J. L., Imamura, T., Sbodio, J. I., Zalevsky, J., Dahiyat, B. I., Chi, N.-W., & Olefsky, J. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504611200 · Cited by 411 · see citing works
AMP-activated protein kinase (AMPK) β1β2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise
O'Neill, H. M., Maarbjerg, S. J., Crane, J. D., Jeppesen, J., Jørgensen, S. B., Schertzer, J. D., Shyroka, O., Kiens, B., van Denderen, B. J., Tarnopolsky, M. A., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105062108 · Cited by 406 · see citing works
Self-citation
Ca2+ and AMPK Both Mediate Stimulation of Glucose Transport by Muscle Contractions
Wright, D. C., Hucker, K. A., Holloszy, J. O., & Han, D. H. (2004) · Diabetes · doi:10.2337/diabetes.53.2.330 · Cited by 398 · see citing works
Evidence that nitric oxide increases glucose transport in skeletal muscle
Balon, T. W., Nadler, J. L., & Jasman), (. T. T. A. O. A. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.82.1.359 · Cited by 393 · see citing works
A glucose transport protein expressed predominately in insulin-responsive tissues.
Charron, M. J., Brosius, F. C., Alper, S. L., & Lodish, H. F. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.8.2535 · Cited by 390 · see citing works
Characterization of the Role of the Rab GTPase-activating Protein AS160 in Insulin-regulated GLUT4 Trafficking
Larance, M., Ramm, G., Stöckli, J., van Dam, E. M., Winata, S. C., Wasinger, V. C., Simpson, F., Graham, M. W., Junutula, J. R., Guilhaus, M., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503897200 · Cited by 385 · see citing works
Four grams of glucose
Wasserman, D. H. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90563.2008 · Cited by 384 · see citing works
Insulin signaling and insulin sensitivity after exercise in human skeletal muscle
Wojtaszewski, J. F., Hansen, B. F., Gade, Kiens, B., Markuns, J. F., Goodyear, L. J., & Richter, E. A. (2000) · Diabetes · doi:10.2337/diabetes.49.3.325 · Cited by 382 · see citing works
Self-citation
Skeletal Muscle Glucose Uptake During Exercise: How is it Regulated?
Rose, A. J., & Richter, E. A. (2005) · Physiology · doi:10.1152/physiol.00012.2005 · Cited by 371 · see citing works
Self-citation
Activation of MEF2 by muscle activity is mediated through a calcineurin‐dependent pathway
Wu, H., Rothermel, B., Kanatous, S., Rosenberg, P. B., Naya, F. J., Shelton, J. M., Hutcheson, K. A., DiMaio, J. M., Olson, E. N., Bassel‐Duby, R., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.22.6414 · Cited by 366 · see citing works
Exercise induces isoform-specific increase in 5'AMP-activated protein kinase activity in human skeletal muscle
Fujii, N., Hayashi, T., Hirshman, M. F., Smith, J. T., Habinowski, S. A., Kaijser, L., Mu, J., Ljungqvist, O., Birnbaum, M. J., Witters, L. A., et al. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3073 · Cited by 351 · see citing works
Regulation of 5′AMP-activated protein kinase activity and substrate utilization in exercising human skeletal muscle
Wojtaszewski, J. F. P., MacDonald, C., Nielsen, J. N., Hellsten, Y., Hardie, D. G., Kemp, B. E., Kiens, B., & Richter, E. A. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00436.2002 · Cited by 348 · see citing works
Self-citation
AMPK signaling in contracting human skeletal muscle: acetyl-CoA carboxylase and NO synthase phosphorylation
Chen, Z., McConell, G. K., Michell, B. J., Snow, R. J., Canny, B. J., & Kemp, B. E. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.5.e1202 · Cited by 342 · see citing works
Free radicals and muscle fatigue: of ROS, canaries, and the IOC
Reid, M. B. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.002 · Cited by 329 · see citing works
The 5′-AMP-activated Protein Kinase γ3 Isoform Has a Key Role in Carbohydrate and Lipid Metabolism in Glycolytic Skeletal Muscle
Barnes, B. R., Marklund, S., Steiler, T. L., Walter, M., Hjälm, Amarger, V., Mahlapuu, M., Leng, Y., Johansson, C., Galuska, D., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405533200 · Cited by 317 · cited 2× · see citing works
“Activation of AMPK by AICAR in resting muscle results in increased glucose uptake (209), and this effect is lost when 2- or 3-AMPK subunits are deficient (21, 152, 216).”
Distinct Signals Regulate AS160 Phosphorylation in Response to Insulin, AICAR, and Contraction in Mouse Skeletal Muscle
Kramer, H. F., Witczak, C. A., Fujii, N., Jessen, N., Taylor, E. B., Arnolds, D. E., Sakamoto, K., Hirshman, M. F., & Goodyear, L. J. (2006) · Diabetes · doi:10.2337/db06-0150 · Cited by 315 · see citing works
Activation of p38 MAP kinase enhances sensitivity of muscle glucose transport to insulin
Geiger, P. C., Wright, D. C., Han, D., & Holloszy, J. O. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00477.2004 · Cited by 306 · see citing works
Effect of Acute Exercise on AMPK Signaling in Skeletal Muscle of Subjects with Type 2 Diabetes
Sriwijitkamol, A., Coletta, D. K., Wajcberg, E., Balbontin, G. B., Reyna, S. M., Barrientes, J., Eagan, P. A., Jenkinson, C. P., Cersosimo, E., DeFronzo, R. A., et al. (2007) · Diabetes · doi:10.2337/db06-1119 · Cited by 304 · see citing works
Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR
Sakamoto, K., Göransson, O., Hardie, D. G., & Alessi, D. R. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00074.2004 · Cited by 299 · see citing works
Exercise-induced histone modifications in human skeletal muscle
McGee, S. L., Fairlie, E., Garnham, A. P., & Hargreaves, M. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.181065 · Cited by 296 · see citing works
Predominant α2/β2/γ3 AMPK activation during exercise in human skeletal muscle
Birk, J. B., & Wojtaszewski, J. F. P. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.120972 · Cited by 293 · see citing works
Regulation of muscle GLUT-4 transcription by AMP-activated protein kinase
Zheng, D., MacLean, P. S., Pohnert, S. C., Knight, J. B., Olson, A. L., Winder, W. W., & Dohm, G. L. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.3.1073 · Cited by 292 · see citing works
AS160 Regulates Insulin- and Contraction-stimulated Glucose Uptake in Mouse Skeletal Muscle
Kramer, H. F., Witczak, C. A., Taylor, E. B., FUJII, N. L., Hirshman, M. F., & Goodyear, L. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605461200 · Cited by 285 · see citing works
AMPK-Mediated AS160 Phosphorylation in Skeletal Muscle Is Dependent on AMPK Catalytic and Regulatory Subunits
Treebak, J. T., Glund, S., Deshmukh, A. S., Klein, D. K., Long, Y. C., Jensen, T. E., Jørgensen, S. B., Viollet, B., Andersson, L., Neumann, D., et al. (2006) · Diabetes · doi:10.2337/db06-0175 · Cited by 281 · see citing works
Self-citation
Increased Phosphorylation of Akt Substrate of 160 kDa (AS160) in Rat Skeletal Muscle in Response to Insulin or Contractile Activity
Bruss, M. D., Arias, E. B., Lienhard, G. E., & Cartee, G. D. (2005) · Diabetes · doi:10.2337/diabetes.54.1.41 · Cited by 273 · see citing works
Insulin responsiveness in skeletal muscle is determined by glucose transporter (Glut4) protein level
Kern, M., Wells, J. A., Stephens, J. M., Elton, C. W., Friedman, J. E., Tapscott, E. B., Pekala, P. H., & Dohm, G. L. (1990) · Biochemical Journal · doi:10.1042/bj2700397 · Cited by 268 · see citing works
Discovery of TBC1D1 as an Insulin-, AICAR-, and Contraction-stimulated Signaling Nexus in Mouse Skeletal Muscle
Taylor, E. B., An, D., Kramer, H. F., Yu, H., FUJII, N. L., Röckl, K. S. C., Bowles, N. P., Hirshman, M. F., Xie, J., Feener, E. P., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708839200 · Cited by 268 · see citing works
Invited Review: Intracellular signaling in contracting skeletal muscle
Sakamoto, K., & Goodyear, L. J. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00167.2002 · Cited by 260 · see citing works
Dissociation of effects of insulin and contraction on glucose transport in rat epitrochlearis muscle
Нешер, Р., Karl, I. E., & KIPNIS, D. M. (1985) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1985.249.3.c226 · Cited by 255 · see citing works
Nitric Oxide Increases Glucose Uptake Through a Mechanism That Is Distinct From the Insulin and Contraction Pathways in Rat Skeletal Muscle
Higaki, Y., Hirshman, M. F., FUJII, N. L., & Goodyear, L. J. (2001) · Diabetes · doi:10.2337/diabetes.50.2.241 · Cited by 254 · see citing works
Ca2+–calmodulin‐dependent protein kinase expression and signalling in skeletal muscle during exercise
Rose, A. J., Kiens, B., & Richter, E. A. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.111757 · Cited by 247 · see citing works
Self-citation
Abundance, localization, and insulin-induced translocation of glucose transporters in red and white muscle
Marette, A., Richardson, J. M., Ramlal, T., Balon, T. W., Vranić, M., Pessin, J. E., & Klip, A. (1992) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1992.263.2.c443 · Cited by 244 · see citing works
Activation of AMP kinase enhances sensitivity of muscle glucose transport to insulin
Fisher, J. S., Gao, J., Han, D.-H., Holloszy, J. O., & Nolte, L. A. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2002.282.1.e18 · Cited by 244 · see citing works
The Kru¨ppel-like Factor KLF15 Regulates the Insulin-sensitive Glucose Transporter GLUT4
Gray, S., Feinberg, M. W., Hull, S., Kuo, C. T., Watanabe, M., Banerjee, S. S., DePina, A., Haspel, R. L., & Jain, M. K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201304200 · Cited by 243 · see citing works
III. Arbeitsfähigkeit und Ernährung1
Christensen, E. H., & Hansen, O. (1939) · Skandinavisches Archiv Für Physiologie · doi:10.1111/j.1748-1716.1939.tb01320.x · Cited by 239 · see citing works
Exercise modulates postreceptor insulin signaling and glucose transport in muscle-specific insulin receptor knockout mice
Wojtaszewski, J. F. P., Higaki, Y., Hirshman, M. F., Michael, M. D., Dufresne, S. D., Kahn, C. R., & Goodyear, L. J. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7961 · Cited by 235 · see citing works
Wortmannin inhibits insulin‐stimulated but not contraction‐stimulated glucose transport activity in skeletal muscle
Lee, A. D., Hansen, P. A., & Holloszy, J. O. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00147-2 · Cited by 234 · see citing works
Turning Signals On and Off: GLUT4 Traffic in the Insulin-Signaling Highway
Thong, F. S. L., Dugani, S. B., & Klip, A. (2005) · Physiology · doi:10.1152/physiol.00017.2005 · Cited by 223 · see citing works
Studies of Tissue Permeability
Holloszy, J. O., & NARAHARA, H. T. (1965) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)97170-x · Cited by 222 · see citing works
Endurance training decreases plasma glucose turnover and oxidation during moderate-intensity exercise in men
Coggan, A. R., Kohrt, W. M., Spina, R. J., Bier, D. M., & Holloszy, J. O. (1990) · Journal of Applied Physiology · doi:10.1152/jappl.1990.68.3.990 · Cited by 221 · see citing works
Hypoglycemia during Prolonged Exercise in Normal Men
Felig, P., Chérif, A., Minagawa, A., & Wahren, J. (1982) · New England Journal of Medicine · doi:10.1056/nejm198204153061503 · Cited by 218 · see citing works
Possible CaMKK-dependent regulation of AMPK phosphorylation and glucose uptake at the onset of mild tetanic skeletal muscle contraction
Jensen, T. E., Rose, A. J., Jørgensen, S. B., Brandt, N., Schjerling, P., Wojtaszewski, J. F. P., & Richter, E. A. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00456.2006 · Cited by 217 · see citing works
Self-citation
Insulin-induced actin filament remodeling colocalizes actin with phosphatidylinositol 3-kinase and GLUT4 in L6 myotubes
Khayat, Z. A., Tong, P. C. Y., Yaworsky, K., Bloch, R. J., & Klip, A. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.2.279 · Cited by 213 · see citing works
Nitric Oxide Stimulates Skeletal Muscle Glucose Transport Through a Calcium/Contraction– and Phosphatidylinositol-3-Kinase–Independent Pathway
Etgen, G. J., Fryburg, D. A., & Gibbs, E. M. (1997) · Diabetes · doi:10.2337/diab.46.11.1915 · Cited by 213 · see citing works
Role of reactive oxygen species in contraction‐mediated glucose transport in mouse skeletal muscle
Sandström, M., Zhang, S., Bruton, J. D., Silva, J., Reid, M. B., Westerblad, H., & Katz, A. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.110601 · Cited by 210 · see citing works
Exercise stimulates the mitogen-activated protein kinase pathway in human skeletal muscle.
Aronson, D., Violán, M., Dufresne, S. D., Zangen, D., Fielding, R. A., & Goodyear, L. J. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119282 · Cited by 209 · see citing works
Ceramide- and Oxidant-Induced Insulin Resistance Involve Loss of Insulin-Dependent Rac-Activation and Actin Remodeling in Muscle Cells
JeBailey, L., Wanono, O., Niu, W., Roessler, J., Rudich, A., & Klip, A. (2007) · Diabetes · doi:10.2337/db06-0823 · Cited by 209 · see citing works
Exercise-stimulated glucose transport in skeletal muscle is nitric oxide dependent
Roberts, C. K., Barnard, R. J., Scheck, S. H., & Balon, T. W. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.1.e220 · Cited by 208 · see citing works
Regulation of GLUT4 biogenesis in muscle: evidence for involvement of AMPK and Ca2+
Ojuka, E. O., Jones, T. E., Nolte, L. A., Chen, M. W., Wamhoff, B. R., Sturek, M. S., & Holloszy, J. O. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00512.2001 · Cited by 208 · see citing works
TBC proteins: GAPs for mammalian small GTPase Rab?
Fukuda, M. (2011) · Bioscience Reports · doi:10.1042/bsr20100112 · Cited by 207 · see citing works
Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators
Chen, S., Murphy, J. E., Toth, R. L., Campbell, D. G., MORRICE, N. A., & MacKintosh, C. (2007) · Biochemical Journal · doi:10.1042/bj20071114 · Cited by 207 · see citing works
Exercise and Myocyte Enhancer Factor 2 Regulation in Human Skeletal Muscle
McGee, S. L., & Hargreaves, M. (2004) · Diabetes · doi:10.2337/diabetes.53.5.1208 · Cited by 205 · see citing works
Self-citation
Acute exercise increases nitric oxide synthase activity in skeletal muscle
Roberts, C. K., Barnard, R. J., Jasman, A. P., & Balon, T. W. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.2.e390 · Cited by 202 · see citing works
Skeletal Muscle-Selective Knockout of LKB1 Increases Insulin Sensitivity, Improves Glucose Homeostasis, and Decreases TRB3
Koh, H.-J., Arnolds, D. E., Fujii, N., Tran, T. T., Rogers, M. J., Jessen, N., Li, Y., Liew, C. W., Ho, R. C., Hirshman, M. F., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00979-06 · Cited by 202 · see citing works
Myocyte Enhancer Factor 2 (MEF2)-Binding Site Is Required forGLUT4 Gene Expression in Transgenic Mice
Thai, M. V., Guruswamy, S., Cao, K. T., Pessin, J. E., & Olson, A. L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.23.14285 · Cited by 201 · see citing works
Mixed meal and light exercise each recruit muscle capillaries in healthy humans
Keske, M. A., Clerk, L. H., Lindner, J. R., Price, W. J., Jahn, L. A., Leong-Poi, H. M., & Barrett, E. J. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00497.2005 · Cited by 201 · see citing works
Enhanced Insulin Action Due to Targeted GLUT4 Overexpression Exclusively in Muscle
Tsao, T., Burcelin, R., Katz, E. B., Huang, L., & Charron, M. J. (1996) · Diabetes · doi:10.2337/diab.45.1.28 · Cited by 201 · see citing works
Uptake and release of free fatty acids and other metabolites in the legs of exercising men.
Havel, R. J., Pernow, B., & Jones, N. L. (1967) · Journal of Applied Physiology · doi:10.1152/jappl.1967.23.1.90 · Cited by 201 · see citing works
A Role for 14-3-3 in Insulin-stimulated GLUT4 Translocation through Its Interaction with the RabGAP AS160
Ramm, G., Larance, M., Guilhaus, M., & James, D. E. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603274200 · Cited by 200 · see citing works
Increased muscle glucose uptake during contractions: no need for insulin
Ploug, T., Galbo, H., & Richter, E. A. (1984) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1984.247.6.e726 · Cited by 199 · see citing works
Self-citation
Leg glucose uptake during maximal dynamic exercise in humans
Katz, A., Broberg, S., Sahlin, K., & Wahren, J. (1986) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1986.251.1.e65 · Cited by 198 · see citing works
Rab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cells
Sun, Y., Bilan, P. J., Liu, Z., & Klip, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009523107 · Cited by 197 · see citing works
Identification and Characterization of an Exercise-sensitive Pool of Glucose Transporters in Skeletal Muscle
Coderre, L., Kandror, K. V., Vallega, G., & Pilch, P. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.46.27584 · Cited by 195 · see citing works
Contraction Regulation of Akt in Rat Skeletal Muscle
Sakamoto, K., Hirshman, M. F., Aschenbach, W. G., & Goodyear, L. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112410200 · Cited by 192 · see citing works
Substrate specificity and effect on GLUT4 translocation of the Rab GTPase-activating protein Tbc1d1
Roach, W. G., Chavez, J. A., Mı̂inea, C. P., & Lienhard, G. E. (2007) · Biochemical Journal · doi:10.1042/bj20061798 · Cited by 192 · see citing works
Exercise induces a transient increase in transcription of the GLUT-4 gene in skeletal muscle
Neufer, P. D., & Dohm, G. L. (1993) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1993.265.6.c1597 · Cited by 192 · see citing works
Increased GLUT-4 translocation mediates enhanced insulin sensitivity of muscle glucose transport after exercise
Hansen, P. A., Nolte, L. A., Chen, M. M., & Holloszy, J. O. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.85.4.1218 · Cited by 189 · see citing works
Calcium stimulates glucose transport in skeletal muscle by a pathway independent of contraction
Youn, J. H., Gulve, E. A., & Holloszy, J. O. (1991) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1991.260.3.c555 · Cited by 189 · see citing works
Effects of Endurance Exercise Training on Insulin Signaling in Human Skeletal Muscle
Frøsig, C., Rose, A. J., Treebak, J. T., Kiens, B., Richter, E. A., & Wojtaszewski, J. F. P. (2007) · Diabetes · doi:10.2337/db06-1698 · Cited by 188 · see citing works
Self-citation
Exercise training, glucose transporters, and glucose transport in rat skeletal muscles
Rodnick, K. J., Henriksen, E. J., James, D. E., & Holloszy, J. O. (1992) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1992.262.1.c9 · Cited by 183 · see citing works
Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR
Geraghty, K. M., Chen, S., Harthill, J. E., Ibrahim, A. F., Toth, R., Morrice, N. A., Vandermoere, F., Moorhead, G. B., Hardie, D. G., & MacKintosh, C. (2007) · Biochemical Journal · doi:10.1042/bj20070649 · Cited by 181 · see citing works
Histone Deacetylase 5 Acquires Calcium/Calmodulin-Dependent Kinase II Responsiveness by Oligomerization with Histone Deacetylase 4
Backs, J., Backs, T., Bezprozvannaya, S., McKinsey, T. A., & Olson, E. N. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01611-07 · Cited by 179 · see citing works
AMP-activated Protein Kinase α2 Activity Is Not Essential for Contraction- and Hyperosmolarity-induced Glucose Transport in Skeletal Muscle
Fujii, N., Hirshman, M. F., Kane, E. M., Ho, R. C., Peter, L. E., Seifert, M. M., & Goodyear, L. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504208200 · Cited by 177 · see citing works
Effects of contractile activity on tyrosine phosphoproteins and PI 3-kinase activity in rat skeletal muscle
Goodyear, L. J., Giorgino, F., Balon, T. W., Condorelli, G., & Smith, R. J. (1995) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1995.268.5.e987 · Cited by 176 · see citing works
Glucose kinetics during prolonged exercise in highly trained human subjects: effect of glucose ingestion
Jeukendrup, A. E., Raben, A., Gijsen, A. P., Stegen, J. H. C. H., Brouns, F. J. P. H., Saris, W. H. M., & Wagenmakers, A. J. M. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.579ac.x · Cited by 176 · see citing works
Effect of increased plasma free fatty acid concentrations on muscle metabolism in exercising men
Hargreaves, M., Kiens, B., & Richter, E. A. (1991) · Journal of Applied Physiology · doi:10.1152/jappl.1991.70.1.194 · Cited by 176 · see citing works
Self-citation
Adrenaline increases skeletal muscle glycogenolysis, pyruvate dehydrogenase activation and carbohydrate oxidation during moderate exercise in humans
Watt, M. J., Howlett, K. F., Febbraio, M. A., Spriet, L. L., & Hargreaves, M. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.t01-1-00269.x · Cited by 173 · see citing works
Self-citation
Influence of muscle glycogen on glycogenolysis and glucose uptake during exercise in humans
Hargreaves, M., McConell, G., & Proietto, J. (1995) · Journal of Applied Physiology · doi:10.1152/jappl.1995.78.1.288 · Cited by 172 · see citing works
Self-citation
Nitric oxide synthase inhibition reduces leg glucose uptake but not blood flow during dynamic exercise in humans.
Bradley, S. J., Kingwell, B. A., & McConell, G. K. (1999) · Diabetes · doi:10.2337/diabetes.48.9.1815 · Cited by 171 · see citing works
Overexpression of Glut4 protein in muscle increases basal and insulin-stimulated whole body glucose disposal in conscious mice.
Ren, J., Marshall, B. A., Mueckler, M. M., McCaleb, M. L., Amatruda, J. M., & Shulman, G. I. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117673 · Cited by 171 · see citing works
Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle
Pehmøller, C., Treebak, J. T., Birk, J. B., Chen, S., MacKintosh, C., Hardie, D. G., Richter, E. A., & Wojtaszewski, J. F. P. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00115.2009 · Cited by 171 · see citing works
Self-citation
GLUT 4 and insulin receptor binding and kinase activity in trained human muscle.
Dela, F., Handberg, A., Mikines, K. J., Vinten, J., & Galbo, H. (1993) · The Journal of Physiology · doi:10.1113/jphysiol.1993.sp019833 · Cited by 170 · see citing works
Activation of p38 mitogen-activated protein kinase alpha and beta by insulin and contraction in rat skeletal muscle: potential role in the stimulation of glucose transport.
Somwar, R., Perreault, M., Kapur, S., Taha, C., Sweeney, G., Ramlal, T., Kim, D., Keen, J., Cote, C. H., Klip, A., et al. (2000) · Diabetes · doi:10.2337/diabetes.49.11.1794 · Cited by 170 · see citing works
5′AMP activated protein kinase expression in human skeletal muscle: effects of strength training and type 2 diabetes
Wojtaszewski, J. F. P., Birk, J. B., Frøsig, C., Holten, M., Pilegaard, H., & Dela, F. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.082669 · Cited by 170 · see citing works
Function and dysfunction of aPKC isoforms for glucose transport in insulin-sensitive and insulin-resistant states
Farese, R. V. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00045.2002 · Cited by 168 · see citing works
SOME CHANGES IN THE CHEMICAL CONSTITUENTS OF THE BLOOD FOLLOWING A MARATHON RACE
Levine, S. A., Gordon, B., & DERICK, C. L. (1924) · JAMA · doi:10.1001/jama.1924.02650480034015 · Cited by 167 · see citing works
Fiber type-specific expression of GLUT4 in human skeletal muscle: influence of exercise training.
Daugaard, J. R., Nielsen, J., Kristiansen, S., Andersen, J. L., Hargreaves, M., & Richter, E. A. (2000) · Diabetes · doi:10.2337/diabetes.49.7.1092 · Cited by 166 · see citing works
Self-citation
Skeletal Muscle Glucose Transport and Metabolism Are Enhanced in Transgenic Mice Overexpressing the Glut4 Glucose Transporter
Gulve, E. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.5.1679 · Cited by 165 · see citing works
Effect of Contraction on Mitogen-activated Protein Kinase Signal Transduction in Skeletal Muscle
Ryder, J. W., Fahlman, R., Wallberg‐Henriksson, H., Alessi, D. R., Krook, A., & Zierath, J. R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.2.1457 · Cited by 162 · see citing works
Adenosine receptors mediate synergistic stimulation of glucose uptake and transport by insulin and by contractions in rat skeletal muscle.
Vergauwen, L., Hespel, P., & Richter, E. A. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117104 · Cited by 162 · see citing works
Self-citation
Skeletal Muscle Cells and Adipocytes Differ in Their Reliance on TC10 and Rac for Insulin-Induced Actin Remodeling
JeBailey, L., Rudich, A., Huang, X., Ciano‐Oliveira, C. D., Kapùs, A., & Klip, A. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0294 · Cited by 161 · see citing works
Mice with AS160/TBC1D4-Thr649Ala Knockin Mutation Are Glucose Intolerant with Reduced Insulin Sensitivity and Altered GLUT4 Trafficking
Chen, S., Wasserman, D. H., MacKintosh, C., & Sakamoto, K. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2010.12.005 · Cited by 161 · see citing works
Exercise Increases Nuclear AMPK α2 in Human Skeletal Muscle
McGee, S. L., Howlett, K. F., Starkie, R. L., Cameron-Smith, D., Kemp, B. E., & Hargreaves, M. (2003) · Diabetes · doi:10.2337/diabetes.52.4.926 · Cited by 160 · see citing works
Self-citation
Rabs 8A and 14 are targets of the insulin-regulated Rab-GAP AS160 regulating GLUT4 traffic in muscle cells
Ishikura, S., Bilan, P. J., & Klip, A. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.12.140 · Cited by 158 · see citing works
Endocytosis, Recycling, and Regulated Exocytosis of Glucose Transporter 4
Foley, K. P., Boguslavsky, S., & Klip, A. (2011) · Biochemistry · doi:10.1021/bi2000356 · Cited by 156 · see citing works
Nitric Oxide Synthase Inhibition Reduces Glucose Uptake During Exercise in Individuals With Type 2 Diabetes More Than in Control Subjects
Kingwell, B. A., Formosa, M. F., Muhlmann, M. H., Bradley, S. J., & McConell, G. K. (2002) · Diabetes · doi:10.2337/diabetes.51.8.2572 · Cited by 155 · see citing works
Vascular recruitment in skeletal muscle during exercise and hyperinsulinemia assessed by contrast ultrasound
Dawson, D. K., Vincent, M. A., Barrett, E. J., Kaul, S., Clark, A., Leong-Poi, H. M., & Lindner, J. R. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00373.2001 · Cited by 152 · see citing works
Progressive increase in human skeletal muscle AMPKα2 activity and ACC phosphorylation during exercise
Stephens, T. J., Chen, Z.-P., Canny, B. J., Michell, B. J., Kemp, B. E., & McConell, G. K. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00101.2001 · Cited by 148 · see citing works
Effects of endurance exercise training on muscle glycogen accumulation in humans
Greiwe, J. S., Hickner, R. C., Hansen, P. A., Racette, S. B., Chen, M. M., & Holloszy, J. O. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.1.222 · Cited by 147 · see citing works
TBC1D1 Regulates Insulin- and Contraction-Induced Glucose Transport in Mouse Skeletal Muscle
An, D., Toyoda, T., Taylor, E. B., Yu, H., Fujii, N., Hirshman, M. F., & Goodyear, L. J. (2010) · Diabetes · doi:10.2337/db09-1266 · Cited by 147 · see citing works
Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle
Chiu, T. T., Jensen, T. E., Sylow, L., Richter, E. A., & Klip, A. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.05.022 · Cited by 145 · see citing works
Self-citation
Skeletal Muscle AMP-activated Protein Kinase Is Essential for the Metabolic Response to Exercise in Vivo
Lee-Young, R. S., Griffee, S. R., Lynes, S. E., Bracy, D. P., Ayala, J. E., McGuinness, O. P., & Wasserman, D. H. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.021048 · Cited by 145 · see citing works
Rac1 Is a Novel Regulator of Contraction-Stimulated Glucose Uptake in Skeletal Muscle
Sylow, L., Jensen, T. E., Kleinert, M., Mouatt, J. R., Maarbjerg, S., Jeppesen, J. F., Prats, C., Chiu, T. T., Boguslavsky, S., Klip, A., et al. (2012) · Diabetes · doi:10.2337/db12-0491 · Cited by 143 · see citing works
Self-citation
Exercise training increases GLUT-4 protein concentration in previously sedentary middle-aged men
Houmard, J. A., Shinebarger, M. H., Dolan, P. L., Leggett-Frazier, N., Bruner, R. K., McCammon, M. R., Israel, R. G., & Dohm, G. L. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.264.6.e896 · Cited by 142 · see citing works
Caffeine-induced Ca2+ release increases AMPK-dependent glucose uptake in rodent soleus muscle
Jensen, T. E., Rose, A. J., Hellsten, Y., Wojtaszewski, J. F. P., & Richter, E. A. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00693.2006 · Cited by 140 · see citing works
Self-citation
Muscle cells engage Rab8A and myosin Vb in insulin-dependent GLUT4 translocation
Ishikura, S., & Klip, A. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00277.2008 · Cited by 139 · see citing works
Effect of carbohydrate ingestion on glucose kinetics during exercise
McConell, G. K., Fabris, S., Proietto, J., & Hargreaves, M. (1994) · Journal of Applied Physiology · doi:10.1152/jappl.1994.77.3.1537 · Cited by 139 · see citing works
Self-citation
Evidence for the involvement of CaMKII and AMPK in Ca2+-dependent signaling pathways regulating FA uptake and oxidation in contracting rodent muscle
Raney, M. A., & Turcotte, L. P. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01282.2007 · Cited by 135 · see citing works
Glucose transporter number, activity, and isoform content in plasma membranes of red and white skeletal muscle
Goodyear, L. J., Hirshman, M. F., Smith, R. J., & Horton, E. S. (1991) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1991.261.5.e556 · Cited by 134 · see citing works
Studies of Tissue Permeability
Ozand, P. T., NARAHARA, H. T., & Cori, C. F. (1962) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)50117-4 · Cited by 133 · see citing works
Eccentric exercise decreases glucose transporter GLUT4 protein in human skeletal muscle.
Asp, S., Daugaard, J. R., & Richter, E. A. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp020553 · Cited by 132 · see citing works
Self-citation
Adenine nucleotide degradation in human skeletal muscle during prolonged exercise
Broberg, S., & Sahlin, K. (1989) · Journal of Applied Physiology · doi:10.1152/jappl.1989.67.1.116 · Cited by 132 · see citing works
Simple model for the dielectric constant of nanoscale silicon particle
Tsu, R., Babić, D., & Ioriatti, L. C. (1997) · Journal of Applied Physics · doi:10.1063/1.365762 · Cited by 131 · see citing works
Contraction- and hypoxia-stimulated glucose transport is mediated by a Ca2+-dependent mechanism in slow-twitch rat soleus muscle
Wright, D. C., Geiger, P. C., Holloszy, J. O., & Han, D. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00561.2004 · Cited by 131 · see citing works
Glucose Transporter Number, Function, and Subcellular Distribution in Rat Skeletal Muscle After Exercise Training
Goodyear, L. J., Hirshman, M. F., Valyou, P. M., & Horton, E. S. (1992) · Diabetes · doi:10.2337/diab.41.9.1091 · Cited by 130 · see citing works
Skeletal Muscle Reprogramming by Activation of Calcineurin Improves Insulin Action on Metabolic Pathways
Ryder, J. W., Bassel‐Duby, R., Olson, E. N., & Zierath, J. R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304510200 · Cited by 130 · see citing works
Training-induced alterations of glucose flux in men
Friedlander, A. L., Casazza, G. A., Horning, M. A., Huie, M. J., & Brooks, G. A. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.82.4.1360 · Cited by 130 · see citing works
Effects of muscle activity and fiber composition on glucose transport and GLUT-4
Megeney, L. A., Neufer, P. D., Dohm, G. L., Tan, M. H., Blewett, C., Elder, G. C. B., & Bonen, A. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.264.4.e583 · Cited by 129 · see citing works
Action of Muscular Work on Transfer of Sugars Across Cell Barriers: Comparison With Action of Insulin
Goldstein, M., Mullick, V., Huddlestun, B., & Levine, R. (1953) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1953.173.2.212 · Cited by 127 · see citing works
Exercise-Induced Phosphorylation of the Novel Akt Substrates AS160 and Filamin A in Human Skeletal Muscle
Deshmukh, A. S., Coffey, V. G., Zhong, Z., Chibalin, A., Hawley, J. A., & Zierath, J. R. (2006) · Diabetes · doi:10.2337/db05-1419 · Cited by 126 · see citing works
Exercise and skeletal muscle glucose transporter 4 expression: Molecular mechanisms
McGee, S. L., & Hargreaves, M. (2006) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2006.04362.x · Cited by 126 · see citing works
Self-citation
Contractile activity increases glucose uptake by muscle in severely diabetic rats
Wallberg‐Henriksson, H., & Holloszy, J. O. (1984) · Journal of Applied Physiology · doi:10.1152/jappl.1984.57.4.1045 · Cited by 126 · see citing works
Kinetics of glucose transport in rat muscle: effects of insulin and contractions
Ploug, T., Galbo, H., Vinten, J., Jørgensen, M. E., & Richter, E. A. (1987) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1987.253.1.e12 · Cited by 123 · see citing works
Self-citation
Regulation of muscle GLUT4 enhancer factor and myocyte enhancer factor 2 by AMP-activated protein kinase
Holmes, B. F., Sparling, D. P., Olson, A. L., Winder, W. W., & Dohm, G. L. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00606.2004 · Cited by 123 · see citing works
AS160 phosphorylation is associated with activation of α2β2γ1- but not α2β2γ3-AMPK trimeric complex in skeletal muscle during exercise in humans
Treebak, J., Birk, J., Rose, A., Kiens, B., Richter, E., & Wojtaszewski, J. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00380.2006 · Cited by 123 · see citing works
Self-citation
Crucial role of the small GTPase Rac1 in insulin‐stimulated translocation of glucose transporter 4 to the mouse skeletal muscle sarcolemma
Ueda, S., Kitazawa, S., Ishida, K., Nishikawa, Y., Matsui, M., Matsumoto, H., Aoki, T., Nozaki, S., Takeda, T., Tamori, Y., et al. (2010) · The FASEB Journal · doi:10.1096/fj.09-137380 · Cited by 123 · see citing works
High glycogen levels enhance glycogen breakdown in isolated contracting skeletal muscle
Richter, E. A., & Galbo, H. (1986) · Journal of Applied Physiology · doi:10.1152/jappl.1986.61.3.827 · Cited by 123 · see citing works
Self-citation
Effects of Exercise Training on Insulin-Regulatable Glucose-Transporter Protein Levels in Rat Skeletal Muscle
Rodnick, K. J., Holloszy, J. O., Mondon, C. E., & James, D. E. (1990) · Diabetes · doi:10.2337/diab.39.11.1425 · Cited by 122 · see citing works
Ca2+/Calmodulin-Dependent Protein Kinase Kinase-α Regulates Skeletal Muscle Glucose Uptake Independent of AMP-Activated Protein Kinase and Akt Activation
Witczak, C. A., FUJII, N. L., Hirshman, M. F., & Goodyear, L. J. (2007) · Diabetes · doi:10.2337/db06-1230 · Cited by 122 · see citing works
Skeletal muscle glucose uptake during contraction is regulated by nitric oxide and ROS independently of AMPK
Merry, T. L., Steinberg, G. R., Lynch, G. S., & McConell, G. K. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00239.2009 · Cited by 122 · see citing works
Insulin can regulate GLUT4 internalization by signaling to Rab5 and the motor protein dynein
Huang, J., Imamura, T., & Olefsky, J. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.241368698 · Cited by 121 · see citing works
Disruption of Cortical Actin in Skeletal Muscle Demonstrates an Essential Role of the Cytoskeleton in Glucose Transporter 4 Translocation in Insulin-sensitive Tissues
Brozinick, J. T., Hawkins, E. D., Strawbridge, A. B., & Elmendorf, J. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402697200 · Cited by 120 · see citing works
Contraction‐associated translocation of protein kinase C in rat skeletal muscle
Richter, E. A., Cleland, P. J. F., Rattigan, S., & Clark, M. G. (1987) · FEBS Letters · doi:10.1016/0014-5793(87)80669-5 · Cited by 120 · see citing works
Self-citation
Clathrin‐Dependent and Independent Endocytosis of Glucose Transporter 4 (GLUT4) in Myoblasts: Regulation by Mitochondrial Uncoupling
Antonescu, C. N., Dı́az, M., Femia, G., Planas, J. V., & Klip, A. (2008) · Traffic · doi:10.1111/j.1600-0854.2008.00755.x · Cited by 120 · see citing works
Increased AS160 phosphorylation, but not TBC1D1 phosphorylation, with increased postexercise insulin sensitivity in rat skeletal muscle
Funai, K., Schweitzer, G. G., Sharma, N., Kanzaki, M., & Cartee, G. D. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00194.2009 · Cited by 119 · see citing works
Physical exercise and fuel homeostasis in diabetes mellitus
Wahren, J., Felig, P., & Hagenfeldt, L. (1978) · Diabetologia · doi:10.1007/bf01219419 · Cited by 119 · see citing works
Insulin and Contraction Stimulate Exocytosis, but Increased AMP-activated Protein Kinase Activity Resulting from Oxidative Metabolism Stress Slows Endocytosis of GLUT4 in Cardiomyocytes
Yang, J., & Holman, G. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410213200 · Cited by 118 · see citing works
Acute exercise and GLUT4 expression in human skeletal muscle: influence of exercise intensity
Kraniou, G. N., Cameron‐Smith, D., & Hargreaves, M. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01489.2005 · Cited by 117 · see citing works
Self-citation
Insulin unmasks a COOH-terminal Glut4 epitope and increases glucose transport across T-tubules in skeletal muscle.
Wang, W., Hansen, P. A., Marshall, B. A., Holloszy, J. O., & Mueckler, M. M. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.135.2.415 · Cited by 116 · see citing works
CaMK activation during exercise is required for histone hyperacetylation and MEF2A binding at the MEF2 site on theGlut4gene
Smith, J. A. H., Kohn, T. A., Chetty, A. K., & Ojuka, E. O. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00747.2007 · Cited by 115 · see citing works
Contractile activity increases plasma membrane glucose transporters in absence of insulin
Goodyear, L. J., King, P. A., Hirshman, M. F., Thompson, C., Horton, E. D., & Horton, E. S. (1990) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1990.258.4.e667 · Cited by 115 · see citing works
Exercise Capacity of Mice Genetically Lacking Muscle Glycogen Synthase
Pederson, B. A., Cope, C. R., Schroeder, J. M., Smith, M. W., Irimia, J. M., Thurberg, B. L., DePaoli-Roach, A. A., & Roach, P. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410448200 · Cited by 114 · see citing works
The many ways to regulate glucose transporter 4This paper is one of a selection of papers published in this Special Issue, entitled 14th International Biochemistry of Exercise Conference – Muscles as Molecular and Metabolic Machines, and has undergone the Journal’s usual peer review process.
Klip, A. (2009) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h09-047 · Cited by 113 · see citing works
Intermittent increases in cytosolic Ca2+ stimulate mitochondrial biogenesis in muscle cells.
Ojuka, E., Jones, T. E., Han, D.-H., Chen, M. M., Wamhoff, B., Sturek, M., & Holloszy, J. (2002) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.00242.2002 · Cited by 112 · see citing works
The MEF2A Isoform Is Required for Striated Muscle-specific Expression of the Insulin-responsive GLUT4 Glucose Transporter
Mora, S., & Pessin, J. E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910259199 · Cited by 111 · see citing works
Influence of active muscle mass on glucose homeostasis during exercise in humans
Kjaer, M., Kiens, B., Hargreaves, M., & Richter, E. A. (1991) · Journal of Applied Physiology · doi:10.1152/jappl.1991.71.2.552 · Cited by 111 · see citing works
Self-citation
Changes in insulin action and GLUT-4 with 6 days of inactivity in endurance runners
Vukovich, M. D., Arciero, P. J., Kohrt, W. M., Racette, S. B., Hansen, P. A., & Holloszy, J. O. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.80.1.240 · Cited by 110 · see citing works
CaMKK is an upstream signal of AMP-activated protein kinase in regulation of substrate metabolism in contracting skeletal muscle
Abbott, M. J., Edelman, A. M., & Turcotte, L. P. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00179.2009 · Cited by 110 · see citing works
Glucose uptake and transport in contracting, perfused rat muscle with different pre‐contraction glycogen concentrations.
Hespel, P., & Richter, E. A. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp018175 · Cited by 108 · see citing works
Self-citation
Regulation of the human GLUT4 gene promoter: Interaction between a transcriptional activator and myocyte enhancer factor 2A
Knight, J. B., Eyster, C. A., Griesel, B. A., & Olson, A. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2432756100 · Cited by 108 · see citing works
The Role of JNK Proteins in Metabolism
Vallerie, S. N., & Hotamışlıgil, G. S. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3001007 · Cited by 108 · see citing works
Skeletal muscle overexpression of nuclear respiratory factor 1 increases glucose transport capacity
Baar, K., Song, Z., Semenkovich, C. F., Jones, T. E., Han, D.-H., Nolte, L. A., Ojuka, E. O., Chen, M. W., & Holloszy, J. O. (2003) · The FASEB Journal · doi:10.1096/fj.03-0049com · Cited by 106 · see citing works
Muscle net glucose uptake and glucose kinetics after endurance training in men
Bergman, B. C., Butterfield, G. E., Wolfel, E. E., Lopaschuk, G. D., Casazza, G. A., Horning, M. A., & Brooks, G. A. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.1.e81 · Cited by 104 · see citing works
Wortmannin inhibits both insulin- and contraction-stimulated glucose uptake and transport in rat skeletal muscle
Wojtaszewski, J. F. P., Hansen, B. F., Ursø, B., & Richter, E. A. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.81.4.1501 · Cited by 104 · see citing works
Self-citation
Enhanced peripheral glucose utilization in transgenic mice expressing the human GLUT4 gene.
Treadway, J. L., Hargrove, D. M., Nardone, N. A., McPherson, R. K., Russo, J., Milici, A. J., Stukenbrok, H., Gibbs, E. M., Stevenson, R. W., & Pessin, J. E. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43974-9 · Cited by 102 · see citing works
Contraction regulates site-specific phosphorylation of TBC1D1 in skeletal muscle
Vichaiwong, K., Purohit, S., An, D., Toyoda, T., Jessen, N., Hirshman, M. F., & Goodyear, L. J. (2010) · Biochemical Journal · doi:10.1042/bj20101100 · Cited by 102 · see citing works
Muscle glycogen content affects insulin-stimulated glucose transport and protein kinase B activity
Derave, W., Hansen, B. F., Lund, S., Kristiansen, S., & Richter, E. A. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.5.e947 · Cited by 102 · see citing works
Self-citation
Insulin induces translocation of GLUT-4 glucose transporters in human skeletal muscle
Gumà, A., Zierath, J. R., Wallberg‐Henriksson, H., & Klip, A. (1995) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1995.268.4.e613 · Cited by 101 · see citing works

Flagged first, then by citations

Sorted by citations

Skeletal muscle energy metabolism during exercise
Hargreaves, M., & Spriet, L. L. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0251-4 · Cited by 1,258 · see citing works
Self-citation
Integrative Biology of Exercise
Hawley, J. A., Hargreaves, M., Joyner, M. J., & Zierath, J. R. (2014) · Cell · doi:10.1016/j.cell.2014.10.029 · Cited by 1,152 · see citing works
Self-citation
Molecular mechanisms of ROS production and oxidative stress in diabetes
Newsholme, P., Cruzat, V. F., Keane, K. N., Carlessi, R., & de Bittencourt, P. I. H. (2016) · Biochemical Journal · doi:10.1042/bcj20160503c · Cited by 878 · see citing works
Molecular Mechanisms Linking Oxidative Stress and Diabetes Mellitus
Yaribeygi, H., Sathyapalan, T., Atkin, S. L., & Sahebkar, A. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/8609213 · Cited by 689 · see citing works
Skeletal muscle: A review of molecular structure and function, in health and disease
Mukund, K., & Subramaniam, S. (2019) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1462 · Cited by 680 · see citing works
Update on the effects of physical activity on insulin sensitivity in humans
Bird, S. R., & Hawley, J. A. (2017) · BMJ Open Sport & Exercise Medicine · doi:10.1136/bmjsem-2016-000143 · Cited by 646 · see citing works
Physical Activity and Sports—Real Health Benefits: A Review with Insight into the Public Health of Sweden
Malm, C., Jakobsson, J., & Isaksson, A. (2019) · Sports · doi:10.3390/sports7050127 · Cited by 664 · see citing works
Glucose transporters in adipose tissue, liver, and skeletal muscle in metabolic health and disease
Chadt, A., & Al-Hasani, H. (2020) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-020-02417-x · Cited by 510 · see citing works
Exercise-stimulated glucose uptake — regulation and implications for glycaemic control
Sylow, L., Kleinert, M., Richter, E. A., & Jensen, T. E. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.162 · Cited by 498 · see citing works
Self-citation
Exercise Promotes Healthy Aging of Skeletal Muscle
Cartee, G. D., Hepple, R. T., Bamman, M. M., & Zierath, J. R. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.007 · Cited by 483 · see citing works
Skeletal Muscle Extracellular Matrix – What Do We Know About Its Composition, Regulation, and Physiological Roles? A Narrative Review
Csapo, R., Gumpenberger, M., & Wessner, B. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00253 · Cited by 435 · see citing works
Metabolic Syndrome Pathophysiology and Predisposing Factors
Bovolini, A., Garcia, J., Andrade, M. A., & Duarte, J. A. (2020) · International Journal of Sports Medicine · doi:10.1055/a-1263-0898 · Cited by 414 · see citing works
Determinants of Maternal Insulin Resistance during Pregnancy: An Updated Overview
Kampmann, U., Knorr, S., Fuglsang, J., & Ovesen, P. (2019) · Journal of Diabetes Research · doi:10.1155/2019/5320156 · Cited by 400 · see citing works
Brown and beige adipose tissue: a novel therapeutic strategy for obesity and type 2 diabetes mellitus
Cheng, L., Wang, J., Dai, H., Duan, Y., An, Y., Shi, L., Lv, Y., Li, H., Wang, C., Ma, Q., et al. (2021) · Adipocyte · doi:10.1080/21623945.2020.1870060 · Cited by 377 · see citing works
The many actions of insulin in skeletal muscle, the paramount tissue determining glycemia
Sylow, L., Tokarz, V. L., Richter, E. A., & Klip, A. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.03.020 · Cited by 366 · see citing works
Self-citation
Exercise and type 2 diabetes: molecular mechanisms regulating glucose uptake in skeletal muscle
Stanford, K. I., & Goodyear, L. J. (2014) · AJP Advances in Physiology Education · doi:10.1152/advan.00080.2014 · Cited by 346 · see citing works
Thirty sweet years of GLUT4
Klip, A., McGraw, T. E., & James, D. E. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.rev119.008351 · Cited by 344 · see citing works
Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy
Myers, R. W., Guan, H.-P., Ehrhart, J., Petrov, A., Prahalada, S., Tozzo, E., Yang, X., Kurtz, M. M., Trujillo, M., Gonzalez Trotter, D., et al. (2017) · Science · doi:10.1126/science.aah5582 · Cited by 346 · see citing works
Diet and Healthy Lifestyle in the Management of Gestational Diabetes Mellitus
Rasmussen, L., Poulsen, C. W., Kampmann, U., Smedegaard, S. B., Ovesen, P. G., & Fuglsang, J. (2020) · Nutrients · doi:10.3390/nu12103050 · Cited by 304 · see citing works
Muscle fiber type diversification during exercise and regeneration
Qaisar, R., Bhaskaran, S., & Van Remmen, H. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.03.025 · Cited by 283 · see citing works
Interleukin 6 as an Energy Allocator in Muscle Tissue
Kistner, T. M., Pedersen, B. K., & Lieberman, D. E. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00538-4 · Cited by 295 · see citing works
Update on GLUT4 Vesicle Traffic: A Cornerstone of Insulin Action
Jaldín‐Fincati, J. R., Pavarotti, M. A., Frendo‐Cumbo, S., Bilan, P. J., & Klip, A. (2017) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2017.05.002 · Cited by 276 · see citing works
Breaking Up Prolonged Sitting With Standing or Walking Attenuates the Postprandial Metabolic Response in Postmenopausal Women: A Randomized Acute Study
Henson, J., Davies, M. J., Bodicoat, D. H., Edwardson, C. L., Gill, J. M. R., Stensel, D. J., Tolfrey, K., Dunstan, D. W., Khunti, K., & Yates, T. (2016) · Diabetes Care · doi:10.2337/dc15-1240 · Cited by 270 · see citing works
Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers
Flockhart, M., Nilsson, L. C., Tais, S., Ekblom, B. T., Apró, W., & Larsen, F. J. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.02.017 · Cited by 264 · see citing works
Heat shock response and autophagy—cooperation and control
Dokładny, K., Myers, O., & Moseley, P. L. (2015) · Autophagy · doi:10.1080/15548627.2015.1009776 · Cited by 254 · see citing works
The Effect of Regular Exercise on Insulin Sensitivity in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
Way, K. L., Hackett, D. A., Baker, M. K., & Johnson, N. A. (2016) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2016.40.4.253 · Cited by 245 · see citing works
Muscle-specific loss of Bmal1 leads to disrupted tissue glucose metabolism and systemic glucose homeostasis
Harfmann, B. D., Schroder, E. A., Kachman, M. T., Hodge, B. A., Zhang, X., & Esser, K. A. (2016) · Skeletal Muscle · doi:10.1186/s13395-016-0082-x · Cited by 231 · see citing works
Cytosolic ROS production by NADPH oxidase 2 regulates muscle glucose uptake during exercise
Henríquez-Olguin, C., Knudsen, J. R., Raun, S. H., Li, Z., Dalbram, E., Treebak, J. T., Sylow, L., Holmdahl, R., Richter, E. A., Jaimovich, E., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12523-9 · Cited by 228 · see citing works
Self-citation
AMPK and the Adaptation to Exercise
Spaulding, H. R., & Yan, Z. (2022) · Annual Review of Physiology · doi:10.1146/annurev-physiol-060721-095517 · Cited by 231 · see citing works
Exercise adaptations: molecular mechanisms and potential targets for therapeutic benefit
McGee, S. L., & Hargreaves, M. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0377-1 · Cited by 221 · see citing works
Self-citation
Physical activity, aging, and physiological function
Harridge, S. D. R., & Lazarus, N. R. (2017) · Physiology · doi:10.1152/physiol.00029.2016 · Cited by 214 · see citing works
AMPK and autophagy in glucose/glycogen metabolism
Ha, J., Guan, K., & Kim, J. (2015) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2015.08.002 · Cited by 211 · see citing works
Physical activity, exercise and rheumatoid arthritis: Effectiveness, mechanisms and implementation
Metsios, G. S., & Kitas, G. D. (2018) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2019.03.013 · Cited by 198 · see citing works
Mechanisms of action of metformin in type 2 diabetes: Effects on mitochondria and leukocyte-endothelium interactions
Apostolova, N., Iannantuoni, F., Gruevska, A., Muntané, J., Rocha, M., & Víctor, V. M. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101517 · Cited by 201 · see citing works
Quercetin for managing type 2 diabetes and its complications, an insight into multitarget therapy
Dhanya, R. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112560 · Cited by 180 · see citing works
Mitohormesis in exercise training
Merry, T. L., & Ristow, M. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.11.032 · Cited by 176 · see citing works
Deep muscle-proteomic analysis of freeze-dried human muscle biopsies reveals fiber type-specific adaptations to exercise training
Deshmukh, A. S., Steenberg, D. E., Hostrup, M., Birk, J. B., Larsen, J. K., Santos, A., Kjøbsted, R., Hingst, J. R., Schéele, C., Murgia, M., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20556-8 · Cited by 169 · see citing works
Self-citation
Carbohydrate Nutrition and Team Sport Performance
Williams, C., & Rollo, I. (2015) · Sports Medicine · doi:10.1007/s40279-015-0399-3 · Cited by 175 · see citing works
Muscle Lipid Metabolism: Role of Lipid Droplets and Perilipins
Morales, P. E., Bucarey, J. L., & Espinosa, A. (2017) · Journal of Diabetes Research · doi:10.1155/2017/1789395 · Cited by 171 · see citing works
Sitting Less and Moving More: Improved Glycaemic Control for Type 2 Diabetes Prevention and Management
Dempsey, P. C., Owen, N. G., Yates, T. E., Kingwell, B. A., & Dunstan, D. W. (2016) · Current Diabetes Reports · doi:10.1007/s11892-016-0797-4 · Cited by 160 · see citing works
Treatments for women with gestational diabetes mellitus: an overview of Cochrane systematic reviews
Martis, R., Crowther, C. A., Shepherd, E., Alsweiler, J., Downie, M. R., & Brown, J. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012327.pub2 · Cited by 159 · see citing works
Roles of TBC1D1 and TBC1D4 in insulin- and exercise-stimulated glucose transport of skeletal muscle
Cartee, G. D. (2014) · Diabetologia · doi:10.1007/s00125-014-3395-5 · Cited by 153 · see citing works
Pathophysiology of exercise-induced muscle damage and its structural, functional, metabolic, and clinical consequences
Stožer, A., Vodopivc, P., & Bombek, L. K. (2020) · Physiological Research · doi:10.33549/physiolres.934371 · Cited by 163 · see citing works
Therapeutic Potential of Quercetin in the Management of Type-2 Diabetes Mellitus
Ansari, P., Choudhury, S. T., Seidel, V., Rahman, A. B., Aziz, M. A., Richi, A. E., Rahman, A., Jafrin, U. H., Hannan, J. M. A., & Abdel‐Wahab, Y. H. A. (2022) · Life · doi:10.3390/life12081146 · Cited by 152 · see citing works
Exercise and regulation of carbohydrate metabolism
Mul, J. D., Stanford, K. I., Hirshman, M. F., & Goodyear, L. J. (2015) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2015.07.020 · Cited by 151 · see citing works
Glucose metabolism in nerve terminals
Ashrafi, G., & Ryan, T. A. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.03.007 · Cited by 146 · see citing works
Mechanisms for greater insulin-stimulated glucose uptake in normal and insulin-resistant skeletal muscle after acute exercise
Cartee, G. D. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00416.2015 · Cited by 140 · see citing works
Structured exercise alters the gut microbiota in humans with overweight and obesity—A randomized controlled trial
Kern, T., Blond, M. B., Hansen, T. H., Rosenkilde, M., Quist, J. S., Gram, A. S., Ekstrøm, C. T., Hansen, T., & Stallknecht, B. (2020) · International Journal of Obesity · doi:10.1038/s41366-019-0440-y · Cited by 130 · see citing works
Effects of Exercise on Tumor Physiology and Metabolism
Pedersen, L., Christensen, J. F., & Højman, P. (2015) · The Cancer Journal · doi:10.1097/ppo.0000000000000096 · Cited by 134 · see citing works
A role of Ficus species in the management of diabetes mellitus: A review
Deepa, P., Sowndhararajan, K., Kim, S., & Park, S. J. (2018) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2017.12.045 · Cited by 132 · see citing works
Expanding roles for AMPK in skeletal muscle plasticity
Mounier, R., Théret, M., Lantier, L., Foretz, M., & Viollet, B. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.02.009 · Cited by 130 · see citing works
Physical Exercise and Selective Autophagy: Benefit and Risk on Cardiovascular Health
Wu, N. N., Tian, H., Chen, P., Wang, D., Ren, J. T., & Zhang, Y. (2019) · Cells · doi:10.3390/cells8111436 · Cited by 130 · see citing works
Interrupting prolonged sitting in type 2 diabetes: nocturnal persistence of improved glycaemic control
Dempsey, P. C., Blankenship, J. M., Larsen, R. N., Sacre, J. W., Sethi, P., Straznicky, N. E., Cohen, N. D., Cerin, E., Lambert, G. W., Owen, N. G., et al. (2016) · Diabetologia · doi:10.1007/s00125-016-4169-z · Cited by 129 · see citing works
The kynurenine connection: how exercise shifts muscle tryptophan metabolism and affects energy homeostasis, the immune system, and the brain
Martin, K. S., Azzolini, M., & Ruas, J. L. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00580.2019 · Cited by 126 · see citing works
Myokines in skeletal muscle physiology and metabolism: Recent advances and future perspectives
Das, D. K., Graham, Z. A., & Cardozo, C. P. (2020) · Acta Physiologica · doi:10.1111/apha.13367 · Cited by 129 · see citing works
Nrf2-Mediated Regulation of Skeletal Muscle Glycogen Metabolism
Uruno, A., Yagishita, Y., Katsuoka, F., Kitajima, Y., Nunomiya, A., Nagatomi, R., Pi, J., Biswal, S. S., & Yamamoto, M. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.01095-15 · Cited by 126 · see citing works
Redox basis of exercise physiology
Margaritelis, N. V., Paschalis, V., Theodorou, A. A., Kyparos, A., & Nikolaidis, M. G. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101499 · Cited by 129 · see citing works
Non-pharmacological Treatment Options in the Management of Diabetes Mellitus
Raveendran, A. V. (2018) · European Endocrinology · doi:10.17925/ee.2018.14.2.31 · Cited by 122 · see citing works
Glucose Uptake by Skeletal Muscle within the Contexts of Type 2 Diabetes and Exercise: An Integrated Approach
Hulett, N. A., Scalzo, R. L., & Reusch, J. E. B. (2022) · Nutrients · doi:10.3390/nu14030647 · Cited by 125 · see citing works
Semaglutide ameliorates cognition and glucose metabolism dysfunction in the 3xTg mouse model of Alzheimer's disease via the GLP-1R/SIRT1/GLUT4 pathway
Wang, Z.-J., Li, X.-R., Chai, S.-F., Li, W.-R., Li, S., Hou, M., Li, J.-L., Ye, Y.-C., Cai, H.-Y., Hölscher, C., et al. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109716 · Cited by 125 · see citing works
Exercise Metabolism: Fuels for the FirePreprint
Hargreaves, M., & Spriet, L. L. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a029744 · Cited by 127 · see citing works
Self-citation
Rosmarinic acid ameliorates hyperglycemia and insulin sensitivity in diabetic rats, potentially by modulating the expression of PEPCK and GLUT4
Inui, A., Cheng, K., Asakawa, A., Amitani, H., Amitani, M. S., Morinaga, A., Takimoto, Y., Kairupan, B. H. R., & Runtuwene, J. (2016) · Drug Design Development and Therapy · doi:10.2147/dddt.s108539 · Cited by 124 · see citing works
Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity
Gnad, T., Navarro, G., Lahesmaa, M., Reverte-Salisa, L., Copperi, F., Cordomí, A., Naumann, J., Hochhäuser, A., Haufs-Brusberg, S., Wenzel, D., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.06.006 · Cited by 124 · see citing works
Rac1 governs exercise‐stimulated glucose uptake in skeletal muscle through regulation of GLUT4 translocation in mice
Sylow, L., Nielsen, I. L., Kleinert, M., Møller, L. L. V., Ploug, T., Schjerling, P., Bilan, P. J., Klip, A., Jensen, T. E., & Richter, E. A. (2016) · The Journal of Physiology · doi:10.1113/jp272039 · Cited by 114 · see citing works
Self-citation
Human muscle fibre type‐specific regulation of AMPK and downstream targets by exercise
Steenberg, D. E., Albers, P. H., Prats, C., Baba, O., Birk, J. B., & Wojtaszewski, J. F. P. (2015) · The Journal of Physiology · doi:10.1113/jphysiol.2014.283267 · Cited by 118 · see citing works
Chlorogenic Acid: A Dietary Phenolic Acid with Promising Pharmacotherapeutic Potential
Singh, A. K., Singla, R. K., & Pandey, A. K. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220816154634 · Cited by 118 · see citing works
Muscle-Adipose Tissue Cross TalkPreprint
Stanford, K. I., & Goodyear, L. J. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a029801 · Cited by 116 · see citing works
Drosophila melanogaster as a genetic model system to study neurotransmitter transporters
Martin, C. A., & Krantz, D. E. (2014) · Neurochemistry International · doi:10.1016/j.neuint.2014.03.015 · Cited by 113 · see citing works
MicroRNAs-Mediated Regulation of Skeletal Muscle GLUT4 Expression and Translocation in Insulin Resistance
Esteves, J. V. D. C., Enguita, F. J., & Machado, U. F. (2017) · Journal of Diabetes Research · doi:10.1155/2017/7267910 · Cited by 109 · see citing works
New Horizons in Carbohydrate Research and Application for Endurance Athletes
Podlogar, T., & Wallis, G. A. (2022) · Sports Medicine · doi:10.1007/s40279-022-01757-1 · Cited by 109 · see citing works
Angiogenin mediates paternal inflammation-induced metabolic disorders in offspring through sperm tsRNAs
Zhang, Y., Ren, L., Sun, X., Zhang, Z., Liu, J., Xin, Y., Yu, J., Jia, Y., Sheng, J., Hu, G., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26909-1 · Cited by 109 · see citing works
Effects of fasted vs fed‐state exercise on performance and post‐exercise metabolism: A systematic review and meta‐analysis
Aird, T. P., Davies, R. W., & Carson, B. P. (2018) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.13054 · Cited by 109 · see citing works
The importance of the cellular stress response in the pathogenesis and treatment of type 2 diabetes
Hooper, P. L., Balogh, G. E., Rivas, E., Kavanagh, K., & Vı́gh, L. (2014) · Cell Stress and Chaperones · doi:10.1007/s12192-014-0493-8 · Cited by 109 · see citing works
Natural Phytochemicals as SIRT Activators—Focus on Potential Biochemical Mechanisms
Wiciński, M., Erdmann, J., Nowacka, A., Kuźmiński, O., Michalak, K., Janowski, K., Ohla, J., Biernaciak, A., Szambelan, M., & Zabrzyński, J. (2023) · Nutrients · doi:10.3390/nu15163578 · Cited by 117 · see citing works
Muscle redox signalling pathways in exercise. Role of antioxidants
Mason, S. A., Morrison, D., McConell, G. K., & Wadley, G. D. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.02.022 · Cited by 103 · see citing works
Management of oxidative stress and inflammation in cardiovascular diseases: mechanisms and challenges
Donia, T., & Khamis, A. A. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-14109-9 · Cited by 108 · see citing works
Obesity as the Main Risk Factor for Metabolic Syndrome in Children
Gepstein, V., & Weiss, R. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00568 · Cited by 107 · see citing works
Hepatic exosome-derived miR-130a-3p attenuates glucose intolerance via suppressing PHLPP2 gene in adipocyte
Wu, J., Dong, T., Chen, T., Sun, J., Luo, J., He, J., Wei, L., Zeng, B., Zhang, H., Li, W., et al. (2019) · Metabolism · doi:10.1016/j.metabol.2019.154006 · Cited by 103 · see citing works
Exercise and the Development of the Artificial Pancreas
Riddell, M. C., Zaharieva, D. P., Yavelberg, L., Çınar, A., & Jamnik, V. (2015) · Journal of Diabetes Science and Technology · doi:10.1177/1932296815609370 · Cited by 102 · see citing works
ERK1/2 inhibition promotes robust myotube growth via CaMKII activation resulting in myoblast-to-myotube fusion
Eigler, T., Zarfati, G., Amzallag, E., Sinha, S., Segev, N., Zabary, Y., Zaritsky, A., Shakked, A., Umansky, K. B., Schejter, E. D., et al. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.11.022 · Cited by 104 · see citing works
Continuous Glucose Monitoring in Healthy Adults—Possible Applications in Health Care, Wellness, and Sports
Holzer, R., Bloch, W., & Brinkmann, C. K. (2022) · Sensors · doi:10.3390/s22052030 · Cited by 102 · see citing works
In vivo radiometric analysis of glucose uptake and distribution in mouse bone
Zoch, M. L., Abou, D. S., Clemens, T. L., Thorek, D. L. J., & Riddle, R. C. (2016) · Bone Research · doi:10.1038/boneres.2016.4 · Cited by 101 · see citing works
A novel atlas of gene expression in human skeletal muscle reveals molecular changes associated with aging
Su, J., Ekman, C., Oskolkov, N., Lahti, L., Ström, K., Brāzma, A., Groop, L., Rung, J., & Hansson, O. (2015) · Skeletal Muscle · doi:10.1186/s13395-015-0059-1 · Cited by 100 · see citing works
Interactions between insulin and exercise
Richter, E. A., Sylow, L., & Hargreaves, M. (2021) · Biochemical Journal · doi:10.1042/bcj20210185 · Cited by 99 · see citing works
Self-citation
Bio-inspired Track-Etched Polymeric Nanochannels: Steady-State Biosensors for Detection of Analytes
Wang, J., Zhou, Y., & Jiang, L. (2021) · ACS Nano · doi:10.1021/acsnano.1c08582 · Cited by 99 · see citing works
Molecular mechanisms by which aerobic exercise induces insulin sensitivity
Yaribeygi, H., Atkin, S. L., Simental‐Mendía, L. E., & Sahebkar, A. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28066 · Cited by 98 · see citing works
p38 MAPK in Glucose Metabolism of Skeletal Muscle: Beneficial or Harmful?
Bengal, E., Aviram, S., & Hayek, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186480 · Cited by 98 · see citing works
Phlorotannins: Towards New Pharmacological Interventions for Diabetes Mellitus Type 2
Lopes, G., Andrade, P. B., & Valentão, P. (2016) · Molecules · doi:10.3390/molecules22010056 · Cited by 98 · see citing works
AMPK and TBC1D1 Regulate Muscle Glucose Uptake After, but Not During, Exercise and Contraction
Kjøbsted, R., Roll, J. L. W., Jørgensen, N. O., Birk, J. B., Foretz, M., Viollet, B., Chadt, A., Al-Hasani, H., & Wojtaszewski, J. F. P. (2019) · Diabetes · doi:10.2337/db19-0050 · Cited by 97 · see citing works
BabaoDan attenuates high-fat diet-induced non-alcoholic fatty liver disease via activation of AMPK signaling
Sheng, D., Zhao, S., Gao, L., Zheng, H. S., Liu, W., Hou, J. Y., Jin, Y., Ye, F., Zhao, Q., Li, R., et al. (2019) · Cell & Bioscience · doi:10.1186/s13578-019-0339-2 · Cited by 96 · see citing works
Cold and Exercise: Therapeutic Tools to Activate Brown Adipose Tissue and Combat Obesity
da Silva, C. P. V., Hernández‐Saavedra, D., White, J. D., & Stanford, K. (2019) · Biology · doi:10.3390/biology8010009 · Cited by 95 · see citing works
Effects of exercise training on intrahepatic lipid content in humans
Brouwers, B., Hesselink, M. K. C., Schrauwen, P., & Schrauwen-Hinderling, V. B. (2016) · Diabetologia · doi:10.1007/s00125-016-4037-x · Cited by 94 · see citing works
Glucose responses to acute and chronic exercise during pregnancy: A systematic review and meta-analysis
Davenport, M. H., Sobierajski, F., Mottola, M. F., Skow, R. J., Meah, V. L., Poitras, V. J., Gray, C. E., Jaramillo Garcia, A., Barrowman, N., Riske, L., et al. (2018) · British Journal of Sports Medicine · doi:10.1136/bjsports-2018-099829 · Cited by 90 · see citing works
Skeletal muscle: molecular structure, myogenesis, biological functions, and diseases
Feng, L., Chen, Z., & Bian, H. (2024) · MedComm · doi:10.1002/mco2.649 · Cited by 95 · see citing works
Treatments for women with gestational diabetes mellitus: an overview of Cochrane systematic reviews
Martis, R., Brown, J., Alsweiler, J. M., Downie, M. R., & Crowther, C. A. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012327 · Cited by 85 · see citing works
Pathophysiology of Physical Inactivity-Dependent Insulin Resistance: A Theoretical Mechanistic Review Emphasizing Clinical Evidence
Yaribeygi, H., Maleki, M., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (2021) · Journal of Diabetes Research · doi:10.1155/2021/7796727 · Cited by 91 · see citing works
Undercarboxylated Osteocalcin: Experimental and Human Evidence for a Role in Glucose Homeostasis and Muscle Regulation of Insulin Sensitivity
Lin, X., Brennan‐Speranza, T. C., Levinger, I., & Yeap, B. B. (2018) · Nutrients · doi:10.3390/nu10070847 · Cited by 86 · see citing works
Palmitoleic acid (n-7) increases white adipocytes GLUT4 content and glucose uptake in association with AMPK activation
Lopes, A. B., Festuccia, W. T., Chimin, P., Farias, T. S. M., Torres‐Leal, F. L., Cruz, M. M., Andrade, P. B., Hirabara, S. M., Lima, F. B., & Alonso‐Vale, M. I. C. (2014) · Lipids in Health and Disease · doi:10.1186/1476-511x-13-199 · Cited by 85 · see citing works
Antioxidants in Personalized Nutrition and Exercise
Margaritelis, N. V., Paschalis, V., Theodorou, A. A., Kyparos, A., & Nikolaidis, M. G. (2018) · Advances in Nutrition · doi:10.1093/advances/nmy052 · Cited by 84 · see citing works
Effects of 120 g/h of Carbohydrates Intake during a Mountain Marathon on Exercise-Induced Muscle Damage in Elite Runners
Viribay, A., Arribalzaga, S., Mielgo‐Ayuso, J., Castañeda-Babarro, A., Seco‐Calvo, J., & Urdampilleta, A. (2020) · Nutrients · doi:10.3390/nu12051367 · Cited by 85 · see citing works

Glucose, exercise and insulin: emerging concepts
Richter, E. A., Derave, W., & Wojtaszewski, J. F. P. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.t01-2-00313.x · Cited by 258 · see citing works
Self-citation
Exercise Causes Muscle GLUT4 Translocation in an Insulin-Independent Manner
Messina, G., Palmieri, F., & Monda, V. (2015) · Biology and Medicine · doi:10.4172/0974-8369.1000s3007 · Cited by 32 · see citing works
Regulation of GLUT4 Gene Expression during Exercise
Holmes, B. F., & Dohm, G. L. (2004) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000132385.34889.fe · Cited by 54 · see citing works
Invited Review: Regulation of skeletal muscle GLUT-4 expression by exercise
Dohm, G. L. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01266.2001 · Cited by 111 · see citing works
Skeletal Muscle Glucose Uptake During Exercise: How is it Regulated?
Rose, A. J., & Richter, E. A. (2005) · Physiology · doi:10.1152/physiol.00012.2005 · Cited by 371 · see citing works
Self-citation

Authors: Richter, E. A., & Hargreaves, M.
Affiliations: University of Copenhagen (DK)
Corresponding author: Richter, Erik A.
ORCID: Richter, Erik A.
Hargreaves, Mark
Venue: Physiological Reviews
Publisher: American Physiological Society
Published: 2013-07
Volume: 93
Issue: 3
Pages: 993-1017
ISSN: 0031-9333 (ISSN-L)
1522-1210
DOI: 10.1152/physrev.00038.2012
OpenAlex: W2030137409
Cited by: 1,407
References: 343
Citations by year: 2026: 168 · 2025: 129 · 2024: 111 · 2023: 114 · 2022: 133 · 2021: 133 · 2020: 117 · 2019: 103 · 2018: 81 · 2017: 100 · 2016: 79 · 2015: 83 · 2014: 52 · 2013: 3
FWCI: 6.80
Type: journal article
Language: en
Open access: closed
Locations: Physiological Reviews (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders: Novo Nordisk Fonden (NNF12OC1016400)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords: GLUT4, skeletal muscle glucose uptake, physical activity, GLUT4 translocation, AMPK, CaMKII, MEF2, histone hyperacetylation, Rab GTPases, SNARE proteins, insulin sensitivity, muscle glycogen storage, glucose metabolism
MeSH terms: Biological Transport, Glucose, Humans, Sarcolemma, Exercise, Muscle, Skeletal, Glucose Transporter Type 4

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Exercise, GLUT4, and skeletal muscle glucose uptake

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks