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Muscle transplantation between young and old rats: age of host determines recovery
Abstract
As compared with age-matched controls, extensor digitorum longus (EDL) muscles autografted in young rats regenerated significantly greater mass (1.8 times) and developed greater maximum contractile force (2.6 times) than EDL muscles autografted in old rats. A cross-age transplantation study showed that the mass and maximum force of old muscles grafted into young hosts were not significantly different from those of young muscles grafted into the same young hosts. Conversely, young muscle grafted into old hosts regenerated no better than old muscles grafted into the same old hosts. We conclude 1) that chronological age alone is not a factor that limits the intrinsic ability of a muscle to regenerate and 2) that the poor regeneration of muscles in old animals is a function of the environment for regeneration provided by the old host.
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“Grafting experiments, in which portions of intact muscle tissues are heterochronically transplanted between young and aged mice, provided the first indication that the chronological age of the muscle microenvironment exerts a profound influence on muscle regenerative capacity32.”
From The central role of muscle stem cells in regenerative failure with aging (2015) · cites this paper as [32]
In the citing paper
“Extrinsic signals from old niches appear to dominate over intrinsic function of young stem cells in transplantation experiments143,144. By contrast, signals from young niches may have only limited rejuvenation effects on old stem cells, at least for HSCs145.”
From Ageing and rejuvenation of tissue stem cells and their niches (2023) · cites this paper as [143]
In the citing paper
“Skeletal muscle possesses the remarkable ability to repair and regenerate after an injury or damage; however, this ability is impaired with aging (4–7).”
From Phytoecdysteroids Accelerate Recovery of Skeletal Muscle Function Following in vivo Eccentric Contraction-Induced Injury in Adult and Old Mice (2021) · cites this paper as [6]
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Metadata
- Authors
- Carlson, B. M., & Faulkner, J. A.
- Affiliations
- University of Michigan (US)
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 1989-06-01
- Volume
- 256
- Issue
- 6
- Pages
- C1262-C1266
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- OpenAlex
- W2323748919
- Cited by
- 417
- References
- 11
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 9 · 2023: 10 · 2022: 9 · 2021: 14 · 2020: 12 · 2019: 18 · 2018: 8 · 2017: 21 · 2016: 19 · 2015: 22 · 2014: 23 · 2013: 25 · 2012: 22
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Cell Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG-06157)
- National Eye Institute (EY-05813)
- National Institute of Dental and Craniofacial Research (DE 07687)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- muscle transplantation, muscle regeneration, aging, host age, extensor digitorum longus, autograft, muscle mass, age-related muscle loss
- MeSH terms
- Aging, Animals, Isometric Contraction, Male, Microscopy, Electron, Muscle Contraction, Muscles, Rats, Inbred Strains, Transplantation, Autologous, Muscle Development, Rats
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