The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Cellular mechanisms of fatigue in skeletal muscle
Abstract
Prolonged activation of skeletal muscle leads to a decline of force production known as fatigue. In this review we outline the ionic and metabolic changes that occur in muscle during prolonged activity and focus on how these changes might lead to reduced force. We discuss two distinct types of fatigue: fatigue due to continuous high-frequency stimulation and fatigue due to repeated tetanic stimulation. The causes of force decline are considered under three categories: 1) reduced Ca2+ release from the sarcoplasmic reticulum, 2) reduced myofibrillar Ca2+ sensitivity, and 3) reduced maximum Ca(2+)-activated tension. Reduced Ca2+ release can be due to impaired action potential propagation in the T tubules, and this is a principal cause of the tension decline with continuous tetanic stimulation. Another type of failing Ca2+ release, which is homogeneous across the fibers, is prominent with repeated tetanic stimulation; the underlying mechanisms of this reduction are not fully understood, although several possibilities emerge. Changes in intracellular metabolites, particularly increased concentration of Pi and reduced pH, lead to reduced Ca2+ sensitivity and reduced maximum tension, which make an important contribution to the force decline, especially with repeated tetanic stimulation.
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Cites
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It is diprotonated inorganic phosphate that depresses force in skinned skeletal muscle fibers
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Self-citation
Cited by
Skeletal muscle fatigue: cellular mechanisms
Allen, D. G., Lamb, G. D., & Westerblad, H. (2008) · Physiological Reviews · doi:10.1152/physrev.00015.2007 · Cited by 2,495
Self-citationMitochondrial fusion is frequent in skeletal muscle and supports excitation–contraction coupling
Eisner, V., Lenaers, G., & Hajnóczky, G. (2014) · Journal of Cell Biology · doi:10.1083/jcb.201312066 · Cited by 177
Muscle Fatigue in Males and Females during Multiple-Sprint Exercise
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Enhanced sarcoplasmic reticulum Ca2+release following intermittent sprint training
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Catchlike property of skeletal muscle: Recent findings and clinical implications
Binder‐Macleod, S., & Kesar, T. (2005) · Muscle & Nerve · doi:10.1002/mus.20290 · Cited by 78
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Metadata
- Authors
- Westerblad, H., Lee, J. A., Lannergren, J., & Allen, D. G.
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 1991-08-01
- Volume
- 261
- Issue
- 2
- Pages
- C195-C209
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- OpenAlex
- W2098910272
- Cited by
- 412
- References
- 5
- FWCI
- 4.57
- Type
- journal article
- Language
- en
- Open access
- closed
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