Arginine vasopressin regulation in pre- and postpubertal male rats by the androgen metabolite 3β-diol

Pak, Toni R.; Chung, Wilson C. J.; Hinds, Laura R.; Handa, Robert J.

doi:10.1152/ajpendo.00037.2009

Cited by 25Neuroendocrine regulation and behaviorHypothalamic control of reproductive hormonesSexual Differentiation and Disorders

Arginine vasopressin regulation in pre- and postpubertal male rats by the androgen metabolite 3β-diol

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Pak, Toni R., Chung, Wilson C. J., Hinds, Laura R., Handa, Robert J.·2009·American Journal of Physiology-Endocrinology and Metabolism

DOI 10.1152/ajpendo.00037.2009PMC PMC2692392

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Abstract

Arginine vasopressin (AVP) is a nonapeptide expressed in several brain regions. In addition to its well-characterized role in osmoregulation, AVP regulates paternal behavior, aggression, circadian rhythms, and the stress response. In the bed nucleus of the stria terminalis (BST), AVP gene expression is tightly regulated by gonadal steroid hormones. However, the degree by which AVP is regulated by gonadal steroid hormones in the suprachiasmatic nucleus (SCN) and medial amygdala (MeA) is unclear. Previous studies have shown that AVP expression in the brain of gonadectomized rats is restored with testosterone, 17β-estradiol, and 5α-dihydrotestosterone (DHT) replacement. In addition, we have demonstrated that 3β-diol, a metabolite of DHT, increased AVP promoter activity in a neuronal cell line and that the effects of 3β-diol on AVP promoter activity were mediated by estrogen receptor-β. To test whether 3β-diol has a physiological role in the regulation of central AVP expression in vivo, we gonadectomized pre- and postpubertal male rats and followed with once daily injections of estradiol benzoate (EB), DHT-propionate, 3β-diol-dipropionate, or vehicle. The SCN, BST, and MeA were analyzed for AVP mRNA expression using in situ hybridization. In the BST, intact juveniles had significantly fewer AVP-expressing cells than adults. GDX abolished all AVP mRNA expression in the BST in both age groups, whereas treatment with EB restored >80% and DHTP <10% of the AVP expression. Interestingly, 3β-diol-proprionate was more effective at inducing AVP expression in juveniles than in adults, suggesting that the regulation of AVP by 3β-diol might be age dependent.

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In pre- and post-pubertal gonadectomized female rats, the DHT metabolite 3β-diol increases the number of Avp mRNA-expressing cells in the BST, though less than estradiol.
“In vivo studies using pre- and post-pubertal gonadectomized female rats showed that the DHT metabolite, 5α androstane 3β-17β-diol (3β-diol), increased the number of Avp mRNA-expressing cells in the BST, although this increment was not as marked as in animals treated with estradiol (Pak, Chung, Hinds, & Handa, 2009).”
From Hypothalamic–pituitary–adrenal and hypothalamic–pituitary–gonadal axes: sex differences in regulation of stress responsivity (2017) · cites this paper as Pak, Chung, Hinds, & Handa, 2009
The Results report that 3β-diol treatment restored AVP expression in the juvenile BST less than estradiol did. But the Animals section identifies the rats as male, not female, and the Results say treated adults had virtually no BST AVP expression (2.4% restored). (LLM, conf=0.88)
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Authors: Pak, T. R., Chung, W. C. J., Hinds, L. R., & Handa, R. J.
Affiliations: Loyola University Chicago (US)
University of Colorado Boulder (US)
University of Arizona (US)
ORCID: Pak, Toni R.
Chung, Wilson C. J.
Handa, Robert J.
Venue: American Journal of Physiology-Endocrinology and Metabolism
Publisher: American Physiological Society
Published: 2009-06
Volume: 296
Issue: 6
Pages: E1409-E1413
ISSN: 0193-1849 (ISSN-L)
1522-1555
DOI: 10.1152/ajpendo.00037.2009
PMC: PMC2692392
OpenAlex: W2096313369
Cited by: 25
References: 37
Citations by year: 2024: 3 · 2023: 1 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 1 · 2014: 1 · 2013: 5 · 2012: 3
FWCI: 2.61
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Neurological Disorders and Stroke (R01NS039951)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (F32HD046301)
Topics: Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
Keywords: vasopressin, androgen metabolites, dihydrotestosterone, sex steroids, suprachiasmatic nucleus, bed nucleus of the stria terminalis, medial amygdala, puberty, age-dependent regulation, gonadectomy, estradiol benzoate, testosterone replacement therapy, estrogen receptor beta
MeSH terms: Amygdala, Androgens, Animals, Arginine Vasopressin, Behavior, Animal, Brain, Male, Orchiectomy, Paraventricular Hypothalamic Nucleus, RNA, Messenger, Septal Nuclei, Sexual Maturation, Suprachiasmatic Nucleus, Supraoptic Nucleus, Androstane-3,17-diol, Gene Expression, Rats, Sprague-Dawley, Anabolic Agents, Rats

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Arginine vasopressin regulation in pre- and postpubertal male rats by the androgen metabolite 3β-diol

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