Organizational effects of testosterone, estradiol, and dihydrotestosterone on vasopressin mRNA expression in the bed nucleus of the stria terminalis
Abstract
In adulthood, male rats express higher levels of arginine vasopressin (AVP) mRNA in the bed nucleus of the stria terminalis (BST) than do female rats. We tested whether this sex difference is primarily due to differences in neonatal levels of testosterone. Male and female rats were gonadectomized on the day of birth and treated with testosterone propionate (TP) or vehicle on postnatal days 1, 3, and 5 (P1, P3, and P5). Three months later, all rats were implanted with testosterone‐filled capsules. Two weeks later, brains were processed for in situ hybridization to detect AVP mRNA. We found that neonatal TP treatment significantly increased the number of vasopressinergic cells in the BST over control injections. We then sought to determine the effects of testosterone metabolites, estradiol and dihydrotestosterone, given alone or in combination, on AVP expression in the BST. Rat pups were treated as described above, except that instead of testosterone, estradiol benzoate (EB), dihydrotestosterone propionate (DHTP), a combination of EB and DHTP (EB+DHTP), or vehicle was injected neonatally. Neonatal treatment with either EB or EB+DHTP increased the number of vasopressinergic cells in the BST over that of DHTP or oil treatment. However, treatment with DHTP also significantly increased the number of vasopressinergic cells over that of oil treatment. Hence, in addition to bolstering evidence that estradiol is the more potent metabolite of testosterone in causing sexual differentiation of the brain, these data provide the first example of a masculinizing effect of a nonaromatizable androgen on a sexually dimorphic neuropeptide system. © 2003 Wiley Periodicals, Inc. J Neurobiol 54: 502–510, 2003
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This sex difference in AVP expression is organized during early postnatal life by steroid hormone actions on ER and AR.
“Moreover, this sex difference is organized during early postnatal life by steroid hormone actions on ER and AR.[24][25][26]”
From Neonatal MeCP2 is important for the organization of sex differences in vasopressin expression (2012) · cites this paper as [24]
Neonatal treatment with dihydrotestosterone, which binds to AR, contributes to male-like AVP mRNA expression in adult rat brain.
“This is in agreement with data indicating that neonatal treatment with dihydrotestosterone, which binds to AR, contributes to male-like AVP mRNA expression in adult rat brain.24”
From Neonatal MeCP2 is important for the organization of sex differences in vasopressin expression (2012) · cites this paper as [24]
How estrogens and androgens contribute to the sexual differentiation and function of the AVP/OT system are sex and species dependent and associated with functional differences in prosociality.
“How estrogens and androgens contribute to the sexual differentiation and function of the AVP/OT system are sex and species dependent and associated with functional differences in prosociality (121, 122).”
From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [122]
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- Authors
- Han, T. M., & De Vries, G. J.
- Affiliations
- University of Massachusetts Amherst (US)
- Corresponding author
- Han, Tina M.
- Venue
- Journal of Neurobiology
- Publisher
- Wiley
- Published
- 2003-01-16
- Volume
- 54
- Issue
- 3
- Pages
- 502-510
- ISSN
- 0022-3034 (ISSN-L)
- 1097-4695
- OpenAlex
- W2057022979
- Semantic Scholar
- a49032ea0b7a9ea66b72a1ff33a237cb630c3cdf
- Cited by
- 116
- References
- 67
- Citations by year
- 2025: 4 · 2024: 2 · 2022: 5 · 2021: 5 · 2020: 1 · 2019: 4 · 2018: 2 · 2017: 5 · 2016: 8 · 2015: 1 · 2014: 7 · 2013: 4 · 2012: 10
- FWCI
- 9.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH011686, MH047538)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- vasopressin, bed nucleus of the stria terminalis, testosterone, estradiol, dihydrotestosterone, neonatal androgen exposure, sex differences, sexual differentiation of the brain, masculinization, gonadectomy, neuropeptide systems
- MeSH terms
- Analysis of Variance, Androgens, Animals, Animals, Newborn, Castration, Estradiol, Female, Male, RNA, Messenger, Septal Nuclei, Sex Characteristics, Dihydrotestosterone, Testosterone, Vasopressins, Gene Expression, Rats, Sprague-Dawley, In Situ Hybridization, Rats
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