Activation of PPARγ enhances myocardial glucose oxidation and improves contractile function in isolated working hearts of ZDF rats
Abstract
It is suggested that insulin resistance and metabolic maladaptation of the heart are causes of contractile dysfunction. We tested the hypothesis whether systemic PPARγ activation, by changing the metabolic profile in a model of insulin resistance and type 2 diabetes (the ZDF rat) in vivo, improves contractile function of the heart in vitro. Male Zucker diabetic fatty (ZDF) and Zucker lean (ZL) rats, at 53–56 days of age, were treated with either GI-262570 (a nonthiazolidinedione PPARγ agonist; A) or vehicle (V) for 1 wk. Agonist treatment resulted in correction of hyperglycemia and dyslipidemia, as well as in reduced hyperinsulinemia. The accumulation of triacylglycerols in the myocardium, characteristic of the ZDF rat, disappeared with treatment. Cardiac power and rates of glucose oxidation in the isolated working heart were significantly reduced in ZDF-V rats, but both parameters increased to nondiabetic levels with agonist treatment. In ZDF-V hearts, transcript levels of PPARα-regulated genes and of myosin heavy chain-β were upregulated, whereas GLUT4 was downregulated compared with ZL. Agonist treatment of ZDF rats reduced PPARα-regulated genes and increased transcripts of GLUT4 and GLUT1. In conclusion, by changing the metabolic profile, reducing myocardial lipid accumulation, and promoting the downregulation of PPARα-regulated genes, PPARγ activation leads to an increased capacity of the myocardium to oxidize glucose and to a tighter coupling of oxidative metabolism and contraction in the setting of insulin resistance and type 2 diabetes.
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Treatment of Zucker rats with a TZD improved systemic glucose homeostasis and intracardiac triglyceride accumulation, increased glucose oxidation rates, and improved cardiac function.
“Treatment of Zucker rats with a TZD improved systemic glucose homeostasis and intracardiac triglyceride accumulation, increased glucose oxidation rates, and improved cardiac function (115).”
From Cardiac remodeling in obesity (2008) · cites this paper as [115]
Cites
Diabetes and cardiovascular disease. The Framingham study
Kannel, W. B. (1979) · JAMA · doi:10.1001/jama.241.19.2035 · Cited by 3,958 · see citing works
Diabetes and Cardiovascular Disease: The Framingham Study
Kannel, W. B. (1979) · JAMA · doi:10.1001/jama.1979.03290450033020 · Cited by 2,936 · see citing works
PPARs and the complex journey to obesity
Evans, R. M., Barish, G. D., & Wang, Y.-X. (2004) · Nature Medicine · doi:10.1038/nm1025 · Cited by 1,621 · see citing works
Lipotoxic heart disease in obese rats: Implications for human obesity
Zhou, Y.-T., Grayburn, P., Karim, A., Shimabukuro, M., Higa, M., Baetens, D., Orci, L., & Unger, R. H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.4.1784 · Cited by 1,265 · see citing works
Adipogenesis and Obesity: Rounding Out the Big Picture
Spiegelman, B. M., & Flier, J. S. (1996) · Cell · doi:10.1016/s0092-8674(00)81359-8 · Cited by 1,254 · see citing works
Fuel selection in human skeletal muscle in insulin resistance: a reexamination.
Kelley, D. E., & Mandarino, L. J. (2000) · Diabetes · doi:10.2337/diabetes.49.5.677 · Cited by 1,017 · see citing works
Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart
Sharma, S., Adrogue, J. V., Golfman, L., Uray, I., Lemm, J., Youker, K., Noon, G. P., Frazier, O. H., & Taegtmeyer, H. (2004) · The FASEB Journal · doi:10.1096/fj.04-2263com · Cited by 790 · see citing works
Self-citationWhat if Minkowski Had Been Ageusic? An Alternative Angle on Diabetes
McGarry, J. D. (1992) · Science · doi:10.1126/science.1439783 · Cited by 657 · see citing works
Adaptation and Maladaptation of the Heart in Diabetes: Part I
Taegtmeyer, H., McNulty, P. H., & Young, M. E. (2002) · Circulation · doi:10.1161/01.cir.0000012466.50373.e8 · Cited by 517 · see citing works
Self-citationFinck, B. N., Han, X., Courtois, M., Aimond, F., Nerbonne, J. M., Kovacs, A., Gross, R. W., & Kelly, D. P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0336724100 · Cited by 501 · see citing works
Utilization of energy-providing substrates in the isolated working rat heart
Taegtmeyer, H., Hems, R., & Krebs, H. A. (1980) · Biochemical Journal · doi:10.1042/bj1860701 · Cited by 467 · see citing works
Self-citationUnloaded heart in vivo replicates fetal gene expression of cardiac hypertrophy
Depré, C., Shipley, G. L., Chen, W., Han, Q., Doenst, T., Moore, M. L. G., Stepkowski, S. M., Davies, P. J., & Taegtmeyer, H. (1998) · Nature Medicine · doi:10.1038/3253 · Cited by 423 · see citing works
Self-citationAltered metabolism causes cardiac dysfunction in perfused hearts from diabetic (db/db) mice
Belke, D. D., Larsen, T. S., Gibbs, E. M., & Severson, D. L. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.5.e1104 · Cited by 401 · see citing works
Belke, D. D., Bétuing, S., Tuttle, M. J., Graveleau, C., Young, M. E., Pham, M., Zhang, D., Cooksey, R. C., McClain, D. A., Litwin, S. E., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci13946 · Cited by 377 · see citing works
Self-citationWay, J. M., Harrington, W. W., Brown, K. K., Gottschalk, W. K., Sundseth, S. S., Mansfield, T. A., Ramachandran, R. K., Willson, T. M., & Kliewer, S. A. (2001) · Endocrinology · doi:10.1210/endo.142.3.8037 · Cited by 338 · see citing works
Self-citationBelke, D. D., Betuing, S., Tuttle, M. J., Graveleau, C., Young, M. E., Pham, M., Zhang, D., Cooksey, R. C., McClain, D. A., Litwin, S. E., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0213946 · Cited by 330 · see citing works
Self-citationRegulation of Energy Metabolism of the Heart during Acute Increase in Heart Work
Goodwin, G. W., Taylor, C. S., & Taegtmeyer, H. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.45.29530 · Cited by 323 · see citing works
Self-citationHenke, B. R., Blanchard, S. G., Brackeen, M. F., Brown, K. K., Cobb, J. E., Collins, J. L., Harrington, W. W., Hashim, M. A., Hull-Ryde, E. A., Kaldor, I. W., et al. (1998) · Journal of Medicinal Chemistry · doi:10.1021/jm9804127 · Cited by 301 · see citing works
Self-citationImpaired Long-Chain Fatty Acid Oxidation and Contractile Dysfunction in the Obese Zucker Rat Heart
Young, M. E., Guthrie, P. H., Razeghi, P., Leighton, B., Abbasi, S., Patil, S. U., Youker, K. A., & Taegtmeyer, H. (2002) · Diabetes · doi:10.2337/diabetes.51.8.2587 · Cited by 295 · see citing works
Self-citationDiabetes Mellitus Induces Changes in Cardiac Myosin of the Rat
DILLMANN, W. H. (1980) · Diabetes · doi:10.2337/diab.29.7.579 · Cited by 290 · see citing works
Evolution of β-Cell Dysfunction in the Male Zucker Diabetic Fatty Rat
Tokuyama, Y., Sturis, J., DePaoli, A. M., Takeda, J., Stoffel, M., Tang, J., Sun, X., Polonsky, K. S., & Bell, G. I. (1995) · Diabetes · doi:10.2337/diab.44.12.1447 · Cited by 280 · see citing works
Subcellular remodeling and heart dysfunction in chronic diabetes
Dhalla, N. S. (1998) · Cardiovascular Research · doi:10.1016/s0008-6363(98)00186-2 · Cited by 252 · see citing works
Linking Gene Expression to Function: Metabolic Flexibility in the Normal and Diseased Heart
Taegtmeyer, H., Golfman, L. S., Sharma, S., Razeghi, P., & Arsdall, M. R. V. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1302.017 · Cited by 245 · see citing works
Self-citationThe diabetic heart: metabolic causes for the development of a cardiomyopathy
Rodrigues, B. B., & McNeill, J. H. (1992) · Cardiovascular Research · doi:10.1093/cvr/26.10.913 · Cited by 225 · see citing works
Santalucı́a, T., Camps, M., Castelló, A., Muñoz, P., Nuel, A., Testar, X., Palacı́n, M., & Zorzano, A. (1992) · Endocrinology · doi:10.1210/endo.130.2.1370797 · Cited by 222 · see citing works
Intrinsic Diurnal Variations in Cardiac Metabolism and Contractile Function
Young, M. E., Razeghi, P., Cedars, A. M., Guthrie, P. H., & Taegtmeyer, H. (2001) · Circulation Research · doi:10.1161/hh2401.100741 · Cited by 204 · see citing works
Self-citationDepré, C., Young, M. E., Ying, J., Ahuja, H. S., Han, Q., Garza, N. L., Davies, P. J., & Taegtmeyer, H. (2000) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2000.1139 · Cited by 194 · see citing works
Self-citationFabiato, A. (1985) · The Journal of General Physiology · doi:10.1085/jgp.85.2.189 · Cited by 187 · see citing works
Fein, F. S. (1990) · Diabetes Care · doi:10.2337/diacare.13.11.1169 · Cited by 181 · see citing works
Gilde, A. J., & Van Bilsen, M. (2003) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2003.01161.x · Cited by 178 · see citing works
Brown, K. K., Henke, B. R., Blanchard, S. G., Cobb, J. E., Mook, R., Kaldor, I. W., Kliewer, S. A., Lehmann, J., Lenhard, J. M., Harrington, W. W., et al. (1999) · Diabetes · doi:10.2337/diabetes.48.7.1415 · Cited by 172 · see citing works
Self-citationSidell, R. J., Cole, M. A., Draper, N. J., Desrois, M., Buckingham, R. E., & Clarke, K. (2002) · Diabetes · doi:10.2337/diabetes.51.4.1110 · Cited by 165 · see citing works
Camps, M., Castelló, A., Muñoz, P., Monfar, M., Testar, X., Palacı́n, M., & Zorzano, A. (1992) · Biochemical Journal · doi:10.1042/bj2820765 · Cited by 163 · see citing works
Nikolaidis, L. A. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2003.11.027 · Cited by 153 · see citing works
Razeghi, P., Young, M. E., Cockrill, T. C., Frazier, O. H., & Taegtmeyer, H. (2002) · Circulation · doi:10.1161/01.cir.0000026392.80723.dc · Cited by 136 · see citing works
Self-citationMechanism of Cloned ATP-sensitive Potassium Channel Activation by Oleoyl-CoA
Gribble, F. M., Proks, P., Corkey, B. E., & Ashcroft, F. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.41.26383 · Cited by 133 · see citing works
Liu, G.-X., Hanley, P. J., Ray, J., & Daut, J. (2001) · Circulation Research · doi:10.1161/hh0901.089881 · Cited by 128 · see citing works
Netticadan, T., Temsah, R. M., Kent, A. F. S., Vijayan Elimban, A., & Dhalla, N. S. (2001) · Diabetes · doi:10.2337/diabetes.50.9.2133 · Cited by 124 · see citing works
Huang, B., Wu, P., Popov, K. M., & Harris, R. A. (2003) · Diabetes · doi:10.2337/diabetes.52.6.1371 · Cited by 122 · see citing works
Cardiac carbohydrate metabolism in Zucker diabetic fatty rats
Chatham, J. C. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00399-1 · Cited by 118 · see citing works
Desrois, M. (2003) · Cardiovascular Research · doi:10.1016/j.cardiores.2003.11.021 · Cited by 117 · see citing works
Atkinson, L. L., Kozak, R., Kelly, S. E., Onay-Beşi̇kçi̇, A., Russell, J. C., & Lopaschuk, G. D. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00360.2002 · Cited by 110 · see citing works
Functional significance of altered myosin adenosine triphosphatase activity in enlarged hearts
Alpert, N. R., Mulieri, L. A., & Litten, R. Z. (1979) · The American Journal of Cardiology · doi:10.1016/0002-9149(79)90227-3 · Cited by 92 · see citing works
Slieker, L. J., Sundell, K. L., Heath, W. F., Osborne, H. E., Bue, J., Manetta, J., & Sportsman, J. R. (1992) · Diabetes · doi:10.2337/diab.41.2.187 · Cited by 90 · see citing works
Wang, P., & Chatham, J. C. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00295.2003 · Cited by 81 · see citing works
Load-induced changes in vivo alter substrate fluxes and insulin responsiveness of rat heart in vitro
Doenst, T., Goodwin, G. W., Cedars, A. M., Wang, M., Stepkowski, S., & Taegtmeyer, H. (2001) · Metabolism · doi:10.1053/meta.2001.25605 · Cited by 76 · see citing works
Self-citationPreferential oxidation of glycogen in isolated working rat heart.
Goodwin, G. W., Ahmad, F., & Taegtmeyer, H. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118561 · Cited by 71 · see citing works
Self-citationHolness, M. J., Smith, N. D., Bulmer, K., Hopkins, T. A., Gibbons, G. F., & Sugden, M. C. (2002) · Biochemical Journal · doi:10.1042/bj20011841 · Cited by 63 · see citing works
Regulation of glucose transporter and hexokinase II expression in tissues of diabetic rats
Burcelin, R., Printz, R. L., Kandé, J., Assan, R., Granner, D. K., & Girard, J. R. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.265.3.e392 · Cited by 63 · see citing works
Uphues, I., Kolter, T., Goud, B., & Eckel, J. (1995) · Biochemical Journal · doi:10.1042/bj3110161 · Cited by 59 · see citing works
Insulin suppresses PDK-4 expression in skeletal muscle independently of plasma FFA
Lee, F. N., Zhang, L., Zheng, D., Choi, W. S., & Youn, J. H. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00461.2003 · Cited by 57 · see citing works
Effects of troglitazone on substrate storage and utilization in insulin-resistant rats
Sreenan, S., Keck, S., Fuller, T., Cockburn, B. N., & Burant, C. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.6.e1119 · Cited by 51 · see citing works
Left ventricular systolic function in middle-aged patients with diabetes mellitus
Mustonen, J. N., Uusitupa, M. I. J., Laakso, M., Vanninen, E. J., Länsimies, E., Kuikka, J. T., & Pyörälä, K. (1994) · The American Journal of Cardiology · doi:10.1016/0002-9149(94)90182-1 · Cited by 43 · see citing works
Golfman, L. S., Dixon, I., Takeda, N., Chapman, D. C., & Dhalla, N. S. (1999) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006950218597 · Cited by 37 · see citing works
Self-citationAcquatella, H., Schiller, N. B., Sharpe, D. N., & Chatterjee, K. (1979) · The American Journal of Cardiology · doi:10.1016/0002-9149(79)90357-6 · Cited by 27 · see citing works
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1 of the 56 references couldn’t be matched to a known paper.
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Myocardial Fatty Acid Metabolism in Health and Disease
Lopaschuk, G. D., Ussher, J. R., Folmes, C. D. L., Jaswal, J. S., & Stanley, W. C. (2010) · Physiological Reviews · doi:10.1152/physrev.00015.2009 · Cited by 2,180 · see citing works
Diabetic Cardiomyopathy Revisited
Boudina, S., & Abel, E. D. (2007) · Circulation · doi:10.1161/circulationaha.106.679597 · Cited by 1,543 · see citing works
Abel, E. D., Litwin, S. E., & Sweeney, G. (2008) · Physiological Reviews · doi:10.1152/physrev.00017.2007 · Cited by 736 · see citing works
The ABC transporter structure and mechanism: perspectives on recent research
Jones, P. M., & George, A. M. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3336-9 · Cited by 578 · see citing works
Poornima, I. G., Parikh, P., & Shannon, R. P. (2006) · Circulation Research · doi:10.1161/01.res.0000207406.94146.c2 · Cited by 567 · see citing works
Role of changes in cardiac metabolism in development of diabetic cardiomyopathy
An, D., & Rodrigues, B. B. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00278.2006 · Cited by 443 · see citing works
Obesity cardiomyopathy: evidence, mechanisms, and therapeutic implications
Ren, J. T., Wu, N. N., Wang, S., Sowers, J. R., & Zhang, Y. (2021) · Physiological Reviews · doi:10.1152/physrev.00030.2020 · Cited by 377 · see citing works
Cardiomyocyte expression of PPARγ leads to cardiac dysfunction in mice
Son, N.-H., Park, T., Yamashita, H., Yokoyama, M., Huggins, L. A., Okajima, K., Homma, S., Szabolcs, M. J., Huang, L., & Goldberg, I. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30335 · Cited by 335 · see citing works
Rodent models of diabetic cardiomyopathy
Bugger, H., & Abel, E. D. (2009) · Disease Models & Mechanisms · doi:10.1242/dmm.001941 · Cited by 284 · see citing works
Taegtmeyer, H., Young, M. E., Lopaschuk, G. D., Abel, E. D., Brunengraber, H., Darley-Usmar, V. M., Rosiers, C. D., Gerszten, R. E., Glatz, J. F. C., Griffin, J. L., et al. (2016) · Circulation Research · doi:10.1161/res.0000000000000097 · Cited by 283 · see citing works
Self-citationMitochondria in the diabetic heart
Bugger, H., & Abel, E. D. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq239 · Cited by 261 · see citing works
The PPAR trio: Regulators of myocardial energy metabolism in health and disease
Madrazo, J., & Kelly, D. P. (2008) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2008.03.021 · Cited by 242 · see citing works
van der Meer, R. W., Rijzewijk, L. J., de Jong, H. W. A. M., Lamb, H. J., Lubberink, M., Romijn, J. A., Bax, J. J., Roos, A., Otto Kamp, B., Paulus, W. J., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.803916 · Cited by 234 · see citing works
Jankauskas, S. S., Kansakar, U., Varzideh, F., Wilson, S. M., Mone, P., Lombardi, A., Gambardella, J., & Santulli, G. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154910 · Cited by 221 · see citing works
PPARs and the Cardiovascular System
Hamblin, M., Chang, L., Fan, Y., Zhang, J., & Chen, Y. E. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2280 · Cited by 205 · see citing works
Of mice and men: models and mechanisms of diabetic cardiomyopathy
Riehle, C., & Bauersachs, J. K. (2018) · Basic Research in Cardiology · doi:10.1007/s00395-018-0711-0 · Cited by 199 · see citing works
Cardiovascular effects of leptin
Sweeney, G. (2009) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2009.224 · Cited by 184 · see citing works
The Emerging Functions of UCP2 in Health, Disease, and Therapeutics
Mattiasson, G., & Sullivan, P. G. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.1 · Cited by 176 · see citing works
Role of Leptin in Cardiovascular Diseases
Poetsch, M. S., Strano, A., & Guan, K. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00354 · Cited by 173 · see citing works
Fülöp, N., Mason, M. M., Dutta, K., Wang, P., Davidoff, A. J., Marchase, R. B., & Chatham, J. C. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00422.2006 · Cited by 130 · see citing works
van den Brom, C. E., Huisman, M. C., Vlasblom, R., Boontje, N. M., Duijst, S., Lubberink, M., Molthoff, C. F. M., Lammertsma, A. A., van der Velden, J., Boer, C., et al. (2009) · Cardiovascular Diabetology · doi:10.1186/1475-2840-8-39 · Cited by 122 · see citing works
An APPL1-AMPK signaling axis mediates beneficial metabolic effects of adiponectin in the heart
Fang, X., Palanivel, R., Cresser, J., Schram, K., Ganguly, R., Thong, F. S. L., Tuinei, J., Xu, A., Abel, E. D., & Sweeney, G. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00086.2010 · Cited by 117 · see citing works
Carley, A. N., Taegtmeyer, H., & Lewandowski, E. D. (2014) · Circulation Research · doi:10.1161/circresaha.114.301863 · Cited by 99 · see citing works
Self-citationObesity cardiomyopathy: diagnosis and therapeutic implications
Wong, C. Y., & Marwick, T. H. (2007) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio0964 · Cited by 87 · see citing works
Hafstad, A. D., Khalid, A. M., How, O.-J., Larsen, T. S., & Aasum, E. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00504.2006 · Cited by 79 · see citing works
Updating Experimental Models of Diabetic Cardiomyopathy
Fuentes‐Antrás, J., Picatoste, B., Gómez‐Hernández, A., Egido, J., Tuñón, J., & Lorenzo, Ó. (2015) · Journal of Diabetes Research · doi:10.1155/2015/656795 · Cited by 72 · see citing works
Liu, Y., Luo, Q., Su, Z., Xing, J., Wu, J., Li, X., Huang, Y., Pan, H., Wu, X., Zhang, X., et al. (2021) · Circulation · doi:10.1161/circulationaha.120.051937 · Cited by 69 · see citing works
Tracing Cardiac Metabolism In Vivo: One Substrate at a Time
Taegtmeyer, H. (2010) · Journal of Nuclear Medicine · doi:10.2967/jnumed.109.068205 · Cited by 66 · see citing works
Self-citationAasum, E., Khalid, A. M., Gudbrandsen, O. A., How, O.-J., Berge, R. K., & Larsen, T. S. (2007) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2007.08.020 · Cited by 62 · see citing works
How Exercise May Amend Metabolic Disturbances in Diabetic Cardiomyopathy
Hafstad, A. D., Boardman, N., & Aasum, E. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6304 · Cited by 63 · see citing works
Biology and Therapeutic Applications of Peroxisome Proliferator- Activated Receptors
P. Menendez-Gutierrez, M., Roszer, T., & Ricote, M. (2012) · Current Topics in Medicinal Chemistry · doi:10.2174/156802612799436669 · Cited by 62 · see citing works
Gerber, L. K., Aronow, B. J., & Matlib, M. A. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00246.2006 · Cited by 62 · see citing works
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Stratmann, B., & Tschoepe, D. (2011) · Diabetes Care · doi:10.2337/dc11-s208 · Cited by 61 · see citing works
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Baskin, K. K., & Taegtmeyer, H. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr060 · Cited by 60 · see citing works
Self-citationBerberine attenuates cardiac dysfunction in hyperglycemic and hypercholesterolemic rats
Dong, S., Hong, Y., Liu, M. R., Hao, Y., Yu, H.-S., Liu, Y., & Sun, J. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.03.024 · Cited by 57 · see citing works
Myocardial Metabolism in Diabetic Cardiomyopathy: Potential Therapeutic Targets
Sung, M. M. Y., Hamza, S. M., & Dyck, J. R. B. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6305 · Cited by 57 · see citing works
Diabetic cardiomyopathy in Zucker diabetic fatty rats: the forgotten right ventricle
van den Brom, C. E., Bosmans, J. W., Vlasblom, R., Handoko, M. L., Huisman, M. C., Lubberink, M., Molthoff, C. F. M., Lammertsma, A. A., Ouwens, D. M., Diamant, M., et al. (2010) · Cardiovascular Diabetology · doi:10.1186/1475-2840-9-25 · Cited by 55 · see citing works
Metabolic Reserve of the Heart: The Forgotten Link Between Contraction and Coronary Flow
Kassiotis, C., Rajabi, M., & Taegtmeyer, H. (2008) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2007.11.005 · Cited by 52 · see citing works
Self-citationDistel, E., Penot, G., Cadoudal, T., Balguy, I., Durant, S., & Benelli, C. (2012) · Biochimie · doi:10.1016/j.biochi.2012.04.014 · Cited by 49 · see citing works
Chima, R. S., Hake, P. W., Piraino, G., Mangeshkar, P., Denenberg, A. G., & Zingarelli, B. (2008) · Critical Care Medicine · doi:10.1097/ccm.0b013e318187810e · Cited by 48 · see citing works
Adaptive Cardiac Metabolism Under Chronic Hypoxia: Mechanism and Clinical Implications
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Maharajan, M. K., & Quine, S. D. (2011) · Food Research International · doi:10.1016/j.foodres.2011.09.018 · Cited by 47 · see citing works
Amin, R., Mathews, S. T., Alli, A., & Leff, T. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01032.2009 · Cited by 45 · see citing works
Assessment of myocardial metabolism in diabetic rats using small-animal PET: a feasibility study.
Welch, M. J., Lewis, J. S., Kim, J., Sharp, T. L., Dence, C. S., Gropler, R. J., & Herrero, P. (2006) · PubMed · Cited by 43 · see citing works
Ouwens, D. M., & Diamant, M. (2007) · Archives of Physiology and Biochemistry · doi:10.1080/13813450701422633 · Cited by 41 · see citing works
Nonischemic heart failure in diabetes mellitus
Guha, A., Harmancey, R., & Taegtmeyer, H. (2008) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e3282fcc2fa · Cited by 40 · see citing works
Self-citationHuang, T. H.-W., He, L., Qin, Q., Yang, Q., Peng, G., Harada, M., Qi, Y., YAMAHARA, J., Roufogalis, B. D., & Li, Y. J. (2007) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2007.00750.x · Cited by 39 · see citing works
Improvement of mechanical heart function by trimetazidine in db/db mice
Li, Y., Wang, P., Chen, C., Zou, M., & Wang, D. W. (2010) · Acta Pharmacologica Sinica · doi:10.1038/aps.2010.31 · Cited by 39 · see citing works
Festuccia, W. T., Laplante, M., Brûlé, S., Houde, V. P., Achouba, A., Lachance, D., Pedrosa, M. L., Silva, M. E., Guerra‐Sá, R., Couët, J., et al. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.04.011 · Cited by 38 · see citing works
Metabolic (In)Flexibility of the Diabetic Heart
Larsen, T. S., & Aasum, E. (2008) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-008-6083-1 · Cited by 37 · see citing works
20years of leptin: Role of leptin in cardiomyocyte physiology and physiopathology
Feijóo‐Bandín, S., Portolés, M., Roselló‐Lletí, E., Rivera, M., González‐Juanatey, J. R., & Lago, F. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.02.016 · Cited by 39 · see citing works
Bariatric surgery to unload the stressed heart: a metabolic hypothesis
Algahim, M. F., Sen, S., & Taegtmeyer, H. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00626.2011 · Cited by 36 · see citing works
Self-citationBurgmaier, M., Sen, S., Philip, F., Wilson, C. R., Miller, C. C., Young, M. E., & Taegtmeyer, H. (2010) · Obesity · doi:10.1038/oby.2009.500 · Cited by 33 · see citing works
Self-citationHeart failure progression is accelerated following myocardial infarction in type 2 diabetic rats
Chandler, M. P., Morgan, E. E., McElfresh, T. A., Kung, T. A., Rennison, J. H., Hoit, B. D., & Young, M. E. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01338.2006 · Cited by 33 · see citing works
Self-citationIn Vivo Metabolic Phenotyping of Myocardial Substrate Metabolism in Rodents
Shoghi, K. I., Finck, B. N., Schechtman, K. B., Sharp, T. L., Herrero, P., Gropler, R. J., & Welch, M. J. (2009) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.108.843227 · Cited by 30 · see citing works
Diabetic cardiomyopathy: the need for adjusting experimental models to meet clinical reality
Lezoualc’h, F., Badimón, L., Baker, H. E., Bernard, M., Czibik, G., de Boer, R. A., d’Humières, T., Kergoat, M., Kowala, M. C., Rieusset, J., et al. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac152 · Cited by 29 · see citing works
Myocardial fatty acid utilization as a determinant of cardiac efficiency and function
Jaswal, J. S., & Ussher, J. R. (2009) · Clinical Lipidology · doi:10.2217/clp.09.18 · Cited by 29 · see citing works
Hovsepian, E., Penas, F., & Goren, N. (2010) · Shock · doi:10.1097/shk.0b013e3181cdc398 · Cited by 29 · see citing works
Kanda, S., Nakashima, R., Takahashi, K., Tanaka, J., Ogawa, J., Ogata, T., Yachi, M., Araki, K., & Ohsumi, J. (2009) · Journal of Pharmacological Sciences · doi:10.1254/jphs.09084fp · Cited by 27 · see citing works
The diabetic, hypertensive heart: epidemiology and mechanisms of a very high-risk situation
Franjic, B., & Marwick, T. H. (2009) · Journal of Human Hypertension · doi:10.1038/jhh.2009.43 · Cited by 24 · see citing works
Edgley, A. J., Thalén, P., Dahllöf, B., Lanne, B., Ljung, B., & Oakes, N. D. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.03.058 · Cited by 24 · see citing works
Sakamoto, A., Hongo, M., Furuta, K., Saito, K., Nagai, R., & Ishizaka, N. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.01.007 · Cited by 23 · see citing works
Myocardial Ischemic‐reperfusion Injury in a Rat Model of Metabolic Syndrome
Mozaffari, M. S., & Schaffer, S. W. (2008) · Obesity · doi:10.1038/oby.2008.356 · Cited by 23 · see citing works
O-GlcNAcylation, an original modulator of contractile activity in striated muscle
Cieniewski‐Bernard, C., Montel, V., Stevens, L., & Bastide, B. (2009) · Journal of Muscle Research and Cell Motility · doi:10.1007/s10974-010-9201-1 · Cited by 21 · see citing works
Palanivel, R., Vu, V. P., Park, M. S., Fang, X., & Sweeney, G. (2008) · Journal of Endocrinology · doi:10.1677/joe-08-0336 · Cited by 21 · see citing works
Cardiac energy metabolism in diabetes: emerging therapeutic targets and clinical implications
Panwar, A., Malik, S. O., Adib, M., & Lopaschuk, G. D. (2025) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00615.2024 · Cited by 19 · see citing works
Baranowski, M., Błachnio-Zabielska, A. U., Zabielski, P., & Górski, J. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.05.015 · Cited by 18 · see citing works
The Diabetic Cardiorenal Nexus
D’Elia, J. A., Bayliss, G. P., & Weinrauch, L. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137351 · Cited by 17 · see citing works
Madhesh, M., & Vaiyapuri, M. (2013) · The Egyptian Heart Journal · doi:10.1016/j.ehj.2013.02.005 · Cited by 17 · see citing works
Pôrto, L. C. J., Castro, C. H., Savergnini, S. Q., Santos, S. H. S., Ferreira, A. V. M., Cordeiro, L. M. D. S., Sobrinho, D. B. D. S., Santos, R. A. S., Almeida, A. P., & Botion, L. M. (2012) · Life Sciences · doi:10.1016/j.lfs.2011.12.012 · Cited by 17 · see citing works
Melo, T., Domingues, P. M., Ribeiro‐Rodrigues, T., Girão, H., Segundo, M. A., & Domingues, M. R. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.02.033 · Cited by 16 · see citing works
Diabetic Cardiomyopathy – to Take a Long Story Serious
Stratmann, B., Gawlowski, T., & Tschoepe, D. (2010) · Herz · doi:10.1007/s00059-010-3336-0 · Cited by 15 · see citing works
Lipoprotein lipase-derived fatty acids: Physiology and dysfunction
Lee, J., & Goldberg, I. J. (2007) · Current Hypertension Reports · doi:10.1007/s11906-007-0085-4 · Cited by 16 · see citing works
Thackeray, J. T., deKemp, R. A., Beanlands, R. S., & DaSilva, J. N. (2014) · Journal of Nuclear Cardiology · doi:10.1007/s12350-014-9900-x · Cited by 12 · see citing works
Yang, H.-I., Kim, W. S., Kim, D.-H., & Kang, J. S. (2013) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2012.101 · Cited by 12 · see citing works
Finck, B. N. (2006) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.4.2.161 · Cited by 12 · see citing works
Taegtmeyer, H., Dilsizian, V., & Dilsizian, V. (2012) · Springer eBooks · doi:10.1007/978-1-4614-5551-6_8 · Cited by 11 · see citing works
Self-citationMyocardial metabolism of triacylglycerol‐rich lipoproteins in type 2 diabetes
Niu, Y., & Evans, R. D. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.173542 · Cited by 11 · see citing works
Myocardial and metabolic dysfunction in type 2 diabetic rats: impact of ghrelin
Hussein, A. M., Abdel‐Aziz, A., Gabr, M., & Hemmaid, K. Z. (2012) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y11-103 · Cited by 11 · see citing works
Fueling the Heart: Multiple Roles for Cardiac Metabolism
Taegtmeyer, H. (2007) · Springer eBooks · doi:10.1007/978-1-84628-715-2_53 · Cited by 11 · see citing works
Self-citationShen, X., Bhatt, N., Xu, J., Meng, T., Aon, M. A., O'Rourke, B. P., Berkowitz, D. E., Cortassa, S. C., & Gao, W. D. (2014) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.113.211144 · Cited by 8 · see citing works
Pôrto, L. C. J., Savergnini, S. Q., Castro, C. H., Mário, É. G., Ferreira, A. V. M., Santos, S. H. S., Andrade, S. P., Santos, R. A. S., Almeida, A. P., & Botion, L. M. (2011) · Therapeutic Advances in Cardiovascular Disease · doi:10.1177/1753944710386282 · Cited by 8 · see citing works
Virchow's Metamorphosis Revealed
Taegtmeyer, H., & Harmancey, R. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.06.024 · Cited by 7 · see citing works
Self-citationPioglitazone Attenuates Acute Cocaine Toxicity in Rat Isolated Heart
Weinberg, G. L., Ripper, R. L., Bern, S., Lin, B., Edelman, L. B., DiGregorio, G., Piano, M. R., & Feinstein, D. L. (2011) · Anesthesiology · doi:10.1097/aln.0b013e318218a7f6 · Cited by 4 · see citing works
Howarth, F. C., Qureshi, M. A., Hassan, Z. A., Kury, L. A., Isaev, D. S., Parekh, K. A., Yammahi, S. R. R. K. D., John, A., Öz, M., Raza, H., et al. (2012) · Hamdan Medical Journal · doi:10.7707/hmj.v5i2.140 · Cited by 4 · see citing works
Role of FDG-PET in Evaluation of Myocardial Viability
Molchanova-Cook, O. P., & Chen, W. (2011) · PET Clinics · doi:10.1016/j.cpet.2011.08.003 · Cited by 4 · see citing works
Hypolipidaemic effects of high-dose insulin therapy
Evans, R. D., & Niu, Y. (2008) · British Journal of Anaesthesia · doi:10.1093/bja/aen027 · Cited by 3 · see citing works
Taegtmeyer, H. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-381510-1.00015-6 · Cited by 2 · see citing works
Self-citationA Short Literature Review on Diabetic Cardiomyopathy in Obese Conditions
(2014) · Journal of Obesity & Weight loss Therapy · doi:10.4172/2165-7904.1000236 · Cited by 1 · see citing works
Un contrato de empeño y un poder en un documento hebreo de Tudela
Riaño, J. L. L. (1984) · Sefarad · Cited by 1 · see citing works
Barretti, D. L. M., do Carmo, E. C., Rosa, K. T., Irigoyen, M. C., & de Oliveira, E. M. (2011) · Revista Brasileira de Educação Física e Esporte · doi:10.1590/s1807-55092011000400005 · Cited by 1 · see citing works
Diabetic cardiomyopathy: phenotypes, mechanisms, and therapeutic targets
Johnson, E. J. (2015) · Research Exchange (Washington State University) · Cited by 1 · see citing works
Metabolic Regulation of mTOR Activation and Endoplasmic Reticulum Stress in the Heart
Sen, S. (2012) · Digital Commons-TMC (Texas Medical Center)
Bhuvaneshwari, R., Narmadha, R., Gomathi, D., Kalaiselvi, M., & Devaki, K. (2014) · Jordan Journal of Pharmaceutical Sciences
Perret, P., Slimani, L., Barone‐Rochette, G., Vollaire, J., Briat, A., Ahmadi, M., Henri, M., Desruet, M.-D., Clerc, R., Broisat, A., et al. (2021) · Journal of Nuclear Cardiology · doi:10.1007/s12350-020-02520-7
Lacôte, M. (2018) · theses.fr (ABES) · doi:10.70675/bc9b8426z5718z40e1zadc2zaa52fb20a6fd
- Authors
- Golfman, L. S., Wilson, C. R., Sharma, S., Burgmaier, M., Young, M. E., Guthrie, P. H., Van Arsdall, M., Adrogue, J. V., Brown, K. K., & Taegtmeyer, H.
- Affiliations
- The University of Texas Health Science Center at Houston (US)
- GlaxoSmithKline (United Kingdom) (GB)
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2005-08
- Volume
- 289
- Issue
- 2
- Pages
- E328-E336
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2133874700
- Cited by
- 99
- References
- 56
- Citations by year
- 2025: 1 · 2022: 3 · 2021: 5 · 2020: 1 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 6 · 2014: 5 · 2013: 2 · 2012: 10
- FWCI
- 3.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- GlaxoSmithKline
- Studienstiftung des Deutschen Volkes
- National Heart, Lung, and Blood Institute (R01-HL-43133, R01-HL-73162, T32HL007591, R01HL073162, T32-HL 07591, R01HL043133)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- PPARγ activation, cardiac contractile function, insulin resistance, type 2 diabetes, Zucker diabetic fatty rats, GLUT4, GLUT1, beta-myosin heavy chain, hyperinsulinemia, hyperglycemia, dyslipidemia, myocardial metabolism
- MeSH terms
- Adaptation, Physiological, Animals, Diabetes Mellitus, Type 2, Disease Models, Animal, Energy Metabolism, Gene Expression Regulation, Glucose, Insulin Resistance, Male, Myocardial Contraction, Myocardium, Oxazoles, Rats, Inbred Strains, Rats, Zucker, Triglycerides, Tyrosine, Signal Transduction, Transcriptional Activation, PPAR gamma, Rats, In Vitro Techniques
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