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Cited by 79Cardiac Ischemia and ReperfusionCardiovascular Function and Risk FactorsDiabetes, Cardiovascular Risks, and Lipoproteins

Glucose and insulin improve cardiac efficiency and postischemic functional recovery in perfused hearts from type 2 diabetic (db/db) mice

Hafstad, Anne D., Khalid, Ahmed M., How, Ole-Jakob, Larsen, Terje S., Aasum, Ellen·2007·American Journal of Physiology-Endocrinology and Metabolism
DOI 10.1152/ajpendo.00504.2006
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Abstract

Hearts from type 2 diabetic ( db/ db) mice demonstrate altered substrate utilization with high rates of fatty acid oxidation, decreased functional recovery following ischemia, and reduced cardiac efficiency. Although db/ db mice show overall insulin resistance in vivo, we recently reported that insulin induces a marked shift toward glucose oxidation in isolated perfused db/ db hearts. We hypothesize that such a shift in metabolism should improve cardiac efficiency and consequently increase functional recovery following low-flow ischemia. Hearts from db/ db and nondiabetic ( db/+) mice were perfused with 0.7 mM palmitate plus either 5 mM glucose (G), 5 mM glucose and 300 μU/ml insulin (GI), or 33 mM glucose and 900 μU/ml insulin (HGHI). Substrate oxidation and postischemic recovery were only moderately affected by GI and HGHI in db/+ hearts. In contrast, GI and particularly HGHI markedly increased glucose oxidation and improved postischemic functional recovery in db/ db hearts. Cardiac efficiency was significantly improved in db/ db, but not in db/+ hearts, in the presence of HGHI. In conclusion, insulin and glucose normalize cardiac metabolism, restore efficiency, and improve postischemic recovery in type 2 diabetic mouse hearts. These findings may in part explain the beneficial effect of glucose-insulin-potassium therapy in diabetic patients with cardiac complications.

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Crossref · 10.1152/ajpendo.00504.2006

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  • Treatment with PPAR-γ or PPAR-α agonists while improving myocardial substrate utilization did not increase postischemic recovery in db/db hearts, but acute treatment with high concentrations of glucose and insulin increased postischemic recovery and cardiac efficiency.

    “Treatment with PPAR-γ or PPAR-α agonists while improving myocardial substrate utilization did not increase postischemic recovery in db/db hearts (3, 36), but acute treatment with high concentrations of glucose and insulin, which substantially increased glucose oxidation rates, increased postischemic recovery and cardiac efficiency (90).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [90]

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Authors
Hafstad, A. D., Khalid, A. M., How, O.-J., Larsen, T. S., & Aasum, E.
Affiliations
UiT The Arctic University of Norway (NO)
ORCID
Venue
American Journal of Physiology-Endocrinology and Metabolism
Publisher
American Physiological Society
Published
2007-05
Volume
292
Issue
5
Pages
E1288-E1294
ISSN
  • 0193-1849 (ISSN-L)
  • 1522-1555
DOI
10.1152/ajpendo.00504.2006
OpenAlex
W2067659080
Cited by
79
References
37
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 1 · 2018: 4 · 2017: 1 · 2016: 3 · 2015: 7 · 2014: 8 · 2013: 5 · 2012: 6
FWCI
4.48
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Harvard Global Health Institute
  • Helse Nord RHF
  • Diabetesforbundet
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
type 2 diabetes, db/db mice, insulin, glucose, cardiac efficiency, myocardial ischemia, postischemic recovery, substrate oxidation, glucose oxidation, fatty acid oxidation, palmitate, insulin resistance, diabetic cardiomyopathy
MeSH terms
Animals, Aorta, Cardiac Output, Diabetes Mellitus, Type 2, Female, Glucose, Insulin, Male, Mice, Inbred C57BL, Myocardium, Oxidation-Reduction, Oxygen Consumption, Palmitates, Regression Analysis, Ventricular Function, Left, Myocardial Ischemia, Mice, In Vitro Techniques

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